Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous. by Szu-Chieh Mei, Charles Brenner

“…However, levels of Sir2 and Pnc1, two enzymes that sequentially convert NAD+ to nicotinic acid (NA), are up-regulated during CR. To test whether factors such as NA might be exported by glucose-restricted mother cells to survive later generations, we developed a replicative longevity paradigm in which mother cells are moved after 15 generations on defined media. …”
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The contributions of fertility during adolescence to disability across the life-course: hypothesized causal pathways, research gaps, and future directions by Catherine M. Pirkle, Maria P. Velez, Tetine L. Sentell, Diego G. Bassani, Marlos R. Domingues, Saionara M. A. Câmara

“…Context Robust associations have been identified between fertility during adolescence and the disablement process, including pathologies, impairments, functional limitations and disability. Limited theoretical or empirical research considers how and why such relationships exist generally or with the individual associated components of disablement.Objective To consolidate and critically evaluate literature to describe testable, theory-based hypotheses to guide future research on the mechanisms by which fertility during adolescence contributes to disablement.Methods Targeted literature review of research from diverse global settings contextualised in two well-accepted theoretical frameworks in life-course epidemiology: the cumulative risk model and the critical period approach.Results Five hypothesised causal pathways linking adolescent fertility to disablement in later life are described: 1) Causal relationship initiated by fertility during adolescence; 2) Common cause(s) for both, such as adverse childhood experiences; 3) Contributing cause(s) to adolescent fertility; 4) Interaction between adolescent fertility and other risk factors; and 5) Critical period effects unique to adolescence. …”
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FEATURE-BASED IMPLEMENTATION OF MACHINE LEARNING ALGORITHMS FOR CARDIOVASCULAR DISEASE PREDICTION by H. Singh, R. Tripathy, P. Kumar Sarangi, U. Giri, S. Kumar Mohapatra, N. Rameshbhai Amin

“…Artificial brain (AI) in the shape of desktop studying (ML) allows software program purposes to predict results greater precisely whilst functioning unbiased of human input. This study employs various machine learning algorithms, including K-Nearest Neighbors, Support Vector Machine, Logistic Regression, Random Forest, Decision Tree, and Naïve Bayes, to assess their accuracy in predicting cardiovascular disease and related conditions This paper makes use of the UCI repository dataset for coaching and testing including some basic parameters such as age and sex. …”
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EXPERIENCE WITH THE DRUG MEMANTINE IN PATIENTS WITH FOCAL EPILEPSY AND COGNITIVE IMPAIRMENT by Yu. V. Solomatin, V. V. Kurbatova, I. E. Serdyuk, Yu. I. Logvinov, M. M. Shamokhova, S. G. Burd, A. V. Lebedeva

“…After the treatment, a statistically significant improvement in cognitive function based on the results of tests: Mini-mental state examination, clock drawing test, the test Luria test “symbols and numbers.” …”
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Relationship between foot posture and static and dynamic balance in athlete and non-athlete girls by Narmin Ghanizadeh hesar, Marzie Vakili, Behnam Ebrahimi

“…Conclusion:this research show that athletes have a propriate foot posture index and balance function. also we can probably say that fitness and neuro-muscular performance affect on balance more than biomechanic factors such as foot posture. …”
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Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life by Marco Lauriola, Manuela Tomai

“…Partial least squares structural equation modeling (PLS-SEM) was applied for model building and hypotheses testing. Results. We found a negative association between advanced stage and physical functioning, a strong positive link between physical functioning and mental health, and significant relations between mental health and helpless-hopelessness, anxious preoccupation, and cognitive avoidance. …”
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How Does Myofascial Physical Therapy Attenuate Pain in Chronic Pelvic Pain Syndrome? by Keren Grinberg, Irit Weissman-Fogel, Lior Lowenstein, Liora Abramov, Michal Granot

“…Morphologic assessment of the levator ani and quantitative sensory testing of the pain system were applied alongside with evaluation of pain-related psychological factors using designated questionnaires. …”
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Exploring the Acceptance and Application of a Humanoid Robot: Insights from Three Field Studies

“…Additionally, acceptance levels vary based on demographic factors such as age and familiarity with technology. …”
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Hypertensive Emergency and Atypical Hemolytic Uremic Syndrome Associated with Cocaine Use: A Diagnostic and Therapeutic Challenge by Elena Jiménez Mayor, José C. De La Flor, André Rocha Rodrigues, Celia Rodríguez Tudero, Rocío Zamora González-Mariño, Jacqueline Apaza, Esperanza Moral Berrio, Javier Deira Lorenzo

“…The patient was treated with therapeutic plasma exchange and four weekly doses of eculizumab, resulting in hematologic remission and significant improvement in renal function, without the need for dialysis. Genetic testing for known atypical HUS-associated mutations was negative; therefore, maintenance therapy with eculizumab was discontinued without clinical relapses. …”
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Low-density lipoprotein apheresis shows a rapid response to proteinuria due to C3 glomerulonephritis: a case report and literature review by Hideki Matsumura, Yuko Fujii, Tomoko Tanaka, Maki Kagitani, Akira Ashida

