Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Integrative clustering analysis identifies three subgroups harboring different resistance mechanisms: ER driven, ER co-driven and ER independent. …”
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Genetic characteristics of coxsackievirus A16 associated with hand, foot, and mouth disease in Nanjing, China by Wei Yong, Mengkai Qiao, Limin Shi, Xuan Wang, Yan Wang, Xuefei Du, Min He, Jie Ding

“…Moreover, six reported conservative regions in VP1 protein were examined, and three of them exhibited high conservation in all CVA16 genotypes except the G-10 prototype and may serve for further vaccine research. …”
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Modelling the species-area relationship using extreme value theory by Luís Borda-de-Água, M. Manuela Neves, Luise Quoss, Stephen P. Hubbell, Filipe S. Dias, Henrique M. Pereira

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Adaptative Variation in a Neotropical Dung Beetle: Females and Gamma Males Present Tunneler Morphology, While Beta and Alpha Males Present Wing Morphology for Velocity by Pedro Henrique deOliveira Ribeiro, Nicholas Ferreira Camargo, Marina Regina Frizzas

“…ABSTRACT In evolutionary terms, plastic traits can covary, providing adaptive value by compensating for certain characteristic costs or enhancing fitness. …”
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Research progress and prospects of clean energy supply chains by WAN Min, YANG Dewei, MENG Haishan, CAI Jingjing, JI Yijia, ZHANG Shuai, ZHANG Yanfei, LONG Tao

“…In both cases, the evolution follows three stages: initiation, fluctuation, and rapid development. …”
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In silico genomic surveillance by CoVerage predicts and characterizes SARS-CoV-2 variants of interest by Katrina Norwood, Zhi-Luo Deng, Susanne Reimering, Gary Robertson, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Martin Hölzer, Frank Klawonn, Alice C. McHardy

“…In a comprehensive assessment of VOIs, VUMs, and VOCs, we demonstrate how CoVerage can be used to swiftly identify and characterize such variants, with a lead time of almost three months relative to their WHO designation. CoVerage can facilitate the timely identification and assessment of future SARS-CoV-2 variants relevant for public health.…”
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Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient by Anna Lucia Spear King, Alexandre Martins Valença, Adriana Cardoso de Oliveira e Silva, Ana Claudia Cerqueira, Lígia Maria Chaves Ferraz, Antonio Egidio Nardi

“…Unprecedented battery of computerized tests, CNSVS (Central Nervous System Vital Signs), was applied at three different moments in 2008, 2009, and 2010. …”
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Analysis of energy storage battery degradation under different electrical stress levels by Yuanyuan Xie, Caihong Li, Tingting Wu, Run Tang, Yanxin Hu, Yishun Zhu, Huihe Qiu, Rui Zhang

“…The results indicate that aging cycle tests conducted using three discharge modes—1C, 3C, and over-discharge—show capacity retention rates with linear, sub-linear, and super-linear evolutionary trajectories, respectively. …”
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Mapping Australian Culture and Society in the Animated Series Bluey—The Use of Audiovisual Material in Early EFL Learning by Amaya Arigita-García, Lidia Mañoso-Pacheco, José Luis Estrada-Chichón, Roberto Sánchez-Cabrero

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Unusual Genetic Diversity Within <i>Thereuopoda clunifera</i> (Wood, 1862) (Chilopoda: Scutigeromorpha) Revealed by Phylogeny and Divergence Times Using Mitochondrial Genomes by Jie-Hong Ji, Hui-Yuan Wu, Yi-Xin Gao, Chen-Yang Shen, Zi-Wen Yang, Kenneth B. Storey, Dan-Na Yu, Jia-Yong Zhang

“…As one of the four primary evolutionary groups within myriapods, centipedes (Chilopoda) comprise approximately 3150 valid species. …”
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Comparing Grid Model Fitting Methodologies for Low-temperature Atmospheres: Markov Chain Monte Carlo versus Random Forest Retrieval by Anna Lueber, Adam J. Burgasser

