Amelioration of histopathological damage in mice with induced hyperlipidemia by terpenes and phytosterols extracted from Iraqi chickpea by N. R. Hwerif, A. R. Abu Raghif, E. J. Kadhim

“…Objective: To compare the amelioration effects of terpenes and phytosterols extracted from Iraqi chickpea on histopathological damage in mice fed on high-fat diet (HFD).Material and methods. Whole chickpea plants of the Fabaceae family were collected during the flowering period in the northern area of Erbil. …”
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Network of cognitive, emotional, and pain perception factors linked to non-suicidal self-injury in Chinese adolescents by Wei Luo, Jingbo Gong, Han-yu Zhou, Juanjuan Guo, Jieyu Xiao, Chao Yan, Yuqi Chen

“…Additionally, we examined the group differences in network structure by level of depressive symptoms. Methods A sample of 2756 adolescents validly completed self-report questionnaires about their emotional experiences, self-cognition, pain perception, depression level and frequency of NSSI. …”
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses by Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

“…This study investigated whether pseudohypoxia induced by HIF-PH inhibitors suppresses Microsatellite stable (MSS) colorectal cancer (CRC) by affecting tumor immune response. Methods The HIF-PH inhibitors Roxadustat and Vadadustat were utilized in this study. …”
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Teachers’ awareness and emotional response to cyberbullying: Exploring emotional regulation strategies in the classroom by Paula da Costa Ferreira, Nádia Pereira, Carlos Martinho, Hugo Marques, Hélio Martins, Alexandra Marques Pinto, Alexandra Barros, Aristides Ferreira, Mafalda Gomes, Ana Margarida Veiga Simão

“…Despite increased attention to students' experiences, there is limited research on teachers' knowledge, emotional responses, and emotion regulation when witnessing student cyberbullying. …”
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“It doesn’t make any sense to even try”: the disruptive impact of COVID-19’s first wave on people with chronic pain using medical cannabis in New York by Yuval Zolotov, Jacinta Lomba, Megan Ghiroli, Mariya Masyukova, Julia H. Arnsten, Joanna L. Starrels, Jonathan Ross, Chinazo O. Cunningham, Deepika E. Slawek

“…Methods We conducted 1:1 semi-structured qualitative telephone interviews from March through May 2020 with a convenience sample of 14 individuals enrolled in a longitudinal cohort study. …”
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Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats by Graziele Halmenschlager, Ernani Luis Rhoden, Gabriela Almeida Motta, Lucas Sagrillo Fagundes, Jorge Luiz Medeiros, Jr., Rosalva Meurer, Cláudia Ramos Rhoden

“…Blood samples and penile tissue were collected on euthanasia. …”
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Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy by Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng

“…Objective: This study endeavors to elucidate the multifaceted roles of cancer-associated fibroblasts within the tumor microenvironment of prostate cancer, with a focus on their implications for disease prognosis and the potential for novel immunotherapeutic strategies. Methods: Leveraging advanced single-cell RNA sequencing technology, we meticulously characterized the diverse CAF subpopulations within prostate cancer samples. …”
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Chemoresistance of PRAME-expressing melanoma cell can be resolved with help of bortezomib by V. A. Misyurin, D. V. Kalenichenko, A. A. Rudakova, Yu. P. Finashutina, N. A. Lyzhko, V. V. Tikhonova, L. A. Kesaeva, O. N. Solopova, A. Е. Misyurina, A. N. Velikanov, M. А. Baryshnikovа, A. V. Misyurin

“…We hypothesized that this phenomenon determines chemoresistance of PRAME-expressing cell, which can be overcome by NF-κB inhibitors, such as bortezomib.Materials and methods. We incubated A875 melanoma cells with cisplatin, bortezomib and dexamethasone, as well as with a mixture  of cisplatin with bortezomib and cisplatin with dexamethasone within 24 hours. …”
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What do patients and informal caregivers value in IBD care? A narrative inquiry by Britt J.M. Thomassen, Evelien M.B. Hendrix, Zlatan Mujagic, Fabiënne G.M. Smeets, Marin J. de Jong, Tom J.G. Gevers, Govert Veldhuijzen, Daniëlle van der Horst, Menne Scherpenzeel, Gerard Dijkstra, Merel L. Kimman, Stephanie M.C. Ament, Marieke J. Pierik

“…In this study, we aimed to identify what IBD patients and their informal caregivers value in IBD care. Methods A purposive sample of 18 IBD patients and 8 informal caregivers was drawn from an academic and a non-academic hospital in the Netherlands. …”
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Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN): protocol for a multicentre randomised controlled trial by David Torgerson, Martin Underwood, Rebecca Samantha Kearney, Nicholas Parsons, Helen Parsons, Jaclyn Brown, James Mason, Howard Bush, Stephen Drew, Gurmit Dhanjal, David Ellard, Aminul Haque, Eleni Karasouli, ZiHeng Liew, Chetan Modi

“…The primary analysis will be the difference in Oxford Shoulder Instability Score at 6 months. A sample size of a minimum of 478 participants will allow us to show a four point difference with 90% power.An embedded qualitative study will explore the participants’ experiences of the trial interventions.Ethics, registration and dissemination Funded by NIHR HTA (16/167/56), 1 June 2018; National Research Ethic Committee approved (18/WA/0236), 26 July 2018. …”
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Machine learning identifies lipid-associated genes and constructs diagnostic and prognostic models for idiopathic pulmonary fibrosis by Xingren Liu, Junmei Song, Shujin Guo, Yi Liao, Jun Zou, Liqing Yang, Caiyu Jiang

