Changes in expression of NLRP3 inflamasome and IL-1β in the development of oxazolone-induced colitis in rats and on the background of administration of simvastatin and interleukin-... by O. S. Zherebiatiev, N. M. Polishchuk

“…To study the expression of mRNA of the NLRP3 inflammasome and proinflammatory cytokine IL-1β in the inflamed colon of rats with experimental oxazolone-induced colitis and against the background of the introduction of simvastatin and antagonist of interleukin-1 receptors. Materials and methods. Experiments were carried out on male Wistar rats aged 8 months (body mass 120–150 g). …”
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Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study by Alexandria Nyembwe, Yihong Zhao, Billy A. Caceres, Daniel W. Belsky, Calen Patrick Ryan, Brittany Taylor, Morgan T. Morrison, Laura Prescott, Stephanie Potts-Thompson, Arezo Aziz, Fisola Aruleba, Erica Matute-Arcos, Olajide Williams, Cindy Crusto, Jacquelyn Y. Taylor

“…Coping strategies may mitigate stress from racial discrimination and protect against long-term adverse health outcomes. <b>Methods:</b> We conducted a secondary analysis of data from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure cohort, an all-African-American sample, to test the hypothesis that social support can protect against accelerated biological aging associated with experiences of racial discrimination. …”
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Bladder cancer microbiome and its association with chemoresponse by Rashida Ginwala, Laura Bukavina, Laura Bukavina, Mohit Sindhani, Erika Nachman, Erika Nachman, Suraj Peri, Jodie Franklin, John Drevik, Sarah Christianson, Daniel M. Geynisman, Alexander Kutikov, Philip H. Abbosh, Philip H. Abbosh

“…Despite the urinary microbiome being one of the most clinically significant microbiomes in human health, it is one of the least well-described.Methods and materialsTo begin to annotate the urinary microbiome present in bladder cancers, we analyzed human genome-filtered sequencing data from the Cancer Genome Atlas (TCGA) from 116 tumors (duplicates from 22 tumors), 22 adjacent normal bladder tissues, and 99 blood samples to classify reads originating from known microbiota. …”
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Design of intelligent human-machine collaborative robot-assisted craniotomy system by Meng Cui, Wenqing Ren, Tengfei Cui, Ruifeng Chen, Yi Shan, Xiaodong Ma

“…Objectives: To develop an intelligent human-machine collaborative control robot-assisted craniotomy system, and test its efficacy by experiments. Methods: The system integrated a UR5 robotic arm (Universal Robots, Denmark), a host computer, a double six-degree-of-freedom force sensor(Nanjing Yuli Instrument Co., Ltd.), a medical drill(AESCULAP®, Germany), a Polaris Optical navigation system(NDI,Canada), with a self-designed navigation procedure and a visual graphical user interface(GUI). …”
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Comparative Effectiveness of After-School Programs to Increase Physical Activity by Sabina B. Gesell, Evan C. Sommer, E. Warren Lambert, Ana Regina Vides de Andrade, Lauren Whitaker, Lauren Davis, Bettina M. Beech, Stephanie J. Mitchell, Nkiruka Arinze, Stevon Neloms, Colleen K. Ryan, Shari L. Barkin

“…We conducted a comparative effectiveness analysis to evaluate the difference in the amount of physical activity children engaged in when enrolled in a physical activity-enhanced after-school program based in a community recreation center versus a standard school-based after-school program. Methods. The study was a natural experiment with 54 elementary school children attending the community ASP and 37 attending the school-based ASP. …”
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“It’s my life, it’s my choice and I want to say when” vs “A good death is to be on good terms with God”. Comparing the views of people with dementia in the UK and Brazil about a go... by Rasa Mikelyte, Karen Harrison Dening, Déborah Oliveira, Julia Maria Vanelli, Adriele Ferreira Neves, Natashe Lemos Dekker, Francelise Pivetta Roque, Edison Iglesias de Oliveira Vida

“…We aimed to compare the meaning of a good death for PLwD in Brazil and in the United Kingdom (UK). Methods In this cross-sectional qualitative study, we conducted semi-structured interviews with a convenience sample of 32 PLwD (16 in Brazil and 16 in the UK) using jointly designed, equivalent interview guides. …”
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RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC‐Mediated MNK2 Alternative Splicing by Zenghui Ma, Jianbin Zhu, Min Chen, Guangming Wu, Xiaolong Liu, Zhanjun Hu, Yufei Feng, Xiaoliang Wang, Feng Liu

“…We aimed to explore the role of RALYL in CRC involved in MNK2 alternative splicing in the present study. Methods Bioinformatics analysis, detection in CRC samples, and experiments in vitro and in vivo combined with gene knockdown and overexpression were conducted. …”
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ECMO Support in Pediatric Populations with the Newborn ECMOLife Centrifugal Pump by Carlo Pace Napoleone, Ignazio Condello, Maria Teresa Cascarano, Enrico Aidala, Licia Peruzzi, Isabella Molinari, Cristina Rivoldini, Maria Stella Di Carlo, Stefania Iannandrea, Enrico Bonaveglio

“…ECMOLife, a new magnetic levitation centrifugal pump, has been introduced for these patients. <i>Materials and Methods</i>: Four patients were supported with the ECMOLife System in a newborn setting, with veno-venous application in two cases and veno-arterial in the other two. …”
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Luteolin attenuates inflammation and apoptosis in LPS-induced ALI mice by activating the HGF/c-Met pathway by Jihong Bi, Yan Li, Lin Lu, Tingting Yin, Shaohua Mao, Run Zhang, Juan He, Xing Ni, Kai Wang, Jirui Bi

