Novel Insights from Comprehensive Bioinformatics Analysis Utilizing Large-Scale Human Transcriptomes and Experimental Validation: The Role of Autophagy in Periodontitis by Liu F, Zhu Z, Zou H, Huang Z, Xiao S, Li Z

“…This investigation involved transcriptomic analysis of a broad range of human samples and complemented by in vitro experimentation.Materials and Methods: We analyzed the transcriptomes of human gingival tissues from individuals with periodontitis and health controls to identify the differential expression of autophagy-related genes (DEARGs) and to investigate their potential interactions and functional pathways. …”
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Proteogenomic verifies targets underlying erythromycin alleviate neutrophil extracellular traps-induced inflammation by Nan Ma, Xiao Na Liang, Quan Fang Chen, Mei Hua Li, Guang Sheng Pei, Xiao Fei Yi, Li Yan Guo, Fu Gang Chen, Zhi Yi He

“…Furthermore, clinical samples and vitro experiments confirm that EM alleviates NETs-induced glucocorticoid resistance via inhibiting PI3K/AKT, thereby repressing inflammation. …”
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Construction and correction of a 3D digital twin for a complex gangue-bearing coal seam by Meichen ZHANG, Lijuan ZHAO, Yadong WANG, Kai ZHANG

“…Objective3D digital twin for complex gangue-bearing coal seams are designed to achieve an information-based description of physical coal seams and faithfully map their virtual forms. digital twin is identified as a prerequisite for exploring the efficient cutting of intelligent shearers while providing an effective data guarantee for achieving unmanned mining. MethodsUsing data on samples from the mining face of coal seam 17 in the Yankuang Energy Group Co., Ltd. …”
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Сomparison of biomechanical properties of non-absorbable and partially absorbable mesh implants used in surgery for urinary incontinence and genital prolapse: experimental study by D. D. Shkarupa, R. A. Shakhaliev, A. S. Shulgin, T. S. Filipenko, N. D. Kubin, I. A. Labetov, D. A. Suchkov

“…During biomechanical animal experiments, the connective tissue capsule formed on the partially absorbable implant was not inferior to the similar parameter of the non-absorbable sample in its tensile strength, which explains a great potential for the use of partially absorbable implants in reconstructive surgery of pelvic organ prolapse and stress urinary incontinence.…”
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Quantifying the Temporal Dynamics of Marine Biodiversity Under Anthropogenic Impacts Using eDNA Metabarcoding by Zhewei Si, Wu Han, Tsz Ying Chan, Gert‐Jan Jeunen, Cheng Qian, Isis Guibert, Cheuk Fung Wong, David Baker, Mathew Seymour

“…Improving our understanding of anthropogenic impact on biodiversity dynamics requires fine‐scale temporal observations, which are logistically challenging using traditional methods. Coral reef ecosystems are key biodiversity hotspots for a wide range of organisms, making them essential for wider marine ecosystem stability and important focal points for marine biodiversity dynamics research. …”
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The impact self-esteem towards the orthodontic issues in the social media: a cross-sectional study by Gil Guilherme Gasparello, Mohamad Jamal Bark, Sergio Luiz Mota-Júnior, Joel Suarez, Matheus Melo Pithon, Elisa Souza Camargo, Orlando Motohiro Tanaka

“…This study aims to investigate how social media usage affects self-esteem, self-perceived aesthetics, and the perceived need for orthodontic treatment among these generational groups. Materials and methods This cross-sectional observational study included 250 participants from three generational groups: Generation Z (born 1997–2012), Generation Y (born 1980–1996), and Generation X (born 1965–1979). …”
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Exploring Motives Behind Ideal Melanoma Survivorship Care Plans With Multiple Stakeholders: A Cocreation Study by Nadia Christina Willemina Kamminga, Marjolein Lugtenberg, Julia Annabel Van den Broek, Tamar Nijsten, Marlies Wakkee, Kasia Tabeau

“…ObjectiveThe aim of this study was to identify the ideal SCP for patients with melanoma in terms of functions and features to be included according to different stakeholders and to explore their underlying motives. MethodsIn total, 3 cocreation sessions were organized with mixed samples of stakeholders, ie, patients with (a history of) melanoma (n=4), health care providers (HCPs) active in melanoma care (n=3), and IT specialists active in hospital IT departments (n=6). …”
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Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway by Xie A, Li W, Ye D, Yin Y, Wang R, Wang M, Yu R

“…We also established TNF-α/IFN-γ induced AD cell models using HaCat cells and collected cell samples for further experiments.Results: The GSVA analysis demonstrated that ferroptosis-related genes could differentiate between healthy children and those with AD. …”
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Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis by Wang L, Liang L, Qian J, Yu C, Shi Y, Yan X, Chen X

“…A total of 68 clinical samples from HCC patients were collected, and hsa_circ_0007991 level was quantified using RT-qPCR. …”
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Integrated Analysis to Reveal Heterogeneity of Tumor‐Associated Neutrophils in Glioma by Wen Wang, Junsheng Li, Qiheng He, Chenglong Liu, Siyu Wang, Zhiyao Zheng, Bojian Zhang, Siqi Mou, Wei Sun, Jizong Zhao

