Repeatability and prognostic value of radiomic features: a study in esophageal cancer and nasopharyngeal carcinoma by Jie Gong, Fan Meng, Changhao Liu, Jianchao Lu, Jie Li, Zhi Yang, Hongfei Sun, Xinzhi Teng, Jiang Zhang, Jing Cai, Mei Shi, Lina Zhao

“…Materials and methods This retrospective study included 234 esophageal cancer (EC) patients (contrast-enhanced computed tomography (CECT) and fluorine-18 fluorodeoxyglucose positron emission tomography (PET)), and 525 nasopharyngeal carcinoma (NPC) patients (CECT). …”
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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice by Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen, Tingting Lin

“…Genetic mutations were identified by whole-exome sequencing. Computer-aided sperm analysis, Papanicolaou staining, and electron microscopy were applied to evaluate the motility, morphology, and ultrastructure of spermatozoa, respectively. …”
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Mandibular reconstruction outcomes for in-house patient-specific solutions by Matthew D. Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E. Reid, Amit Agarwal, Enver K. Ozer, Ricardo L. Carrau, James W. Rocco, Catherine T. Haring, Stephen Y. Kang, Nolan B. Seim, Matthew O. Old, Kyle K. VanKoevering

“…Since little has been published on the accuracy and outcomes of this approach, this study sought to evaluate the reconstructive accuracy and clinical outcomes of patients who received in-house patient-specific mandible models. …”
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Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose... by Tilal Elsaman, Magdi Awadalla Mohamed, Abozer Y. Elderdery, Abdullah Alsrhani, Badr Alzahrani, Heba Bassiony Ghanem, Jeremy Mills, Musaed Rayzah, Nasser A. N. Alzerwi, Afnan Al-sultan, Bandar Idrees, Fares Rayzah

“…Nonetheless, there remains a critical need for the development of novel KHK-C inhibitors that offer improved pharmacokinetics, enhanced efficacy, and superior safety profiles.MethodsIn the present study, a comprehensive computational strategy was employed to screen 460,000 compounds from the National Cancer Institute library for potential KHK-C inhibitors. …”
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BioBone – A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed... by Simon Reinke, Anja Maria Bauer, Michael Dahne, Georg Duda, Denis Gümbel, Christian Kleber, Georg Matziolis, Sven Märdian, Georg Osterhoff, Carsten Perka, Michael J. Raschke, Sebastian Rohe, Klaus-Dieter Schaser, Philipp Schwabe, Frederik Maximilian Schäfer, Richard Stange, Maik Stiehler, Ulrich Stöckle, Hans-Dieter Volk, Stefan Weber, Sven Geißler, the BioBone Author Consortium

“…Fracture consolidation will be assessed through radiographs or computed tomography (CT) scans in conjunction with clinical assessments such as range of motion and weight-bearing capacity. …”
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Level of non-adherence and associated factors among children on antiretroviral therapy in public hospitals of South Wollo Zone, Northeast Ethiopia by Endalk Birrie Wondifraw, Fekadeselassie Belege Getaneh, Muluken Amare, Setegn Mihret, Gebeyaw Biset, Birhanu Desu Tefera, Mulusew Zeleke, Fuad Ahmed, Ermias Sisay Chanie

“…Binary logistic regression was employed to evaluate the relationship between the factors and the outcome variable. …”
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A deep learning approach versus expert clinician panel in the classification of posterior circulation infarction by Leon S. Edwards, Milanka Visser, Cecilia Cappelen-Smith, Dennis Cordato, Andrew Bivard, Leonid Churilov, Christopher Blair, James Thomas, Angela Dos Santos, Longting Lin, Chushuang Chen, Carlos Garcia-Esperon, Kenneth Butcher, Tim Kleinig, Phillip MC Choi, Xin Cheng, Qiang Dong, Richard I. Aviv, Mark W. Parsons

“…Studies suggest expert inspection of Computed Tomography Perfusion (CTP) improves diagnosis of POCI. …”
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Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach by Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris

