Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related protein by Chenyi Shao, Yingyi Zhang, Hang Li, Jiajia Chen, Ting Huang, Jiaze Li, Simeng Wen, Sen Wang, Saijun Fan, Yu Zhao

“…Here, we aimed to isolate and characterize these diverse subgroups of tumor post‐RT to understand the molecular mechanisms of their resistance to ICB. Methods Single‐cell RNA‐sequencing (scRNA‐seq) was used to profile senescent cancer cell clusters induced by RT in LNCaP cells. …”
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ALG3 as a prognostic biomarker and mediator of PD-1 blockade resistance in hepatocellular carcinoma by Pengju Tang, Zhenwei Han, Yiming Zhao, Tianxin Xu, Yu Zhang, Lirong Zhu, Fei Song, Cheng Gao, Jinbo Gong, Ji Cheng, Chenggui Wang, Tianlun Wang, Jie Xu, Yu Wang, Zhong Chen

“…Although ALG3 expression has been studied in various tumors, its role in regulating the immune microenvironment and its prognostic significance in HCC remain unclear.MethodsThis study comprehensively evaluates ALG3 expression in HCC and its relationship with the immune microenvironment using various techniques. …”
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Biodesulfurization of high-sulfur oil from the Karazhanbas field of Kazakhstan with deep eutectic solvents by A.O. Akimbek, G.A. Jamalova, A.K. Yernazarova, G.K. Kaiyrmanova, B.K. Yelikbayev, M.C. Pagano, A.G. Zazybin, Kh. S. Rafikova

“…The research methodology was based on the application of the Koch methods to determine the total number of microorganisms; light microscopy – for the study of microbiological preparations; genetic identification of bacteria based on the analysis of the nucleotide sequence of a fragment of the 16S rRNA gene; synthesis of deep eutectic solvents; testing of isolated bacteria – for sensitivity to Cr (VI), for the ability of microorganisms to use hydrocarbons of high-sulfur oil, for activity in sulfur-containing crude oil, for determination of the mass fraction of sulfur. …”
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Identifying understudied correlations between autism & phenotypic attributes in a large family dataset by Maya McNealis, John Kent, Kelley Paskov, Kaitlyn Dunlap, Jordan Lane, Brittani Phillips, Melissa Armstrong-Brine, Shanna Kralovic, Anastasia Dimitropoulos, Leonard Abbeduto, Dennis P. Wall

“…Despite accounting for family structure in our experiments, the relationships between attributes and diagnosis are likely stronger in the general population because our “control” sample is comprised of biological siblings who may still possess subclinical autistic traits, given the heritability of autism. …”
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Mesenchymal stem cells improve ovarian function by suppressing fibrosis through CTGF/FAK signalling in systemic lupus erythematosus by Min Xu, Hui Yang, Lingyun Sun, Hongwei Chen, Yueyang Zhang, Haiwei Zhang, Yingyi Wu, Yirui Shi

“…This study investigated the therapeutic efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in ameliorating ovarian impairment and restoring ovarian function through the inhibition of fibrosis in a lupus mouse model.Methods Serum levels of sex hormones were quantified via ELISA. …”
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Magnitude and determinants of intimate partner controlling behavior among women in sub-Saharan African countries from the recent demographic and health survey data: a multilevel an... by Fantahun Andualem, Girum Nakie, Gidey Rtbey, Mamaru Melkam, Techilo Tinsae, Getasew Kibralew, Berihun Agegn Mengistie, Gebresilassie Tadesse, Getachew Muluye Gedef, Setegn Fentahun

“…This study aims to assess the magnitude and determinants of IPCB among reproductive-age women in SSA. Methods This study is a secondary data analysis based on the DHS conducted in eight Sub-Saharan African countries between 2021 and 2024. …”
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DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1 by Yepeng Hu, Shu Ye, Jing Kong, Qiao Zhou, Zhe Wang, Yikai Zhang, Han Yan, Yaqiong Wang, Tiekun Li, Yi Xie, Bingbing Chen, Yiming Zhao, Tianyue Zhang, Xianan Zheng, Junjia Niu, Bibi Hu, Shengyao Wang, Zhida Chen, Chao Zheng

