Improving Equity, Diversity, and Inclusion in LIS Education: Insights for Curriculum Development and Professional Preparation by Lili Luo

“…Subjects – 59 recent graduates from the MA/PG Diploma program in LIS at University College, London (UCL).  Methods – Using the descriptive survey methodology, a 13-item online questionnaire was sent to a purposive sample of 733 alumni from the MA/PG Diploma program in LIS at University College, London (UCL). …”
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RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer by Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang, Lishuang Qi, Shilong Liu

“…This study aims to explore whether and how N6-methyladenosine (m6A) modification regulates CBR3-AS1 expression and promotes NSCLC radioresistance. Methods Integrative bioinformatics analyses were used to investigate the m6A methyltransferases that were associated with CBR3-AS1 expression and radioresistance of patients using data from The Cancer Genome Atlas of lung adenocarcinoma and squamous cell carcinoma. …”
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Effect of Nickel Content and Cooling Rate on the Microstructure of as Cast 316 Stainless Steels by Lei Chen, Yang Wang, Yafeng Li, Zhengrui Zhang, Zhixuan Xue, Xinyu Ban, Chaohui Hu, Haixiao Li, Jun Tian, Wangzhong Mu, Kun Yang, Chao Chen

“…The austenite-forming element nickel of three different industrial samples is 10%, 12%, and 14%, respectively. The effect of the cooling rate on the ferrite content and precipitation phases of the high Ni content of the 316 stainless steel casting (H-316) is studied by remelting experiments and different methods of quenching of liquid steel. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…To provide detailed understanding of parent and health professionals’ attitudes to, and experiences of, participating in the BATCH RCT. Methods A pragmatic, multicentre, open-label, parallel two-arm, individually RCT conducted in 15 hospitals in the UK. …”
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A Re-Examination of a Previous Study Relating to Topical Body Formulations: Validating Gene Expression Transcription at Multiple Time Points, and Protein Expression and Translation... by Alan D. Widgerow, Mary E. Ziegler, Faiza Shafiq

“…Given the unique response reported for FTB, we conducted this study to assess the reproducibility of these results and explore gene expression at multiple time points, along with validating protein expression in an ex vivo model. Materials and Methods: Experiments were conducted using an ex vivo model with photodamaged skin from facelift patients, under an Institutional Review Board-approved study. …”
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Second transplantation after kidney graft loss in primary hyperoxaluria type 2: a pedigree study and mutation analysis by Yushi Peng, Yingchun Zheng, Fu Xiong, Mingming Zhang, Yuchen Wang, Jia Luo, Wenli Zeng, Jialiang Hui, Wenfeng Deng, Jian Xu, Yun Miao, Renfei Xia, Yiling Fang

“…Research on the mutation spectrum and pedigree of PH2 helps in comprehending its pathogenesis and clinical outcomes, guiding clinical diagnosis and treatment.Methods We report a case of PH2 with a three-generational pedigree. …”
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Associations between single nucleotide polymorphisms of cytokines and hepatitis B virus‐related liver cirrhosis: A case‐control study by Yijun Li, Haowei Zhou, Weikang Wu, Wenhua Zhang, Yancheng Ye, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Zhongjun Shao, Xiaojie Yuan, Weilu Zhang

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Liquid biopsy-derived extracellular vesicle protein biomarkers for diagnosis and prognostic assessment of lung squamous cell carcinoma by Sheng Ma, Na Zhao, Xin Dong, Yaru Wang, Lei Song, Ruiqi Zheng, Xiaochen Zhi, Congcong Ma, Shujun Cheng, Jie Li, Yutao Liu, Ting Xiao

“…The diagnostic efficacy of RPS7 and VTN was further validated in independent samples using ELISA experiments. Furthermore, DPYD, GALK1, CDC23, UBE2L3, RHEB, and PSME1 were determined as potential prognostic biomarkers. …”
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Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo by Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Fumiya Harada, Dedy Ariwansa, Sarita Giri, Jun Sato, Hiroki Nagayasu, Yoshihiro Abiko

