Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
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Interleukin-2 Receptor as a Marker of Oxidative Stress in Paediatric Patients with Chronic Kidney Disease or Hypertension by Nataša Marčun Varda, Mirjam Močnik, Martina Filipič, Evgenija Homšak, Mateja Svetej, Sonja Golob Jančič

“…Interleukin-2 receptor levels exhibited significant negative correlations with various anthropometric measurements, body composition, and liver damage and a positive correlation with kidney function tests. <b>Conclusions</b>: Children diagnosed with hypertension or obesity exhibited notably lower interleukin-2 receptor levels.…”
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Primary prevention of cardiotoxicity in cancer patients treated with fluoropyrimidines: a randomized controlled trial by Johanne D. Lyhne, Vibeke B. Hansen, Lone D. Vestergaard, Susanne E. Hosbond, Martin Busk, Mayooran Gnanaganesh, Else Maae, Birgitte M. Havelund, Torben F. Hansen, Signe Timm, Lars H. Jensen, Mads D. Lyhne

“…Data were analyzed using Kaplan–Meier survival function with log-rank test and ROC-analyses. Results Of the 192 patients included, the primary endpoint occurred in 9/95 (9.5%) patients in the intervention group and 15/97 (15.5%) patients in the control group (log-rank p = 0.19) with an incidence rate ratio (IRR) of 0.57 (95% CI [0.22 – 1.39]). …”
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Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment by Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic, Andrew Gumbert, Jack Bergman, Preston Ge, Myriam Heiman, Marie-Eve Di Raddo, Sarah L. Withey, Bertha K. Madras, Susan R. George

“…Primary rat astrocyte cultures provided mechanistic insight into THC activation of astrocyte inflammatory function. Results: THC-induced upregulation of GFAP and complement factor-B (CF-B) signified proinflammatory glial activation exclusively in the adolescent amygdala, an effect absent in other brain regions and in adults. …”
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Exposure to Silica, Arsenic, and Chromium (VI) in Cement Workers: A Probability Health Risk Assessment by Noor Haziqah Kamaludin, Juliana Jalaludin, Shamsul Bahri Mohd Tamrin, Abdah Md Akim, Tri Martiana, Noeroel Widajati

“…The Fractional Exhaled Nitric Oxide levels and lung function test were obtained by using NIOX MINO and Chestgraph H1-105 spirometer. …”
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Research on the Effects of Chemotherapy on Survival Outcomes for Older Patients with Primary Triple-Negative Breast Cancer after Surgery: A Propensity Score Matching and Competing... by Chongwu He, Jing Chen, Bing Hu, Ming Jiang, Ru Chen, Jianglong Li, Gongxian Wang, Tenghua Yu

“…We used propensity score matching (PSM), cumulative incidence function (CIF) and multivariate Fine and Gray competitive risk analyses to explore the effects of chemotherapy on survival for older patients with primary TNBC after surgery. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…The investigation of immune cell infiltration and possible functional enrichment followed. Additionally, tissue chips containing regional liver cancer specimens were used to confirm ACTR6 expression and the clinical impact of prognosis using an immunohistochemistry (IHC) test. …”
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Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military... by Michele L Okun, Jennifer L Payne, Lauren M Osborne, Leilani Feliciano, Andrew Lac

“…Six separate mixed 2 (treatment vs control) × 6 (assessment period) multivariate analysis of variance and analysis of variance models will be conducted to test the hypotheses that SB will have a greater impact on infant and maternal sleep than TB, SB will be associated with a greater reduction in postpartum mood symptoms than TB, and immune system function will be less dysregulated in birthing individuals using SB compared to those using TB. …”
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The Paradox of Clean Eating: Neuroactive Dysbiosis and Pesticide Residues in Fruit- and Vegetable-Based Diets by Ramona Alina Tomuța, Andrada Florina Moldovan, Loredana Matiș, Lavinia Maris, Timea Claudia Ghitea, Florin Banica

“…Markers of proinflammatory activity, such as LPS-positive bacteria and histamine producers, were also elevated. (4) Conclusions: These findings suggest that even in diets rich in plant-based foods, microbial dysbiosis with neuroactive relevance can occur, potentially linked to environmental or dietary factors. The study underscores the need for a comprehensive evaluation of food safety and microbiome function as interconnected determinants of neurological health.…”
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Prostaglandin endoperoxide synthase 2 regulates neuroinflammation to mediate postoperative cognitive dysfunction in mice by Xuelian Li, Xuemei Li, Qixin Zhang, Yiyun Li, Yingshun Zhou, Jun Zhou, Xiaoxia Duan

