Pathologic Changes in the Liver During Acute Exposure to Clozapine and Its Combination with Ethanol (Experimental Study) by O. L. Romanova, D. V. Sudukov, M. A. Golubev, M. L. Blagonravov, V. V. Goshkoev, A. A. Churilov

“…Purpose: identification of pathological changes in the liver at early stages of the effect of clozapine and clozapine combined with ethanol to improve the diagnosis of this acute exposure.Materials and methods. The experiments were carried out on outbred male rats (n=15). …”
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Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway by Li Liu, Wenxuan Liu, Wenhong Deng

“…Research has shown that insulin plays a vital role in the growth and progression of cancer; however, the relationship between amylin and gastric cancer (GC) is unclear.Methods This study used a combination of in vitro and in vivo experiments to investigate the role of amylin in the progression of GC. …”
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Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis by Liuzhu Chen, Linpei Zhuo, Jie Zheng, Xiaoyun Sun, Jing Sun, Jiaming Liu

“…Methods Male mice were induced with bilateral common carotid artery occlusion (BCCAO) to establish an IS animal model, and then intragastrically treated with atorvastatin. …”
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Evaluating self-assistance during functional reach with a passive hydrostatic exoskeleton under artificial impairment by Julia Manczurowsky, Henry Mayne, David Nguyen, Meghan Kenney, John Peter Whitney, Christopher J. Hasson

“…To address this question, we developed a passive hydrostatic exoskeleton (hEXO) that enables self-assistance and paired it with an artificial impairment paradigm using Dysfunctional Electrical Stimulation (DFES), which induces involuntary hand closure during reaching. Methods Twenty neurologically typical adults (26 ± 3 yrs) performed a reach-to-grasp and object lift task under challenging sensorimotor conditions: as fast as possible with their non-dominant hand while experiencing an artificial impairment induced by DFES. …”
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Testing source elevation versus genotype as predictors of sugar pine performance in a post‐fire restoration planting by Emily V. Moran, Rainbow DeSilva, Courtney Canning, Jessica W. Wright

“…Of these, 323 either had annotations that suggested potential functional importance or were identified by two different methods. We then built Bayesian models of survival and growth for all seedlings in a separate post‐fire planting experiment, to test the relative predictive ability of source elevation (a common proxy for source climate) versus the proportion of seedling alleles expected to be locally advantageous based on GEA. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Peizhi Lu,1,2,* Ya Li,1,2,* Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bizhi Tu, Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China, Tel +86 15357483840, Email 1301535636@qq.com Rende Ning, Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Tel +86 13956966305, Email nrd1972@outlook.comObjective: The objective of this study was to characterize the activation and differentiation of B cells in the synovium of osteoarthritis (OA) and to explore the underlying molecular mechanisms.Methods: Peripheral blood and synovial samples from OA patients at different stages were collected, and flow cytometry was employed to analyze the activation and differentiation of B cells. …”
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Weight bias in mental health settings: a scoping review by Samantha R. Philip, Erin C. Standen, Jordan Schueler, Sherecce A. Fields, Sean M. Phelan, Sean M. Phelan

“…Qualitative studies from client samples revealed experiences of weight stigma during treatment, including MHPs’ expressions of implicit and explicit weight bias, assumptions and misattributions based on the clients’ weight, unsolicited (direct or subtle) weight loss advice, and differential treatment based on size. …”
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Prevention of Gut Barrier Dysfunction During Acute Massive Blood Loss (Experimental Study) by A. Y. Yakovlev, G. A. Boyarinov, D. V. Ryabikov, M. A. Ryabikova, D. M. Protasov, I. V. Mukhina

“…Purpose of the study: to investigate the influence of hypovolemia correction by infusion of malate-containing preparations and subsequent glutamine-enriched nutritional support on the maintenance of gut barrier and overhydration in animals with acute massive blood loss/  Materials and methods. Blood samples were harvested from the tail and portal veins of rats (n=100) at different time points after the acute blood loss (>30% V/V) . …”
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Herbs impact on poultry health and antimicrobial resistance: a scoping review with one health perspective by Maha Dardouri, Meriem Maher Mtibaa, Sana Azaiez, Ahlem Mahjoub Khachroub, Wejdene Mansour

“…Sources of evidence From December 2022 to February 2023, a systematic search on PubMed, Science Direct, and Google Scholar was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews guidelines. Charting methods Data charting was performed using a standardized form on Excel 365 that included study identification features, population and sample size, study groups, intervention description, follow-up period, and main outcomes. …”
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Enhancing STEM outcomes through mentorship (Mis)matching: an identity grafting approach by Daphnee Hui Lin Lee, Sze Wing Bertha Mak, Kam Kong Derek Lit, Kwan Choi Thomas Tse, Ching Sing Chai

“…Results We adopted a case study approach to interpret mixed methods data collected from an interschool STEM competition in Hong Kong, correlating mentors’ and mentees’ survey scores to sample a team for observation. …”
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PIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation by Wen Li, Kan Ze, Xufeng He, Lili Yang, Huimin Zhang, Weian Yuan, Wuqing Wang

