GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy by Xiaoli Yang, Yong Li, Min Min, Nan Jiang, Lijuan Sun, Dandan Zhang, Yuan Cao, Yanhong Zhang, Yufei Wang, Hui Zhong, Xueping Ma, Qi Gao, Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Xufeng Hou, Muyi Liu, Xuemiao Zhang, Congwen Wei

“…In this study, we investigated the mechanism by which GP73 regulates T-cell-mediated antitumor immunity within the tumor microenvironment.Methods We used T-cell specific GP73 knockout mice to establish MC38 and B16 tumor models to investigate the impact of GP73-deficient T cells on tumor growth. …”
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A Study on the Possibility of Molecular Communication between Honey Bees and Sunflower through the Interspecies Transfer of Small RNAs by Leila Gharehdaghi, Gholamhosein Tahmasbi, Taher Harkinezhad

“…Therefore, the present study aims to investigate the molecular relationship between this beneficial social insect and its host plants through the dietary transfer of exogenous miRNAs, potentially illuminating new and extensive dimensions of the beneficial effects of this interaction. Methods: Pollens were collected using pollen traps from honeybee hives located on a sunflower farm in the Shal region of Qazvin, Iran, during thepeak flowering days of the plant. …”
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Evaluation the Effect of Seed Priming with Zinc Sulfate on Photosynthesis and Yield Components, of Two Varieties of Cowpea (Vigna unguiculata L.) under Water Deficit Stress by Sara Raisi Bidkani, Mohammad Javad Zarea

“…The experiment was carried out as a pot experiment in 2022 at the greenhouse of the Faculty of Agriculture, Ilam University. …”
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Study on physiological characteristics of fruit cracking of different jujube varieties by LIU Wei, WANG Jianyu, WANG Zhenlei, LIN Minjuan

“…[Methods] The fruits of Fucuim (easy cracking) and Dalizhizao (anti-cracking) were used as materials collected from the Jujube Germplasm Resource Nursery of the Horticultural Experiment Station of Tarim University. …”
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NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer by Guang Yang, Chengsheng Ding, Xiao Yang, Jiang Jiang, Shiyuan He, Yanfei Shao, Enkui Zhang, Xiaodong Fan, Xueliang Zhou, Ling Huang, Cindy Xinyu Zhang, Jing Sun, Yu Wang, Lu Zang, Minhua Zheng, Junjun Ma

“…Objective: Our study aimed to identify a novel mechanism by which NDRG1 affects CTX sensitivity. Methods: Through mass spectrometry analysis of our previously constructed CTX-resistant RKO and HCT116 cells, we found that the signal transducer and activator of transcription-1 (Stat1) might be a potential target of NDRG1. …”
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SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program by Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan

“…Spontaneous regression is often accompanied by tumor differentiation, but the mechanisms underlying this process remain largely unclear. Methods Single-nucleus transcriptomics (snRNA-seq) data of neuroblastoma samples were obtained from the Synapse repository to investigate the composition of heterogeneous tumor cell clusters. …”
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日本解決學力下降問題之政策分析： 以課綱修訂和全國學力測驗為主 The Policy Analysis to Solve Academic Decline in Japan– Course of Study and National Assessment of Academic Ability... by 李宜麟 Yi-Lin Lee, 楊思偉 Szu-Wei Yang

“…This survey aimed to evaluate student learning outcomes and use the results to refine curriculum, teaching methods, assessments, and teacher quality. Consequently, Japan saw an improvement in PISA and TIMSS scores, suggesting that its policies effectively addressed academic decline. …”
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MG53 deficiency mediated skeletal muscle dysfunction in chronic obstructive pulmonary disease via impairing mitochondrial fission by Liwei Liao, Ziwen Zheng, Mingming Deng, Weidong Xu, Qin Zhang, Zilin Wang, Chang Li, Jiaye Li, Yiding Bian, Kai Wang, Jinrui Miao, Ruixia Li, Yan Yin, Xiaoming Zhou, Gang Hou

