The Therapeutic Potential of West Indian Lemongrass (<i>Cymbopogon citratus</i>) Essential Oil-Based Ointment in the Treatment of Pitted Keratolysis by György Schneider, Bettina Schweitzer, Anita S. Steinbach, Ágnes S. Hodován, Marianna Horváth, Eszter Bakó, Anna Mayer, Szilárd Pál

“…This was also confirmed by the Franz diffusion cell drug release test; after 30 min, several active compounds could be detected in the HM samples, in contrast to the other bases. Shelf-life experiments showed that the HM base supported the antibacterial features of 3% LEO for at least 2 years without significant loss of efficacy. …”
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Enhancing ovarian cancer prognosis with an artificial intelligence-derived model: Multi-omics integration and therapeutic implications by You Wu, Kunyu Wang, Yan Song, Bin Li

“…The heterogeneity of ovarian cancer poses challenges for traditional therapeutic approaches, necessitating the exploration of novel, precision medicine techniques. Methods: This study leveraged multi-dataset analysis to construct and validate an Artificial Intelligence-Derived Prognostic Index (AIDPI) for ovarian cancer. …”
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Social network characteristics of COVID-19 vaccination and preventive health behaviors: Cross-sectional findings from the US northeast during the early COVID-19 pandemic by Aditya S. Khanna, Mollie A. Monnig, Samantha E. Clark, Peter M. Monti

“…Background: The link between individuals’ vaccine attitudes and their social networks has been widely studied, but less is known about how these networks impact broader health behaviors like precautionary measures during the COVID-19 pandemic. Methods: Egocentric social network data were collected from June 7–21, 2021, via an online survey by researchers based at the Brown University School of Public Health. …”
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Divergent gene expression of PTGS1 and PTGS2 along the disease course of chronic myeloid leukaemia by Denise K. Wosniaki, Bianca N. Kusma, Anelis M. Marin, Eduardo C. Munhoz, João S. de H. Farias, Eduarda B. Mendes, Mateus N. Aoki, Dalila L. Zanette

“…Consequently, these genes are critical targets for studying CML due to their involvement in leukemogenesis.MethodsWe investigated the expression levels of PTGS1 and PTGS2 genes in peripheral blood samples from CML patients. …”
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Adolescents’ perspectives on health literacy interventions for reducing epilepsy misconceptions and stigma, and enhancing epilepsy management in Uganda by Mayanja M. Kajumba, Paula Njeru, Neil S. Prose, Aryn Mason, Pratamesh Ramasubramanian, Joanita Berytah Tebulwa, Angelina Kakooza-Mwesige, Isabelle Andrews, Tyler Johnson, Sylvia Nshemerirwe, Peter Kalubi, Deborah Koltai

“…Methods We recruited 30 AWE receiving treatment from one regional and two national referral hospitals. …”
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Phospholipase C Beta 2 as a Key Regulator of Tumor Progression and Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Renal Cell Carcinoma by Shijin Wang, Deqian Xie, Hongzhe Yue, Guandu Li, Bowen Jiang, Yaru Gao, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…Despite its significant importance, the specific expression patterns and molecular mechanisms of <i>PLCB2</i> in the progression of RCC are not well understood. <b>Methods:</b> This investigation employed a combination of bioinformatics analyses, scRNA-seq, functional assays, transcriptome sequencing, real-time quantitative PCR (RT-PCR), immunofluorescence, rescue experiments, and Western blotting to explore the regulatory function of <i>PLCB2</i> in driving the epithelial-mesenchymal transition (EMT) in RCC through the PI3K/AKT signaling pathway. …”
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…For the QIDS-SR outcome, simulation and the non-central chi-squared method provided a value of 96.5% power to detect an effect size of 0.38 (a minimum clinically significant difference between treatments), with 40% occasion-wise nonresponse assumed. …”
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Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors by Tao Wang, Tuanjie Guo, Juanjuan Sun, Xinyue Zang, Lei Dong, Jian Zhang, Siteng Chen, Guihua Chen, Sicong Ma, Xinyu Zhai, Chuanmin Chu, Chaofu Wang, Xiang Wang, Dongliang Xu, Mingyue Tan

“…Gene set variation analysis and Gene set enrichment analysis revealed that epithelial-mesenchymal transition (EMT) and immune-related processes were significantly enriched in BLCA samples with low OBSCN expression. In vitro experiments identified that OBSCN-deficient BLCA cells enhanced invasion, migration and EMT. …”
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Removing metals concentration in water and common carp using sheet type adsorbent reared in modified aquarium by N.D. Takarina, N. Matsue, E. Johan, A. Adiwibowo

“…The goal is to present a comprehensive analysis of the influence of the zeolite-embedded sheet on heavy metal levels in both the aquatic environment and the common carp cultivated in modified glass aquariums.METHODS: This study involved the fabrication and characterization of zeolite-embedded sheets, aquarium modification, fish acclimatization, preparation and dosing of test solutions, adsorption experiments, and the measurement of heavy metal levels in water and fish samples. …”
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GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…Transcriptomic sequencing, bioinformatics analysis, animal experiments, and clinical sample collection were conducted to validate the role of GATA1 in PE. …”
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Crosstalk between CD180-overexpression macrophages and glioma cells worsens patient survival through malignant phenotype promotion and immunosuppressive regulation by Wen Wang, Junsheng Li, Qiheng He, Chenglong Liu, Zhiyao Zheng, Bojian Zhang, Siqi Mou, Wei Sun, Jizong Zhao

