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9681
Role conflict, satisfaction, and performance in administrative staff at public universities: The role of optimism and sex differences.
Published 2025-01-01“…Moreover, this study will explore whether the effects of role conflict and optimism vary based on the employee's sex (women/men), considering potential differences in how these factors influence their experiences and outcomes in the workplace.<h4>Design and methods</h4>Data were collected from 334 employees with administrative and customer service roles at a public university (172 men and 162 women). …”
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9682
TET1 methylation and mRNA expression in renal cell carcinoma: implications for tumor staging and prognosis
Published 2025-08-01“…This research examines TET1 gene methylation’s involvement in RCC development and its viability as a diagnostic marker. Methods We evaluated TET1 expression in 532 RCC tumor samples and 72 adjacent normal tissues using data from the TCGA database. …”
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9683
Influence of platelet-rich plasma on RANKL and IL-1 immunohistochemical expression in periodontitis-related bone cell proliferation and differentiation
Published 2024-12-01“…The rats were sacrificed after both experiment durations (7 and 30 days), and the incisor teeth were fixed and decalcified in HCl for a day and in 10 % EDTA solution for eight weeks at room temperature then samples were processed for H&E stain for bone healing scores and bone cells counting, and the samples were utilized by IHC for detection of both RANKL and IL-1β expression. …”
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9684
Decellularized porcine liver scaffold for maintaining the viability and capacity of pancreatic islets
Published 2025-03-01“…Objective: to investigate in vitro the effect of decellularized porcine liver scaffold (DPLS) on the viability and insulin-producing capacity of isolated human PIs. Materials and methods. The resulting DPLS was subjected to histological examination, DNA quantification, and cytotoxic effect testing. …”
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9685
Role of senescent CD4+ T cells in breakthrough infection of the new variant strain of SARS-CoV-2 in elderly patients
Published 2025-07-01“…However, the impact of COVID-19 vaccines on elderly breakthrough-infected patients’ antibodies and immune cells response was unclear. Methods We recruited 329 inpatients over 65 with BF.7 breakthrough infections. …”
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9686
Effect of TiN-Al system binder ratio on structure and properties of PcBN
Published 2025-02-01“…But the existing literature studying the TiN-Al bonding system always focuses on the single property variation, such as relative density, hardness, fracture toughness, impact resistance or abrasion resistance, rather than the comprehensive performance when analyzing the samples. In this paper, the TiN-Al ratio and its effect on the structure and the comprehensive performance of PcBN is explored.MethodsThe raw materials for the experiment are cBN powder sized 0.5-1.0 µm and binders of TiN powder sized of 2-10 µm and Al powder sized 1-2 µm. …”
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9687
ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis
Published 2025-06-01“…Preliminary studies indicate that ENTR1 is involved in the growth of certain tumor types. Methods In this study, we analyzed ENTR1 expression levels in normal and tumor tissues using clinical sample data from multiple databases. …”
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9688
Youth Culturally adapted Manual Assisted Problem Solving Training (YCMAP) in Pakistani adolescent with a history of self-harm: protocol for multicentre clinical and cost-effectiven...
