The effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases: objectives and design of a randomized controlled trial by Aylin Akça Sümengen, Abdul Veli İsmailoğlu, Pelin İsmailoğlu, Terman Gümüş, Alpay Çeliker, Deniz Namlısesli, Ezgi Poyraz, Damla Özçevik Subaşı, Ceren Zeren Erdem, Gökçe Naz Çakır

“…The experimental group’s heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. …”
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Optimized Whole-Slide-Image H&E Stain Normalization: A Step Towards Big Data Integration in Digital Pathology by Jose L. Agraz, Carlos Agraz, Andrew A. Chen, Charles Rice, Robert S. Pozos, Sven Aelterman, Amanda Tan, Angela N. Viaene, MacLean P. Nasrallah, Parth Sharma, Caleb M. Grenko, Tahsin Kurc, Joel Saltz, Michael D. Feldman, Hamed Akbari, Russell T. Shinohara, Spyridon Bakas, Parker Wilson

“…The approach is validated through a tripartite methodology: 1) Stain vector euclidean distances analysis, 2) Distance computation timing, and 3) Qualitative and quantitative assessments of SCN across cancer tumors regions of interest. …”
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Identification of key factors for malnutrition diagnosis in chronic gastrointestinal diseases using machine learning underscores the importance of GLIM criteria as well as addition... by Karen Rischmüller, Vanessa Caton, Markus Wolfien, Markus Wolfien, Markus Wolfien, Luise Ehlers, Matti van Welzen, David Brauer, Lea F. Sautter, Fatuma Meyer, Luzia Valentini, Mats L. Wiese, Ali A. Aghdassi, Robert Jaster, Olaf Wolkenhauer, Olaf Wolkenhauer, Georg Lamprecht, Saptarshi Bej, Saptarshi Bej

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NeSyDPP-4: discovering DPP-4 inhibitors for diabetes treatment with a neuro-symbolic AI approach by Delower Hossain, Delower Hossain, Ehsan Saghapour, Ehsan Saghapour, Jake Y. Chen, Jake Y. Chen, Jake Y. Chen

“…These challenges highlight the urgent need for efficient in-silico approaches to facilitate the discovery and optimization of safer and more effective DPP-4 inhibitors.MethodologyQuantitative Structure-Activity Relationship (QSAR) modeling is a widely used computational approach for evaluating the properties of chemical substances. …”
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Classifying Dry Eye Disease Patients from Healthy Controls Using Machine Learning and Metabolomics Data by Sajad Amouei Sheshkal, Morten Gundersen, Michael Alexander Riegler, Øygunn Aass Utheim, Kjell Gunnar Gundersen, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Hugo Lewi Hammer

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Dissimilar joining of aluminum alloy and low-alloy carbon steel by resistance spot welding by Yong Xu, Qianwei Chen, Bingxu Wang, Feng Qiu, Baixin Dong, Hongjun Li, Zude Feng, Gary C. Barber

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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

“…Combined PET and MRI improve the evaluation of tumor activity, extent, type/grade prediction, and therapy-induced changes in patients with glioma and serve information highly relevant for diagnosis and management.…”
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New Perspectives in the Etiology of Chronic Rhinosinusitis—Haller Cells by Alin Horatiu Nedelcu, Razvan Tudor Tepordei, Ancuta Lupu, Vasile Valeriu Lupu, Marius Constantin Moraru, Simona Alice Partene Vicoleanu, Gabriel Statescu, Cosmin Gabriel Popa, Manuela Ursaru, Cristina Claudia Tarniceriu

“…<i>Materials and Methods</i>: We conducted a randomised retrospective study that included 255 consecutive multi-detector computed tomography (MDCT) scans of the head. To carry out a comparative evaluation of the association of Haller cells with chronic rhinosinusitis, we divided the patients into two subgroups, a seasonal-based sample, between November 2022 and January 2023, and June 2023 and August 2023, respectively. …”
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A perspective on the current state of smartphone-based mobile applications for scar assessment by Peter Moortgat, Jill Meirte, Mieke Anthonissen, Koen Maertens, Thibau Demarbaix, Ulrike Van Daele

“…Traditionally, these assessments required specialized, bulky equipment that needed a wired connection to computers, making these assessment tools less accessible and efficient. …”
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Dilatation of the main pulmonary artery in patients with isolated pulmonary stenosis: Arteriopathy or hemodynamic consequence? by Pietro Paolo Tamborrino, Michela Miglianti, Dario Freitas, Camelia Demetrescu, Christopher Rush, Claudia Montanaro, Alessandra Frigiola

“…Echocardiography, cardiovascular magnetic resonance (CMR), and computed tomography (CT) were reviewed. MPA dilatation was defined as ≥2 Z-Score in children and ≥30 mm diameters in adults, while giant (aneurysmal) mPA dilatation was defined as ≥4 Z-Score in children and ≥40 mm in adults. …”
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Narrative review on applications of artificial intelligence in vascular trauma by Zachary Tran, MD, Michael C. Wilkinson, MD, Glenn Guardamondo, MD, Mohamed H. El-Farra, MD, MS, Allan B. Peetz, MD, Roger T. Tomihama, MD, MBA, Sharon C. Kiang, MD

