Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…This study employs various computational tools to investigate the molecular effects of disease-vulnerable germ-line missense and non-coding SNPs of the CXCR4 gene. …”
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Identification of natural compounds as potential inhibitors of Interleukin-23: virtual screening, ADMET, drug-likeness, and dynamic simulation by Davood Gheidari, Morteza Mehrdad, Mahan Etedali

“…The top 50 ligands were subsequently re-evaluated using standard precision (SP), and for enhanced accuracy, the top 19 from the SP protocol were further screened using the extra precision (XP) protocol.Results and Discussion The computational screening revealed that the docking energy values for the nineteen ligands binding to the target enzyme ranged from -3.669 to -7.143 kcal/mol. …”
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Observational study of sudden cardiac arrest risk (OSCAR): Rationale and design of an electronic health records cohort by Kyndaron Reinier, Harpriya S. Chugh, Audrey Uy-Evanado, Elizabeth Heckard, Marco Mathias, Nichole Bosson, Vinicius F. Calsavara, Piotr J. Slomka, David A. Elashoff, Alex A.T. Bui, Sumeet S Chugh

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A systematic review of data privacy in Mobility as a Service (MaaS) by Zineb Garroussi, Antoine Legrain, Sébastien Gambs, Vincent Gautrais, Brunilde Sansò

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Limbic system abnormalities in episodic cluster headache: a 7T MRI multimodal study by Xinyu Wang, Luhua Zhang, Yongqin Xiong, Mengmeng Hou, Shuhua Zhang, Caohui Duan, Song Wang, Xiaoyu Wang, Haoxuan Lu, Jiayu Huang, Yan Li, Zhixuan Li, Zhao Dong, Xin Lou

“…Automated volumetry and resting-state functional MRI analyses were performed after adjusting for age, Generalized Anxiety Disorder scale, sex (and intracranial volume when evaluating volumetric measures). Then functional-structural coupling indices were computed to assess network-level relationships. …”
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Serum carbohydrate antigen 153 as a predictor of interstitial lung disease associated with rheumatoid arthritis is positively correlated with serum Krebs von den Lungen-6 by Jiaxi Guo, Heqing Huang, Shaowei Lin, Guangdong Wang, Fengbei Cen, Shenhui Huang, Dehao Liu, Yikai Lin, Xinhua Yu, Sien Shi, Aiping Ma

“…Abstract Objective The objective of this study was to evaluate the clinical significance of carbohydrate antigen (CA) 153 and its correlation with Krebs von den Lungen-6 (KL-6) in the prediction and determination of the severity of interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. …”
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Multipool-CEST and CEST-based pH assessment as predictive tools for glioma grading, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation in gliomas by Xinli Zhang, Jue Lu, Xiaoming Liu, Peng Sun, Qian Qin, Zhengdong Xiang, Lan Cheng, Xiaoxiao Zhang, Xiaotong Guo, Jing Wang

“…Histogram features of these metrics were computed to characterize tumor heterogeneity. These features were subsequently employed for glioma grading and molecular genotyping of IDH, 1p/19q and MGMT. …”
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A follow-up study on the novel use of contrast-enhanced susceptibility-weighted imaging for extremity desmoid fibromatosis response assessment by Raul F. Valenzuela, Elvis Duran-Sierra, Mathew Antony, Behrang Amini, Sam Lo, Keila. E. Torres, Ken-Pin Hwang, Jingfei Ma, R. Jasson Stafford, Ravin Ratan, John E. Madewell, Dejka Araujo, William A. Murphy, Colleen M. Costelloe