“…These mutations may disrupt EPCR stability and impair its anticoagulant function, thereby increasing the risk of thrombosis.MethodsWe employed a multi-layered computational approach to analyze 217 nsSNPs in the PROCR gene. …”
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Awake prone positioning effectiveness in moderate to severe COVID-19 a randomized controlled trial. [version 1; peer review: 2 approved, 1 approved with reservations] by Nguyen Thanh Phong, Nguyen Thanh Truong, Du Hong Duc, C Louise Thwaites, Nguyen Thanh Dung, Nguyen Thi My Linh, Lam Minh Yen, Nguyen Le Nhu Tung, Luu Hoai Bao Tran, Ho Bich Hai, Le Thuy Thuy Khanh, Nguyen Thi Diem Trinh, James Anibal, Dang Phuong Thao, Pham Tieu Kieu, Nguyen Thi Phuong Dung, Nguyen Thanh Ngoc, Vo Tan Hoang, Tran Thi Dong Vien, Ronald Geskus, Nguyen Thanh Nguyen, Vo Trieu Ly, Tran Dang Khoa, Cao Thi Cam Van, Le Dinh Van Khoa, Abigail Beane, Guy Glover, David Clifton, Evelyne Kestelyn, Guy E Thwaites, Le Van Tan

“…Patients were allocated by a computer-generated random number sequence in a 1:1 ratio to standard care or APP, where a dedicated team provided bedside support. …”
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Impact of Live <i>Ligilactobacillus salivarius</i> CCFM1332 and Its Postbiotics on <i>Porphyromonas gingivalis</i> Colonization, Alveolar Bone Resorption and Inflammation in a Rat... by Qing Hong, Yu Ren, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui, Zhenmin Liu

“…Emerging evidence suggests that probiotics may mitigate periodontal pathology. To systematically evaluate the alleviative effects and mechanisms of different forms of probiotics, including live bacteria and postbiotics, on periodontitis, we first screened and identified <i>Ligilactobacillus salivarius</i> CCFM1332 (<i>L. salivarius</i> CCFM1332) through in vitro antibacterial and anti-biofilm activity assays. …”
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Multicentre randomised trial of screening with sFlt1/PlGF and planned delivery to prevent pre-eclampsia at term: protocol of the PE37 study by M Timmermans, Josefina Mora, Francesc Figueras, I Casas, H Castillo, Eduard Gratacos, Ladislav Krofta, Francesca Crovetto, Fatima Crispi, Carmina Comas, Alicia Martínez-Varea, Anna Kajdy, Elisa Llurba, Lina Youssef, Juan Luis Delgado, Isabel Puig, Katerina Mackova, Albert Tubau, Aina Ruiz, Antoni Paya, Maria Prat, Frederic Chantraine, Maria Fernanda Lopez-Tinajero, RJ Campos, V Parriego, D Sys, J Modzelewski

“…The efficacy variables will be analysed and compared between groups primarily following an intention-to-treat approach, by ORs and their 95% CI. This value will be computed using a Generalised Linear Mixed Model for binary response (study group as fixed effect and the centre as intercept random effect).Ethics and dissemination The study is conducted under the principles of Good Clinical Practice. …”
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Quantitative CT Analysis of Lung Features in Patients with Polymyositis/Dermatomyositis without Interstitial Lung Disease by He HEI, Kai YANG, Liyu HE, Yadan SHENG, Yaqi YAN, Bingjie ZHU, Yuting ZHANG, Jiayin TONG, Jingping ZHANG, Chenwang JIN

“…Objective: This study aims to analyze the lung differences between patients with interstitial lung disease (ILD) and non-interstitial (Non-ILD) diseases related to polymyositis/dermatomyositis (PM/DM) and healthy controls through quantitative computed tomography (CT) parameters. The objective is to establish a theoretical basis for early diagnosis and timely treatment of the disease. …”
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Psychosocial and clinical characteristics in Takotsubo syndrome by Okezi Obrutu, Yujie Cui, Jenna Maughan, Paul Marano, Janet Wei, Martha Gulati, Marie Lauzon, Romana Herscovici, Chrisandra Shufelt, Natalie Rojas, Benita Tjoe, Thomas Rutledge, C. Noel Bairey Merz

