HIIT versus MICT in MASLD: mechanisms mediated by gut-liver axis crosstalk, mitochondrial dynamics remodeling, and adipokine signaling attenuation by Dongkun Deng, Lin Xu, Yufei Liu, Chang Li, Qingfeng Jiang, Jiaming Shi, Shuo Feng, Yunhua Lin

“…After eight weeks, the HFD group was randomly divided into three groups: (1) MICT-8; (2) HIIT-8; and (3) HFD-8. At the end of the experiment, blood, liver, ileum, and skeletal muscle samples were collected for analysis of the rats' baseline conditions, mitochondrial function, hepatic lipid metabolism, bile acid pathway and gut microbiota, and synthesis of analyses. …”
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Self‐stigma among people with epilepsy: Comparison between Germany and Japan by Izumi Kuramochi, Takayuki Iwayama, Hiroaki Okajima, Satsuki Watanabe, Koji Matsuo, Haruo Yoshimasu, Christian G. Bien, Christian Brandt, Anne Hagemann

“…It also explored cultural differences influencing these experiences. Methods Participants were recruited from the Bethel Epilepsy Center in Germany and the Comprehensive Epilepsy Centers at Saitama Medical University in Japan. …”
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The mediating role of self-compassion in the relationship between childhood trauma and the symptoms of body dysmorphic disorder by Motahhareh Kargar Shooroki, Azadeh Choobforoushzadeh, Azra Mohammadpanah Ardakan

“…Abstract Background Body dysmorphic disorder (BDD) is a prevalent concern among adolescent girls. Childhood experiences of security or insecurity are recognized as significant foundational factors influencing body image and, consequently, the development of BDD. …”
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EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV by Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul

“…In this study, we investigate the ephrin-B/EphB axis, which regulates inflammation, in post-mortem brain specimen of PLWH and experimental models in order to assess its potential role in HIV induced neuroinflammation. Methods We analyze mRNA samples of post-mortem brain specimen of PLWH and uninfected controls obtained from the National NeuroAIDS Tissue Consortium (NNTC) and, for comparison, of a transgenic mouse model of neuroHIV using quantitative reverse transcription polymerase chain reaction (qRT-PCR). …”
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A Novel Oncogenic and Drug-Sensitive KIF5B-NTRK1 Fusion in Lung Adenocarcinoma by Hui Li, Huicong Liu, Lisha Xiao, Huabin Gao, Huiting Wei, Anjia Han, Gengpeng Lin

“…Moreover, <i>KIF5B</i>-<i>NTRK1</i> gene chimera has been shown to be an oncogene, activating both the MAPK and PI3K/AKT signaling pathways. The biopsy sample was analyzed using various methods such as hematoxylin–eosin staining (HE), immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS) based on a 1267-gene panel. …”
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Maternal exposure to intimate partner violence and breastfeeding practices in 51 low-income and middle-income countries: A population-based cross-sectional study. by Rishi Caleyachetty, Olalekan A Uthman, Hana Nekatebeb Bekele, Rocio Martín-Cañavate, Debbie Marais, Jennifer Coles, Briony Steele, Ricardo Uauy, Peggy Koniz-Booher

“…We examined the association of maternal exposure to IPV with early initiation of breastfeeding (within 1 hour of birth) and exclusive breastfeeding in the first 6 months.<h4>Methods and findings</h4>We assessed population-based cross-sectional Demographic and Health Surveys (DHS) from 51 LMICs. …”
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Screening and Validation of Potential Biomarkers of Immune Cells in Childhood Asthma Patients via Mendelian Randomization and Machine Learning by Zhang Y, Hai Y, Song B, Xu J, Cao L, Yasen R, Xu W, Zhang J, Hu J

