Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running. by Gregory N Ruegsegger, Joseph M Company, Ryan G Toedebusch, Christian K Roberts, Michael D Roberts, Frank W Booth

“…In wheel locked rats, IPA revealed enrichment of transcripts for the following functions: extracellular matrix, macrophage infiltration, immunity, and pro-inflammatory. …”
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Exploring the impact of deubiquitination on melanoma prognosis through single-cell RNA sequencing by Su Peng, Jiaheng Xie, Xiaohu He

“…Dimensionality reduction and clustering were executed through Principal Component Analysis (PCA) and Uniform Manifold Approximation and Projection (UMAP). …”
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Implementation and Evaluation of Wet Bulb Globe Temperature Within Non‐Urban Environments in the Community Land Model Version 5 by Jonathan R. Buzan

“…A default configuration of CLM5 is executed and shows the advantages of simulating the WBGT within multiple environments. …”
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Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories by Yiguo Zhang, Xi Chen, Meng Wang, Yuping Zhu, Wei Shi, Chao Li, Zhengwen Zhang, Hiroaki Taniguchi, Ping Ao

“…This is attributable to the facts that Nrf2 has exerted certain ‘double-edged sword’ effects on life process, whereas Nrf1 executes its essential physiobiological functions, along with unique pathophysiological phenotypes, by integrating its ‘three-in-one’ roles elicited as a specific triplet of direct sensor, transducer and effector within multi-hierarchical stress responsive signaling to redox metabolism and target gene reprogramming. …”
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Systematic exploration of the molecular characteristics of CD8+ T cells to predict the response to immunotherapy and the prognosis of patients with colon adenocarcinoma by Xin Shen, Lifeng Shang, Junwei Han, Yi Zhang, Wenkai Niu, Haiwang Liu, Hai Shi

“…Additionally, a series of in vitro experiments were executed to validate the reliability of the signatures associated with CD8+ T cells. …”
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Social networks of educational purpose as a subject of protection in the preparation of specialists of information security by I. D. Rudinskiy, D. Ya. Okolot

“…The paper also describes threats that may arise when using such networks in an educational organization, suggests measures to mitigate risks and discusses functions of information security specialists in ensuring security of social networks used in the educational process. …”
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Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cells by Maissa Ben Mahmoud, Anikó Rátkai, Krisztina Bauer, Norbert Bencsik, Attila Szücs, Katalin Schlett, Krisztián Tárnok

“…In this study, we conducted comprehensive cellular and network level analysis of the functional development of human neurons, generated from iPSCs obtained from healthy young female peripheral blood mononuclear cells by BDNF and GDNF treatment. …”
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Legal Means of Providing the Principle of Transparency of the Artificial Intelligence by Yu. S. Kharitonova

“…Objective: to analyze the current technological and legal theories in order to define the content of the transparency principle of the artificial intelligence functioning from the viewpoint of legal regulation, choice of applicable means of legal regulation, and establishing objective limits to legal intervention into the technological sphere through regulatory impact.Methods: the methodological basis of the research is the set of general scientific (analysis, synthesis, induction, deduction) and specific legal (historical-legal, formal-legal, comparative-legal) methods of scientific cognition.Results: the author critically analyzed the norms and proposals for normative formalization of the artificial intelligence transparency principle from the viewpoint of impossibility to obtain the full technological transparency of artificial intelligence. …”
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INTEGRATION OF DISTRIBUTED INERTIAL NAVIGATION SYSTEMS BUILT AROUND FIBER-OPTIC AND MICROELECTROMECHANICAL SENSORS by A. V. Chernodarov, A. P. Patrikeev, I. I. Merkulova, S. I. Ivanov

“…Moreover, the SINS-MEMSs cannot execute the initial alignment from attitude angles in the autonomous mode. …”
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DISYNCRO: Perceived roles of clinical study coordinators and data managers: results from a web-based survey of professionals from contract research organizations by Susanna Yedro, Elena Tinari, Daniele Napolitano, Giulia Wlderk, Eleonora Ribaudi, Luciana Giannone, Gianluca Ianiro, Mattia Bozzetti, Antonio Gasbarrini, Vincenzina Mora

“…Most partecipants (98.4 %) identified the CSC as the primary figure within a research center, and 77.9 % considered the CSC essential for clinical trial execution. Regarding functional overlap, 57.4 % of respondents believed that the CSC could perform the duties of a DM, whereas only 42.6 % thought the DM could assume the CSC's responsibilities. …”
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The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study by Violante Di Donato, Ottavia D'Oria, Andrea Giannini, Maria Scudo, Carmel Sher, Margherita Fischetti, Giorgia Perniola, Innocenza Palaia, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici

“…Hormonal therapy seems to be an effective treatment, often not executable for contraindication or patient’s low compliance to local or systemic medical therapy. …”
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Molecular Simulation of Graphene Growth Reactions at Various Temperatures Derived from Benzene in Coal Tar Aromatic Hydrocarbons by Shuhan Zhao, Zhongyang Luo, Mengxiang Fang, Qinhui Wang, Jianmeng Cen

“…Furthermore, we apply density functional theory (DFT) calculations, executed through the Vienna Ab initio Simulation Package (VASP), to assess the dehydrogenation energy associated with the adsorption of benzene on vapor-deposited copper foils. …”
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Implementation of a Neural Network for Adaptive PID Tuning in a High-Temperature Thermal System by Juan Carlos Almachi, Ramiro Vicente, Edwin Bone, Jessica Montenegro, Edgar Cando, Salvatore Reina

“…Implemented on an 18 kW retrofitted Blue-M furnace, the system was characterized by second-order transfer functions for heating and forced convection cooling. …”
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SCUP-HPC: System for Constructing and Utilizing Provenance on High-Performance Computing Systems by Yuta Namiki, Takeo Hosomi, Hideyuki Tanushi, Akihiro Yamashita, Susumu Date

“…We evaluated SCUP-HPC with well-known HPC applications, assessing both the functionality of the constructed provenance and the performance impacts on the applications. …”
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Medial plantar flap for reconstruction of heel defects after resection of acral lentiginous melanoma: A series of seven cases by Giulia Godoy Takahashi, Renan Diego Américo Ribeiro, Vitor Penteado Figueiredo Pagotto, Caio Augusto Lima de Araújo, Fábio de Freitas Busnardo, Rolf Gemperli

“…The tissues on the sole of the foot have unique characteristics essential for maintaining the limbs functionality. The heel has the most significant weight support and is subjected to the entire soles greatest impact. …”
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Assessing Root Causes and Solutions to Address Cross-Programmatic Inefficiencies in a Subnational Health System: A Case Study of Anambra State, Nigeria by Obinna Onwujekwe, Uchenna Ezenwaka, Prince Agwu, Chukwudi Nwokolo, Francis Ukwuije, Alexandra J. Earle, Agnes Gatome-Munyua, Susan Sparkes

“…The governance- and finance-related cross-programmatic inefficiencies identified were duplicative and misaligned roles within and between state and federal agencies, functions, and activities within and across health programs; misaligned donor priorities with that of the state; and poor formulation and implementation of the approved annual state health budget. …”
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Technical stakeholders' perspective of solar photovoltaic system failure in Sub-Saharan Africa: The case of Ghana by Jacob Junior Owusu, Edmund C. Okoroigwe, Chigbo A. Mgbemene, Gabriel Takyi, Onyemaechi Valentine Ekechukwu

“…Most installed PV systems in sub-Saharan Africa have often not achieved their anticipated functionality and/or fail frequently. Take-up of PV systems consequently remains low, with long pay-back times. …”
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An Analysis of Wrist Motions During Daily Activities From a Directional Perspective: The Significance of Directions Beyond the Dart‐Throwing Motion by Qipei Wei, Shijie Jia, Shengfang Zhang, Xiaofeng Qiao, Zhixin Wang, Chang Liu, Shanlin Chen

“…Twenty‐six right‐handed subjects executed 22 ADLs, with angular wrist positions tracked via retroreflective markers on the dominant limb. …”
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Measuring and Improving the Efficiency of Python Code Generated by LLMs Using CoT Prompting and Fine-Tuning by Ramya Jonnala, Jeong Yang, Young Lee, Gongbo Liang, Zechun Cao

“…The evaluation metrics encompass execution time, memory utilization, and peak memory consumption, while maintaining the functional correctness of the generated code. …”
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Federal statehood of Russia and Germany in the mirror of constitutional and judicial law enforcement: the importance of German experience for Russian practice by Elena V. Gritsenko

“…First of all, the Basic Law for Germany focuses on the horizontal separation of powers and uses the functional principle of the separation of state powers between the Bund and the Federal lands making a distinction, respectively, primarily in the areas of legislation, execution of laws (management) and justice. …”
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