Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4−related op... by Yu Yang, Yu Yang, Yujiao Wang, Xuelian Jin, Weimin He

“…This study aimed to investigate the differences between these two diseases based on their cellular composition, transcriptional heterogeneity, and the immune microenvironment using single-cell RNA transcriptional sequencing (scRNA-seq) technology.MethodsWe collected orbital lacrimal gland region tissue samples from three patients with MALT lymphoma and another three with IgG4-ROD and performed single-cell sequencing experiments. …”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…However, its significance in ccRCC has not yet been explored. Methods We utilized external datasets and bioinformatics analyses to investigate the significance of DBF4 in ccRCC. …”
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Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice by Huijing Gao, Qinwei Xu, Jiang Zhu, Kadierya Kuerban, Bei Chen, Jun Zhao, Kalibixiati Aimulajiang, Liang Teng

“…This study aims to assess the in vivo and in vitro efficacy of H-2-104 against E. granulosus and to elucidate the mechanism of action of H-2-104 against CE from a metabolomics perspective. Methods In vitro pharmacodynamics experiments were conducted to assess the inhibitory activity of H-2-104 against E. granulosus protoscoleces (PSCs). …”
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Morphological Changes Depending on the Contentof Clozapine and its Metabolites in the Lungs and Serum (Experimental Study) by O. L. Romanova, D. V. Sundukov, A. M. Golubev, M. I. Blagonravov

“…The purpose of the study: to assess the morphological changes in the lungs depending on the content of clozapine and its metabolites in the lungs and serum.Materials and methods. The experiments were performed on male outbred rats weighing 290-350 g at the age of 20 weeks (n=15). …”
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Involvement of miR-205-5p in mediating the development of nodular thyroid disease associated with coal worker’s pneumoconiosis via pulmonary extracellular vesicles by Feng Zhao, Yu Hao, Hongzhen Zhang

“…This study aimed to investigate the role of miR-205-5p (miR-205-5p) in the development of nodular thyroid disease associated with coal worker’s pneumoconiosis.MethodsThe potential role of pulmonary extracellular vesicles in triggering coal worker’s pneumoconiosis-associated nodular thyroid disease was explored. …”
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Design, spectroscopic analysis, DFT calculations, adsorption evaluation, molecular docking, comprehensive in silico and in vitro bioactivity studies of thiocarbohydrazide grafted d... by Magda A. Akl, Aya G. Mostafa, Abdelrahman S. El-Zeny, El-Sayed R. H. El-Gharkawy

“…Subsequent characterization of DAC@TCH was carried out utilizing various analytical methods such as elemental analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), and thermogravimetric analysis (TGA and DTA). …”
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BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancy by Shengpeng Li, Weiying Zhu, Zhixuan Xing, Dan Chen, Huimin Zhao, Yanli Zhang, Wenlong Zhang, Jiaojiao Sun, Yaxian Wu, Ling Ai, Qingfeng Pang

“…This study aims to investigate the role of BACH1 in ICP. Methods The study used clinical samples and two distinct mouse models of ICP to validate BACH1 alterations in ICP through immunohistochemistry (IHC), immunofluorescence (IF), and western blot (WB) analyses. …”
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Probiotic efficacy of Cetobacterium somerae (CGMCC No. 28843): promoting intestinal digestion, absorption, and structural integrity in juvenile grass carp (Ctenopharyngodon idella) by Yuanxin Chen, Weidan Jiang, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Jun Jiang, Ruinan Zhang, Hua Li, Lin Feng, Xiaoqiu Zhou

“…Methods A cohort of 2,160 juvenile grass carp with an initial mean body weight of 11.30 ± 0.01 g were randomly allocated into 6 treatment groups, each comprising 6 replicates (60 fish per replicate). …”
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Construction of dynamic ceRNA regulatory networks in osteogenesis during fracture healing based on transcriptomic analysis by Shuhang Guo, Shen Wang, Shaoxun Yuan, Xinyi Gu, Jin Deng, Chen Huang, Xinyi Zeng, Qingguo Lu, Xiaofeng Yin

“…This study aimed to investigate the key molecules involved in fracture healing and their potential competing endogenous RNA (ceRNA) regulatory mechanisms within the first 28 days post-fracture using bioinformatics methods. The experiment was conducted on 15 adult male SD rats, with tibia callus tissue samples collected at days 0, 3, 7, 14, and 28 (n = 3) post-fracture. …”
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Incomplete Thermal Ablation-Induced FOXP4-Mediated Promotion of Malignant Progression in Liver Cancer via NDST2 by Wan W, Pan Y, Pang J, Bai X, Li L, Kang T, Chen J, Wen R, Wen D, Yang H, He Y

