Aircraft Multi-stage Altitude Prediction Under Satellite Signal Loss by Mengchan HUANG, Qiang MIAO

“…This study proposes a multi-stage altitude prediction model using attention mechanisms and temporal convolutional neural networks (TCNs).Methods The aircraft’s flight stages are determined to facilitate targeted altitude prediction for different flight phases. …”
Get full text

LEAVES: An Expandable Light-curve Data Set for Automatic Classification of Variable Stars by Ya Fei, Ce Yu, Kun Li, Xiaodian Chen, Yajie Zhang, Chenzhou Cui, Jian Xiao, Yunfei Xu, Yihan Tao

“…With the increasing amount of astronomical observation data, it is an inevitable trend to use artificial intelligence methods for automatic analysis and identification of light curves for full samples. …”
Get full text

Study of Essential Oils Changes and some Biochemical Properties of Ziziphora clinopodioides Lam. under Application of Salicylic Acid by S. Sadeqifard, M. Azizi, S. Karimi Zinkanlu

“…For biochemical characteristics first samples extract were obtained. To prepare extracts, dry samples were milled then one gram of each sample was transferred to the 50 ml Erlen and 10 ml of 80% methanol was added and shaken for 24 hours. …”
Get full text

Hemoglobin-associated CALR in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy by Shuting Pang, Shuting Pang, Qiuyan Tan, Qiuyan Tan, Boji Xie, Boji Xie, Bingmei Feng, Rongbin Zhou, Zige Liu, Zige Liu, Haiyuan Wei, Yian Huang, Mujia Jili, Yuli Xie, Yuli Xie, Shanshan Li, Shanshan Li, Binran Zhao, Binran Zhao, Wei Li, Rirong Yang, Rirong Yang

“…Given the limited diagnostic options currently available, we performed RNA sequencing (RNA-seq) of urinary cells to identify potential urinary biomarkers for IMN and to investigate its underlying disease mechanisms.MethodsWe conducted RNA-seq analysis on cells isolated from both first-void and second-void morning urine samples. …”
Get full text

Clinical effectiveness and cost-effectiveness of the rehabilitation enablement in chronic heart failure facilitated self-care rehabilitation intervention for people with heart fail... by John G F Cleland, Kate Jolly, Christi Deaton, Louise Taylor, Rod S Taylor, Aynsley Cowie, Alex McConnachie, Julia Frost, Colin Greaves, Chim C Lang, Emma McIntosh, Valerie Smith, Samantha van Beurden, Patrick J Doherty, Hasnain M Dalal, Tracy Ibbotson, Melvyn Hillsdon, Anna Placzek, Jessica C Bollen, Iain Squire, Emma Burrell, Nick Hartshorne-Evans, Elizabeth A Thomson, Claire O’Hare, Katie Dudman, Heather Fraser, Mohammad Jarallah

“…This trial will assess the clinical and cost-effectiveness of a 12-week health professional-facilitated, home-based rehabilitation intervention (REACH-HF), in people with HFpEF, for participants and their caregivers.Methods and analysis REACH-HFpEF is a parallel two group multicentre randomised controlled trial with 1:1 individual allocation to the REACH-HF intervention plus usual care (intervention group) or usual care alone (control group) with a target sample size of 372 participants with HFpEF and their caregivers recruited from secondary care centres in United Kingdom. …”
Get full text

Targeting TBK1 potentiates oncolytic virotherapy via amplifying ICAM1-mediated NK cell immunity in chemo-resistant colorectal cancer by Yong Li, Ji Zhou, Xin Guo, Yucheng Zhang, Yuhan Zhang, Huolun Feng, Zhihui Xi, Zuda Huang, Jieqing Guo, Jiabin Zheng, Zejian Lyu, Yongfeng Liu, Jianlong Zhou, Fan Xing

“…However, whether the adaptive process that fosters chemotherapy resistance influences the efficacy of OV therapy is unknown.Methods We analyzed chemo-resistant colorectal cancer (CRC) using in vitro, in vivo, and patient-derived organoid models to assess sensitivity to OVs. …”
Get full text

From gut to joint: the protective impact of Eubacterium rectale on rheumatoid arthritis by Xiaoyang Liu, Xiaoyang Liu, Xiaoyang Liu, Ruihe Wu, Ruihe Wu, Ruihe Wu, Yuxin Fan, Yuxin Fan, Yuxin Fan, Kaili Qin, Kaili Qin, Kaili Qin, Baochen Li, Baochen Li, Baochen Li, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Chong Gao, Caihong Wang, Caihong Wang, Caihong Wang