“…This study aimed to identify lipid-related genes implicated in IPF pathogenesis. Methods Lipid-associated genes were retrieved from the GeneCards database and analyzed using unsupervised consensus clustering to classify IPF samples. …”
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The contribution of BTK signaling in myeloid cells to neuroinflammation by Claudia Bassani, Marta Molinari, Valentina Romeo, Vittorio Martinelli, Ursula Boschert, Gianvito Martino, Luca Muzio, Cinthia Farina

“…Here we investigated the role of BTK in human and mouse myeloid cells in in vitro and in vivo studies.MethodsWe evaluated i) the impact of the BTK inhibitor (BTKi) evobrutinib on monocyte markers for activation, costimulation, adhesion and phagocytosis in peripheral blood mononuclear cell (PBMC) cultures from healthy and MS subjects; ii) the therapeutic effects and the action of evobrutinib on myeloid cell phenotype in the experimental autoimmune encephalomyelitis (EAE) model of MS; iii) the contribution of BTK in short-lived vs. long-lived myeloid cells to EAE expression via experiments with double transgenic mice allowing inducible inactivation of BTK in CX3CR1 expressing cells. …”
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The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) by Aigul T. Altynbekova, Elmira M. Mamytova, Yusuf Kh-M Shidakov, Aicholpon T. Israilova, Bolotbek Alymjan ulu, Rustam R. Tuhvatshin

“…The aim of the study was to investigate the effect of an isolated fat diet on lactate blood level and histomorphological changes in microcirculation of the rats` brain. Methods: The design of the study is experimental randomized. …”
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Psychometric proprieties analyses of Psychological Vulnerability Scale for secondary school students by Odete Araújo, Odete Araújo, Odete Araújo, Otília Freitas, Otília Freitas, Gilberta Sousa, Gilberta Sousa, Isilda Ribeiro, Isilda Ribeiro, José Carlos Carvalho, José Carlos Carvalho, Silvana Martins, Silvana Martins

“…BackgroundThe concept of psychological vulnerability is associated with the individual’s maladaptive cognitive beliefs, such as self-criticism, perfectionism, and the need for external validation and approval, reducing the individual’s ability to cope with negative life experiences. This study aimed to explore psychometric proprieties of the Psychological Vulnerability Scale in secondary school students.MethodsA psychometric study was conducted with a non-probabilistic sample of 1,875 secondary school students (55.5% female) aged 15 to over 18 years. …”
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Thematic analysis of COVID-19's impacts on transitions among emerging adults by Keely H. Bieniak, Helen Bedree, Nicole Geanous, Rachel Neff Greenley, Steven A. Miller, Joanna Buscemi, Susan T. Tran

“…Methods: Qualitative and quantitative data gathered in July 2020 (n = 145) and January 2021 (n = 143) as part of a longitudinal study of emerging adults (18–24 years) who were enrolled at a Midwestern United States University at baseline were analyzed to explore impacts of COVID-19, particularly in relation to stress. …”
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Mental states and temperaments contributing to suicidal crisis in psychiatric inpatients: a cross-sectional and validation study by Marco Innamorati, Denise Erbuto, Elena Rogante, Salvatore Sarubbi, Maria Anna Trocchia, Mariarosaria Cifrodelli, Monica Migliorati, Anna Comparelli, Isabella Berardelli, Maurizio Pompili

“…More studies are necessary to confirm and expand our results in independent samples.…”
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Generation of Vaccine Candidate Strains That Antigenically Match Classical Swine Fever Virus Field Strains by Maya Kobayashi, Loc Tan Huynh, Saho Ogino, Lim Yik Hew, Miki Koyasu, Hikaru Kamata, Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda

“…This study aimed to understand the antigenicity of recent field isolates in Japan and develop new vaccine candidates that antigenically match field strains. Methods: The serum samples of 20 pigs vaccinated with GPE⁻ were subjected to a serum neutralizing test (SNT) using one of the field strains, CSFV/wb/Jpn-Mie/P96/2019 (Mie/2019). …”
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T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope by Leisan F. Bulatova, Vera S. Skripova, Aisylu R. Sagdeeva, Ramilia A. Vlasenkova, Tatiana A. Bugaenko, Rezeda R. Galimova, Alfiya I. Nesterova, Yuliya V. Filina, Ramziya G. Kiyamova

“…However, variations in the NaPi2b protein structure may limit the efficacy of therapeutic antibodies by affecting the accessibility of the MX35 epitope. <b>Methods:</b> An in silico analysis was performed using data from 101,562 tumor samples. …”
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Fractal characteristics of spontaneous combustion of gas-bearing coal under different temperature and adsorption pressure conditions by Zhenrong LI, Fuchao TIAN, Gang WANG, Bo TAN, Yujin QIN

“…To study the disaster mechanism of the composite disaster of gas and coal spontaneous combustion, the experiments of low-temperature oxidation microstructure and thermal analysis of coal under different CH4 adsorption pressures were carried out in the paper by low-temperature liquid nitrogen adsorption, scanning electron microscopy and TG-FTIR testing methods, and a pore fractal calculation model was set up based on the fractal theory to investigate the influence of adsorbed CH4 on the pore structure and thermal stability of coal. …”
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Assessment of Fraud Deterrence and Detection Procedures Used in a Web-Based Survey Study With Adult Black Cisgender Women: Description of Lessons Learned and Recommendations by Amber I Sophus, Jason W Mitchell

“…ObjectiveThe purpose of this study was to assess the strengths and limitations of fraud deterrence and detection procedures implemented in an incentivized, cross-sectional, online study about HIV prevention and sexual health with Black cisgender women living in Texas. MethodsData for this study came from a cross-sectional web-based survey that examined factors associated with potential pre-exposure prophylaxis use among a convenience sample of adult Black cisgender women from 3 metropolitan areas in Texas. …”
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