Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress‐Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway by Wanqi Chen, Qi Feng, Chan Zhang, Lu Yang, Jingyi Qi

“…This, in turn, results in the repair of oxidative stress‐induced damage and the enhancement of the function of damaged cells and ovaries. Conclusion Our findings indicate that exosomes derived from human umbilical cord stem cells have the beneficial effect of ameliorating oxidative stress‐induced POI by activating AMPK and regulating autophagic homeostasis.…”
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Latarjet Procedure for Recurrent Anterior Shoulder Instability by Marc Lubitz MD, Anup Shah MD, Evan Lederman MD

“…Discussion/Conclusion: While the Latarjet procedure provides excellent stability and functionality for shoulder instability, risks such as graft fragmentation and screw malposition require careful planning and execution. …”
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AutoGEEval: A Multimodal and Automated Evaluation Framework for Geospatial Code Generation on GEE with Large Language Models by Huayi Wu, Zhangxiao Shen, Shuyang Hou, Jianyuan Liang, Haoyue Jiao, Yaxian Qing, Xiaopu Zhang, Xu Li, Zhipeng Gui, Xuefeng Guan, Longgang Xiang

“…The framework integrates both question generation and answer verification components to enable an end-to-end automated evaluation pipeline—from function invocation to execution validation. AutoGEEval supports multidimensional quantitative analysis of model outputs in terms of accuracy, resource consumption, execution efficiency, and error types. …”
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Krylov diagonalization of large many-body Hamiltonians on a quantum processor by Nobuyuki Yoshioka, Mirko Amico, William Kirby, Petar Jurcevic, Arkopal Dutt, Bryce Fuller, Shelly Garion, Holger Haas, Ikko Hamamura, Alexander Ivrii, Ritajit Majumdar, Zlatko Minev, Mario Motta, Bibek Pokharel, Pedro Rivero, Kunal Sharma, Christopher J. Wood, Ali Javadi-Abhari, Antonio Mezzacapo

“…Variational quantum algorithms can be used to prepare ground states on pre-fault-tolerant quantum processors, but their lack of convergence guarantees and impractical number of cost function estimations prevent systematic scaling of experiments to large systems. …”
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Data-Driven Model Predictive Control for Trajectory Tracking in UAV-Manipulator Systems by Bryan S. Guevara, Jose Varela-Aldas, Viviana Moya, Manuel Cardona, Daniel C. Gandolfo, Juan M. Toibero

“…Additionally, the redundancy of the UAV-manipulator system allows for the integration of secondary objectives into the cost function, supporting flexible task execution. To meet real-time requirements, the control problem is solved using the Acados solver. …”
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Condition optimization for organizing the operation of connected trains on an ongoing basis on the Trans-Siberian Railway of the Eastern operational range of the railway network by M. I. Mekhedov, E. A. Sotnikov, P. S. Kholodnyak, D. A. Kursin, N. V. Kornienko

“…A target function has been developed for solving the problem of increasing the carrying capacity of loaded lines by organizing the motion of connected (double) trains on an ongoing basis, providing for the minimization of investment and operating costs. …”
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Research on Algorithms for Local Robot Positioning Using Methods of Discrete Optimization by Vyacheslav Korolyov, Maksim Ogurtsov, Oleksandr Khodzinskyi

“…The algorithm from the scipy.optimize.minimize library numerically finds the solution to the discrete optimization problem with a combined objective function considering the specified constraints, ensuring coordinate recovery accuracy of approximately 10 % and acceptable program execution speed for fixed-wing UAVs.…”
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Optimal Baseflow Separation Through Chemical Mass Balance: Comparing the Usages of Two Tracers, Two Concentration Estimation Methods, and Four Baseflow Filters by Yiwen Mei, Dagang Wang, Jinxin Zhu, Guoping Tang, Chenkai Cai, Xinyi Shen, Yi Hong, Xinxuan Zhang

“…Additionally, using monthly maximum and minimum values to represent tracer concentration in flow components produces better separation than using a power function relationship between flow rate and concentration. …”
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Stolt Interpolation-Free Range Migration Algorithm for Dynamic-Aperture-Based Computational MIMO Microwave Imaging by Vasiliki Skouroliakou, Maria Garcia-Fernandez, Guillermo Alvarez-Narciandi, Simon Cotton, Okan Yurduseven

“…This is because in microwave CI the transfer function of the antennas is used to encode information from the imaged target scene and compress it into a single (or a few) channel(s). …”
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Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks by Christopher D. Todd, Jannat Ijaz, Fereshteh Torabi, Oleksandr Dovgusha, Stephen Bevan, Olivia Cracknell, Tim Lohoff, Stephen Clark, Ricard Argelaguet, Juliette Pierce, Ioannis Kafetzopoulos, Alice Santambrogio, Jennifer Nichols, Ferdinand von Meyenn, Ufuk Günesdogan, Stefan Schoenfelder, Wolf Reik