“…Therefore, a deeper investigation of the correlation between immune cells and childhood asthma could lead to a better understanding of asthma’s origin, the identification of potential treatment targets, and the development of personalized treatment strategies.Patients and Methods: We used a two-sample Mendelian randomization (MR) analysis to investigate the possible causal relationship between childhood asthma and a total of 731 immune cells, including B cell (190), Maturation stages of T cell (79), Monocyte (43), Myeloid cell (64), TBNK (124), Treg (167), and CDC (64). …”
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CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model by Shih-Hsuan Chan, Chin-Yu Lin, Hsuan-Jung Tseng, Lu-Hai Wang

“…Here, we investigated the role of CD24a, the murine CD24 gene, in tumor progression and TME immune dynamics in a murine triple-negative breast cancer (TNBC) model. Methods Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 knockout technology was employed to generate CD24a knockout in the murine TNBC cell line 4T1. …”
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Behavior, hormone, and gut microbiota change by YYNS intervention in an OVX mouse model by Huajuan Lei, Huajuan Lei, Jian Liu, Juan Deng, Pan Zou, Zixiang Zou, Ziou Li, Honghui Li, Lin Luo, Zhoujin Tan

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Potassium fertilization modulates potato (Solanum tuberosum L. V7) yield and rhizosphere microbiome dynamics by Jing Yang, Jing Yang, Xiaodong Han, Qi Li, Dong Wang, Yuankai Li, Ziyi Zhang

“…This study investigated the effects of varying K fertilization rates on potato yield and associated rhizosphere microbial community dynamics throughout the key developmental stages.MethodsA field experiment using potato (Solanum tuberosum L. …”
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Influence of Personal Traits, Social Relationships, and External Resources on the Development of Emotional Resilience in Children From East London: Protocol for an Observational Ac... by Francois van Loggerenberg, Milena Nikolajeva, Daniele Porricelli, Imogen Hensler, Aisling Murray, Eleanor Keiller, Julia Michalek, Dennis Ougrin, Jennifer Y F Lau

“…MethodsWe will conduct an accelerated longitudinal cohort study in primary schools across the broad geographical area of East London. …”
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Effect of Autolyzed Yeast on Performance and Physiological Indices of Broiler Chickens Reared at High Stock Density by Samaneh Ghaseminejad, Smayyeh Salari

“…In broiler chickens, the effects of prebiotics are partially dependent on the blocking of pathogen-adherent receptor sites, regulation of the immune system, production of antimicrobial molecules by the intestinal microbial community, and changes in the intestinal microbial structure. Materials and Methods: This experiment was carried for 37 days in 3 periods including starter (1-10 days old), grower (11-24 days old) and finisher (37-25 days old) using 520 one-day-old broiler chickens of Ross 308 commercial strain in a completely randomized design based on factorial arrangement 4 x 2 with 5 replicates. …”
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Coproducing a culturally sensitive storytelling video intervention to improve psychosocial well-being: a multimethods participatory study with Nepalese migrant workers by Jackie Cassell, Daniel Michelson, Padam Simkhada, Priyamvada Paudyal, Kavian Kulasabanathan, Anjum Memon, Sharada Prasad Wasti, Ram Silwal, Edwin R van Teijlingen, Pimala Neupane, Jib Lal Sapkota, Carol Watts, Prajaya Shukla, Ram Sharan Pathak, Clio Berry, Alice Moult

“…Despite these limitations, the project is testament to the value of participatory methods in the development of culturally sensitive public health interventions for marginalised groups, and points to the utility of coproduced storytelling formats in migrant health contexts. …”
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Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet by Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian

“…However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) conditions remain unclear.ObjectiveUsing the liver as a reference, this study aimed to investigate the tissue-specific regulation of ABCA1 in the lung under HCD or CYP27A1 knockout (KO) conditions, and to explore its potential regulatory mechanism.MethodsCYP27A1 KO and wild-type (WT) mice on a C57BL/6J background were fed either a normal diet (ND) or HCD for 12 weeks. …”
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“Our work is recognized and we are prepared:” A qualitative evaluation of a peer-led research best practices training for community health workers and promotoras by Alexandra E. Harper, Analay Perez, M. Miaisha Mitchell, Daphne Watkins, Gina M. Jay, Vanessa I. Trujillo, Kristen Weeks-Norton, Shannen McIntosh, Brenda Eakin, Elias Samuels, Gretchen Piatt, Catherine Striley, Linda Cottler, Sergio Aguilar-Gaxiola, Susan L. Murphy