“…The onset of RA is closely associated with intestinal flora, which is essential for immune regulation.MethodsFecal samples of 22 healthy controls and 38 patients with newly diagnosed RA were used for performing 16S rRNA sequencing, microbiota diversity assessment, and functional enrichment analysis. …”
Get full text

Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms by Deborah L. Harrington, Deborah L. Harrington, Qian Shen, Qian Shen, Annemarie Angeles-Quinto, Annemarie Angeles-Quinto, Sharon Nichols, Tao Song, Hayden Hansen, Kate A. Yurgil, Kate A. Yurgil, Roland R. Lee, Roland R. Lee, Dewleen G. Baker, Dewleen G. Baker, Dewleen G. Baker, Ming-Xiong Huang, Ming-Xiong Huang

“…IntroductionExposure to trauma produces abnormal intrinsic brain activity, but its association to stress-related symptom severity is often elusive, and the relationships with co-occurring psychiatric and cognitive changes are poorly understood.MethodsThis study investigated the neurobehavioral mechanisms of persistent disability in male combat-exposed military personnel and veterans with symptoms of post-traumatic stress disorder (CE-PTSD) (n=19) and trauma-exposed healthy controls with similar combat experiences (n=24). …”
Get full text

Perceived technology usefulness for caregiving among unpaid caregivers: a National Cross-Sectional Study by Matthew Lee Smith, Matthew Lee Smith, Shinduk Lee, Malinee Neelamegam, Deborah Vollmer Dahlke, Deborah Vollmer Dahlke, Deborah Vollmer Dahlke, Jodi L. Southerland, Zachary G. Baker, Kris Pui Kwan Ma, Darina V. Petrovsky, Zahra Rahemi, Justine S. Sefcik, Juanita-Dawne R. Bacsu, Chung Lin Kew, Chung Lin Kew, Marcia G. Ory, Marcia G. Ory

“…To assist with technology adoption among the 53 million unpaid caregivers nationwide, efforts are needed to better understand caregivers’ perceptions about the usefulness of certain technologies for caregiving.MethodsData were analyzed from a national sample of 483 unpaid caregivers using an internet-delivered questionnaire. …”
Get full text

Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…Objective To construct a molecular classification system for head and neck squamous cell carcinoma (HNSCC) utilizing hypoxia-related gene (HAG) expression profiles, and to comprehensively examine the clinicopathological significance and biological functions of the hypoxia gene stanniocalcin 2 (STC2) in HNSCC. Methods Transcriptomic data and clinical information of 546 HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) database, and based on the expression profiles of 200 HRGs, HNSCC was classified subclasses using non-negative matrix factorization (NMF). …”
Get full text

NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…Background This study comprehensively investigates the association between the expression of nicotinamide N-methyltransferase (NNMT) and clinical outcomes of urothelial bladder cancer (UBC), as well as the molecular mechanisms by which NNMT in cancer-associated fibroblast (CAF) modulates tumor progression and immunotherapy resistance in UBC.Methods Single-cell transcriptomic analyses, immunohistochemical and immunofluorescence assays were performed on bladder cancer samples to validate the relationship between NNMT expression and clinical outcomes. …”
Get full text

ENHANCE-D: protocol for a pragmatic, 3-arm, randomised controlled trial comparing the impact of enhanced smoking cessation interventions to very brief advice for adult smokers in d... by Richard Holliday, Nina Wilson, Vicky Ryan, Chrissie Butcher, Tara Homer, Philippa Watts, Dorcas Kareithi, Paul Blaylock, Laura Ternent, Roland Finch, Susan M. Bissett, Adam Todd, Helen Hancock, Fiona Ellwood, David I. Conway, Nicholas S. Jakubovics, Ralf Kist, Richard D. Holmes, Linda Bauld, Philip M. Preshaw, Elaine McColl

“…A large definitive trial is needed to confirm whether this would lead to improved smoking quit rates, improved oral health, and be good value for money. Methods The ENHANCE-D trial is a multi-centre, pragmatic, definitive, 3-arm, parallel group, individually randomised controlled superiority trial, including an internal pilot, conducted in NHS dental settings. …”
Get full text

New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer by Lin Xu, Wanli Ma, Xiaoyu Huo, Jiao Luo, Ruoxi Li, Xiaoxiao Zhu, Xiangbin Kong, Kunming Zhao, Yuan Jin, Meihua Zhang, Xianshu Li, Ling Wang, Wei Han, Dianke Yu

“…Objectives: We aimed to explore the oncogenic role of piRNA in lung cancer induced by PM2.5 exposure, as well as the underlying mechanisms. Methods: We conducted a PM2.5-induced human lung epithelial cell malignant transformation model. …”
Get full text

Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization by Qingling He, Jianyang Hu, Fung-Yin Ngo, Huiqi Zhang, Lin He, Hao Huang, Tan Wu, Yilin Pan, Zihan Yang, Yuanyuan Jiang, William C. Cho, Wah Cheuk, Gary M. Tse, Julia Y. Tsang, Mengsu Yang, Liang Zhang, Xin Wang, Pui-Chi Lo, C. Geoffrey Lau, Y. Rebecca Chin

“…However, its functional roles in breast cancer or metastasis remain unclear. Methods To identify TUBB2B as a novel molecular target in TNBC, we performed bioinformatics analysis to assess the association of TUBB2B expression and survival of patients. …”
Get full text

Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma by Min Yang, Wei Wang, Wei Li, Yanan Li, Juan Zhang, Pengfei Rong, Di Wu, Qi Liang, Yao Deng, Xiaoqian Ma, Lu Cao, Muqi Liu, Linzhe Li, Xingshi Gu, Cejun Yang, Huaping Liu

“…To address this, our study investigates the role of C-C motif chemokine ligand 3 (CCL3) in modulating the HCC TIME.Methods We analyzed CCL3 expression in human HCC samples from The Cancer Genome Atlas database, focusing on its correlation with inflammatory gene signatures and immune cell infiltration. …”
Get full text

Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation o... by Lin Zheng, Lin Zheng, Lin Zheng, Chengyun Pan, Chengyun Pan, Dan Ma, Dan Ma, Dan Ma, Qin Shang, Qin Shang, Tianzhen Hu, Tianzhen Hu, Tianzhuo Zhang, Tianzhuo Zhang, Qian Kang, Qian Kang, Xiuying Hu, Xiuying Hu, Shuyun Cao, Shuyun Cao, Li Wang, Li Wang, Li Wang, Hong Luo, Hong Luo, Hong Luo, Jishi Wang, Jishi Wang, Jishi Wang

“…The present work focused on investigating the effect of Nrf2 overexpression within MSCs on leukemia cell invasion, extramedullary infiltration and proliferation as well as its downstream pathway.MethodsThrough clinical sample detection, in vitro cell experiments and in vivo animal experiments, the role of Nrf2 within MSCs within adult B-ALL cell migration and invasion and its potential molecular mechanism was explored through transcriptome sequencing analysis, RT-PCR, Western blot, cell migration, cell invasion, lentivirus transfection and other experiments.ResultsNrf2 was highly expressed in BM-MSCs from patients with B-ALL as well as in BM-MSCs co-cultured with leukemia cells. …”
Get full text

Deep Penetration of Shear Deformation in Ferritic Stainless Steel via Differential Speed Rolling Considering Contact Condition by Siti Fatimah, Warda Bahanan, Jee-Hyun Kang, I Putu Widiantara, Young Gun Ko

“…Rolling is a widely utilized industrial processing method, and understanding its inherent characteristics can optimize the process and help achieve the desired microstructure and texture. …”
Get full text

Detrimental Effects of β2‐Microglobulin on Muscle Metabolism: Evidence From In Vitro, Animal and Human Research by Shibo Wei, So Jeong Park, Eunah Choi, Il‐Young Jang, Yan Zhang, Yingqi Xue, Yunju Jo, Hee‐Won Jung, Eunhye Ji, Jin Young Lee, Yujin Moon, Eunju Lee, Dongryeol Ryu, Beom‐Jun Kim

“…To explore this hypothesis, we conducted a comprehensive investigation into the impact of B2M on cellular and animal muscle biology, as well as its clinical implications concerning sarcopenia parameters in older individuals. Methods In vitro myogenesis was induced in mouse C2C12 myoblasts with 2% horse serum. …”
Get full text

α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback by Ying-Hao Hu, Ying-Hao Hu, Jun Han, Jun Han, Lin Wang, Chao Shi, Chao Shi, Yan Li, Yan Li, Opeyemi Joshua Olatunji, Xiu Wang, Xiu Wang, Jian Zuo, Jian Zuo, Jian Zuo

“…Expression of nicotinamide phosphoribosyltransferase (NAMPT), sirtuin 1 (SIRT1), peroxisome proliferator activated receptor gamma (PPAR-γ), stearoyl-coa desaturase 1 (SCD-1), toll like receptor 4 (TLR4), prostaglandin-endoperoxide synthase 2 (COX-2), (p)-JNK, (p)-p65 and IL-1β were investigated by either RT-qPCR or immunobloting methods. In in vitro experiments, we treated (pre)-adipocytes with monocytes/macrophages and MAN, and investigated the changes of macrophages brought by pre-adipocytes co-culture. …”
Get full text

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer by Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu

“…However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear. Methods The correlation between m6A and APA was analyzed by using RNA methylation sequencing of OC cells and single‐cell sequencing of clinical samples from public databases. …”
Get full text