What Is Endangered Now? Climate Science at the Crossroads by Scott R. Saleska, Steven C. Wofsy, David Battisti, William E. Easterling, Christopher Field, Inez Fung, James E. Hansen, John Harte, Daniel Kirk‐Davidoff, Pamela A. Matson, James C. McWilliams, Jonathan T. Overpeck, Joellen Russell, John M. Wallace

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Genome Editing and Defense against Its Misuse by J. Lakota

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Molecular epidemiology and genomic features of Bordetella pertussis in Tianjin, China, 2023 by Xiaohui Lu, Wen Li, Xuan Chen, Wei Zhang, Aiping Yu, Guangwen Liu, Baolu Zheng, Xin Gao, Yamin Liu, Xiaoyan Li

“…Specifically, 16 isolates (59.3%) carried the virulence genotype ptxA-1/ptxC-4/ptxP-3/prn-150(truncated)/fim2-1/fim3-1/fhaB-1, while 11 isolates (40.7%) carried the genotype ptxA-1/ptxC-4/ptxP-3/prn150/fim2-1/fim3-1/fhaB-1. …”
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Epidemiology and clinical features of Rotavirus infection among children in Rawalpindi, Pakistan. by Kiren Mustafa, Rani Faryal, Muhammad Masroor Alam, Suleman Rana, Massab Umair, Tawaf Ali Shah

“…This study reports G3P[4], G3P[6] and G12P[4] for the first time in Pakistan. …”
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Establishment of a genotyping criteria for Bandavirus dabieense and confirmation of new genotypes by Bingyan Liu, Tengfei He, Changtai Wang, Guomei Xia, Shijun Zhou, Shanshan Sun, Xinlei Chen, Xiaodan Hong, Jie Zhu, Zhenhua Zhang

“…Nucleotide differences within the same genotype were mostly below 3%, whereas those between different genotypes ranged from 3 to 7%. …”
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APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans. by Andrei V Tkatchenko, Tatiana V Tkatchenko, Jeremy A Guggenheim, Virginie J M Verhoeven, Pirro G Hysi, Robert Wojciechowski, Pawan Kumar Singh, Ashok Kumar, Gopal Thinakaran, Consortium for Refractive Error and Myopia (CREAM), Cathy Williams

“…Here, we found that low-frequency variants near the 5'-end of APLP2 were associated with refractive error in a prospective UK birth cohort (n = 3,819 children; top SNP rs188663068, p = 5.0 × 10-4) and a CREAM consortium panel (n = 45,756 adults; top SNP rs7127037, p = 6.6 × 10-3). …”
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Evolving Many-Objective Job Shop Scheduling Dispatching Rules via Genetic Programming With Adaptive Search Based on the Frequency of Features by Atiya Masood, Mansoor Ebrahim, Fahad Najeeb, Syed Muhammad Daniyal

“…The proposed algorithm, Adaptive Feature Selection-GP-NSGA-III (AFS-GP-NSGA-III), is compared with the FS-GP-NSGA-III and standard GP-NSGA-III on a four-objective JSS problem. …”
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RORA Regulates Autophagy in Hair Follicle Stem Cells by Upregulating the Expression Level of the <i>Sqstm1</i> Gene by Xuefei Zhao, Yanchun Xu, Shuqi Li, Suying Bai, Wei Zhang, Yu Zhang

“…The hair coat is an adaptive evolutionary trait unique to mammals, aiding them in adapting to complex environmental challenges. …”
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The importance of distinguishing between natural and managed tree cover gains in the moist tropics by Xueyuan Gao, Peter B. Reich, Jeffrey R. Vincent, Matthew E. Fagan, Robin L. Chazdon, Steffen Fritz, Dmitry Schepaschenko, Matthew D. Potts, Matthew C. Hansen, Martin Jung, Pedro H. S. Brancalion, María Uriarte, Trevor F. Keenan, Thomas W. Crowther, Ralph O. Dubayah, Myroslava Lesiv, Shunlin Liang, Dongdong Wang

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Influence of enzymatic parapancreatitis on the early phase of acute destructive pancreatitis by D. V. Kulikov, A. Yu. Korolkov

“…The average age of patients was (46.6±3.2) years (p≤0.05). The sum of points according to the express diagnostic scale of the SPb I. …”
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Shoreline dynamics of an urbanised estuarine beach under the influence of changing sediment budgets by David M. Kennedy, Runjie Yuan, R. Jak McCarroll, Jin Liu, Eddie Beetham, Daniel Ierodiaconou