“…ObjectiveTo investigate the protective effects of luteolin on ALI induced by lipopolysaccharide (LPS) in male mice and to explore the underlying mechanisms.MethodsA two-sample Mendelian randomization (MR) analysis was conducted to assess the causal relationship between hepatocyte growth factor (HGF) and acute respiratory distress syndrome (ARDS). …”
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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer by Xu Li, Xu Li, Xiwen Li, Yanlin Ren, Ling Wang, Zehao Mao, Shikun Gao, Shikun Gao, Peng Ma, Junjie Chen, Junjie Chen

“…Considering its functions in centromere stability and DNA repair, investigating HJURP’s role in GC may offer novel therapeutic perspectives.MethodsHJURP expression was examined in a dataset comprising TCGA-STAD samples and an internal group of GC patients, utilizing RNA sequencing and Western blot techniques. …”
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Innovative strategies to optimise colorectal cancer immunotherapy through molecular mechanism insights by Quanjun Lin, Zhiqiang Wang, Jue Wang, Ming Xu, Xinyi Zhang, Peng Sun, Yihang Yuan

“…A comprehensive analysis of the molecular profile of tumor cells is crucial for identifying novel molecular targets for drug sensitivity analysis and for uncovering the pathophysiological mechanisms underlying CRC.MethodsWe utilized single-cell RNA sequencing technology to analyze 13 tissue samples from 4 CRC patients, identifying key cell types within the tumor microenvironment. …”
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Influence of protein-peptide bioregulator isolated from bovine sclera and incorporated into an albumin-based cryogel on the sclera in a model cultivation of a posterior eye segment by O. V. Yamskova, M. S. Krasnov, E. V. Sidorsky, V. I. Lozinsky

“…At the end of cultivation, the samples were fixed, washed, dehydrated, and embedded in paraffin. …”
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FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription by Xie Y, Yan F, Liu X, Yu L, Yan H, Shang Z, Kong Y, Yang Z

“…The regulatory effect of YFJP on T cell was evaluated by detecting samples from patients with HCC. The molecular mechanism of YFJP in treating HCC was validated through in vivo and in vitro experiments.Results: Constructing networks and analyse indicated that the key targets of YFJP in the treatment of HCC is FoxO1. …”
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The mental health of survivors of violence against women who accessed supportive services during the COVID-19 pandemic: A narrative thematic analysis by Bridget Steele, Priya Shastri, Catherine Moses, Elizabeth Tremblay, Monique Arcenal, Patricia O’Campo, Robin Mason, Janice Du Mont, Maria Hujbregts, Amanda Sim, Alexa R. Yakubovich

“…Methods: We used narrative thematic analysis to analyze our interview data and identified how life histories and sociodemographic factors intersected with themes about their mental health. …”
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Use of NIRS technology for predicting the nutritional value of silage made from tropical grasses enriched with corn ethanol co-products and intercropped with corn by Joadil Gonçalves de Abreu, Daniele Cristina da Silva Kazama, Wender Mateus Peixoto, Edegar Matter, Luciano da Silva Cabral, Ernando Balbinot, Patrícia Orlando Royer, Eduardo André Ferreira

“…In Experiment III, the experiment was conducted in randomized blocks with five replicates, and the treatments were organized in a 2×4 arrangement. …”
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Dual Attention-Based Global-Local Feature Extraction Network for Unsupervised Change Detection in PolSAR Images by Dazhi Xu, Ming Li, Yan Wu, Peng Zhang, Xinyue Xin

“…Specifically, the feature constraint loss function is constructed to eliminate feature redundancy and fully exploit the complementarity between features, while the focal loss function is introduced to balance the impact of the inequality between changed and unchanged samples on the network. Numerical experiments on five real spaceborne PolSAR datasets demonstrate that our DA-GLN is more competitive than other state-of-the-art methods.…”
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Kynurenic acid derived from mesentery regulates mesenteritis and colitis via inducing white adipose browning in Crohn’s disease by Yongheng Wang, Ritian Lin, Fangtao Wang, Huijun Fu, Xia Wang, Fengshan Jin, Qiao Wang, Weigang Shu

“…However, its underlying causes and mechanisms remain unknown. Methods: The beige MAT samples from patients with CD and normal white MAT samples from patients without CD were collected, and targeted metabolome analysis was performed. …”
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Aging time influences fatty acid profiles and volatile compounds in cooked Thai native beef. by Watcharawit Meenongyai, Kunwadee Kaewka, Kannika Wongpanit, Piyamas Phongkaew, Pichad Khejornsart, Panuwat Khumpeerawat, Alexander Michael Stelzleni.

“…Objective: This study aims to assess the impact of aging time on the quality of meat, fatty acid profiles, and volatile compounds in cooked Thai native beef. Materials and Methods: The experiment utilized a randomized complete block design, where the aging time (0, 7, 14, 21, and 28 days) served as the treatment and the longissimus thoracis et lumborum muscle from Thai native cattle (n = 4) was considered a block. …”
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Technical note: Flow cytometry assays for the detection, counting and cell sorting of polyphosphate-accumulating bacteria by C. Bouquet, H. Billard, H. Billard, C. C. Bidaud, J. Colombet, J. Colombet, Y.-T. Chang, J. Artigas, I. Batisson, K. Benzerara, F. Skouri-Panet, E. Duprat, A.-C. Lehours

“…This requires high-throughput methods to characterize their structure and dynamics in ecosystems. …”
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Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC by Yulin Zhang, Yixu Wang, Jilin Peng, Kun Zhao, Ling Li, Yuan Zhang, Ziyu Zhai, Sijie Yuan, Shichao Li, Shichao Li, Shichao Li, Fanglei Ye, Le Wang

“…Further experiments were performed in patient samples, stable cell lines, and a murine xenograft tumor model.ResultsA reliable survival risk model of m6A was constructed based on the TCGA database. …”
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