“…However, whether DOT1L exerts beneficial effects in diabetes induced podocyte injury and the underlying molecular mechanisms need further exploration. Methods The expression of DOT1L was confirmed by Western blotting in MPC-5 cells and cortex of kidney from db/db mice, as well as immunofluorescence staining in human renal biopsy samples. …”
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Research on the micro-pore structure and multiscale fractal characteristics of shale under supercritical CO2 action: A case study of the Chang 73 submember in the Ordos Basin, Chin... by Lili Jiang, Leng Tian, Zhangxing Chen, Zechuan Wang, Wenkui Huang, Xiaolong Chai

“…Utilizing a combination of organic geochemical and mineral composition analyses, low-temperature gas (CO2 and N2) adsorption experiments and nuclear magnetic resonance (NMR) scanning methods are employed—combined with multiscale fractal theory—the research comprehensively analyze the changes in shale microporous structure and its fractal characteristics under ScCO2 treatment. …”
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Single exposure to near-threshold 5G millimeter wave modifies restraint stress responses in rats by Akiko Matsumoto, Ikumi Endo, Etsuko Ijima, Akimasa Hirata, Sachiko Kodera, Masayoshi Ichiba, Mikiko Tokiya, Takashi Hikage, Hiroshi Masuda

“…Here, we further analyzed the near-threshold stress response for the first time, using biological samples from the aforementioned and additional experiments. …”
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Effect of nitrogen fixating, potassium and phosphorus solubilizing bacteria on Mungbean (Vigna radiata) yield and components yield by Afsaneh Yousefi, Reza Mirzaeitalarposhti, Fatemeh-Sadat Aghamir, Jafar Nabati

“…The purpose of this study was to reduce the harmful effects of chemical fertilizers on the agroecosystem and to reduce the cost associated with crop production through application of biofertilizers (free-living nitrogen-fixating bacteria, and potassium and phosphate solubilizing bacteria) on mung bean. Material and methods: A field experiment was carried out as a randomized complete block design with factorial arrangement of treatments. …”
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A Liposome-Based Nanoparticle Vaccine Induces Effective Immunity Against EBV Infection by Ping Li, Zihang Yu, Ziyi Jiang, Yike Jiang, Jingjing Shi, Sanyang Han, Lan Ma

“…Then we assessed the immunogenicity of the biomimetic Lipo-gp350D<sub data-eusoft-scrollable-element="1">123</sub> nanoparticle vaccine in Balb/c mice immunized experiments. <b data-eusoft-scrollable-element="1">Results</b>: The results showed that the sera samples from Lipo-gp350D<sub data-eusoft-scrollable-element="1">123</sub> nanoparticle vaccine immunized mice collected at weeks 8, 10 and 12 had higher titers of gp350D<sub data-eusoft-scrollable-element="1">123</sub> protein-specific antibodies, compared to monomer gp350D<sub data-eusoft-scrollable-element="1">123</sub> protein control, and higher titers of neutralizing antibodies to block EBV-GFP infection in AKATA cells. …”
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Breeding and genetic peculiarities of modern spring barley varieties for grain number per main ear by С. П. Васильківський, В. М. Гудзенко, О. А. Демидов, О. Б. Барбан, С. С. Коляденко, І. В. Смульська

“…To reveal breeding and genetic peculiarities of modern spring barley varieties for the “number of grains per main ear” trait and identify genetic sources of increased combining ability for involving in hybridization. Methods. Investigations were carried out at the V. …”
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Effects of traditional Chinese exercises on cardiopulmonary function in stroke patients: A meta-analysis by Danmeng Tong, Hongyu Li, Wei Zhao, Wang Guo, Bin Chen, Qiang Tang

“…However, due to methodological flaws in the literature quality included in the study, there is a need for a multi-center, large-sample, and more rigorously designed experiment to validate these findings and ensure the accuracy of the results.…”
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Improving Mental Health and Well-Being Through the Paradym App: Quantitative Study of Real-World Data by Athina Marina Metaxa, Shaun Liverpool, Mia Eisenstadt, John Pollard, Courtney Carlsson