“…CD180, primarily expressed in macrophages, remains unclear and requires further investigation. Methods RNA-seq data were obtained to analyze CD180 expression in gliomas and assess its prognostic value. …”
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Developing a Behavioral Phenotyping Layer for Artificial Intelligence–Driven Predictive Analytics in a Digital Resiliency Course: Protocol for a Randomized Controlled Trial by Trevor van Mierlo, Rachel Fournier, Siu Kit Yeung, Sofiia Lahutina

“…ResultsThis protocol was designed in January 2025. α and β testing of the intervention are scheduled to begin in July 2025, with a soft launch anticipated in August 2025. The experiment will remain active until the sample size requirements are met. …”
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Effects of mallotus furetianus extract on CYP3A activities in rats by Wei Huang, Hyo In Kim, Feng Cao, Shuang Li, Jinbong Park, Peiqiong Li

“…In the pharmacokinetics experiment, rats were administered MFE as described above. …”
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CHANGES IN THERMALLY STIMULATED CONDUCTIVITY OF CsPbBr3 AND CsPbCl3 CRYSTALS EXPOSED TO X-RAY IRRADIATION by Bohdan Pavlyk, Roman Lys, Roman Gamernyk, Mykola Goydalo

“…However, an unsolved problem is the degradation of these perovskites under the influence of external factors. Materials and Methods. This study investigates monocrystals of perovskites CsPbBr3 and CsPbCl3 subjected to X-ray irradiation. …”
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Influence of ambient NO and NO₂ on the quantification of total peroxy nitrates (ΣPNs) and total alkyl nitrates (ΣANs) by thermal dissociation cavity ring-down spectrosco... by L. Wüst, P. Dewald, G. N. T. E. Türk, J. Lelieveld, J. N. Crowley

“…Here we review the sources of the bias and the methods used to reduce it and/or correct for it and report new experiments using (for the first time) atmospherically relevant, unsaturated, biogenic alkyl nitrates as well as two different peroxyacetyl nitrate (PAN) sources. …”
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Examining the Dose-Response Effects of Mindfulness Meditation Interventions on Well-Being: Protocol for a Randomized Controlled Trial by Nicholas Bowles, Alexander Burger, Jonathan N Davies, Julie A Simpson, Julieta Galante, Simon Dennis, Benjamin Stone, Nicholas T Van Dam

“…In addition, we will systematically monitor for possible adverse experiences. ResultsThis study began screening and recruitment in May 2024. …”
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Exploring the self-perceived causes of eating disorders among Chinese social media users with self-reported eating disorders by Jinbo He, Yuchen Zhang, Zhiyuan Liu, Wesley R. Barnhart, Shuqi Cui, Shi’ting Chen, Yuru Fu, Feng Ji, Jason M. Nagata, Shaojing Sun

“…Methods We extracted and analyzed data through content analysis. …”
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Comparing mechanochemical endovenous ablation using Flebogrif with endovenous laser ablation in the treatment of primary great saphenous vein incompetence: protocol for a multicent... by Çaĝdaş Ünlü, Sharon Oud, Tamana Alozai, Michiel A Schreve, Michael C Mooij, Clarissa J van Vlijmen

“…To determine the role of MOCA using Flebogrif, a well-designed, randomised controlled clinical trial of sufficient sample size and follow-up time is required. In this article, we provide the study protocol for the REBORN trial, aiming to demonstrate that MOCA using Flebogrif is not inferior to EVLA for the outcome of anatomical success in the treatment of GSV incompetence.Methods and analysis This multicentre, open-label, non-inferiority, observer-blinded, randomised controlled trial randomises patients who are diagnosed with GSV incompetence and aged 18–80 years between Flebogrif and EVLA. 310 patients in 3 participating centres (Northwest Clinics Alkmaar, Skin and Vein Clinic Oosterwal Alkmaar and Red Cross Hospital Beverwijk) will be included. …”
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Interactions of factors in self-injuries among enrolled students: a network approach by Yu-Min Zhang, Xiao-Mei Jiang, Ya Xie, Nan Lang, Min-Lu Liang, Pei Zhang, Li-Chen OuYang, Zhang-Wei Lv, Cong-Wei Liu, Li-Ping Zhang, Chun Wang

“…This study assessed how and to what degree the factors of self-injuries are interrelated among enrolled students. Methods A total of 1481 students were recruited from college and middle or secondary schools, and 1465 (98.92%) subjects comprised the final sample. …”
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Examining factorial validity and internal consistency of Professional Quality of Life (ProQoL-9) among care aides working in Long-term Care (LTC) by Seyedehtanaz Saeidzadeh, Anni Wang, Yinfei Duan, Isaiah Hipel, Peter G. Norton, Carole A. Estabrooks

“…Methods We used surveys collected by the Translating Research in Elder Care (TREC), a pan-Canadian program that collects longitudinal surveys from the healthcare workforce in the LTC. …”
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