“…The medium-term (last 30 years) sediment budget is approximately +3,000 m3/year due to longshore drift and nourishment. …”
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Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 by Hisato Kobayashi, Tatsushi Igaki, Soichiro Kumamoto, Keisuke Tanaka, Tomoya Takashima, So I Nagaoka, Shunsuke Suzuki, Masaaki Hayashi, Marilyn B Renfree, Manabu Kawahara, Shun Saito, Toshihiro Kobayashi, Hiroshi Nagashima, Hitomi Matsunari, Kazuaki Nakano, Ayuko Uchikura, Hiroshi Kiyonari, Mari Kaneko, Hiroo Imai, Kazuhiko Nakabayashi, Matthew Lorincz, Kazuki Kurimoto

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Chemical Abundances in the Nuclear Star Cluster of the Milky Way: Alpha-element Trends and Their Similarities with the Inner Bulge by Nils Ryde, Govind Nandakumar, Mathias Schultheis, Georges Kordopatis, Paola di Matteo, Misha Haywood, Rainer Schödel, Francisco Nogueras-Lara, R. Michael Rich, Brian Thorsbro, Gregory N. Mace, Oscar Agertz, Anish M. Amarsi, Jessica Kocher, Marta Molero, Livia Orglia, Giulia Pagnini, Emanuele Spitoni

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Tandem mass tag-based quantitative proteomics and targeted hormone analysis reveal the response to insect herbivory stress in Ginseng (Panax ginseng, L.). by Haitao Li, Lixin Zhang, Xiang Han, Qi Zhang, Guangna Liu, Guofeng Zhang, Yurong Zhu, Hongyang Liu, Haowei Deng, Shuangli Liu, Guangsheng Xi

“…Ginseng has developed certain insect resistance properties during the course of evolutionary environmental adaptation. However, the mechanism underlying the insect resistance of ginseng is poorly understood. …”
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Structural insights into Type II-D Cas9 and its robust cleavage activity by Kangkang Wang, Jiuyu Wang, Xiaoqi Yang, Wei Sun, Gang Sheng, Yanli Wang

“…NsCas9d recognizes the 5′-NRG-3′ protospacer adjacent motif (PAM), with 5′-NGG-3′ showing the highest cleavage efficiency. …”
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Bulk viscous matter interacting with decaying vacuum energy density: a model for late-time evolution of the Universe by Tanmay Nandi, Amitava Choudhuri

“…The interaction term is defined as $$ Q=3H\alpha (\rho _m+\rho _\Lambda )$$ Q = 3 H α ( ρ m + ρ Λ ) , where $$\alpha $$ α , the interaction parameter. …”
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High-Quality Assembly of the Apple Fungal Pathogen <i>Marssonina coronaria</i> Genome and Functional Analysis of Candidate Effectors by Huiting Guo, Yicong Fu, Lichi Zhong, Qiang Cheng

“…Two signal peptide-dependent cell death-inducing effectors were identified: McNLP1, containing an NPP1 domain, and McCEP3. McCEP3 exhibited evolutionary conservation within Ascomycota, with its homologous gene <i>VmMcCEP3</i> from <i>Valsa mali</i> inducing cell death in <i>N. benthamiana</i>. …”
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Transcriptomics-driven exploration of genetic variation and peptide discovery in the sea anemones Anthopleura midori and Actinia equina by Han Zhang, Xinghua Pan, Chen Weigang

“…Abstract Exploring sea anemone polypeptides enables us to understand the evolutionary history and ecological adaptation strategies of species at the microscopic level. …”
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Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality. by Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu, Anatoliy I Yashin

“…Meta-analysis of the results from these comprehensive analyses shows that the minor allele increases risks of death by about 50% (p = 4.6×10-9), CHD by 35% (p = 8.9×10-6), HF by 55% (p = 9.7×10-5), stroke by 25% (p = 4.0×10-2), and ND by 100% (p = 1.3×10-3). This allele also significantly influences each of two diseases, diabetes and cancer, in antagonistic fashion in different populations. …”
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Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs. by Elizabeth Pollom, Kristen K Dang, E Lake Potter, Robert J Gorelick, Christina L Burch, Kevin M Weeks, Ronald Swanstrom

“…However, structures with known function represent only a fraction of the secondary structure reported for HIV-1(NL4-3). One tool to assess the importance of RNA structures is to examine their conservation over evolutionary time. …”
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