“…The Morris water maze test was used to assess the cognitive function. PTGS2 expression in the hippocampus and plasma was measured. …”
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Differences in perceived chromatic aberration between emmetropic and myopic eyes using adaptive optics by Victor Rodriguez-Lopez, Paulina Dotor-Goytia, Elena Moreno, Maria Vinas-Pena

“…However, in the myopic group, CDF was similar in absolute value for G-Blue and G-Red (0.61 ± 0.34 and 0.73 ± 0.58, respectively, p &gt; 0.05 Mann-Whitney U test), whereas, in the emmetropic group, the chromatic difference was greater for G-Blue than for G-Red (0.58 ± 0.32 D and 0.22 ± 0.38 D, respectively, p &lt; 0.05 Mann-Whitney U test). …”
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Activities of daily living mediate the association between balance and falls in middle aged and older adults by Jiaran Jiang, Quan Zhou, Chuanxia Zhang, Keer Cong

“…Balance ability was assessed using the Short Physical Performance Battery (SPPB), while ADL were evaluated through the CHARLS ADL questionnaire. Demographic factors and health-related indicators were incorporated as covariates.Data analysis was conducted in StataMP 17, employing chi-square tests, independent samples t-tests, correlation analysis, and parallel mediation analysis. …”
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Self-Adjusting Look-Ahead Distance of Precision Path Tracking for High-Clearance Sprayers in Field Navigation by Xu Wang, Bo Zhang, Xintong Du, Huailin Chen, Tianwen Zhu, Chundu Wu

“…Finally, this algorithm was verified in simulations and bumpy field tests under various different conditions, with the average value of the lateral error reduced by more than 0.06 m and the tuning steps also significantly reduced compared to the fixed look-ahead distance in field tests. …”
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Improvement of Glycogenic Hepatopathy With Minimal Corresponding Improvement of Glycemic Control in a Person With Type 1 Diabetes: Case Report and Literature Review by Joselyn Tessa Tonleu, BS, Nicolas A. Reyes, MD, Natalie D. Hillerson, MD, William B. Horton, MD, MSc, FACP

“…At laboratory reassessment 3 weeks later, liver function tests remained elevated and hepatic ultrasound was unrevealing. …”
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An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. by Sophie Thiolloy, James R Edwards, Barbara Fingleton, Daniel B Rifkin, Lynn M Matrisian, Conor C Lynch

“…Given the role of MMP-2 in extracellular matrix degradation and growth factor/cytokine processing, we tested whether osteoblast derived MMP-2 contributed to the vicious cycle of tumor progression in the bone microenvironment.…”
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Predicting Cervical Lymph Node Metastasis Using Preoperative Multiparameter Data Based on Imaging, Serology, and Clinical Features in Unifocal Papillary Thyroid Carcinoma by Junlin HE, Wenjing CHEN, Lili HU, Yongsheng WANG, Jing CHEN, Ming WU

“…Radiologists with varying levels of experience analyzed the multiparameter data, including clinical features, CT, ultrasound, and thyroid function tests. The correlation between these characteristics and CLNM was assessed using univariate analysis, and independent risk factors (IRFs) were identified via forward selection in multivariate logistic regression analysis. …”
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Construction of a Surface Roughness and Burr Size Prediction Model Through the Ensemble Learning Regression Method by Ali Khosrozadeh, Seyed Ali Niknam, Fatemeh Hajizadeh

“…Therefore, burr size cannot be formulated simply as a function of direct parameters. This study proposes an ensemble learning regression model to accurately predict burr size and surface roughness during the slot milling of aluminum alloy (AA) 6061. …”
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Exploring the relationship between life expectancy at birth and economic growth in 56 developing countries by Metin Gürler, Özlem Özsoy

“…In traditional economic growth theory, labour force which is one of the factors of production function has got an important effect on the country's economic growth. …”
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The dichotomy of human decision-making: An experimental assessment of stone tool efficiency. by David Nora, João Marreiros, Walter Gneisinger, Antonella Pedergnana, Telmo Pereira

“…In addition, it may be pertinent to extend this approach to other blunt artefactssuch as scrapers, burins, anvils, and hammerstones when investigating aspects of interconnected behaviours such as artefact variability, resource economy, group mobility, and site function. Such choices and decisions are coded in the archaeological record and represent cultural factors that were transmitted through learning and likely triggered the human decision-making process of past hunter-gatherers.…”
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The Comparison of Psychological Barriers Between Individuals with a History of Anterior Knee Pain, Anterior Cruciate Ligament Reconstruction, and Healthy Individuals by Emma F Zuk, Sungwan Kim, Julie P Burland, Neal R Glaviano

“…Mann-Whitney U tests were performed to determine where group differences occurred. …”
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