“…The objective of this study is to explore the role of myokines and mitochondrial dysfunction in sarcopenia in chronic obstructive pulmonary disease. Methods: We identified mitsugumin 53 and its clinical correlation through an enzyme-linked immunosorbent assay using the plasma samples of patients with chronic obstructive pulmonary disease. …”
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In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup by Olga Sokol, Anders Tobias Frederiksen, Mateusz Sitarz, Brita Singers Sørensen, Elham Santina, Christopher Smith, John-William Warmenhoven, Marie Davídková, Anna Jelínek Michaelidesová, Irina Danilová, Oldřich Zahradníček, Amélia Maia Leite, Ludovic de Marzi, Frederic Pouzoulet, Paweł Olko, Justyna Miszczyk, Barbara Orzechowska, Eleftherios Papalanis, Mehran Hariri, Diana Spiegelberg, Bo Stenerlöw, Alexandru Dasu, Elisabeth Bodenstein, Elke Beyreuther, Jörg Pawelke, Dorothee Pfitzmann, Karen Kirkby, Nicholas Henthorn, Marco Durante

“…Background and purpose: This study presents a multi-center comparison of in vitro cell survival measurements and RBE calculations following proton irradiations conducted under harmonized experimental conditions across six European institutions participating in the INSPIRE framework. Materials and methods: V79-4 cells were irradiated using spread-out Bragg peak (SOBP) proton fields of two configurations delivering 6 and 8 Gy with widths of 6 and 4 cm, respectively. …”
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Study on dispersion of abrasive particles in electro Fenton CMP slurry and design of green polishing fluid in neutral environment by Feng CHENG, Zirui WANG, Rui ZHU, Yongguang WANG, Yang PENG, Tianyu ZHANG, Dong ZHAO, Cheng FAN

“…The effects on the anti-settling ability of diamond abrasive particles, the Zeta potential of polishing slurry, and the polishing solution abrasive particle size are studied, and the polishing effect on the GaN wafer is verified.MethodsNano-diamond abrasive particles with an average particle size of 180 nm were added to deionized water, and H2O2 with a mass fraction of 5% and FeSO4·7H2O with a mass of 0.2 g were added as the original reactants of the Fenton reaction. …”
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A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis by Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Lina Zhao, Lina Zhao, Lina Zhao, Lina Zhao, Sen Zhao, Zhihong Wu, Zhihong Wu, Zhihong Wu, Nan Wu, Nan Wu, Nan Wu

“…In this study, we identified and characterized a pathogenic GPC5 variant (c.776C>T, p.Pro259Leu) within a Chinese LUAD pedigree, systematically investigating its oncogenic mechanisms through comprehensive molecular and cellular analyses.MethodsOur investigation employed a multifaceted approach beginning with the recruitment of a LUAD-affected family cohort (n=4 patients, 1 healthy control), followed by exome sequencing of matched blood and FFPE tumor samples. …”
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Machine-learning detection of stress severity expressed on a continuous scale using acoustic, verbal, visual, and physiological data: lessons learned by Marketa Ciharova, Khadicha Amarti, Ward van Breda, Ward van Breda, Martin J. Gevonden, Sina Ghassemi, Annet Kleiboer, Christiaan H. Vinkers, Christiaan H. Vinkers, Christiaan H. Vinkers, Christiaan H. Vinkers, Milou S. C. Sep, Milou S. C. Sep, Milou S. C. Sep, Milou S. C. Sep, Sophia Trofimova, Alexander C. Cooper, Xianhua Peng, Xianhua Peng, Mieke Schulte, Mieke Schulte, Eirini Karyotaki, Eirini Karyotaki, Eirini Karyotaki, Pim Cuijpers, Pim Cuijpers, Pim Cuijpers, Heleen Riper, Heleen Riper