“…In vivo, a xenograft tumor formation assay was conducted using male BALB/Slc-nu nude mice, in accordance with the Basel Declaration and The ARRIVE guidelines 2.0. Tumor samples were analyzed by qRT-PCR, and qMSP. Results In vitro experiments using the HSC4 and SAS cell lines revealed significant cytotoxic effects and upregulation of tumor suppressor genes (P16, P21, NPY, and RASSF1) after treatment with Zeb + Vpa. …”
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ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis by Ruikai Zhou, Hongyu Wu, Hao You, Xiaofei Wang, Xiuchen Yuan, Zhengyi Sun, Dong Zhou, Yuqing Jiang, Yifei Shen

“…To further evaluate its clinical significance, we performed immunohistochemical analysis on osteosarcoma tissue samples and benign osteochondroma (OC) tissues. The biological function of ESPN in osteosarcoma was confirmed by a series of experiments conducted both in vitro and in vivo. …”
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Effect of Age at First Calving on the Reproduction Parameters, Metabolic Profile, and Fatty Acid Composition of Polish Holstein Friesian (PHF) and Crossbreds PHF × Swedish Red (SRB... by Paweł Solarczyk, Marcin Gołębiewski, Jan Slósarz, Antonio Natalello, Martino Musati, Ruggero Menci, Tomasz Sakowski, Karol Tucki, Kamila Puppel

“…Breeders are, therefore, looking for alternatives to the PHF breed using crossbreeding. Methods: This experiment involved 30 PHF cows and 30 PHF × Swedish Red (SRB) crossbred hybrid cows, divided into two age groups, <2 years and >2 years, at first calving. …”
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Integrating multi-omics to unveil PSMD12 as a critical gene in promoting brain metastases of lung adenocarcinoma by Xin Li, Juxuan Zhang, Meng Zhang, Wenbin Jiang, Dexin Jia, Ruxiong Wang, Hao Li, Zhihui Wang, Yixin Liu, Lefan Tang, Jiaxing Deng, Wenyuan Zhao, Yan Yu, Shilong Liu, Lishuang Qi

“…This study aimed to systematically identify crucial genes associated with BM in patients with LUAD, and develop a heuristic search algorithm combining information filtering and multiple stepwise regression to construct a multi-layered transcription factor regulatory network. Methods We used the mRNA expression profiles of primary tumours derived from LUAD patients with different organ metastasis and adjacent normal tissue samples to identify differentially expressed genes specific to BM, and validated it in bulk, spatial and single-cell RNA-sequencing data. …”
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Correction of regulatory molecules expression at the inflammation stage using photobiomodulation therapy in chronic wound modeling by М.V. Kumechko, N.М. Babenko, S.B. Pavlov, О.B. Litvinova, І.І. Torianyk, О.І. Babaieva

“…Purpose – correction of interleukin-8, vascular endothelial growth factor, and aminoterminal procollagen type III propeptide expression at the inflammation stage using photobiomodulation therapy in chronic wound modeling. Materials and Methods. The experiment involved 18 rats randomized into intact, control, and experimental groups. …”
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Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota [version 2; peer review: 1 approved, 2 approved with reservations] by Maddalena Querci, Alessandro Benedetti, Guy Van den Eede, Gabriele Leoni, Simone Cristoni, Carlo Brogna, Thierry Wiss, Jessica Ponti, Mauro Petrillo, Andrea Valsesia, Peter V Markov