“…This study aimed to investigate the heterogeneity and role of TANs in glioma and to develop a prognostic model. Methods Analysis of scRNA‐seq data identified cellular subpopulations and differentially expressed neutrophil‐related genes (DE‐NRGs). …”
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The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer by Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad

“…This study focuses on the SAL-repressed lncRNA MIR503HG, examining its involvement in androgen-controlled cellular senescence in PCa. Methods Transcriptome and ChIP-Seq analyses of PCa cells treated with SAL were conducted to identify SAL-downregulated lncRNAs. …”
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Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting by Wenqing Shi, Mengqi Jia, Xiao Li, Xin Zhao, Chenxi Wang, Guorong Fan, Guorong Fan, Guorong Fan, Yuefen Lou

“…However, current research has primarily focused on ethanol extracts, leaving the active ingredients and mechanisms responsible for the uric acid-lowering effects of SGR standard decoction unclear.MethodsFirstly, the chemical components in the standard decoction of SGR were characterized by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), and the pharmacodynamic experiments in mice with a high uric acid model were used to rapidly screen out the uric acid-lowering active ingredient group. …”
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Experimental study of the piezoelectricity of Middle Pleistocene loess in the Weibei region, China by Yanlin JING, Jie LIU, Qingying LIU, Xiaoxiao DUAN, Na XIE, Dengke YANG

“…However, there is a lack of studies on the piezoelectricity of loess both domestically and internationally. MethodsThis study investigated the \begin{document}${\mathrm{Q}}_2^{{\mathrm{eol}}} $\end{document} loess from the Weibei Loess Tableland in Shaanxi Province as an example to explore the piezoelectricity of loess. …”
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Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis by Lu L, Zhou X, Zheng J, Li D

“…We investigated the diagnostic and prognostic value of COIL expression in HCC.Patients and Methods: This study evaluated the expression and prognostic significance of COIL using data from the TCGA and local hospital samples, with 374 and 118 liver cancer patients in the TCGA database and local hospital, respectively. …”
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Comparing school age thalassemia children\'s behavioral problem referring to ‎children center in Rasht with their healthy classmates by fatemeh meskiny, minomitra chehrzad, haydeh mahmoodi

“…‎ Objective: This research was conducted to compare school-age thalassemic children's ‎behavioral problem with their healthy classmates.‎ Methods: This is comparative – descriptive study that ‎‏50‏‎ children with thalassemia referred to ‎children Hospital in Rasht and ‎‏100‏‎ peers with their mothers participated. …”
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Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration by Qiang Liu, Hua Zhang, Heng Xiao, Ao Ren, Ying Cai, Rui Liao, Huarong Yu, Zhongjun Wu, Zuotian Huang

“…Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.Materials and methods In this study, we downloaded mRNA expression profiles of HCC from the GEO database and used random forest and machine learning algorithms, such as least absolute shrinkage and selection operator, to screen for reliable diagnostic genes. …”
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EBV-miR-BART5-5p regulates RORA to promote proliferation and migration of gastric cancer cells. by Changqi Du, Shuang Liang, Xia Wang, Yujiao Qi, Shangdong Li, Hongling Li

“…Our analysis revealed that RORA expression is lower in tumor samples compared to normal samples, and single-cell analysis showed significant upregulation of RORA in CD8 + T cells. …”
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Research of Impact by Mechanical Device on Winter Wheat Seeds by V. P. Zabrodin, A. F. Butenko, M. V. Sukhanova, S. M. Cheptsov

“…The experiment was carried out with the help of simulation system, which allows to create conditions of impact on the studied sample of wheat grains, close to the realone, to obtain objective and scientifically based data. …”
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Engineered Mg-modified biochar-based sorbent for arsenic separation and pre-concentration by Vladimír Frišták, Kristína Beliančínová, Lucia Polťáková, Eduardo Moreno-Jimenéz, Andrew R. Zimmerman, Libor Ďuriška, Ivona Černičková, Haywood Dail Laughinghouse IV, Martin Pipíška

“…Abstract The utilization of biochar as a relatively efficient sorbent or stationary phase for the separation and preconcentration of a wide range of analytes represents an innovative approach in current sample pretreatment methods. Appropriate pre- and post-pyrolysis modification of the input precursor and pyrolysis product, respectively, allows targeted design of the physicochemical properties and sorption characteristics of the resulting sorbent. …”
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Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma by Shunshun Zhao, Mingyao Meng, Ruochuan Cheng, Min Zhang, Chuanyuan Liu, Qiuyu Meng, Tingting Yang, Haohan Huang, Bin Liu, Xiaodan Wang, Yanjun Su

“…Abstract Objective This study explored the therapeutic effects of anlotinib in anaplastic thyroid carcinoma (ATC) models and the underlying molecular mechanisms. Methods Human C643 and CAL-62 anaplastic thyroid carcinoma cell lines were cultured in vitro and treated with anlotinib. …”
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