SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β by Chun Liu, Kun Wu, Chuwen Li, Zhen Zhang, Peisong Zhai, Haiyan Guo, Jianjun Zhang

“…This study aimed to identify and validate the role and function of SPP1 + Macs in the malignant progression of HNSCC. Methods In this study, we applied single-cell RNA sequencing (scRNA-seq) analyses of paired tumor and normal tissues from 5 HNSCC patients to identify tumor-specific SPP1 + Macs. …”
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The role and mechanism of action of endoplasmic reticulum transmembrane protein 166 in liver lipid metabolism by LI Lianhui, YANG Di, ZANG Kailai, SUN Yani, DU Qiyuan, LI Ning

“…Objective To investigate the role and specific molecular mechanism of action of endoplasmic reticulum transmembrane protein 166 (TMEM166) in liver lipid metabolism. Methods Tmem166flox/flox mice were crossed with Alb-Cre mice, and the offspring Tmem166+/+ mice were selected as group A, while the Tmem166-/- mice were selected as group B, with 8 mice in each group. …”
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A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma by Kuo Kang, Hui Nie, Weilu Kuang, Xuanxuan Li, Yangying Zhou

“…However, the precise role of telomere-associated genes in HCC remains incompletely elucidated. Methods The Cancer Genome Atlas (TCGA) database was utilized to download data from 374 HCC and 50 normal liver tissue samples. …”
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Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study by Anna Damia, Ines Marongiu, Elena Spinelli, Francesco Damarco, Clarissa Uslenghi, Giovanni Lorenzo Rumi, Michele Battistin, Caterina Lonati, Alessandra Maria Storaci, Gianluca Lopez, Maria Rosaria De Filippo, Fabiana Madotto, Cristina Banfi, Alice Mallia, Lorenzo Rosso, Valentina Vaira, Tommaso Mauri

“…Histological scoring was performed blindly as well as proteomic analysis of broncho-alveolar lavage (BAL) fluids and lung tissue samples at the end of the experiment. Results The left lung of both groups received similarly low fraction (< 20%) of blood flow. …”
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GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Notably, while inherited genetic variations account for part of this heterogeneity, the dynamic regulatory role of modifiable epigenetic mechanisms—particularly DNA methylation in mediating platelet reactivity—remains inadequately characterized, presenting a critical knowledge gap in optimizing precision antiplatelet strategies. Methods We utilized the 850k methylation array to measure DNA methylation levels in blood samples from 47 healthy controls and 93 patients with CHD. …”
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Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial by E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko

“…A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine derivatives, in a classical formalin-induced paw oedema test in white rats.Methods. Originally synthesised 1,4-dihydropyridine derivatives were preliminarily subjected to virtual screening using the SwissTargetPrediction toolkit. …”
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Expression of serpin family E member 1 in gastric cancer and its mechanisms in promoting gastric cancer by CHEN Yongyu, HUANG Yiren, CHEN Zheyi, ZHOU Bingqian, CHEN Shiyu, ZHENG Yingxia

“…Objective·To investigate the expression of serpin family E member 1 (SERPINE1) in gastric cancer and its potential mechanisms in promoting gastric cancer.Methods·Pan-cancer analysis of SERPINE1 was performed by using the TIMER2.0 online website, and the differences in the expression of SERPINE1 in samples with different tumor stages of gastric cancer were analysed by the clinical data of gastric cancer from The Cancer Genome Atlas (TCGA) database. …”
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EVALUATION OF ANTIPROLIFERATIVE OF A POTENTIAL THERAPEUTIC ASSOCIATION OF SILVER COMPLEXES WITH LIMONENE IN SQUAMOUS CELL CARCINOMA AND MELANOMA CELL LINES by Daniele Daiane Affonso, Juliana Carron, Francisco Mastrobuono Cordeiro de Almeida, Gabriele de Menezes Pereira, João Ernesto de Carvalho, Pedro Paulo Corbi, Ana Lucia Tasca Gois Ruiz, Carmen Silvia Passos Lima

“…Objectives: Our study aimed to evaluate the in vitro antiproliferative effects of silver complexes and limonene, isolated and in association. Materials and Methods: The silver complexes identified as I and II were synthesized at the Institute of Chemistry of University of Campinas. …”
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Effect of antagomir-22-3p treatment on skeletal muscle growth in intrauterine growth-restricted lambs by S. K. Duckett, M. A. Greene, A. N. S. Udoka, R. R. Powell, T. F. Bruce, T. F. Bruce, J. L. Klotz

“…Previous research identified miR-22-3p as being differentially regulated during muscle hypertrophy, and in vitro experiments found that antagomir-22-3p enhanced satellite cell proliferation. …”
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The Improvement of Intestinal Mucosal Epithelial Barrier Integrity by 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone in Rat Experimental Colitis by Szandruk-Bender M, Wiatrak B, Merwid-Ląd A, Dzimira S, Szeląg A, Magdalan JM, Szczukowski Ł, Świątek P, Duda-Madej A, Gębarowski T, Nowak B

“…In this study, we aimed to elucidate the effects of the new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone, compounds 7b, 10b, and 13b, in intestinal epithelial damage.Methods: In this study, we used biobank colon and feces samples collected during our previous original experiment, in which we induced colitis in rats by trinitrobenzenesulfonic acid (TNBS) administration. …”
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Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure by Zirui Liu, Rui Feng, Ying Xu, Meili Liu, Haocheng Wang, Yu Lu, Weiqi Wang, Jikai Wang, Cao Zou