“…This article qualitatively explores the training experiences from the perspectives of CHW/Ps. Methods: CHW/Ps were recruited from communities and partners affiliated with study sites in Michigan, Florida, and California to participate in peer facilitated trainings in English and Spanish. …”
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Family-to-work conflict linked to psychological distress and family life satisfaction during the second year of the COVID-19 pandemic in dual-earner parents with adolescents by Berta Schnettler, Berta Schnettler, Berta Schnettler, Berta Schnettler, Edgardo Miranda-Zapata, Ligia Orellana, Ligia Orellana, Mahia Saracostti, Mahia Saracostti, Héctor Poblete, Andrés Concha-Salgado, Germán Lobos, Cristian Adasme-Berríos, María Lapo, Katherine Beroiza, Leonor Riquelme-Segura, José A. Sepúlveda, José A. Sepúlveda, Enid Thomas

“…Moreover, the potential mediating role of psychological distress among FtoWC and family life satisfaction and the moderating role of household monthly income were tested.MethodsThe non-probabilistic sample in Chile comprised 860 dual-earner parents and one of their adolescent children (mean age 13.5 years, 50.8% female). …”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…This study aimed to explore differences in DNA methylation (DNAm) and gene expression profiles that may account for the worse prognosis in younger patients; and to investigate possible new therapeutic targets. Methods: We conducted whole-genome DNAm and transcriptome analyses on 10 parameningeal head and neck ARMS patients, including 4 patients under 1 year old and 6 over 10 years old. …”
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Duodenal Adenocarcinoma Is Characterized by Acidity, High Infiltration of Macrophage, and Activated Linc01559–GRSF1 Axis by Xinxin Huang, Ying Shi, Zekun Liu, Yihang Wu, Xiaotong Luo, Dongwen Chen, Zhengyu Wei, Chong Chen, Huaiqiang Ju, Xiaojian Wu, Xuanhui Liu, Zhanhong Chen, Peishan Hu

“…Hence, this study aimed to identify novel biomarkers for early diagnosis and potential therapeutic targets for DA. <b>Methods</b>: Surgical resection samples and normal tissues from DA patients were collected for RNA sequencing (RNA-seq). …”
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Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway by Zhipeng Wang, Zhijun Liu, Lili Cui, Jianguo Sun, Chen Bu, Mao Tang, Mingming Li, Shouhong Gao, Wansheng Chen, Xia Tao

“…Objectives: To assess if the endogenous metabolic profile could prodict the diarrhea induced by Cap and explore and validate underlying mechanisms. Methods: Untargeted and targeted bile acids(BAs) metabolomics were performed to analyzed the metabolic profile of baseline samples from colorectal cancer(CRC) patients and the association with the diarrhea induced by Cap was assessed. …”
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Deciphering the viral landscape in gastric cancer: comprehensive characterization and identification of the gastric cancer virome by Dan Xiang, Shaoying Li, Jiayi Zuo, Chenchen Mao, Yangxuan Lin, Cong Long, Pingping Cai, Weiwei Liu, Xiaorong Lu, Miaofang Xiao, Wangkai Xie, Chenbin Chen, Dianfeng Mei, Kezhi Lin, Zheng Han, Xian Shen, Xiangyang Xue, Shurong Shen

“…This method enhances our understanding of the role viruses play in cancer, which may assist scientists and medical professionals in identifying viral presence in cancers and could offer new angles for cancer prevention and the development of related measures. …”
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