“…Measurements of maximum diameter, volume, and the modified Choi (m-Choi: tumor/muscle T2 ratio) were computed based on CE-SWI and T2-STIR volumetric tumor segmentations. 107 shape, first-order, and textural radiomic features were calculated. …”
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Randomised phase II trial of CAPTEM or FOLFIRI as SEcond-line therapy in NEuroendocrine CArcinomas and exploratory analysis of predictive role of PET/CT imaging and biological mark... by Ivan Lolli, Daniele Santini, Rossana Berardi, Giuseppe Badalamenti, Toni Ibrahim, Alfredo Berruti, Alberto Bongiovanni, Chiara Liverani, Sara Pusceddu, Silvana Leo, Giovanni Di Meglio, Stefano Tamberi, Fabio Gelsomino, Francesca Pucci, Francesca Bergamo, Sergio Ricci, Flavia Foca, Stefano Severi, Mauro Cives, Davide Campana, Nicola Silvestris, Angela Buonadonna, Maria Pia Brizzi, Francesca Spada, Sara Cingarlini, Lorenzo Antonuzzo, Davide Pastorelli

“…Secondary aims are to correlate the serum miRNA profile and primary mutational status of MEN1, DAXX, ATRX and RB-1 with prognosis and outcome and to investigate the prognostic and predictive role of the Ki-67 score and 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) or 68Ga-PET/CT. …”
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Investigating the spatial limits of somatotopic and depth-dependent sensory discrimination stimuli in rats via intracortical microstimulation by Thomas J. Smith, Hari Srinivasan, Madison Jiang, Ghazaal Tahmasebi, Sophia Vargas, Luisa R. Villafranca, Shreya Tirumala Kumara, Ashlynn Ogundipe, Ajaree Massaquoi, Shreya Chandna, Yovia Mehretab, Riya Shipurkar, Pegah Haghighi, Stuart F. Cogan, Ana G. Hernandez-Reynoso, Joseph J. Pancrazio

“…Next, we utilized a nose-poking, two-choice sensory discrimination task to evaluate each rat’s ability to accurately differentiate between these patterns. …”
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Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control compared with albendazole and no treatment: An open-l... by Yvonne Kamau, Mercy Tuwei, Caroline Wanjiku, Kelly Ominde, Mwanajuma Ngama, Jonathan Karisa, Lawrence Babu, Martha Muturi, Mwaganyuma Mwatasa, Jane Adetifa, Charlotte Kern, Urs Duthaler, Felix Hammann, Regina Rabinovich, Carlos Chaccour, Marta Ferreira Maia

“…Participants were randomly assigned (2:1:1:1) using computer random-sequence generation, unstratified, with one block of six pharmacokinetics-only participants (single-dose ivermectin) and six blocks of four participants (3:1 intervention vs control), to receive single-dose ivermectin (400 mcg/kg, n = 12), three daily doses (3-day regimen 300 mcg/kg, n = 6), albendazole (400 mg, n = 6), or no treatment (negative control, n = 6). …”
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Embedding electronic patient-reported outcome measures into routine care for patients with stage III MELanoma (ePROMs-MEL): protocol for a prospective, longitudinal, mixed-methods... by Serigne Lo, Andrew Spillane, Donna Milne, Robyn Saw, Mbathio Dieng, Iris Bartula, Rachael Morton, Frances Boyle, Julia Lai-Kwon, Kathy Dempsey, Craig Lawn, Thomas Pennington, Skye Dong, Linda Seaman, Dina Saks, Jake Robert Thompson

“…All participants will complete the Distress Thermometer and EQ-5D-5L questionnaires in the clinic using a tablet computer at baseline and two to three subsequent follow-up appointments. …”
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Effects of work cessation on cognitive functioning in rural older adults in China: a cross-sectional study based on CHARLS by Xiao-hui Liu, Liang Zhu, Xiao-Yu Li, Wenwen Cheng, Ning-li Zhu, Jia-Xue Li, Sun Jing-Jing, Si-Yu Zhang, Dong-Guang Wang

