Evaluating the influence of anti-PD-1 immunotherapy combined with IMRT on thyroid dysfunction in nasopharyngeal carcinoma by Liqianqi Chen, Zihuang Li, Xianming Li, Shihai Wu, Long Gong, Gang Xu, Shanyi Chen, Yucong Zhang

“…Data collected included smoking status, BMI, presence of thyroid nodules, staging, treatment modality, thyroid mean dose (Dmean), percentage of thyroid volume receiving more than x Gy, pituitary mean dose (Dmean), and TSH and FT4 levels per cycle. T-tests, rank-sum tests, multivariate logistic regression analysis, ROC curves, and Cox proportional hazards models were used to evaluate the effects of anti-PD-1 immunotherapy combined with chemoradiotherapy on thyroid function.ResultsPatients with pre-treatment smoking history, thyroid nodules, and cervical lymph node metastasis were more likely to develop thyroid dysfunction (P<0.05). …”
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Surface crack growth subject to bending and biaxial tension-compression by V. Shlyannikov, A. Tumanov, A. Zakharov, A. Gerasimenko

“…For the experimental surface crack paths in tested specimens the T-stress, the local triaxiality parameter h, the out-of-plane TZ factor and the governing parameter for the 3D-fields of the stresses and strains at the crack tip in the form of In-integral were calculated as a function of aspect ratio by finite element analysis to characterization of the constraint effects along semi-elliptical crack front. …”
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Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia by Aris Kaltsas, Sofoklis Stavros, Zisis Kratiras, Athanasios Zikopoulos, Nikolaos Machairiotis, Anastasios Potiris, Fotios Dimitriadis, Nikolaos Sofikitis, Michael Chrisofos, Athanasios Zachariou

“…<b>Methods</b>: A comprehensive literature review was conducted, examining studies on clinical and hormonal factors, imaging techniques, molecular biology biomarkers, and genetic testing related to TESE outcomes in NOA patients. …”
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Integrative analysis of seed morphology, geographic origin, and genetic structure in Medicago with implications for breeding and conservation by Seunghyun Lim, Sunchung Park, Insuck Baek, Jacob Botkin, Jae Hee Jang, Seok Min Hong, Brian M. Irish, Moon S. Kim, Lyndel W. Meinhardt, Shaun J. Curtin, Ezekiel Ahn

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Statistical assessment of the activity of collective accommodation facilities and their contribution to the economy of the Russian Federation regions by V. N. Salin, M. V. Vakhrameeva, V. V. Narbut

“…The study focuses on:analysis of the activity of collective accommodation facilities on the territory of Russia,testing the hypothesis that the differences in the main indicators, characterizing the activity of collective accommodation facilities are due to the influence of the territorial factor,evaluate the efficiency of functioning of collective accommodation facilities and their profitability, and highlight the regions of Russia with low, medium and high levels of profitability of tourist accommodation facilities,assess the contribution of the activity of collective accommodation facilities for tourists to the economy of the regions of Russia. …”
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Invasive Vagus Nerve Stimulation Activates Microglia α7nAChR to Reduce Striatal Neuroinflammation in Mouse Model of Parkinson's Disease and Its Mechanism by GENG Yao, WANG Ruiyu, ZHU Zhuang, SHEN Ying, ZHANG Kezhong

“…The rotarod test was used to detect the balance and coordination function of each group. …”
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Case Report: Beyond type 1 diabetes: a case of delayed MODY1 diagnosis and successful transition to sulfonylurea therapy by Chiara Gulisano, Concetta Aloi, Alessandro Salina, Camilla Marazzi, Giordano Spacco, Serena Cappato, Renata Bocciardi, Renata Bocciardi, Dario Iafusco, Giacomo Tantari, Giuseppe d'Annunzio, Nicola Minuto, Mohamad Maghnie, Marta Bassi, Francesca Faravelli

“…Initially diagnosed with Type 1 diabetes (T1D), she required low insulin doses and displayed negative autoimmune markers. Genetic testing revealed the heterozygous variant inherited from her father and functional studies confirmed the variant's impact on splicing. …”
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The abundance and sett ecological characteristics of the Asian badger (Meles leucurus) in the Northeast Tiger and Leopard National Park (NE China) by Jiawei Li, Dongrui Li, Yanwen Fu, Yiwen Ma, Jianping Ge, Limin Feng

“…The sett is a crucial resource for badgers, serving various functions and significantly influencing their spatial ecology. …”
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A spectrum of cysteine mutations in fibulin-3 highlight its disulfide bonding complexity and potential to induce ER stress by Gracen E. Collier, Anna L. Roovers, John D. Hulleman