“…On the basis of histological findings and clinical course, the patient was diagnosed with C3GN. Genetic testing identified a rare complement B factor mutation linked to complement pathway dysregulation. …”
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Hypertension may lead to cognitive dysfunction in older adults via methylmalonic acid: evidence from NHANES 2011–2014 population by Ying Xu, Rucheng Chen, Paulus Torkki, Weijun Zheng, An Chen

“…Methods A total of 2762 adults (age > = 60 years) from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 participated. Cognitive function was assessed using a combination of the Animal Fluency Test (AFT), the Digit Symbol Substitution Test (DSST), and the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Learning Test. …”
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The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression by Di Luan, Yifan Li, Aini Zhang, Qingqing Bai, Te Zhao, Xi Chen, Xinglun Dang, Junyang Wang, Shaolei Jiang, Yun Sun, Yingjie Zhu, Yan Kong, Xiong-Jian Luo, Zhijun Zhang

“…Here, we aim to explore the regulatory function of rs1950834 on leucine-rich repeat and fibronectin type III domain containing 5 (LRFN5) expression in MDD. …”
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Pathogen Distribution, Drug Resistance, and Postoperative High-Quality Nursing Intervention Effectiveness in Knee Osteoarthritis Patients After Knee Arthroplasty With Postoperative... by Tang Y, Fu B, Tong Q

“…Deep wound exudate samples were collected from the infection group for pathogen culture, isolation, and identification. Drug susceptibility testing was performed using the K-B disk diffusion method. …”
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Features of heart failure with preserved ejection fraction (HFpEF) in diabetic patients with resistant hypertension by M. A. Manukyan, A. Y. Falkovskaya, V. F. Mordovin, T. R. Ryabova, I. V. Zyubanova, A. M. Gusakova, T. E. Suslova

“…All patients underwent baseline office and 24-hour BP measurement, echocardiography with assess diastolic function, lab tests (basal glycemia, HbA1c, creatinine, aldosterone, TNF-alpha, hsCRP, brain naturetic peptide, metalloproteinases of types 2, 9 (MMP-2, MMP-9) and tissue inhibitor of MMP type 1 (TIMP-1)). …”
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Assessment of Bite Force in Patients with Periodontitis Before and after Splinting in Anterior Teeth using Computerised Occlusal Analysis System: A Clinical Study by Sathyalakshmi Ravikumar, Dhanvanthraj Venkatesan, Tarunkumar Kanmani, Rajalakshmi Ashokkumar, Vamsi Lavu

“…Measuring bite force can yield valuable information for assessing the activity and function of the jaw muscles. Recording devices and techniques are important factors in obtaining bite force measurements. …”
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Mortality and outcome of acute kidney injury in hospitalized patients with cirrhosis, kidney injury and bacterial infection. by Karina Cazarin-Chávez, Paloma M. Diego-Salazar, Diego F. Abendaño-Rivera, Santiago Camacho-Hernández, Fatima Higuera-De la Tijera, José L. Pérez-Hernández

“…Conclusions: In patients with cirrhosis, AKI associated with IB increases mortality and worsens renal function outcome. Therefore, IB is not only a precipitant of cirrhosis decompensations but also represents a significant risk factor for a severe clinical course.…”
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Effect of FTY720 on Angiotensin Ⅱ-mediated chronic kidney diseases by HAN Qi, LI Ming-mei, YANG Guo-sheng, PENG Qing-ping, WANG Xiao-hui

“…Conclusions FTY720 can alleviate pathological damage of the kidney in rats induced by Ang Ⅱ, which may decrease urinary proteins and improve the renal function by reducing expression of inflammatory factors.…”
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Development and validation of a predictive model for frailty risk in older adults with cardiovascular-metabolic comorbidities by Lulu Yan, Lulu Yan, Entong Ren, Chenjiao Guo, Yuanyuan Peng, Hao Chen, Weihua Li

“…Binary logistic regression analyses revealed that depression, social activity, history of falls, life satisfaction, ADL scores, cognitive function, age and the number of CMDs were significantly associated with frailty. …”
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Adipose Tissue Dysfunction and Hepatic Steatosis in New-Onset Diabetes by Emilia Rusu, Mariana Jinga, Raluca Cursaru, Georgiana Enache, Adrian Costache, Ioana Verde, Andra Nica, Anca Alionescu, Florin Rusu, Gabriela Radulian

“…The biochemical assessment encompassed the measurements of fasting serum lipids, fasting plasma glucose (FPG), liver function tests, adiponectin, leptin, resistin, tumor necrosis factor (TNF-α), and interleukin 6 (IL-6). …”
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Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19 by Xiangyuan Chen, Niyuan Hu, Huifeng Han, Guoliang Cai, Ying Qin

“…Future research should further explore the mechanisms by which sedentary behavior, post-COVID-19 recovery status, and adaptation to cold environments collectively influence cardiovascular function and cerebral hemodynamics, providing a more comprehensive understanding of these factors.…”
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