“…We aimed to detect laboratory-induced stress using multimodal data and identify challenges researchers may encounter when conducting a similar study.MethodsWe conducted a preliminary exploration of performance of a machine-learning algorithm trained on multimodal data, namely visual, acoustic, verbal, and physiological features, in its ability to detect stress severity following a partially automated online version of the Trier Social Stress Test. …”
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Bisphenol F exposure induced vascular toxicity through intestinal microbiota imbalance by Jianlong Yan, Yanbin Pan, Huadong Liu, Jie Yuan, Jie Chen, Yannan Gao, Chaolan Lin, Feng Lin, Rongning Wang, Yaqiong He, Caiping Wang, Cong Xu, Tangzhiming Li, Peng Zhang, Yu Lan, Wenming Shao, Xinli Pang, Da Yin, Xin Sun, Weixiang Luo

“…This study investigated BPF’s role in vascular calcification (VC) and underlying mechanisms.MethodsDifferences in the intestinal microbiota were analyzed by 16S ribosomal RNA gene sequencing. …”
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The Effect of L-glutathione Postharvest Treatment on the Physicochemical Characteristics of Sabrina Strawberry Fruit during Cold Storage by Karim Mandahakki, Hamid Hassanpour

“…It has been reported that application of glutathione after harvesting okra has reduced browning and prevented its weight loss, which has created a suitable market for it, also GSH has increased the level of total phenol and the activity of ascorbate peroxidase enzyme and reduced the level of ROS and malondialdehyde, which can increase the shelf life of okra in cold storage after harvesting (Li et al., 2023).Materials and MethodsSabrina strawberry fruit was obtained from a commercial greenhouse located in Urmia in the full maturity stage. …”
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Investigation of important morphological traits and grain yield of lentil under shading and bio-priming by feresteh darabi, Ali Hatami, Mohammad Javad Zarea, Rahim Naseri

“…Undoubtedly, before massive production and widely application of such products, it is necessary to implement and replicate this experiment in different regions.…”
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The Effect of Different Lysophospholipid Levels on Blood and Milk Biochemical Parameters, Liver and Rumen Enzymes, and Rumen Microbial Population in Early Lactation of Holstein Dai... by Matin Movagharnezhad, Yadollah Chashnidel, Asadollah Teymouri Yansari, Mohsen Gholizadeh

“…In this research, the effects of using this emulsifier on blood and milk biochemical parameters, liver enzymes, and rumen microbial population are studied in the early lactation period of Holstein dairy cows. Methods: This experiment was carried out on 15 multi-calving Holstein dairy cows (three groups of five cows) with an average weight of 720 ± 50 kg and lactation days of 16 ± 5 days in a completely randomized design. …”
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Nonlinear Relationship Between the Elderly’s Perception of Green Spaces and Their Activity Characteristics by Yuanjing WU, Yongyi YOU, Wei ZHOU, Siren LAN

“…To address this gap, this research employs the extreme gradient boosting (XGBoost) model to investigate the nonlinear relationship between the elderly’s perception of urban park green spaces and their activity characteristics, aiming to inform age-friendly park design and evidence-based green space planning strategies.MethodsThis research is based on 779 valid questionnaires collected from five representative urban parks in Fuzhou, a city experiencing rapid demographic aging and urban expansion. …”
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Preparation, microstructure and properties of LaCePr polishing slurry for optical glass CMP by Quanxin ZHANG, Huping LI, Junlong SHI, Ai SU, Guiqing CHEN, Hao XIE, Yupei JIN, Guangshou HU

“…Methods: The LaCePr chlorination solution was prepared using the product of Baotou mixed rare earth ore, which underwent concentrated sulfuric acid enhanced roasting, water leaching, neutralization and impurity removal, P507 extraction transformation and grading. …”
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Studying and Comparing the Soil Characteristics of Gullies (Case Study: Chabar and Sistan Region) by Mansour Jahantigh, Marzieh Tabe

“…The present research aims at studying and comparing soil characteristics of Gullies (Case study: chabar and Sistan region). 2- Materials and Methods The present study was carried out in Chabahar located in the south of Sistan and Baluchistan state, Iran. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Work package 2: optimising care for patients with dementia and hip fracture We used an action research approach, with a mixed-methods case study design to study implementation on an orthopaedic ward in each of three hospitals, using a series of plan, do, study, act (PDSA) cycles. …”
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