Published 2022-05-01“…YCMAP is a brief, culturally relevant, scalable intervention that can be implemented in routine clinical practice if found to be effective.Method and analysis A multicentre rater blind randomised controlled trial to evaluate the clinical and cost-effectiveness of YCMAP including a sample of 652 participants, aged 12–18 years, presenting to general physicians/clinicians, emergency room after self harm or self referrals. …”
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9689
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2
Published 2024-12-01“…The impact of exosomal ANXA2-activated HPMCs on tumour progression was assessed via functional experiments. Results Primary OvCa samples with high ANXA2 expression exhibited a stronger tendency to metastasize to the abdominal cavity. …”
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9690
A comprehensive analysis of the uterine microbiome in endometrial cancer patients - identification of Anaerococcus as a potential biomarker and carcinogenic cofactor
Published 2025-01-01“…Bioinformatic analyses were performed with QIIME2, and statistical comparisons were conducted to assess differences in microbial composition and diversity. In vitro experiments were conducted to assess the functional impact of Anaerococcus on human uterine fibroblasts, including its ability to adhere to the human cells and induce oxidative stress.ResultsThe α-diversity metrics, including Shannon entropy and observed amplicon sequence variants (ASVs), revealed significantly higher microbial diversity in EC samples compared to EM. …”
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9691
Addressing the Minority Tax by Building Diversity Capital: A Case-Based Discussion
Published 2025-06-01“…Methods Kern's six-step model guided development of a 60-minute workshop describing minority tax, diversity capital, and approaches for addressing tax by building diversity capital, including minority tax mitigation, value-based alignment, and tax reform. …”
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9692
Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance
Published 2025-02-01“…Nevertheless, the role of NAT10 in gastric cancer (GC), a type of gastrointestinal tumor, is not fully understood. Methods Throughout this investigation, our team evaluated NAT10 expression levels in GC patient samples and databases available to the general public. …”
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9693
The expression pattern of butyric acid transporter in the large intestine with growth and development of suckling lambs
Published 2025-05-01“…Objective The objective of this research was to explore the changes of morphological parameters, short chain fatty acid contents and butyric acid transporter expression levels in the large intestine with growth and development of sucking lambs. Methods A total of 48 newborn male Hu sheep lambs (body weight = 2.94±0.22 kg) were selected in this experiment. …”
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9694
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype
Published 2025-04-01“…The formation of a pre-metastatic niche (PMN) is essential for this process, but how the primary colon tumor orchestrates the PMN formation remains unclear. Methods This study investigated the role of CRC-derived exosomes using CT-26 murine colon carcinoma cells. …”
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9695
Unraveling metabolic shifts in peach under agrochemical treatments during flower bud endodormancy in the context of global warming
Published 2025-03-01“…As a result, identifying novel pathways to modulate endodormancy release is critical and essential for developing effective, non-toxic agrobiochemicals.MethodsIn this study, we investigated the effect of two different agrochemicals mixes: 1% Broston® + 5% NitroActive® and 3% Erger® + 5% Activ Erger®, sprayed on peach trees during endodormancy over two years, followed by non-target metabolomic analyses on flower buds to identify metabolic changes in treated versus control trees.Results and discussionSignificant variations were observed in metabolites from the abscisic acid and phenylpropanoid pathways. …”
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9696
Multi-Stage Simulation of Residents’ Disaster Risk Perception and Decision-Making Behavior: An Exploratory Study on Large Language Model-Driven Social–Cognitive Agent Framework
Published 2025-03-01“…Yet, conventional research methods—such as surveys, laboratory experiments, and field observations—often struggle with limited sample sizes, external validity concerns, and difficulties in controlling for confounding variables. …”
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9697
Dispersion Characteristics of Complex Resistivity and Petroelectric Parameters of Deep Coal Seam in the Ordos Basin
Published 2025-06-01“…In order to clarify the electrical properties and core electrical parameters of deep coal seams, based on the samples of deep coal seam from the Benxi group in the Ordos basin, a series of supporting petrophysical experiments on complex resistivity under different test frequencies and different saturation states are carried out. …”
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9698
Anti-Hangover and Hepatoprotective Effects of the Leaf Extract of <i>Thunbergia laurifolia</i> in Sprague–Dawley Rats
Published 2025-05-01“…<b>Background/Objectives:</b> The present study aims to evaluate the anti-hangover and hepatoprotective activities of the leaf extract of <i>T. laurifolia</i> in experimental animals. <b>Methods:</b> Two experiments were conducted that involved giving a single dose of the leaf extract of <i>T. laurifolia</i> (1, 10, or 100 mg/kg body weight) to rats 30 min either before or after administration of 40% ethanol (5 g/kg body weight). …”
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9699
POC1A induces epithelial–mesenchymal transition to promote growth and metastasis through the STAT3 signaling pathway in triple-negative breast cancer
Published 2025-08-01“…However, the underlying mechanisms that drive POC1A-induced metastases in TNBC remain to be elucidated. Methods The expression of POC1A changes and their clinical significance have been evaluated using TNBC tissues and a database. …”
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9700
Staying afloat on a realm of shifting sands: carers navigating palliative care in their rural settings
Published 2025-07-01“…Meaningful support for carers in rural areas needs to be informed by carers' actual experiences rather than relying on routine data collection. …”
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