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    Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China by Xuedan Qiu, Min Jiang, Jianqiang Xu, Qiaoping Wu, Chenyao Lin, Weiying Li, Qingcao Li

    Published 2025-05-01
    “…Multi-locus sequence typing (MLST) was employed to analyze the molecular characteristics and evolutionary trends of the strains to determine their clonal relationships.ResultsThe 150 strains of CRKP exhibit high resistance rates to various conventional drugs; The sensitivity rates to tigecycline, polymyxin B, and ceftazidime-avibactam were 98.7, 98.0, and 68%, respectively; Conversely, the sensitivity rates to fosfomycin, amikacin, and chloramphenicol were 72.0, 40.0, and 16.7%, respectively; The main proportions of carbapemen genes producing in CRKP are as follows: KPC-2 (61.3%), NDM-5 (14.7%), IMP-4 (8.0%), OXA-232 (6.0%), and OXA-181 (1.3%); The main proportions of β-lactamase resistance genes are as follows: CTX-M-1 (13.33%), CTX-M-3 (25.33%), CTX-M-9 (17.33%), CTX-M-14 (34.67%), SHV-1 (26.66%), SHV-11 (66.66%), SHV-12 (18.66%), and SHV-28 (10.00%); CRKP carrying class A, B, and D carbapenemases had a sensitivity rate greater than 96% for tigecycline and polymyxin B, while their sensitivities to ceftazidime-avibactam, aztreonam, and amikacin varied significantly (p < 0.01). …”
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  6. 7006

    The Structure of the Molecular Envelope of the Ring Nebula (NGC 6720) by Joel H. Kastner, David J. Wilner, Diana Ryder, Paula Moraga Baez, Orsola De Marco, Raghvendra Sahai, Alwyn Wootten, Albert Zijlstra

    Published 2025-01-01
    “…The SMA ^12 CO(2–1) mapping data, with ∼3″ spatial resolution and 2 km s ^−1 velocity resolution, provide an unprecedentedly detailed, 3D view of the Ring’s clumpy molecular envelope. …”
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