“…These cysteines, which are distributed across one atypical and five canonical calcium-binding epidermal growth factor (EGF) domains, are important for regulating FBLN3 structure, secretion, and presumably function. …”
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Model for predicting risk of developing drug-induced liver injury during remdesivir therapy: observational prospective open case-control study by Yu. V. Shevchuk, A. V. Kryukov, I. I. Temirbulatov, I. V. Sychev, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev

“…According to a number of studies, the incidence of adverse reactions during remdesivir therapy reaches 66%, with the most common is an increase in liver function tests.The aim of the work was to study the influence of clinical, demographic and pharmacogenetic factors on the development of drug-induced liver damage during remdesivir therapy in COVID-19 patients.Materials and methods. …”
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GDP per capita vs foreign direct investment: key drivers of a country's technological leadership by Aleksy Kwilinski

“…The research covers 21 developed countries across Western Europe, the Americas, Asia, Africa, and Australia, for the period 2011 to 2022. The Bartlett test, Kaiser-Meyer-Olkin (KMO) criterion, and exploratory factor analysis (EFA) were employed to identify the most relevant indicators for the study. …”
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Bayesian Optimized ANFIS Network Using Grid Partition and Feature Spectrum for Urban Light Pollution Assessment by Nuoqi Wang, Cheng Wang, Zhihong Zhao, Peiyu Wu, Wenqian Xu, Bang Qin, Dong Wang, Rongjun Zhang, Qi Yao

“…To alleviate this challenge, we selected a low-cost smartphone camera sensor as an alternative tool and investigated the various factors that could influence the accuracy of the measurements by controlling the function of the sensor and assessing its performance, including light illumination conditions and device parameters. …”
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Biostimulatory Effects of Foliar Application of Silicon and <i>Sargassum muticum</i> Extracts on Sesame Under Drought Stress Conditions by Soukaina Lahmaoui, Rabaa Hidri, Hamid Msaad, Omar Farssi, Nadia Lamsaadi, Ahmed El Moukhtari, Walid Zorrig, Mohamed Farissi

“…However, drought stress remains one of the most significant abiotic factors influencing its development, physiological function, and overall output. …”
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The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol by Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, Sarah Brode, Theodore K. Marras, Ryan Cooper, Maeve Smith, Julie Jarand

“…It aims to enrol at least 2000 participants to collect data such as medical history, aetiological assessments, lung function tests, microbiological profiles, radiographic evaluations, comorbidities and quality of life (QoL) metrics. …”
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Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus by Akanksha Bafna, Gareth Banks, Vadim Vasilyev, Robert Dallmann, Michael H Hastings, Patrick M Nolan

“…Here, we used chromatin immunoprecipitation sequencing to map the genomic localization of ZFHX3-binding sites in SCN chromatin. To test for function, we then conducted comprehensive RNA sequencing at six distinct times-of-day to compare the SCN transcriptional profiles of control and ZFHX3-conditional null mutants. …”
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Correlation between mitral annular plane systolic excursion (MAPSE) at different degrees of ejection fraction in patients with diabetes mellitus by Muhammad Rido, Khalid Saleh, A. Makbul Aman, Syakib Bakri, Haerani Rasyid, Andi Alfian Zainuddin

“…Diabetic cardiomyopathy is characterized by myocardial structure and function abnormality in the absence of other cardiovascular risk factors. …”
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Training to Move an Evidence-based Dementia Caregiver Support Program into Practice: A pragmatic, randomized, non-inferiority trial protocol by Nancy A. Hodgson, Miranda V. McPhillips, Karen B. Hirschman, Emily Summerhayes, Catherine Verrier Piersol, Laura N. Gitlin

“…The study utilizes a type III hybrid effectiveness design with a primary focus on measuring implementation factors and a secondary focus on measuring COPE effectiveness through caregiver and patient outcomes and therapeutic alliance. …”
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Insights into the interplay among zinc, biological aging, fasting, energy intake, and inflammation: A cross-sectional analysis using 2015-2018 NHANES participants by Rebecca Lake, Juan Liuzzi, Changwon Yoo

“…Introduction: Although it is documented that zinc plays an essential role in immune function, little is known about its relationship to factors that influence biological aging. …”
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Immunohistochemical analysis of microglial changes in the experimental acute hepatic encephalopathy by T. V. Shulyatnikova

“…Hepatic encephalopathy (HE) is a syndrome of impaired brain function in patients with advanced liver failure and it manifests in form of psychometric tests alterations up to decreased consciousness and coma. …”
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The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease by Akbar Nouri-habashi, Sajad Ahmadizad, Morteza Salimian, Hiwa Rahmani

“…It seems that regular high-intensity exercise may improve platelet function, due to a decrease in CD62P expression and an increase in sensitivity to NO production by endothelial cells.…”
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