“…Methods: A narrative review of full text articles evaluating AI-based interventions in vascular trauma from inception to 2025 was performed. …”
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A comparison of granule-based material extrusion and fused filament fabrication in the performances of TPS/PBS blend by Ke Gong, Yinshi Lu, Handai Liu, Alexandre Portela, Tielidy de Lima, Han Xu, Maurice N. Collins, Yuanyuan Chen

“…This study explores the characteristics and applicability of a self-fabricated, bio-based thermoplastic starch (TPS)–polybutylene succinate (PBS) filament in FFF processing. A comparative evaluation was conducted between the filament and its corresponding preformed pellets, assessing properties such as density, melt flow index (MFI), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and rheological behavior. …”
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Chemoreactome screening of aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid cytotoxic effects on tumor cells with experimental confirmation on BT-474 and A549 cell by I. Yu. Torshin, M. V. Filimonova, O. A. Gromova, L. A. Maiorova, M. A. Sorokina, D. E. Frolova, A. N. Gromov, I. A. Reyer

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Patient-Specific Hyperparameter Optimization of a Deep Learning-Based Tumor Autocontouring Algorithm on 2D Liver, Prostate, and Lung Cine MR Images: A Pilot Study by Gawon Han, Keith Wachowicz, Nawaid Usmani, Don Yee, Jordan Wong, Arun Elangovan, Jihyun Yun, B. Gino Fallone

“…Six hyperparameters were optimized for each patient, for which intrafractional images and experts’ manual contours were input into the algorithm to find the optimal set of hyperparameters. For evaluation, Dice’s coefficient (DC), centroid displacement (CD), and Hausdorff distance (HD) were computed between the manual contours and autocontours. …”
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Comparison of predicted postoperative forced expiratory volume in the first second (FEV1) using lung perfusion scintigraphy with observed forced expiratory volume in the first seco... by Boon Mathew, Sudipta Nag, Archi Agrawal, Priya Ranganathan, Nilendu Purandare, Sneha Shah, Ameya Puranik, Venkatesh Rangarajan

“…Lung perfusion scintigraphy is done as a part of preoperative evaluation in lung cancer patients for the prediction of postoperative forced expiratory volume in the first second (FEV1). …”
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Global, regional, and national trends in depressive disorder prevalence and DALYs among women of childbearing age from 1990 to 2021 and projections to 2040: a comprehensive analysi... by Yuhang Yang, Yuyuan Hu, Yuan He, Wei Zhang, Jinghan Jia, Yibo Xu, Yan Li, Jinxi Wang

“…Furthermore, the average annual percentage change (AAPC) was computed to be 0.4789 (95% CI: 0.3289–0.6295; P &lt; 0.001) for prevalence and 0.524 (95% CI: 0.3756–0.6725; P &lt; 0.001) for DALYs. …”
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Transumbilical single-site laparoscopic resection of splenic papillary angioendothelioma in a pediatric patient: a rare case report and review of literature by Meng Kong, Meng Kong, Qingfei Zhai, Shisong Zhang, Shisong Zhang, Hongzhen Liu, Hongzhen Liu, Yuexia Bai, Shuai Chen, Shuai Chen, Jinhua Jia, Jinhua Jia, Dong Wang, Xiang Ma

“…Following multidisciplinary evaluation, a transumbilical single-port laparoscopic exploration was performed. …”
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Rethinking femoral neck anteversion assessment: a novel automated 3D CT method compared to traditional manual techniques by Honghu Xiao, Sutuke Yibulayimu, Chunpeng Zhao, Yudi Sang, Yimin Chen, Yufeng Ge, Qingnan Sun, Yang Ming, Mingjian Bei, Gang Zhu, Yingchun Song, Yu Wang, Xinbao Wu

“…These results indicate its potential utility for preoperative planning, postoperative evaluation, and computer-assisted orthopedic procedures. …”
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Simultaneous occurrence of cutaneous melanocytic neoplasia in Duroc and German Saddleback pigs from three smallholder farms by Thies J. Nicolaisen, Melanie Stoff, Manon Mikic, Anna Lena Maschmeier, Johannes Buchallik-Schregel, Alexandra von Altrock, Maybrit Wirtz, Saskia Neubert, Andreas Beineke, Doris Höltig, Isabel Hennig-Pauka, Martin Ganter

“…These cases underwent thorough diagnostic evaluation employing a spectrum of modalities including clinical examination, hematological analysis, pathohistological examination, X-ray imaging, broncho-alveolar lavage, computed tomography, and autopsy. …”
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A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis by Mitsuhiro Shimura, Masamichi Mizuma, Hiroki Hayashi, Akiko Mori, Tomoyoshi Tachibana, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Kyohei Ariake, Shimpei Maeda, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Takeshi Naitoh, Takashi Kamei, Fuyuhiko Motoi, Michiaki Unno

“…CT scan showed tumor shrinkage (21 mm), determined as stable disease (SD) according to Response Evaluation Criteria in Solid Tumors (RECIST). Although the abdomen was opened for radical resection, a small nodule on the liver was detected and removed. …”
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