Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection [Cor... by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Page 1721, Materials and Methods, Human Aortic Collection section, line 7, the text “confirmed by coronary CTA. …”
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METTL14 mediates the m6A methylation of miR-29a-3p, thereby activating the MAP2K6 signaling pathway and exacerbating the inflammatory response associated with spinal tuberculosis by Lijun Feng, Mengqi Zhu, Xu Zhang, Ningkui Niu, Zhiyun Shi

“…Through the construction of a BCG-infected THP-1 macrophage model, the expression of METTL14 and miR-29a-3p in spinal tuberculosis was verified by means of clinical sample analysis and cell experiments such as RT-qPCR, immunohistochemistry, and Western blot. …”
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Classifying the Information Needs of Survivors of Domestic Violence in Online Health Communities Using Large Language Models: Prediction Model Development and Evaluation Study by Shaowei Guan, Vivian Hui, Gregor Stiglic, Rose Eva Constantino, Young Ji Lee, Arkers Kwan Ching Wong

“…When suboptimal results were observed, we generated additional samples of the misclassified ones to give them more attention. …”
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The “pressure” of being an adolescent in the West Bank, Palestine: prevalence of prehypertension and hypertension by Dina Hamideh, Dina Hamideh, Hamzeh Al Zabadi, Noe C. Crespo, John Alcaraz, Mariam Mansour, Marcos Real, Baseel Hamideh, Nargis Ahmadi, Lamees Mahmoud, David Strong

“…A random sample of adolescents was recruited from schools from November 2022 to January 2023. …”
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Comparison of Biocompatibility of 3D-Printed Ceramic and Titanium in Micropig Ankle Hemiarthroplasty by Si-Wook Lee, Donghyun Lee, Junsik Kim, Sanghyun An, Chul-Hyun Park, Jung-Min Lee, Chang-Jin Yon, Yu-Ran Heo

“…We aimed to investigate the feasibility of partial talar components using ceramic and titanium 3D printing technology in terms of biocompatibility and stability through animal experiments. Methods: Preoperative 3D CT was acquired and converted to STL files to fabricate a partial talus component for ankle hemiarthroplasty using ceramic and titanium. …”
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Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Systematic review 2: quantitative, qualitative, mixed-methods research on patient/provider experiences. …”
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Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study by Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu, Xi Dong, Yue Zhao, Liangshan Mu

“…Methods We applied two‐sample Mendelian randomization (MR) and colocalization analysis using summary‐level data from genome‐wide association studies of GCKR and GDM. …”
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Transdiagnostic clustering of self-schema from self-referential judgements identifies subtypes of healthy personality and depression by Geoffrey Chern-Yee Tan, Ziying Wang, Ethel Siew Ee Tan, Rachel Jing Min Ong, Pei En Ooi, Danan Lee, Nikita Rane, Sheryl Yu Xuan Tey, Si Ying Chua, Nicole Goh, Glynis Weibin Lam, Atlanta Chakraborty, Anthony Khye Loong Yew, Sin Kee Ong, Jin Lin Kee, Xin Ying Lim, Nawal Hashim, Sharon Huixian Lu, Michael Meany, Serenella Tolomeo, Christopher Lee Asplund, Hong Ming Tan, Jussi Keppo

“…SRJs have been used to characterize personality in the general population and shown to be prognostic in depressive and anxiety disorders.MethodsIn this study, we used SRJs from a Self-Referential Encoding Task (SRET) to identify clusters from a clinical sample of 119 patients recruited from the Institute of Mental Health presenting with depressive or anxiety symptoms and a non-clinical sample of 115 healthy adults. …”
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Genetic transformation of Lentil (Lens culinaris M.) and production of transgenic fertile plants by Fatemeh zaker tavallaie, Behzad Ghareyazie, Abdorreza Bagheri, Kiran Komar Sharma

“…The objective of this research is gene transformation of lentil using codA gene to enhance its tolerance against abiotic stress especially cold tolerance. Materials and Methods Seeds of lentil (Lens culinaris Medik) variety of Gachsaran (ILL6212) collected from Shiravan Agriculture Research center in Iran were used in this investigation. …”
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Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhan... by Toshi A Furukawa, Pim Cuijpers, Tatsuo Akechi, Masaru Horikoshi, Yan Luo, Hisashi Noma, Takeo Nakayama, Helen Christensen, Naoki Kondo, Norito Kawakami, Aran Tajika, Ronald C Kessler, Shingo Fukuma, Masatsugu Sakata, Rie Toyomoto, James M S Wason

“…In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysis Based on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. …”
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Novel coronaviruses and mammarenaviruses of hedgehogs from Russia including the comparison of viral communities of hibernating and active specimens by A. V. Lukina-Gronskaya, I. K. Chudinov, I. K. Chudinov, E. V. Korneenko, E. V. Korneenko, S. D. Mashkova, T. A. Semashko, M. A. Sinkova, L. N. Penkin, E. M. Litvinova, N. Yu Feoktistova, A. S. Speranskaya