“…However, the impact of 5-methylcytosine (m5C) on HF and its relationship with the immune microenvironment (IME) remains elusive. Methods GSE141910 (200 HF, 166 NFDs) was used as training cohort. …”
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Effects of Temperature on Reproductive Performance and Embryo Quality of Female Eriocheir sinensis by Chaoyue CUI, Zhi GENG, Guangpeng FENG, Tao ZHANG, Feng ZHAO, Gang YANG, Ping ZHUANG, Xiaorong HUANG

“…The crude protein content of embryos was determined using the Kjeldahl method; the total fat content was determined using acid hydrolysis; the composition and content of fatty acids were detected using gas chromatography; the moisture content of embryos was determined by taking 2–3 mg of wet embryos from each temperature group and drying them at 70 ℃ until constant weight; the ash content was determined by burning them at 550 ℃ until a constant weight; and the triglyceride, phospholipids, and cholesterol contents were determined using an enzyme immunoassay kit. …”
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Effects of Dioscorea oppositifolia L. on growth performance, biochemical indicators, immunity, and intestinal health of weaned piglets by Xiang-Yi Pan, Xiang-Yi Pan, Xiang-Yi Pan, Zheng-Ying Qiu, Zheng-Ying Qiu, Zheng-Ying Qiu, Chen Liu, Chen Liu, Chen Liu, Chuan Wang, Xiaowu Wang, Li-Na Huang, Si-Fan Li, Si-Fan Li, Si-Fan Li, Xiong-Wei Shi, Xiong-Wei Shi, Xiong-Wei Shi, Shao-Guang Ge, Shao-Guang Ge, Shao-Guang Ge, Rui-Hua Xin, Rui-Hua Xin, Rui-Hua Xin

“…During the experiment, the piglets’ feed intake was recorded, and blood and fecal samples were collected. …”
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Pharmacokinetics, Mass Balance, and Biotransformation of [14C]tinengotinib, A Novel Multi-target Kinase Inhibitor, in Healthy Subjects by Shumao Ni, Sheng Ma, Yingying Yu, Zhenwen Yu, Yujia Zhu, Xiaofen Sun, Lin Li, Caixia Sun, Hui Wang, Peng Peng, Zheming Gu, Hua Zhang, Frank Wu, Liyan Miao, Jean Fan

“…The purpose of this open-label study was to investigate the absorption, metabolism, and excretion of [14C]tinengotinib following a single oral dose in healthy subjects. Methods Six healthy male subjects received a single oral dose of [14C]tinengotinib capsules at 10 mg/100 µCi, and blood, urine, and feces samples were collected. …”
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PIDLF+: A Novel Adaptive PIDLF for Forestry Height Mapping Based on Single-Baseline PolInSAR Data by Dandan Li, Hailiang Lu, Mercedes E. Paoletti, Juan M. Haut, Juntao Gu, Chao Li, Weipeng Jing

“…Meanwhile, the lack of training samples imposes additional constraints on the efficacy of supervised DL-based methods. …”
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A Novel DNA Repair‐Gene Model to Predict Responses to Immunotherapy and Prognosis in Patients With EGFR‐Mutant Non‐Small Cell Lung Cancer by Fen Wang, Xue‐Wu Wei, Ming‐Yi Yang, Chang Lu, Xiao‐Rong Yang, Jia‐Yi Deng, Zhi‐Hong Chen, Qing Zhou

“…However, the role and mechanism of DDR in the genesis and progression of EGFRm NSCLC remain unclear. Methods This study included 101 EGFRm NSCLC samples from The Cancer Genome Atlas (TCGA) dataset and a GSE31210 dataset (external set) from the GEO database. …”
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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…This study investigated the role of gut microbiota related bile acid metabolism in colonic inflammation in both patients with inflammatory bowel disease (IBD) and a murine model of dextran sulfate sodium (DSS)-induced colitis. Methods Bile acids in fecal samples from patients with IBD and DSS-induced colitis mice, with and without antibiotic treatment, were analyzed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). …”
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DETERMINAÇÃO DAS ISOTERMAS DE ADSORÇÃO E DO CALOR DE SORÇÃO DE FARINHA DE BABAÇU COMERCIAL by Elys Nayanne Vieira Matos, Romildo Martins Sampaio, Maria do Livramento de Paula

“…For the adsorption experiments, samples of babassu flour were dried previously. …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…In this experiment, common carp fry with an average weight of 19 g was used. …”
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A Data-Driven Approach to Link GC-MS and LC-MS with Sensory Attributes of Chicken Bouillon with Added Yeast-Derived Flavor Products in a Combined Prediction Model by Simon Leygeber, Carmen Diez-Simon, Justus L. Großmann, Anne-Charlotte Dubbelman, Amy C. Harms, Johan A. Westerhuis, Doris M. Jacobs, Peter W. Lindenburg, Margriet M. W. B. Hendriks, Brenda C. H. Ammerlaan, Marco A. van den Berg, Rudi van Doorn, Roland Mumm, Age K. Smilde, Robert D. Hall, Thomas Hankemeier

“…Methods: Chicken bouillon samples containing diverse YPs were chemically and sensorially characterized using statistical multivariate analyses. …”
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