Molecular dynamics simulations reveal proton transfer pathways in cytochrome C-dependent nitric oxide reductase. by Andrei V Pisliakov, Tomoya Hino, Yoshitsugu Shiro, Yuji Sugita

“…That pathway is equivalent to the functional periplasmic cavity postulated in cbb(3) oxidase, which illustrates that the two enzymes share some elements of the proton transfer mechanisms and confirms a close evolutionary relation between NORs and C-type oxidases. …”
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Bioinformatic approach to identifying causative missense polymorphisms in animal genomes by Mykyta Peka, Viktor Balatsky

“…The study included an evaluation of the effect of polymorphisms on protein functions, considering the evolutionary and physicochemical characteristics of amino acids at polymorphic sites. …”
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Unveiling plasmid diversity and functionality in pristine groundwater by Olga María Pérez-Carrascal, Akbar Adjie Pratama, Matthew B. Sullivan, Kirsten Küsel

“…Conclusions Overall, our study emphasizes the diversity, composition, and eco-evolutionary role of plasmids in the groundwater microbiome. …”
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Enhanced RT-DETR with Dynamic Cropping and Legendre Polynomial Decomposition Rockfall Detection on the Moon and Mars by Panpan Zang, Jinxin He, Yongbin Yang, Yu Li, Hanya Zhang

“…Our coordinated optimization strategy integrates dynamic cropping optimization with architectural innovations: Kolmogorov–Arnold Network based C3 module (KANC3) replaces RepC3 through Legendre polynomial decomposition to strengthen feature representation, while our dynamic cropping strategy significantly improves small-target detection in low-contrast grayscale imagery by mitigating background and target imbalance. …”
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Genomic landscape of diffuse glioma revealed by whole genome sequencing by Ben Kinnersley, Josephine Jung, Alex J. Cornish, Daniel Chubb, Ross Laxton, Anna Frangou, Andreas J. Gruber, Amit Sud, Giulio Caravagna, Andrea Sottoriva, David C. Wedge, Thomas Booth, Safa Al-Sarraj, Samuel E. D. Lawrence, Erminia Albanese, Giulio Anichini, David Baxter, Alexandros Boukas, Yasir A. Chowdhury, Pietro D’Urso, Robert Corns, Andrew Dapaah, Ellie Edlmann, Fay Greenway, Paul Grundy, Ciaran S. Hill, Michael D. Jenkinson, Sandhya Trichinopoly Krishna, Stuart Smith, Susruta Manivannan, Andrew J. Martin, Samir Matloob, Soumya Mukherjee, Kevin O’Neill, Puneet Plaha, Jonathan Pollock, Stephen Price, Ola Rominiyi, Bobby Sachdev, Fozia Saeed, Saurabh Sinha, Lewis Thorne, Ismail Ughratdar, Peter Whitfield, Amir Saam Youshani, Helen Bulbeck, Prabhu Arumugam, Richard Houlston, Keyoumars Ashkan

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Orphan crops of archaeology‐based crop history research by Daniel Fuks, Frijda Schmidt, Maite I. García‐Collado, Margot Besseiche, Neal Payne, Giovanna Bosi, Charlène Bouchaud, Elisabetta Castiglioni, Vladimir Dabrowski, Suembikya Frumin, Dorian Q. Fuller, Roman Hovsepyan, Sureshkumar Muthukumaran, Leonor Peña-Chocarro, Guillem Pérez Jordá, Jérôme Ros, Mauro Rottoli, Philippa Ryan, Robert Spengler, Chris J. Stevens, Soultana Maria Valamoti, Ehud Weiss, Michelle Alexander, Muriel Gros-Balthazard

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Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution. by Robert W B Brown, Peter W Collingridge, Keith Gull, Daniel J Rigden, Michael L Ginger

“…Here, we characterize Trypanosoma brucei flagellar proteins resembling glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK): we show the latter associates with the axoneme and the former is a novel paraflagellar rod component. …”
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Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms. by Kaiyu Chen, Sikou Shen, Zhimeng Lv, Ming Guo, Yina Shao, Chenghua Li

“…All our results proved first evidence that lytic cell death was activated through MLKL cleavage, not MLKL phosphorylation in echinoderm, which offered insights into the functional, evolutionary mechanisms of lytic cell death in invertebrates.…”
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Evolving understanding of Guillain-Barré syndrome pathophysiology and the central role of the classical complement pathway in axonal injury by Kenneth C. Gorson