“…IntroductionSmall mammals, especially rodents and bats, are known reservoirs of zoonotic viruses, but little is known about the viromes of insectivorous species including hedgehogs (order Eulipotyphla), which often live near human settlements and come into contact with humans.MethodsWe used high-throughput sequencing and metaviromic analysis to describe the viromes of 21 hedgehogs (Erinaceus sp.) sampled from summer 2022 to spring 2023. …”
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Integrated machine learning identifies disulfidptosis-related and ferroptosis-related genes to evaluate survival prognosis and treatment efficacy in kidney renal clear cell carcino... by Yuan Xiang, Zijian Zhou, Tong Mu, Shunyao Zhang, Lei Xie, Yajie Zhou, Wenxiong Zhang, Liuxiang Fu

“…Our objective is to establish an innovative prognostic model for KIRC. Methods: We sourced KIRC patients’ information that contains clinical and genomic from The Cancer Genome Atlas (TCGA) database. …”
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Expression of CCR6 on <i>Helicobacter pylori</i>-specific circulating CD4+ T cells by Vladimir Yu. Talayev, I. Ye. Zaichenko, M. V. Svetlova, E. V. Voronina, O. N. Babaykina, N. V. Neumoina, K. M. Perfilova

“…In this work, we assessed the in vitro response of circulating CD4+CCR6+ and CD4+CCR6– T cells against H. pylori antigens in infected and intact individuals. Materials and methods. Monocytes and lymphocytes were isolated from blood samples. …”
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Identification of Glycolysis-Related Genes in MAFLD and Their Immune Infiltration Implications: A Multi-Omics Analysis with Experimental Validation by Jiawei Chen, Siqi Yang, Diwen Shou, Bo Liu, Shaohan Li, Tongtong Luo, Huiting Chen, Chen Huang, Yongjian Zhou

“…This study aims to identify glycolysis-associated key genes driving MAFLD progression and elucidate their crosstalk with immune infiltration through bioinformatics analysis and experimental validation. <b>Methods</b>: Integrative multi-omics analysis was performed on bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomic datasets from MAFLD patients and controls. …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Our qualitative process evaluation suggested that implementation methods need to include: Creating opportunities for discussing antidepressant discontinuation (more active reviews of people on long-term treatment and fewer routinely repeated prescriptions). …”
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CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer by Zi-Xin Wu, Tian-Tian Da, Chuan Huang, Xiao-Qing Wang, Liang Li, Zhi-Bin Zhao, Ting-Ting Yin, Hai-Qing Ma, Zhe-Xiong Lian, Jie Long, Fei Wang, Jie Cao

“…However, the characteristic surface molecules and functions of CD8+ TRM cells exhibit significant heterogeneity. Methods The roles and anti-tumor biological functions of different CD8+ TRM subsets in CRC were determined by clinical CRC samples, bioinformatics analysis, and in vitro experiments including co-culture experiments and transwell migration assays. …”
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Associations of per- and polyfluoroalkyl substances in follicular fluid with polycystic ovarian syndrome in infertile women may be mediated by sex hormones by Yating Bian, Yingxiao Yue, Yufan Cheng, Dan Wang, Lu He, Peixia Yan, Huan Song, Tong Wang, Weidong Zhou, Xu Zhang, Zhizhen Pan, Liangpo Liu, Liangpo Liu

“…Additionally, in-vitro experiment with human ovarian granulosa cell line (KGN cells) was conducted.ResultsThe study showed that perfluoro-n-octanoic acid (PFOA) and potassium perfluoro-1-octanesulfonate (PFOS) were the dominant PFAS in the follicular fluid samples, with the median concentration of 4.35 ng/mL and 5.22 ng/mL, respectively. …”
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Regional and aging-specific cellular architecture of non-human primate brains by Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu

“…However, systemic delineation of the cellular composition and molecular connections among multiple brain regions and their alterations induced by aging in NHPs remain largely unresolved. Methods In this study, we performed single-nucleus RNA sequencing on 39 samples collected from 10 brain regions of two young and two aged rhesus macaques using the DNBelab C4 system. …”
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SNRPB2: a prognostic biomarker and oncogenic driver in esophageal cancer via β-catenin/c-Myc signaling by Jiaqian Bao, Jiaqian Bao, Xiong Tian, Xiong Tian, Yixiao Pan, Yixiao Pan, Yiqing Guo, Yiqing Guo, Zhenyu Yang, Zhenyu Yang, Meifu Gan, Meifu Gan, Jingmin Zheng, Jingmin Zheng

“…While SNRPB2 dysregulation has been observed in various cancers, its role in esophageal cancer (ESCA) remains unclear.MethodsThe mRNA level of SNRPB2 in ESCA was evaluated in combination with TCGA, GTEX, and GEO databases. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Aim To either identify or develop and validate a patient-reported outcome measure (PROM) to assess patient-centredness in consultations for patients with multimorbidity in general practice. Methods We attempted to identify an existing PROM through a systematic literature review. …”
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