“…We investigated the mechanism by which Forkhead box P4 (FOXP4) promotes the malignant transformation of residual HCC cells through N-deacetylase and N-sulfotransferase 2 (NDST2) after incomplete thermal ablation.Methods: The clinical significance of FOXP4 and NDST2 in HCC was evaluated using big data analysis. …”
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Establishing a System for Medical Certification of Cause of Death for Noninstitutional Deaths in a Selected Area of Kolar District, Karnataka, India: Protocol for a Population-Base... by Madhusudan Muralidhar, Sukanya Rangamani, Vaitheeswaran Kulothungan, Priyanka Das, Monesh B Vishwakarma, Prashant Mathur

“…ObjectiveThis study will assess the feasibility of a physician-derived cause of death (PhyCoD) approach for deducing CoD in noninstitutional deaths in a selected area of Kolar Taluk, Karnataka, and validate this approach. MethodsThis population-based feasibility and validation study will be conducted in 4 selected hospitals and 2 Primary Health Centre (PHC) areas in Kolar taluk, Kolar district, Karnataka, India. …”
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User accommodation to an active microprocessor-controlled knee in individuals with unilateral transfemoral amputation: a 5-week non-randomized trial by Elke Lathouwers, Alexandre Maricot, Bruno Tassignon, Sybille Geers, Louis Flynn, Tom Verstraten, Kevin De Pauw

“…Our findings indicate that five one-hour sessions are insufficient for achieving user accommodation, and underscore the need for further research with a larger sample, continued prosthetic use and user accommodation to enhance prosthetic functioning and user experiences. …”
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MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma by Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi

“…We aimed to elucidate the molecular mechanisms underlying MTMR6 with cisplatin resistance in OSCC. Methods MTMR6 expression was compared between UMSCC1 and cisplatin-resistant UM-Cis cells. …”
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Olympic combat sports and mental health in children and adolescents with disability: a systematic review of controlled trials by Youngjun Lee, Flavia Guidotti, Flavia Guidotti, Laura Capranica, Caterina Pesce, Valentin Benzing, Janet Hauck, Simone Ciaccioni, Simone Ciaccioni

“…However, not much is known about their mental health impact on this population.MethodsFollowing PRISMA-P protocols (PROSPERO registration: CRD42023452489), we searched seven databases for randomized controlled trials or non-randomized trials that evaluated the impact of OCS on mental health in children and adolescents (5–18 years) with developmental or physical disabilities. …”
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Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage by Dandan Gao, Bin Zou, Kunyuan Zhu, Shijun Bi, Wenxu Zhang, Xinyu Yang, Jieyu Lai, Guobiao Liang, Pengyu Pan

“…Peripheral blood and cerebrospinal fluid (CSF) samples were assessed by ELISA and flow cytometry. …”
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Extração de fósforo em solos cultivados com cana-de-açúcar e suas relações com a capacidade tampão Extraction of phosphorus in soils cultivated with sugarcane and relationship with... by Djalma E. Simões Neto, Alexandre C. de Oliveira, Fernando J. Freire, Maria B. G. dos S. Freire, Clístenes W. A. do Nascimento, Alexandre T. da Rocha

“…Therefore, this work had as objective to evaluate extraction methods to estimate P availability considering content and quality of clay fraction as well mineralogical, chemical and physical soil characteristics. …”
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Differential effects of left DLPFC anodal and cathodal tDCS interventions on the brain in children with autism: A randomized controlled trial by Jiannan Kang, Juanmei Wu, Xinping Huang, Wenqin Mao, Xiaoli Li

“…In future research, we will continue to improve the experiments to address these limitations.…”
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Choosing, changing or adhering to a registered doctor in a managed care plan: what will it take? A qualitative survey in rural Mpumalanga, South Africa by Nzapfurundi Chabikuli, Montagu Murray, Sam G. Fehrsen, Jannie F. Hugo

“…The participants in this study were purposively sampled to include a wide range of opinions about the characteristics of a good doctor. …”
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Plant-beneficial bacteria are promoted in pasture-crop rotations in the Uruguayan Pampa, contributing to soil health and crop performance by Victoria Cerecetto, Victoria Cerecetto, Kornelia Smalla, Doreen Babin, Carolina Leoni

“…This study examines how land use intensity and grazed pasture legacy influence soil and rhizosphere prokaryotic diversity, composition, functionality, and crop productivity.MethodsA gradient of land use intensities ranging from continuous cropping (CCG), short (SR) and long (LR) pasture-crop rotations, permanent improved pasture (PIP), and natural grassland (NGL) were sampled in a long-term field experiment established in 1995 in the Uruguayan Pampa. …”
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Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis by Xinping Huang, Hailong Shu, Man Xu, Weixiao Ke, Wanting Chen, Wenbin Huang, Hai Wang, Yifan Zhu, Yongxia Yang

“…Taurine, as an important metabolite, shows significant changes during breast cancer development, while the taurine transporter SLC6A6 may play a key role in breast cancer progression. Methods This study systematically investigated the relationship between taurine level changes and breast cancer development through cell experiments, animal models, and clinical sample analysis. 1H NMR and HPLC techniques were used to measure taurine levels in different breast cancer cell lines, MMTV-PyMT transgenic mouse models, and clinical patient serum. …”
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