“…Regression analysis assessed the impact of work cessation on cognitive function and the moderating effects of social activities, health behaviours and internet use.Setting Data were collected from 150 districts, 450 villages, and urban community units in China.Participants The study included 6,318 participants, with 4,045 currently employed and 2,273 no longer working.Main outcome measures Cognitive function was evaluated using measures of mathematical computation, temporal and image cognition, and situational memory was tested through 20 memory-related questions. …”
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Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects by Theresa Urban, Florian T. Gassert, Manuela Frank, Rafael Schick, Henriette Bast, Jannis Bodden, Alexander W. Marka, Lisa Steinhelfer, Manuel Steinhardt, Andreas Sauter, Alexander Fingerle, Gregor S. Zimmermann, Thomas Koehler, Marcus R. Makowski, Daniela Pfeiffer, Franz Pfeiffer

“…Abstract Background Dark-field chest radiography is sensitive to the lung alveolar structure. We evaluated the change of dark-field signal between inspiration and expiration. …”
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The SHA.LIN renal stone scoring system for predicting stone-free status and postoperative outcomes after percutaneous nephrolithotomy by Lei Jia, Lei Jia, Jiuyi Wang, Jiuyi Wang, Tao Wang, Shaogang Wang, Qiang Li, Qinzhang Wang, Jihong Liu, Kai Zeng, Kai Zeng

“…Correlations between scores from the 3 systems (i.e., SHA.LIN, STONE, and Guy's) and stone-free status (SFS), hemoglobin change, estimated blood loss (EBL), operative time (OT), and postoperative length of hospital stay (PLOS) were evaluated using standard statistical methods.ResultsThe overall stone-free rate was 69.7% (248/356), and complications occurred in 111 (30.9%) patients. …”
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Prognostic Implications of Initial Radiological Findings of Pulmonary Fibrosis in Patients with Acute SARS-CoV-2 Infection: A Prospective Multicentric Study by Roxana-Elena Cîrjaliu, Sri Vidhya Gurrala, Balaji Nallapati, Vamsi Krishna, Cristian Oancea, Emanuela Tudorache, Monica Marc, Felix Bratosin, Iulia Bogdan, Ovidiu Rosca, Paula Irina Barata, Laurentiu Tony Hangan, Sergiu Ioachim Chirilă, Ariadna-Petronela Fildan

“…This study aimed to evaluate the prognostic value of initial high-resolution computed tomography (HRCT) findings of pulmonary fibrosis in hospitalized COVID-19 patients and to examine how these findings relate to disease severity and clinical outcomes, with a particular focus on the development and validation of predictive scoring systems. …”
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Comparative Analysis of qSOFA, PRIEST, PAINT, and ISARIC4C Scores in Predicting Severe COVID-19 Outcomes Among Patients Aged over 75 Years by Daniela Rosca, Vamsi Krishna, Chandramouli Chetarajupalli, Adelina Maria Jianu, Ilona Emoke Deak, Claudia Raluca Balasa Virzob, Sorina Maria Denisa Laitin, Madalina Boruga, Rodica Lighezan

“…Clinical scores were computed at admission and five days after symptom onset. …”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…A 10-fold cross-validation strategy was used to evaluate model performance based on metrics including accuracy, balanced accuracy, and recall. …”
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Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation by Ran Cheng, Ran Cheng, Ran Cheng, Ying Zhu, Sheng-kai Wang, Chun-Xiao Zong, Hong-Li Zhao, Hong-Li Zhao, Hong-Li Zhao, Qin Zhang, Qin Zhang, Qin Zhang

“…The stability of the AR/CYP19A1-melatonin complex was verified through computational simulations using molecular dynamics techniques. …”
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Clinical manifestations and prognosis of giant cell arteritis: A retrospective cohort study by E. E. Filatova, N. M. Bulanov, A. D. Meshkov, O. O. Borodin, I. O. Smitienko, E. V. Chachilo, A. A. Nartov, A. L. Filatova, A. V. Naumov, P. I. Novikov, S. V. Moiseev

“…The aim of the study was to evaluate the clinical manifestations and survival of patients with giant cell arteritis (GCA).Methods. …”
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