Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment by Chuanyu Ma, Chuanyu Ma, Guandu Li, Xiaohan Song, Xiaochen Qi, Tao Jiang

“…Therefore, we set out to investigate the feasibility of judging patients’ disease and knowing the clinical treatment based on the level of ITH.MethodsClinical information and transcriptome expression matrices of PRAD samples were gained from The Cancer Genome Atlas (TCGA) database. …”
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Surface damage in tungsten induced by high heat flux helium irradiation at high temperatures across melting point by Hanqing Wang, Yue Yuan, Baoqin Fu, H. Greuner, B. Böswirth, Mengchong Ren, Yufei Nie, Peng Zhang, Xingzhong Cao, Guang-Hong Lu

“…In this study, surface modifications occurring at high temperatures (>2200 K) up to the melting point were investigated by conducting experiments involving two campaigns of vertical displacement events like HHF He neutral beam pulse irradiation on polycrystalline W samples at the test facility Garching LArge DIvertor Sample. …”
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Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage by Shuchen Huangfu, Chaoting Lan, Sitao Li, Huijuan Wang, Chun Yan, Yuling Yang, Bowen Tian, Yide Mu, Peizhi Zhao, Yan Tian, Yijia Wang, Wei Zhong, Limei Zhong, Yongyan Shi, Yufeng Liu

“…In vivo experiments were performed using ACOD1−/‐ and ACOD1fl/flLysMcre NEC mouse models. …”
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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression by Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

“…Methods Non-targeted quantitative proteomics were performed on cytosolic and nuclear fractions of liver samples [HCC vs. non-tumour adjacent tissue (NTAT), n = 42 patients]. …”
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Improving equity and wellness in cancer care with people of Latin American and African Descent: a study protocol by Anna Santos Salas, Sharon M. Watanabe, Aynharan Sinnarajah, Nahyeni Bassah, Fleur Huang, Jacqueline Alcalde-Castro, Harkeert Judge, Hannah M. O'Rourke, Pilar Camargo Plazas, Bukola Salami, María J. Santana, Omar Abdel Rahman, Iqmat Iyiola, Tracy Wildeman, Lisa Vaughn, Sadia Ahmed, The Patient Advisory Council

“…We aim to delineate together with people of African and Latin American descent a patient-oriented pathway to improve their equity and wellness in cancer care.MethodsThis is a 3-year community-based and patient-oriented participatory research study. …”
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KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients by Ao Wang, Xiao-Fei Zhang, Cong-Jian Luo, Yu-Dong Liu, Pei-Ru Chen, An-Lan Wang, Jun Zhang, Song-Yu Huang, Xin-Yi Huang, Shi-Ling Chen, Xing-Yu Zhou

“…While KAT2B has been documented to participate in various biological processes, its specific role and mechanism in the pathogenesis of PCOS remain largely unknown. Methods We collected GCs from PCOS patients to quantify the expression levels of KAT2B and analyzed the correlation between KAT2B expression and clinical characteristics. …”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…The aim of our study is to explore whether there are genes related to the pathogenesis of LUAD in the ELOVLs family, and even to guide clinical medication and potential prognostic indicators. Methods Gene expression profiling interactive analysis (GEPIA), human protein atlas (HPA), cBioPortal, Kaplan–Meier (KM) plotter, single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm and SubMap algorithms were utilized to analyze the role of ELOVLs in the LUAD. …”
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Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer by Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

“…Validation for the prognostic model gene OAT was performed to identify the prognostic significance, combined with in vitro experiments to explore its expressions in OV cells. qRT-PCR assay was performed to examine the expression of OAT in human ovarian cancer cell samples and normal ovarian epithelial cells. …”
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Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…Therefore, our study seeks to elucidate the intricate mechanisms of ferroptosis within the lipid metabolism pathway in AS.MethodsDifferentially expressed genes were identified from the GSE100927 dataset, subsequently isolating AS lipid metabolism-related ferroptosis genes (ASLMRFeGs). …”
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Targeting the AURKB-MAD2L2 Axis Disrupts the DNA Damage Response and Glycolysis to Inhibit Colorectal Cancer Progression by Shengjie Li, Jiayou Ye, Kaifeng Yang, Chengfan Xu, Zhixiang Qin, Yiyang Xue, Lanjian Yu, Tianyu Zhou, Ziming Yin, Bin Sun, Jun Xu

“…The mitotic arrest deficient-like 2 (MAD2L2) and aurora kinase B (AURKB) genes play roles in cell cycle regulation and the DDR, making them potential targets for CRC therapy. Methods: Differential expression analysis was performed using The Cancer Genome Atlas-Colon Adenocarcinoma (TCGA-COAD) and GSE47074 datasets. …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

“…This study aimed to fill the gap by exploring patients’ perceptions and acceptability of AI conversational agents in mental healthcare.MethodsAdults with self-reported mild to moderate anxiety were recruited from the UMass Memorial Health system. …”
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“They Know You Better Than the Transplant Team”: An Interpretive Description Study Exploring the Perspectives of Living Kidney Donors About Care Received From Family Physicians by Katya Loban, Charo Rodriguez, Antoine Przybylak-Brouillard, Elie Fadel, Heather Badenoch, Peter Nugus, Ann Bugeja, Justin Gill, Marie-Chantal Fortin, Emilie Trinh, Scott McKay, Shaifali Sandal