“…The clinical trial program of the C1q inhibitor ANX005, including placebo-controlled, double-blind phase 1b and phase 3 trials in GBS, provides insight into the pathophysiology of GBS and the efficacy of C1q inhibition regardless of neurophysiologic classification or geographic location.…”
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Restriction site-associated DNA sequencing (RAD-seq) of tea plant (Camellia sinensis) in Sichuan province, China, provides insights into free amino acid and polyphenol contents of... by Xiaoping Wang, Minshan Sun, Yuanyuan Xiong, Xiao Liu, Chunhua Li, Yun Wang, Xiaobo Tang

“…Evolutionary analysis revealed that genetic divergence was not closely linked to the collection location. …”
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Origin and evolution of HIV-1 subtype A6. by Syed Hani Abidi, Lazzat Aibekova, Salima Davlidova, Aidana Amangeldiyeva, Brian Foley, Syed Ali

“…The current study used phylogenetic/phylodynamic and signature mutation analyses to determine likely evolutionary relationship between subtype A6 and other subtype A sub-subtypes.…”
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The Effect of Job Stress on Diet Quality and Emotional Eating Among Hospital Employees by Aliye Ozenoglu, Cahit Erkul

“…As workload increases, the role of evolutionary survival mechanisms in decreasing KID-MED scores becomes evident, suggesting that higher levels and intensity of stress lead to a predominance of homeostatic eating. …”
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Vertical sonar beam width and scanning behavior of wild belugas (Delphinapterus leucas) in West Greenland. by Marie J Zahn, Kristin L Laidre, Peter Stilz, Marianne H Rasmussen, Jens C Koblitz

“…We report the first sonar beam estimate of in situ recordings of wild belugas with an average -3 dB asymmetrical vertical beam width of 5.4°, showing a wider ventral beam. …”
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Enhancing Resilience and Efficiency in Power System: A Five-Level Dynamic Planning Model by Mahnaz Rezaei, Mohammad Tolou Askari, Meysam Amirahmadi, Vahid Ghods

“…Also, the expected profit of the generation units increases by as much as 3.75%. Accordingly, the results show that the model is both feasible and effective.…”
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Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton. by Jinlei Han, Guanjing Hu, Yan Dai, Xin Zhang, Jingjing Tian, Jialiang Zhou, Xinqi Xu, Qi Chen, Xiaobing Kou, Lei Xu, Xinyu Wu, Ziying Sun, Jiahui Geng, Lin Li, Chenyu Qiu, Teame Gereziher Mehari, Baohua Wang, Hui Zhang, Xinlian Shen, Zhenzhen Xu, Jonathan F Wendel, Kai Wang

“…Hi-C analysis reveals a reorganized 3D chromatin architecture within the introgression line centromeres, including the formation of new topologically associating domains linked to H3K36me2 dynamics, emphasizing the importance of H3K36me2 in centromere organization. …”
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The Search for a Universal Influenza Vaccine: Possibilities and Limitations by E. P. Kharchenko

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Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator. by Danielle Ciren, Sophia Zebell, Zachary B Lippman

“…In contrast, Arabidopsis CLV3 function is tolerant to severe disruptions both upstream and downstream of the coding sequence. …”
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Living with ticks: Results of an online survey of the knowledge, attitudes and practices (KAP) regarding ticks and tick-borne pathogens in academic environments across Europe by Agustín Estrada-Peña, Sandra Antunes, Ana Domingos, Helen Esser, Gábor Földvári, Hans-Peter Fuehrer, Aysen Gargili, Mats van Gestel, Giulio Grandi, Maria Kazimirova, Dorota Kiewra, Tero Klemola, Lene Jung Kjær, Vivian Kjelland, Katarzyna Kubiak, Daniele de Meneghi, Andrei Daniel Mihalca, Sarah Moutailler, Aleksandar Potkonjak, Pavel Prokop, Käthe Robert, Renate Ranka, Angel Sainz, Jani Sormunen, Smaragda Sotiraki, Christina Strube, Snorre Stuen, Pavel Široký, Laura Tomassone, Annetta Zintl

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Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148 by Isabelle Bonnet, Mickael Orgeur, Florence Brossier, Fadel Sayes, Wafa Frigui, Jan Madacki, Hugo Varet, Aurélie Chauffour, Alexandra Aubry, Nicolas Veziris, Wladimir Sougakoff, Roland Brosch, Régis Tournebize

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Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle by Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Rinat I. Sultanov, Andrey V. Zhelankin, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, Takashi Kudo, Satoru Takahashi, Ryo Fujita

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