“…PIEZO1, a mechanically activated ion channel, has been implicated in various cellular processes, but its role in psoriasis pathogenesis remains unclear. Methods We examined PIEZO1 expression in skin samples from psoriatic patients and healthy individuals using western blot, immunohistochemistry, and mRNA expression analyses. …”
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Physical activity and bone turnover in women with osteopenia by Perić Dušan, Kovačev-Zavišić Branka, Međedović Bojan, Romanov Romana, Ahmetović Zlatko, Novaković-Paro Jovanka, Dimitrić Mirjana

“…The aim was to quantify the impact of this program on: the concentration of bone metabolism blood markers, muscle strength, aerobic capacity, and physical dimensions. Methods. The sample consisted of 26 women in postmenopause (age 46–58) divided into two groups – experimental group (n = 15) and control group (n = 11). …”
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MAPK4 Accelerates Progression of Cervical Squamous Cell Carcinoma by Positively Regulating SLC3A2 Expression by Jing YU, Lu DENG, Yuting ZHAO, Zhenlong YUAN, Lingying WU

“…Immunohistochemistry experiments were conducted on clinical samples to explore the correlation between MAPK4 and patient prognosis. …”
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MIR155HG suppresses the osteogenic differentiation of bone marrow mesenchymal stem cells through regulating miR-155-5p and DKK1 expression by Weimin Li, Cheng Yang, Jiamu Xu, Dongcheng Ran, Chunqing Wang

“…In the current study, we studied MIR155HG function in regulation of osteogenic differentiation and tried to reveal the underlying mechanisms. Methods Forty blood samples taken from 20 PMOP patients (PMOP group) and 20 postmenopausal individuals without osteoporosis (control group) were used to compare the contents of MIR155HG and miR-155-5p via RT-PCR. …”
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Metallophosphide poisoning, a rising public health problem in Ethiopia: a systematic review and meta-analysis by Kassaye Demeke Altaye, Bethelhem Yenenew Assefa, Adina Worku Teka, Saron Mulugeta Worku, Geta Bayu Genet, Bikis Liyew, Nahom Worku Teshager

“…This systematic review and meta-analysis aim to determine the pooled prevalence and mortality rate from metallophosphide poisoning in Ethiopia. Methods As of August 2024, PUBMED, EMBASE, SCOPUS, and GOOGLE SCHOLAR were inclusively searched. …”
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Using deep neural networks and LASSO regression to predict miRNA expression changes based on mRNA data by Franz Leonard Böge, Helena U. Zacharias, Stefanie C. Becker, Klaus Jung

“…While much public data from mRNA experiments are available for many diseases, few paired datasets with both miRNA and mRNA expression profiles are available. …”
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Unexplored strains and job satisfaction for individuals with visual and auditory impairments: an Italian study by Maria Donata Orfei, Desirée Estela Porcari, Gabriella Daneluzzi, Francesca Maggi, Emiliano Ricciardi, Davide Bottari

“…In particular, it investigated for the first time three specific job strains: technostress (TS), cognitive overload (COL), and aging (AG) in PwSD as compared with typical development (PwTD), along with job satisfaction and accessibility. Methods A multidimensional web survey was administered across the Italian national territory to a sample of PwSD (n = 202) and a sample of PwTD (n = 2283). …”
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STUDY OF THE DISTRIBUTION OF LARVAE IN MUSCLES AND SOME PERIPHERAL BLOOD PARAMETERS OF GALLUS GALLUS IN EXPERIMENTAL INFECTION WITH TRICHINELLA PSEUDOSPIRALIS by Olga B. Zhdanova, Olga V. Chasovskikh

“…The aim of the study was to study the distribution of larvae in the muscles and some indicators of peripheral blood of birds during experimental infection with Trichinella pseudospiralis. Materials and methods. The birds of the experimental group were weighed and T. pseudospiralis larvae isolate was injected into the tooth at a dose of 2 lich./ g of body weight (3600±400 larvae per bird). …”
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Bioinformatics screening and clinical validation of CircRNA and related miRNA in male osteoporosis by Jiayi Li, Sijia Guo, Qingyun Sun, Ning An, Jisheng Lin, Qi Fei

“…Finally, a ceRNA network of four circRNAs derived from three hub genes was constructed. Validation experiments were performed on selected circRNAs and related miRNAs in this ceRNA network using peripheral blood clinical samples. …”
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Gender Differences in the Support of Medical Marijuana Use Among Primary Care Providers by Kathryn Polak, Anna Wiese, Taylor B. Crouch, Wally Smith, Dace S. Svikis

“…Methods: Participants (N = 85) were primary care providers recruited through ResearchMatch.org who completed a 10-minute computer-administered survey on perceptions, attitudes, and experiences involving chronic pain management and medical marijuana/THC. …”
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