“…Setting and Participants: Canadian LKDs who donated a kidney prior to 2020. Methods: Qualitative interviews and inductive thematic analysis. …”
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ADORA2B promotes proliferation and migration in head and neck squamous cell carcinoma and is associated with immune infiltration by Pian Li, Ke-ling Pang, Shuang-jing Chen, Dong Yang, Ai-tao Nai, Gui-cheng He, Zhe Fang, Qiao Yang, Man-bo Cai, Jun-yan He

“…This study aims to elucidate the expression profile, prognostic value, immune modulatory role, and therapeutic potential of ADORA2B in HNSC. Methods Comprehensive bioinformatics analyses were performed using TCGA and GEO datasets to evaluate ADORA2B expression, clinical correlations, and prognostic significance in HNSC. …”
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Evaluation of the electrocoagulation process in API oil refinery wastewater treatment (case study: Arak , Shazand) by Toktam Shahriari, Abdolreza Karbasi, Milad Reihani

“…At each stage of the experiment, after measuring the pH and COD of the initial wastewater, the volume of 2 L was poured out as an internal sample into the coagulation reactor; after the electrochemical process, the secondary pH and COD were measured to determine the effect of the electrocoagulation process. …”
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The prognostic model of low-grade glioma based on m6A-associated immune genes and functional study of FBXO4 in the tumor microenvironment by Yiling Zhang, Na Luo, Xiaoyu Li, Chuanfei Zeng, Xin Chen, Xiaohong Peng, Yuanyuan Zhang, Guangyuan Hu

“…However, research on m6A-related immune markers in low-grade gliomas is still limited and requires further investigation. Methods All data was obtained from the Chinese Glioma Genome Atlas database and The Cancer Genome Atlas. …”
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A proposed workflow to robustly analyze bacterial transcripts in RNAseq data from extracellular vesicles by Alex M. Ascensión, Miriam Gorostidi-Aicua, Miriam Gorostidi-Aicua, Ane Otaegui-Chivite, Ane Otaegui-Chivite, Ainhoa Alberro, Ainhoa Alberro, Rocio del Carmen Bravo-Miana, Rocio del Carmen Bravo-Miana, Tamara Castillo-Trivino, Tamara Castillo-Trivino, Laura Moles, Laura Moles, David Otaegui, David Otaegui

“…As a proof of concept, we applied this workflow to a dataset from individuals with multiple sclerosis (MS).MethodsWe analyzed total EV RNA-seq data from blood samples of healthy controls and individuals with MS, encompassing both the Relapsing-Remitting (RR) and Secondary Progressive (SP) phases of the disease. …”
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Germicidal Efficiency of 272 nm LED in Relation to the Hospital Strain of Klebsiella Pneumoniae by A. S. Kamrukov, T. V. Chernenkaya, L. Yu. Volodin, S. S. Petrikov, K. A. Popugaev, V. V. Bagrov, I. V. Bukhtiyarov, E. V. Zibarev, K. A. Semenov, V. I. Krylov

“…OF STUDY To evaluate the bactericidal efficacy of 272 nm LED radiation against hospital strains of Klebsiella pneumoniae bacteria characterized by multidrug resistance.Materials and Methods. The studies were carried out with an experimental sample of the LED apparatus for UV irradiation. …”
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A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome by Xiaoxiao Wang, Yingxue Liu, Guanghui Yuan, Jingjie Yang, Xiaowen Liu, Shuyuan Chen, Huaiqian Dou, Panpan Lu, Linfang Han, Duan Li, Cuifang Hao

“…A clinical and experimental analysis of two pedigrees was performed in this study to investigate the genetic basis of EFS. Methods Genomic DNA was extracted from peripheral blood samples for whole-exome sequencing in EFS patients. …”
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CD11b/CD86 involved in the microenvironment of colorectal cancer by promoting Wnt signaling activation by Junyu Ke, Guirong Chen, Yihui You, Qinghua Xie, Zheng‐lin Liu, Chunhui Song, Yanqiu Zheng, Zejun Shan, Jinbin Song, Zhangyu Jiang, Haiyan Wang, Qun Du, Yongqiang Wu, Xin‐lin Chen, Yanwu Li

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Remapping Body Representation Using Virtual Reality in Chronic Neuropathic Pain: Systematic Review by Maria Grazia Maggio, Mirjam Bonanno, Andrea Calderone, Amelia Rizzo, Nebahat Bulut, Mahmood Bahramizadeh, Alessandra Benenati, Francesco Tomaiuolo, Angelo Quartarone, Daniela Floridia, Rocco Salvatore Calabrò

“…Furthermore, this review seeks to identify gaps in current research, offering recommendations for future research directions and clinical applications. MethodsWe performed a comprehensive literature search in PubMed, Web of Science, and Scopus for studies published between January 2014 and December 2024. …”
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