Biochar amendment alters rare microbial taxa and enhances wheat growth in alkaline farmland: insights into soil microbiome dynamics by Jian-Qing Qi, Hai-Yan Yuan, Shu-Chen Sun, Eric Fru Zama, Bao-Xian Tao, Jin Liu, Bao-Hua Zhang

“…In particular, the responses of rare microbial communities, such as rare protists and phoD-harboring microbial taxa, to biochar and their relationship with crop biomass remain largely unexplored.MethodsIn this study, topsoil (0–10 cm) samples were collected from a three-year field experiment in a wheat (Triticum aestivum cv. …”
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Inhibition of adenosine/A2A receptor signaling suppresses dermal fibrosis by enhancing fatty acid oxidation by Xiaoye Zhang, Jinjian Sun, Jia Guo, Xiaoru Hu, Junyu Zhou, Xiaoyun Xie, Xiang Chen, Hui Luo, Hong Liu, Yuzi Tian

“…While the role of metabolism in fibrosis has gained increasing attention, the crucial alterations of metabolic pathway and the underlying signaling of metabolic interconnections in regulating SSc-related skin fibrosis remain largely elusive. Methods Metabolomic analysis was performed on plasma samples from 35 SSc patients to identify metabolic alterations. …”
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Cover crop impacts on soil organic matter dynamics and its quantification using UAV and proximal sensing by Nikolaos-Christos Vavlas, Rima Porre, Liang Meng, Ali Elhakeem, Fenny van Egmond, Lammert Kooistra, Gerlinde B. De Deyn

“…Furthermore, accurate quantification of SOM at field scale is severely constrained by the labour intensity and destructive nature of traditional methods, which limits the ability to quantify and monitor cover crop impacts on SOM. …”
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Electrochemical Immunosensors on Laser-Induced Graphene Platforms for Monitoring of Anti-RBD Antibodies After SARS-CoV-2 Infection by Beatriz R. Martins, Cristhianne Molinero R. Andrade, Guilherme F. Simão, Rhéltheer de Paula Martins, Lucas V. de Faria, Tiago A. Matias, Virmondes Rodrigues Júnior, Rodrigo Alejandro Abarza Munoz, Renata Pereira Alves

“…The development of fast, accurate, and accessible diagnostic methods is essential in controlling the disease and mitigating its impacts. …”
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High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer by Yufei Deng, Xiaoying Hou, Qian Fang, Haiping Wang, Xiaoxuan Li, Zhiyong Hu, Zhaolu Liu, Limei Fan, Yunyi Liu, Zhengqi Fu, Xiji Shu, Binlian Sun, Lijun Huang, Yuchen Liu

“…Therefore, we aimed to investigate the effect and mechanism of high-salt diets on the anti-CRC effect of FOLFOX. Methods We performed 16 S rRNA sequencing and T500 targeted metabolomics analysis on fecal samples from CRC patients and healthy adults. …”
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Citrate regional anticoagulation of 500 ml/min of extracorporeal blood flow: an experimental study by Sebastiano Maria Colombo, Luigi Vivona, Michele Battistin, Vittorio Scaravilli, Alessandro Galli, Chiara Anzanello, Elisa Cipriani, Francesca Gori, Serena Todaro, Carlo Valsecchi, Daniele Dondossola, Anna Paola Marcello, Andrea Carlin, Antonio Pesenti, Giacomo Grasselli, Alberto Zanella

“…Citrate concentrations in blood samples were stable within 30 min, then slowly increased. …”
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Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation by Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo

“…This study aimed to examine the molecular mechanisms underlying the involvement of NSUN2 in immune evasion and metabolic reprogramming of HCC. Methods Single‐cell transcriptomic sequencing was applied to examine cellular composition changes, particularly immune cell dynamics, in HCC and adjacent normal tissues. …”
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Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hep... by Sara Ahmadi Badi, Hananeh Tavakoli Aval, Hamid Reza Moradi, Amin Malek, Seyed Amirhesam Seyedi, Mehdi Davari, Ahmad Bereimipour, Soghra Khani, Shohreh Khatami, Seyed Davar Siadat

“…Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC) were used to evaluate the effects of the interventions on gene expression related to the hepcidin-ferroportin axis in liver, colon and brain samples. Additionally, qPCR was used to determine alterations in the relative abundance of key gut microbiota members in fecal samples. …”
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VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation by Wu W, Cai H, Nan Y, Tang J, Wang Y

“…In this paper, we identified new susceptibility genes in RA and investigated their underlying mechanisms using integrated Mendelian randomization (MR) analysis.Methods: Two-sample MR analyses were used to determine the causative links among eQTLs, metabolites, and RA risk. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Therefore, we hypothesized that MT2A could promote angiogenesis in chronically ischemic brains by neutralizing excessive copper ions during copper overload (CPO). Methods We first collected dura matter (DM) samples from CICD patients and examined the expression of cuproptosis-related genes (DLAT, FDX1, and SDHB) to confirm the inhibitory effect of CPO on angiogenesis. …”
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Differential Analysis of Oral Microbiota in db/db Mouse Model of Type 2 Diabetes Utilizing 16S rRNA Sequencing by PAN Qianjia, GE Junyi, HU Nan, HUA Fei, GU Min