“…ObjectiveThis study aimed to explore usage patterns and preliminary outcomes related to mental health and well-being among users of an app (Paradym; Paradym Ltd) designed to promote emotional well-being and positive mental health. MethodsThis is a pre-post, single-arm evaluation of real-world data provided by users of the Paradym app. …”
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Efficacy of a Self-Guided Internet Intervention With Optional On-Demand Feedback Versus Digital Psychoeducation on Sleep Hygiene for University Students With Insomnia: Randomized C... by Anna-Carlotta Zarski, Karina Bernstein, Harald Baumeister, Dirk Lehr, Stella Wernicke, Ann-Marie Küchler, Fanny Kählke, Kai Spiegelhalder, David Daniel Ebert

“…Analyses of covariance were conducted in an intention-to-treat sample. Secondary outcomes included diagnoses of insomnia and major depression, sleep quality, sleep efficiency, worrying, recovery experiences, recovery activities, presenteeism, procrastination, cognitive irritation, and recuperation in sleep. …”
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Research on nitrogen transformation pathways of a thermophilic heterotrophic nitrifying bacterial consortium GW7 by Yongqi Ma, Jiali Wang, Yindi Zhang, Wenping Guan, Wenrui Qi, Xisheng Tai, Dong Lin, Rong He, Likun Sun, Aiwen Zhang

“…The study aims to isolate and characterize a high-temperature-tolerant heterotrophic nitrifying bacterial consortium to enhance nitrogen transformation during aerobic composting.MethodsAn excellent high-temperature-tolerant heterotrophic nitrifying bacterial consortium, designated GW7, was enriched from compost samples at elevated temperatures. …”
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Combined microbial inoculation and reduced inorganic fertilization enhances diversity and functionality in potato rhizosphere microbiome at field scale by Irene Ollio, Raúl Zornoza, Josefa Contreras Gallego, Catalina Egea-Gilabert, Juan A. Fernández, Eva Lloret

“…Nevertheless, their effect on potato rhizosphere and tuberosphere require further elucidation. Methods A field experiment was conducted in Southeast Spain on potato using a randomized block design involving four fertilization treatments: conventional mineral fertilization (F100); 50% fertilization reduction (F50); and F50 combined with two distinct microbial inoculants (F50 + BA, containing Azospirillum, Bacillus, and Pseudomonas; and F50 + BAFU, containing Azotobacter, Bacillus, and non-mycorrhizal fungi). …”
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Exploring the role of negative expectations and emotions in primary dysmenorrhea: insights from a case-control study by Verena Thomann, Nadya Gomaa, Marina Stang, Susanne A. Funke, Karin Meissner

“…In this study, we investigated the role of pain expectations and negative anticipatory emotions as potential contributing factors to hyperalgesia in women with severe menstrual pain, compared to women with absent or mild menstrual pain. Methods We conducted a prospective case-control study in women with severe menstrual pain due to primary dysmenorrhea, comparing them with age-matched women with absent or mild menstrual pain. …”
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MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients by Ye R, Wei Y, Li J, Xu M, Xie H, Huang J, Deng L, Li C

“…We sought to investigate the profile of extracellular vesicles (EVs)-mediated communication between plasma and polymorphonuclear neutrophils (PMNs) in sepsis, and to elucidate whether miRNAs and PMN-related membrane proteins from plasma-derived EVs (plasma-EVs) are associated with sepsis-induced organ dysfunction and prognosis.Methods: PMN-derived EVs (PMN-EVs) were isolated from the blood samples of healthy controls (N=3) and patients with septic shock (N=3) after ICU admission. …”
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A család ereje: A házasságban élés és a nagycsaládos lét kapcsolata a jóllét különböző mutatóival by Andrea FERENCZI, Zsuzsanna KÖVI, Veronika MÉSZÁROS

“…The investigation also explores how these psychological phenomena relate to key sociodemographic variables such as age, gender, and religiosity. METHODS – A cross-sectional, quantitative survey was conducted with 809 participants (626 women and 183 men; M_age = 40.8 years, SD = 13.85). …”
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