“…Hedge’s g effect sizes were computed to compare differences in perceived stress, depression symptoms, and post-traumatic stress disorder (PTSD) symptoms relative to TTS status. …”
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Utility of quantitative measurement of T 2 using restriction spectrum imaging for detection of clinically significant prostate cancer by Mariluz Rojo Domingo, Christopher C. Conlin, Roshan Karunamuni, Courtney Ollison, Madison T. Baxter, Karoline Kallis, Deondre D. Do, Yuze Song, Joshua Kuperman, Ahmed S. Shabaik, Michael E. Hahn, Paul M. Murphy, Rebecca Rakow-Penner, Anders M. Dale, Tyler M. Seibert

“…Data includes two cohorts scanned for csPCa with 3T multi-b-value diffusion-weighted sequences acquired at multiple TEs. cT 2 values were computed from multi-TE RSI data and compared by compartment. …”
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Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology by Luce Perie, Selina Stippa, Christoph Saffer, Christoph Saffer, Andrea Hartmann, Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, Peter F. Zipfel, Peter F. Zipfel

“…Therefore, we compared FHR1 isoforms with sequence-variations in SCR3, and pathogenic mutants with sequence variations in SCR5.MethodsFHR1 binding to apoptotic cells was evaluated EM and fluorescent microscopy and in kidney biopsies. …”
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Malignant perivascular epithelioid cell neoplasm in the liver: report of a pediatric case by Tokuro Baba, Takafumi Kawano, Yusuke Saito, Shun Onishi, Koji Yamada, Waka Yamada, Ryuta Masuya, Kazuhiko Nakame, Yota Kawasaki, Satoshi Iino, Masahiko Sakoda, Mari Kirishima, Tatsuru Kaji, Akihide Tanimoto, Shoji Natsugoe, Takao Ohtsuka, Hiroshi Moritake, Satoshi Ieiri

“…Abdominal ultrasonography was performed to evaluate the fever’s origin, revealing a large tumor in the liver. …”
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Hemorrhage Expansion Rates Before and After Minimally Invasive Surgery for Intracerebral Hemorrhage: Post Hoc Analysis of MISTIE II/III by Wendy C. Ziai, Shervin Badihian, Natalie Ullman, Carol B. Thompson, Meghan Hildreth, Pirouz Piran, Nataly Montano, Paul Vespa, Neil Martin, Mario Zuccarello, Steven W. Mayo, Issam Awad, Daniel F. Hanley

“…We investigated intracranial hemorrhage expansion (HE) in the pre‐ and postrandomization phase of 2 clinical trials of surgical candidates with protocolized computed tomography (CT) imaging up to 10 days after presentation. …”
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Role of positron emission tomography in predicting early tumor response to neoadjuvant chemotherapy for breast cancer by N. G. Chanchikova, E. A. Karlova, A. S. Savelyeva, O. A. Silkina, V. I. Chernov, R. V. Zelchan, O. D. Bragina, A. A. Medvedeva

“…The aim of this study was to evaluate the possibility of using PET/CT with 18F-FDG to determine the early tumor response to NACT.Materials and methods. …”
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Assessing the global burden of interstitial lung disease and pulmonary sarcoidosis using multiple statistical models: analysis and future projections by Luna Zhao, Yue Zhou, Yun Jia, Lang Wang, Ye Liu, Guizhen Lv, Yihao Zhang, Jinyang Li, Junfeng Ren, Hongzheng Liu, Yufeng Zhang, Ning Wang, Wenwen Zhang, Wenqiang Mo, Jiaqi Liu, Yilin Wang, Junhao Ma, Chao Wu, Dong Liu, GBD Collaborator

“…Temporal trends were evaluated using average annual percentage change (AAPC), age-period-cohort (APC), and Bayesian APC (BAPC) models. …”
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Characterizing extravascular lung water—A dual-contrast agent extracellular volume approach by cardiovascular magnetic resonance by Felicia Seemann, Rim N. Halaby, Andrea Jaimes, Kendall O’Brien, Peter Kellman, Daniel A. Herzka, Robert J. Lederman, Adrienne E. Campbell-Washburn

“…Therefore, we develop and evaluate a novel method to measure extravascular lung water by distinguishing intravascular from extracellular fluid compartments using two different contrast agents, extracellular gadolinium chelates and iron-based intravascular ferumoxytol. …”
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