“…ObjectiveTo investigate the changes in oral microbiota of db/db mice and provide an experimental basis for exploring the relationship between type 2 diabetes mellitus and oral microecology.MethodsEight 10-week-old male db/db mice were designated as the diabetes experimental group (db/db group), while eight 10-week-old male db/m mice were assigned as the normal control group (db/m group). …”
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The Role of the Amygdala in Facial Trustworthiness Processing: A Systematic Review and Meta-Analyses of fMRI Studies. by Sara Santos, Inês Almeida, Bárbara Oliveiros, Miguel Castelo-Branco

“…Studies using ROI analysis / small volume correction methods were more often devoted specifically to the amygdala region, with some results reporting uncorrected p-values based on mainly clinical a priori evidence of amygdala involvement in these processes. …”
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Cerebral hemodynamics and functional connectivity changes in stroke patients with dysphagia under acidic taste stimulation: a preliminary study by Jiliang Kang, Jiliang Kang, Junyue Lu, Mengbi Gu, Shuang Gong, Xiaohan Li, Xiaojuan Li, Lifeng Tang, Lifeng Tang, Yu Jin, Youliang Wen, Min Tang

“…Additionally, relative changes in HbO2 concentration throughout the experiment were extracted for functional connectivity analysis. …”
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Evidence for Better Lives Study: a comparative birth-cohort study on child exposure to violence and other adversities in eight low- and middle-income countries - foundational resea... by Adriana Băban, Siham Sikander, Mark Tomlinson, Susan P Walker, Claire Hughes, Sara Valdebenito, Aja Murray, Asvini D Fernando, Bernadette J. Madrid, Catherine Ward, Joseph Osafo, Michael Dunne, Vo Van Thang, Pasco Fearon, Yulia Shenderovich, Marguerite Marlow, Deshanie Chathurika, Diana Taut, Manuel Eisner

“…Alongside epidemiological estimates of levels and predictors of exposure to violence and adversity during pregnancy, we plan to explore mechanisms that may link exposure to violence to mothers’ biological stress markers and subjective well-being.Methods and analyses EBLS-FR is a short longitudinal study with a sample of 1200 pregnant women. …”
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Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy by Xiongbao Wang, Xiongbao Wang, Xiongbao Wang, Liang Fang, Liang Fang, Lixiang Xiao, Guangxin Zhong, Minghao Han, Bingshen Wang, Juchao Ren, Yuanwei Zang, Yuanwei Zang

“…However, the expression of LAMP1 and its underlying molecular mechanism with ccRCC remain elusive.MethodsFirstly, the expression of LAMP1 in ccRCC and its clinical significance were analyzed using various databases. …”
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Auto Machine Learning and Convolutional Neural Network in Diabetes Mellitus Research—The Role of Histopathological Images in Designing and Exploring Experimental Models by Iulian Tătaru, Simona Moldovanu, Oana-Maria Dragostin, Carmen Lidia Chiţescu, Alexandra-Simona Zamfir, Ionut Dragostin, Liliana Strat, Carmen Lăcrămioara Zamfir

“…Images were acquired from vaginal, uterine, and ovarian samples from both MD and AD_DC specimens. The experiment received the approval of the Medical Ethics Committee of the “Gr. …”
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Optimizing Flammulina velutipes residue use: impact on health metrics and performance in three-yellow chickens by Yuanxiao Li, Yuanxiao Li, Dan Liu, Wang Li, Wang Li, Longmei Zhao, Pinghua Cao, Yanbo Ma, Yanbo Ma, Ke Ding, Cai Zhang, Cai Zhang, Ning Liu

“…The control group (CON) was fed a basal diet, while the remaining three groups were supplemented with FVR in the basal diet, adding 2%, 4% and 6% of the basal diet, respectively. The experiment lasted for 48 days. Blood samples were collected from the jugular vein on days 28 and 48 to determine serum biochemical indices. …”
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High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression by Zhengyi Wu, Chao Li, Shouhua Zhang, Liang Sun, Junwen Hu, Bingbing Qiu, Shuiqiu Liu, Yiran Hong, Tianxiang Chen, Kai Wang, Xiangbao Yin, Jinlong Yan

“…However, the mechanisms behind this phenomenon are not fully understood. Methods This study investigates the role of kinesin family member 11 (KIF11) in HCC under HIFP conditions, using both in vivo and in vitro models. …”
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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in US adults: results from the NHANES 2011–2018 by Mengmeng Yang, Junwei Zhang, Zhenyu Feng, Meiling Wang, Quanguan Feng, Runping Zhang, Chuanling Wu, Tian Wu, Genggeng Zhang, Yuanzhi Niu, Qiuju Dong, Qinghua Han, Tao Lin

“…However, its association with CVD mortality and all-cause mortality remains uncertain.Methods and resultsAnalyzing HDL-C and non-HDL-C used to calculate NHHR were sourced from the National Health and Nutrition Examination Survey (2011–2018). …”
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Social determinants of financial stress and association with psychological distress among young adults 18–26 years in the United States by Anaiya Nasir, Umair Javed, Kobina Hagan, Ryan Chang, Harun Kundi, Zahir Amin, Sara Butt, Sadeer Al-Kindi, Sadeer Al-Kindi, Zulqarnain Javed, Zulqarnain Javed

“…This study examines the burden, social determinants and mental health consequences of experienced FS among young adults in the United States, based on objective measures of financial stress.MethodsWe studied young adults aged 18–26 years using pooled data from the 2013–18 National Health Interview Survey. …”
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