“…These observations are compatible with a ‘bacteriophage-like’ behaviour of SARS-CoV-2. Methods We have further elaborated on these unusual findings and here we present the results of three different supplementary experiments: (1) an electron-microscope analysis of samples of bacteria obtained from a faecal sample of a subject positive to SARS-CoV-2; (2) mass spectrometric analysis of these cultures to assess the eventual de novo synthesis of SARS-CoV-2 spike protein; (3) sequencing of SARS-CoV-2 collected from plaques obtained from two different gut microbial bacteria inoculated with supernatant from faecal microbiota of an individual positive to SARS-CoV-2. …”
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Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation by Pu Xi, Dejun Zeng, Miao Chen, Lingmin Jiang, Yu Zhang, Dailei Qin, Zehui Yao, Chaobin He

“…This study aimed to investigate whether the H101 oncolytic virus can serve as a supplementary therapeutic approach to kill tumors combined with RE.MethodsWe first explored how RE and the H101 oncolytic virus, both individually and together, affected tumor cell proliferation and migration in cellular experiments. …”
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Schisandrin B downregulates exosomal fibronectin 1 expression to inhibit hepatocellular carcinoma growth by Baoyi Jiang, Jie Yang, Qingtian Huang, Qingtian Huang, Wei Li, Qian Peng, Huoye Gan, Tieli Peng, Leyi Yao, Ling Qi, Ling Qi

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The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury by Jinsha Liu, Jinsha Liu, Wenwen Fu, Xue Wang, Xue Wang, Zuowen Liang, Fanbo Meng, Fanbo Meng

“…Histone deacetylase 2 (HDAC2) plays a significant role in oxidative stress, apoptosis, and mitochondrial dysfunction and is implicated in many human diseases, This study investigated the relationship between HDAC2 expression and DOX-induced myocardial injury using the in vivo rat model of DOX-induced cardiotoxicity and in vitro experiments with the H9c2 cardiomyocytes.MethodsThe rat model of DOX-induced myocardial injury was established by administering DOX via intraperitoneal injections. …”
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The public health significance of prior homelessness: findings on multimorbidity and mental health from a nationally representative survey by N. Chilman, P. Schofield, S. McManus, A. Ronaldson, A. Stagg, J. Das-Munshi

“…Using nationally representative data collected in private households in England, this study aimed to examine Common Mental Disorders (CMDs), physical health, alcohol/substance dependence, and multimorbidities in people who formerly experienced homelessness compared to people who never experienced homelessness. Methods This cross-sectional study utilised data from the 2007 and 2014 Adult Psychiatric Morbidity Surveys. …”
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Integrative analysis of T cell-mediated tumor killing-related genes reveals KIF11 as a novel therapeutic target in esophageal squamous cell carcinoma by Xinxin Cheng, Huihui Zhao, Zhangwang Li, Liping Yan, Qingjie Min, Qingnan Wu, Qimin Zhan

“…As the fundamental principle of ICI therapy is T cell-mediated tumor killing (TTK), we aimed to develop a unique TTK-related gene prognostic index (TTKPI) for predicting survival outcomes and responses to immune-based therapy in ESCC patients. Methods Transcriptomic and clinical information of ESCC patients were from the GSE53625, GSE53624, GSE47404 and TCGA datasets. …”
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Serum Pharmacochemistry and Network Pharmacology Reveal Active Compounds and Mechanisms of the Huaxian Formula in Alleviating Radiation-Induced Pulmonary Fibrosis by Gong C, Chen J, Zou P, Fang Z, Quan L, Wang J, Yin J, Lin B, Lang J, Chen M

“…The Huaxian formula (HXF), a traditional Chinese herbal remedy, shows promise in alleviating RIPF; however, its active ingredients and underlying mechanisms remain poorly understood.Methods: Through serum pharmacochemistry, network pharmacology, molecular docking, and experimental validation, we investigate the potential mechanisms of HXF in the prevention and treatment of radiation-induced pulmonary fibrosis (RIPF).Results: Histological examination and non-invasive computed tomography (CT) scans in animal experiments revealed that HXF improved extracellular matrix collagen deposition in the lung tissue of irradiated mice and reduced fibrosis manifestations on CT images. …”
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