“…Abstract Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. …”
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Evaluating the effect of chronic and continuous use of methadone on the glomerular filtration rate of patients receiving oral methadone (syrup) by Valiollah Goudarzvand Chegini, Amir Mohammad Kazemifar, Amir Ershad Tavakolian, Arian Ghannadi Karimi, Arsalan Jamali Pour Sofi, Darya Ipchian, Sahand Kamali, Mehran Ebrahimi Varkiani, Zohreh Yazdi

“…In contrast, the duration of methadone use did not significantly affect GFR.ConclusionThese findings indicate that, although methadone dosage may influence renal function, long-term methadone therapy does not inherently exacerbate the risk of chronic kidney disease (CKD) in this population. …”
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Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats by Jiangzihui Guo, Qingying Cao, Huicong Jie, Yuqing Li, Wenwen Bai, Tiaotiao Liu, Xuyuan Zheng

“…The pathogenesis of depression is fundamentally linked to the dysregulation of neural circuit structure and function. Notably, the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are critical brain regions in the regulation of depression-related behaviors. …”
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Incidental mishaps and learning curves during free fibula reconstruction of mandible: a case report by Dharnappa Poojary, K. M. Sandeep, K. P. Shetty, Sameep Shetty, Premalatha Shetty, Joanna Baptist, Ritesh Singh

“…Meticulous presurgical planning of harvesting fibula, resection of diseased bone, contouring the fibula to the created defect to restore the anatomy and function, microvascular anastomosis, and postoperative medical care are vital for the survival of the flap. …”
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Platelets and diseases: signal transduction and advances in targeted therapy by Yuchen Tian, Yao Zong, Yidan Pang, Zhikai Zheng, Yiyang Ma, Changqing Zhang, Junjie Gao

“…Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized structure that enables them to execute a wide range of physiological functions. The platelet cytoplasm is enriched with functional proteins, organelles, and granules that facilitate their activation and participation in tissue repair processes. …”
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Efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial by Run-Nan Xu, Run-Nan Xu, Jun Guo, Chun-He Zhang, Qing Zhou, Qiang Gen, Qiang Gen, Fu Wang, Yu Zhao, Yu Zhao, Xin-Yun Luo, Yan-Feng Li, Yi-Jia Fu, Yi-Jia Fu, Xin Zhang, Xin Zhang, Wen-Zhi Wang, Jian-Xiong Ma, Jian Wang, Jian Wang, Xiao-Jun Huang, Wen-Jie Huang, Bo-Dong Lv, Bo-Dong Lv

“…Primary outcome measures encompass the International Index of Erectile Function-Erectile Function domain (IIEF-EF) score, the Sexual Encounter Profile (SEP), and scores derived from the traditional Chinese medicine symptom evaluation.ResultsOf the 122 men enrolled, the baseline IIEF-EF score averaged 16.00 [IQR: 13.00, 18.00]. …”
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Ferroptosis triggers mitochondrial fragmentation via Drp1 activation by Lohans Pedrera, Laura Prieto Clemente, Alina Dahlhaus, Sara Lotfipour Nasudivar, Sofya Tishina, Daniel Olmo González, Jenny Stroh, Fatma Isil Yapici, Randhwaj Pratap Singh, Nils Grotehans, Thomas Langer, Ana J. García-Sáez, Silvia von Karstedt

“…Importantly, Drp1 accelerated ferroptotic cell death kinetics. Notably, this function was mediated by the regulation of mitochondrial dynamics, as overexpression of Mitofusin 2 phenocopied the effect of Drp1 deficiency in delaying ferroptosis cell death kinetics. …”
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Technological Resources and Problem-Solving Methods to Foster a Positive Attitude Toward Formative Research in Engineering Students by Ronald Paucar-Curasma, Klinge Orlando Villalba-Condori, Sara Hermelinda Gonzales-Agama, Freddy Toribio Huayta-Meza, David Rondon, Ninna Nyberg Sapallanay-Gomez

“…Formative research, within the context of the pedagogical function of research, employs investigative teaching methods and practices commonly used in universities. …”
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The Investigation of Caspase-3 and Tumor Necrosis Factor-Alpha Expression in Placentas of Patients with Preterm Premature Rupture of Membranes by Işılay Sezen Ermiş, Fırat Aşır, Süleyman Cemil Oğlak, Özge Kaplan, Gül Ebru Aydeniz, Engin Deveci

“…Background: Caspase-3 is involved in the execution of apoptosis and is widely used as an apoptotic marker. …”
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Accelerated development of multi-component alloys in discrete design space using Bayesian multi-objective optimisation by Osman Mamun, Markus Bause, Bhuiyan Shameem Mahmood Ebna Hai

“…Bayesian optimisation (BO) protocols grounded in active learning (AL) principles have gained significant recognition for their ability to efficiently optimize black-box objective functions. This capability is critical for advancing autonomous and high-throughput materials design and discovery processes. …”
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Detection of Parabolic Antennas in Satellite Inverse Synthetic Aperture Radar Images Using Component Prior and Improved-YOLOv8 Network in Terahertz Regime by Liuxiao Yang, Hongqiang Wang, Yang Zeng, Wei Liu, Ruijun Wang, Bin Deng

“…Ultimately, the effectiveness of the suggested method is confirmed through the execution of comprehensive simulations and anechoic chamber tests.…”
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