GPD1L as a potential biomarker associated with Treg cell infiltration and lipid metabolism in clear cell renal cell carcinoma by Ming Yang, Dejiang Pang, Chuhui Gong, Kangping Song, Hongbo Ma, Yu Yang, Shujin Guo, Liqiong Wang

“…Understanding the mechanisms underlying this abnormal infiltration and identifying prognostic biomarkers in this regard is crucial for improving therapeutic outcomes. Methods The expression of GPD1L in ccRCC was analyzed using a common database (TCGA). …”
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Influence of bottled salad dressings on the development of enamel erosion in the presence or absence of salivary pellicle – An in vitro study by Aishwarya Lakshmi Billa, Jagadeeswara Rao Sukhabogi, Dolar Doshi, Prashant Sharma, T.V.S. Subrahmanyam, Sasikala Jummala

“…Therefore, the current study aimed to investigate the influence of bottled salad dressings on the development of enamel erosion in the presence or absence of pellicle through in vitro experiment. Methods: Preliminary pH and calcium analyses of solutions were performed. …”
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A multi-filter deep transfer learning framework for image-based autism spectrum disorder detection by Rodrigo Colnago Contreras, Monique Simplicio Viana, Victor José Souza Bernardino, Francisco Lledo dos Santos, Önsen Toygar, Rodrigo Capobianco Guido

“…The use of frozen pre-trained networks allows for a lightweight, deterministic pipeline without the need for fine-tuning. Experiments are conducted using eight pre-trained models on a well-established benchmark facial dataset in the literature, comprising samples of autistic and non-autistic individuals. …”
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Levels of apoptosis factors in mitochondria of brain cortex cells in female С57ВL/6 mice in dynamics of B16/F10 melanoma growth combined with comorbidity by E. M. Frantsiyants, I. V. Neskubina, N. D. Cheryarina, E. I. Surikova, A. I. Shikhlyarova, V. A. Bandovkina, L. A. Nemashkalova, I. V. Kaplieva, L. K. Trepitaki, P. S. Kachesova

“…To analyze the apoptosis indicators in mitochondria of brain cortex cells in female С57ВL/6 mice in the dynamics of B16/F10 melanoma growth alone and in combination with comorbidity, i.e. chronic neurogenic pain.Materials and methods. Female С57ВL/6 mice (n = 168) were used in the experiment. …”
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Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma by Taibo Huang, Lijie Kou, Qianqian Zhang, Xueya Liu, Xingang Hu

“…However, its role in shaping cellular complexity and predicting outcomes in LUAD patients is not yet fully clarified. Methods: We examined single-cell RNA sequencing datasets from LUAD samples to identify distinct malignant cell groups. …”
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MIR4726EccDNA drives bortezomib resistance in multiple myeloma by enhancing MIR4726-5p/NXF1/NKIRAS2 axis dependent autophagy by Fangfang Li, Xinyi Long, Sishi Tang, Jinhua Yan, Jing Liu, Yunfeng Fu

“…Characterized by efficient transcription without being limited by the double helix structure and promoter, extrachromosomal circular DNA (EccDNA) has been proven to be widely involved in cancer development and drug resistance. Methods We performed circle-seq and mRNA-seq on samples from three MM patients at the time of complete response and relapse to screen EccDNA candidate molecules. …”
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Frequency and determinants of words, gestures, and attitudes experienced as disrespectful during childbirth and postpartum: A national population‐based study by Marianne Jacques, Anne Alice Chantry, Anne Evrard, Nathalie Lelong, Camille Le Ray, the ENP 2021 Study Group

“…The aim was to assess the frequency and determinants of professionals' words, gestures and attitudes experienced as disrespectful by women during childbirth and postpartum stays. Material and Methods This national quantitative observational study used the population‐based Enquête Nationale Périnatale (ENP) 2021 database, which provides a representative sample of women who gave birth in metropolitan France and includes a 2‐month postpartum follow‐up (n = 7394). …”
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RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m6A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenoty... by Jinkun Fu, Chao Wei, Yijian Chen, Xiaoming He, Kun Zhang

“…However, the development of drug resistance in tumor cells to chemotherapeutic agents poses great challenges to anticancer treatment. Methods Bioinformatics analysis was used to screen the up-regulated genes in paclitaxel (PTX)-resistant TNBC cells. …”
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Two-dimensional modeling of nitrate transport in canola field under Moistube irrigation using HYDRUS 2D/3D by Tinashe Lindel Dirwai, Tinashe Lindel Dirwai, Aidan Senzanje, Aidan Senzanje, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi

“…While previous studies have explored wetting patterns under Moistube Irrigation (MTI) and discussed qualitative nitrate retention, few have quantitatively simulated nitrate transport through variably saturated zones with fine temporal-spatial resolution.MethodsA field experiment was conducted in a 20 m × 8 m naturally ventilated greenhouse using three irrigation regimes: (i) full irrigation (100% ETc), (ii) optimal deficit irrigation (75% ETc), and (iii) extreme deficit irrigation (55% ETc). …”
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The Effect of Transfusion and Hypoxia on Cells in an in vitro Model of the Neurovascular Unit by A. A. Ivkin, E. V. Grigoriev, E. D. Khilazheva, A. V. Morgun