“…Here, we compare two grid model fitting approaches: a Markov Chain Monte Carlo (MCMC) algorithm interpolating across spectral fluxes, and a random forest retrieval (RFR) algorithm trained on a grid model set. We test these with three low-temperature model grids—Sonora Diamondback, Sonora Elf Owl, and Spectral ANalog of Dwarfs (SAND)—and a sample of 11 L and T dwarf companions to FGKM stars with known distances, compositions, and ages. …”
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Neighbours vs. strangers discrimination in Water Rail (Rallus aquaticus) by Alexandru Nicolae STERMIN, Alin DAVID, Cătălina DRAGOI, Mirela CÎMPEAN, Karina Paula BATTES

“…In each point the acoustic reactions to spontaneous and playback of territorial Water Rail’s call were counted for three days (18, 19 and 20 April 2011), between 6:00 – 8:00 p.m.. …”
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Characteristics and Deformation Mechanisms of Neogene Red-Bed Soft Rock Tunnel Surrounding Rock: Insights from Field Monitoring and Experimental Analysis by Jin Wu, Geng Cheng, Zhiyi Jin, Zhize Han, Feng Peng, Jiaxin Jia

“…The findings reveal that the surrounding rock deformation follows a three-stage evolutionary pattern of “rapid, slow, and stable”. …”
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Multi-omics and single-cell approaches reveal molecular subtypes and key cell interactions in hepatocellular carcinoma by Xueqing Zou, Xueqing Zou, Yongmei Wang, Mingyuan Luan, Yizheng Zhang

“…IntroductionHepatocellular carcinoma is a highly aggressive and heterogeneous malignancy with limited understanding of its heterogeneity.MethodsIn this study, we applied ten multi-omics classification algorithms to identify three distinct molecular subtypes of HCC (C1–C3). …”
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Visualization Analysis of Research on Inefficient Stock Space by Mapping Knowledge Domains by Wangyang Gui, Xu Li, Bin Xu

“…In relation to policy frameworks and evolutionary trends, the study of inefficient stock space in urban and rural contexts has evolved through three distinct phases, the embryonic stage (2004–2013), the exploration stage (2013–2020), and the growth stage (2020–present). …”
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Drought Modulates Root–Microbe Interactions and Functional Gene Expression in Plateau Wetland Herbaceous Plants by Yuanyuan Chen, Shishi Feng, Qianmin Liu, Di Kang, Shuzhen Zou

“…In this context, nine typical wetlands with three different moisture statuses were selected from the eastern Tibetan Plateau in this study to analyze the relationships among herbaceous plant root traits and microbial communities and functions. …”
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Complete Mitochondrial Genome Analysis Reveals Genetic Diversity in the Narrow–Ridged Finless Porpoise (Neophocaena asiaeorientalis) Across East Asian Waters by Sunmin Kim, Youngran Lee, Dong‐Yeop Lee, Heesu Lee, Seon‐Mi Lee, Nari Kim, Seongjun Choe, Dong‐Hun Lee

“…Phylogenetic analyses based on maximum likelihood and Bayesian inference revealed three major, well‐supported monophyletic clades within the species. …”
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Building and Visualising Ordinations of Shape Data in R With Morphospace by Pablo S. Milla Carmona, Oscar E. R. Lehmann, William J. Deakin, Eduardo M. Soto, Ignacio M. Soto

“…Then, we showcase its applications by working three examples focused on phenomena commonly targeted in palaeontological and evolutionary research. …”
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The Effectiveness of Husbands\' ‌Awareness of Menopausal Complications on Physical Psychological Experiences of Postmenopausal Women by Sedigheh Shariat Moghani, Mahdieh Ebrahimzadeh, Ali Safari, Jamshid Jamali

“…The husbands of the intervention group received ‎three ‏sessions ‎(60 ‏minutes) ‏of the menopause training program with one-week intervals.  ‏…”
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A novel comprehensive system for analyzing and evaluating storm surge disaster chains based on complex networks by Hongbo Guo, Chong Huang, Chong Huang, Caixia Zhang, Qinglong Shao

“…The system consists of three modules: evaluation, prediction, and measurement. …”
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