“…In vitro evaluation of hypoxia and SIR effects on the neurovascular unit (NVU) cells might contribute to finding the answer.The aim of the study was to compare the effect of varying severity hypoxia and SIR on the functional activity of NUV cells in vitro.Materials and methods. An in vitro NVU model was designed including neurons, astrocytes and endotheliocytes. …”
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Yinzhihuang Oral Liquid Alleviates Intrahepatic Cholestasis of Pregnancy: Integrated Bioinformatics and Experimental Mechanistic Insight by Ting Liu, Xinrun Zhuang, Wei Gu, Wei Liu, Jin Zhang, Weijian Zeng, Jue Li, Yang Pan

“…To systematically study the mechanisms by which Yinzhihuang (YZH), a traditional Chinese medicine, ameliorates intrahepatic cholestasis of pregnancy (ICP), a liver disorder associated with significant maternal and fetal complications. Methods:. This experimental study was conducted from January 2024 to August 2024, utilizing data from public databases (Traditional Chinese Medicine Systems Pharmacology, GeneCards, Online Mendelian Inheritance in Man, DisGeNET, Proteome Xchange) alongside in vitro cell culture experiments. …”
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Inequalities in COVID-19 impact on preschool mental health in India: key moderators of adverse outcome by Andrew Pickles, Jonathan Hill, Helen Sharp, Nicky Wright, Laura Bozicevic, Thirumalai Ananthanpillai Supraja, Prabha S. Chandra

“…We provide the first empirical evidence for the impact of the pandemic on emotional and behavioural problems in Indian preschool children, after accounting for normative age-related change, and test whether the impact varied depending on COVID-19-related inequalities.Methods Families participating in an Indian-based prospective longitudinal birth cohort (Bangalore Child Health and Development Study) provided data at age 2 years (before COVID-19) and again during COVID-19 (n=528). …”
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Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas by Yu Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou

“…Serum samples were collected to quantify the expression levels of SFTA3 in LUAD patients. …”
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Needs and Wishes Towards Sex- and Gender-Sensitive Chronic Pain Management: A Qualitative Study with German General Practitioners by Piotrowski A, Schmidt A, Seuken N, Goldberg L, Kufeld N, Kersting C, Bencheva V, Thürmann P, Mortsiefer A

“…To inform the intervention design, we explored general practitioners’ (GPs) experiences and needs in managing this patient group, with a particular focus on the role of sex and gender.Methods: We conducted semi-structured telephone interviews with five GPs in Germany using a convenience sample. …”
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PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma by Ranran Feng, Yilin Guo, Meilin Chen, Ziying Tian, Yijun Liu, Su Jiang, Jieyu Zhou, Qingluan Liu, Xiayu Li, Wei Xiong, Lei Shi, Songqing Fan, Guiyuan Li, Wenling Zhang

“…Currently, the relationship between PLUNC (as a tumor-suppressor) and PD-L1 in NPC is unclear. Methods We collected clinical samples of NPC to verify the relationship between PLUNC and PD-L1. …”
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The m6A modification of LINC01133 suppresses ER+ breast cancer progression by modulating IGF2BP2 protein stability via a ubiquitination-dependent mechanism by Mai-dong Li, Mai-dong Li, Ben-jie Shan, Lei Wang, Shuang Gao, Li Hao, Hai-yang Yu, Yue-yin Pan, Yue-yin Pan

“…LINC01133 exhibits opposing expressing patterns across different breast cancer subtypes, yet its roles and mechanisms in ER+ breast cancer remain a loaded question.MethodsThe expression of LINC01133 was initially assessed utilizing a public dataset TCGA and subsequently validated within clinical samples through RT-qPCR and in situ hybridization (ISH). …”
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Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…We investigated whether H. pylori eradication would protect against aspirin-associated ulcer bleeding. Methods The Helicobacter Eradication Aspirin Trial was a randomised placebo-controlled trial (European Union Drug Regulating Authorities Clinical Trials 2011-003425-96), conducted in United Kingdom primary care using routinely collected clinical data. …”
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Association of PM2.5 and its elemental components with plasma metabolome in healthy older adults: Evidence from epidemiological and experimental studies by Quan Zhou, Liangping Chen, Chenzhou He, Xiaoying Liu, Wenli Wang, Shuling Kang, Yu Jiang, Jianjun Xiang, Xiaoyang Zhang, Chuancheng Wu

“…Objective: To identify key metabolites associated with PM2.5 exposure and its elemental components, with validation through animal experiments. Methods: A total of 112 healthy older adults were enrolled in the cross-sectional study between winter 2020 and summer 2021. …”
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Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…We performed a molecular characterization of CdLS in a multiplex Rwandan family. Methods After a clinical evaluation of two affected siblings, DNA isolated from peripheral whole blood of the affected patients and their parents underwent Exome Sequencing (ES). …”
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Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway by Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu, Benyu Liu

“…Nevertheless, the functions of the vast majority of non-coding RNAs are yet to be clearly elucidated. Methods Long non-coding RNA (lncRNA) LINC02320 was screened out by RNA-sequencing using paired CRC samples. …”
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