In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design by Rayhan Chowdhury, Samia Akter Saima, Md. Al Amin, Md. Kawsar Habib, Ramisa Binti Mohiuddin, Ali Mohamod Wasaf Hasan, Roksana Khanam, Shahin Mahmud

“…To ensure feasible synthesis, molecular architecture comparison and computational retrosynthesis were performed, confirming the likelihood of successful laboratory synthesis. …”
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Optimal risk assessment intervals for primary prevention of cardiovascular disease: a population-based two-stage landmarking study by Angela M Wood, Katrina Poppe, Emanuele Di Angelantonio, David Stevens, Ellie Paige, Juliet Usher-Smith, Michael Sweeting, Matthew Arnold, Zander Gu, Francesca Gasperoni, Jessica K Barrett

“…We grouped people based on their sex, initial risk level and age, and computed various percentiles of the expected crossing times per group. …”
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SYNTHESIS OF NEW N-HYDROXYPHENYL AND TOLYL DERIVATIVES OF PYRIMIDINE-4(1H) –ONE WITH ANTI-INFLAMMATORY ACTIVITY by I. P. Kodonidi, O. O. Novikov, S. A. Kuleshova, Ju. I. Rjabukhin, S. S. Shatokhin, A. V. Ivchenko, M. I. Kodonidi, O. M. Zhilina

“…The research was carried out using the logical-structural approach and information technologies. The computer analysis of biological activity was carried out by the PASS program. …”
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Genetic variants of leptin receptor gene (rs1137101) and obesity risk in prakriti individuals and its pathogenicity prediction using in silico approaches by Manoranjani Murugan, Sourav Musib, Yogesh Vetriselvan, Ilangovan Karthiga, Artchoudane Soccalingam, Melissa Shaelyn Samuel, Irisappan Ganesh, Sambandam Ravikumar

“…Additionally, the pathogenicity of the Q223R variant was evaluated using computational tools such as PANTHER, PhD-SNP, SIFT, SNAP, META-SNP, I-Mutant 2.0, MUpro, and iStable, employing sequence- and structure-based methods. …”
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Mapping Nationwide Subfield Division Dynamics in Saudi Arabia Using Temporal Patterns of Sentinel-2 NDVI and Machine Learning by Ting Li, Oliver Miguel Lopez Valencia, Matthew F. McCabe

“…The performance of discrete wavelet transformation(DWT) and Savitzky–Golay filtering was compared for processing the NDVI time series. When evaluated against a reference dataset, the approach achieved a maximum accuracy of 93.38% with DWT level 1 decomposition using the “haar” wavelet function. …”
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Functional and Anatomical Outcomes of Faricimab in Previously Treated Wet Age-Related Macular Degeneration: Systematic Review and Pooled Analysis by Ali Khodor, Jonathan T. Caranfa, Tavish Nanda, Raul E. Ruiz-Lozano, Manuel E. Quiroga-Garza, Stephanie Choi, Ali Chehab, Eugenia M. Ramos-Dávila, Jeffrey S. Heier, Chirag P. Shah, Andre J. Witkin

“…Mean differences (MD) with 95% confidence intervals (CI) were used to compute the effect size of the change in outcomes. …”
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COVID-19’s effect on healthcare disparities: delivery, reimbursement, and premature mortality in residentially segregated populations by Kasabji Feras, Kasabji Feras, Ferenc Vincze, Kinga Lakatos, Kinga Lakatos, Anita Pálinkás, László Kőrösi, László Ulicska, Karolina Kósa, János Sándor, János Sándor

“…Key indicators included General Practitioner (GP) visits, outpatient services, Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) usage, hospitalizations, healthcare reimbursement, and premature mortality.ResultsIn 2020, there was a notable reduction in healthcare services utilization due to COVID-19 restrictions, with GP visits declining by 10.43% in SAs and 4.13% in CAs. …”
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Plasmodium falciparum merozoite surface protein 2 genetic polymorphism and multiplicity of infection in selected malarious areas of Northwest Ethiopia by Agenagnew Ashagre, Jimma Dinsa Deressa, Daniel Abebe Mekonnen, Melat Abdu, Tegegne Eshetu, Migbaru Keffale, Aberham Abere, Mulugeta Aemero Tegegne

“…The merozoite surface protein 2 allele frequency and multiplicity of infection were computed. Linear regression was employed to evaluate the associations between the multiplicity of infection, parasite density, and age by calculating Spearman’s rank correlation coefficients. …”
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Proposing a framework for body mass prediction with point clouds: A study applied in typical swine pen environments by Gabriel Pagin, Luciane Silva Martello, Rubens André Tabile, Rafael Vieira de Sousa

“…Recent advances in computer vision have enabled scientific studies for predicting the body mass of production animals through indirect measurements. …”
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A pilot study investigating the effectiveness, appreciation, and feasibility of a cognitive stimulation program in dementia patients: online versus face-to-face by Simona Cintoli, Giulia Spadoni, Valeria Giuliani, Valentina Nicoletti, Eleonora del Prete, Daniela Frosini, Roberto Ceravolo, Roberto Ceravolo, Gloria Tognoni

“…Remote participants received an introduction to basic computer literacy. Assessments were conducted using the Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) at the start (T0) and end (T1) of the intervention. …”
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Synthesis and Structure–Activity Relationship (SAR) Studies on New 4-Aminoquinoline-Hydrazones and Isatin Hybrids as Promising Antibacterial Agents by Ayesha Ubaid, Mohd. Shakir, Asghar Ali, Sobia Khan, Jihad Alrehaili, Razique Anwer, Mohammad Abid

“…Remarkably, <b>HD6</b> also inhibited a multidrug-resistant (MDR) bacterial strain, marking it as a critical addition to our antimicrobial arsenal. Computation studies were performed to investigate the possible mechanism of action of the most potent hybrid <b>HD6</b> on biofilm-causing protein (PDB ID: 7C7U). …”
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Exploring ethnic fermented drink ‘Pakhoi’ for its therapeutic properties: An in-silico perspective by Shikha Tomar, Shalini Kotnala, Riya, Kuldeep Chauhan, Anmol Sharma, Manu Pant, Pallavi Singh, Sumit Sharma, Kumud Pant

“…The present study investigates the antiproliferative activity of key compounds found in this drink. Numerous computational tools have assessed the physicochemical properties, pharmacokinetics, drug likeness, and medicinal chemistry of these compounds. …”
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Double-J stenting during TURBT increases risk of metachronous upper tract urothelial carcinoma by Zhengfeng Wu, Canhui Qu, Guangyao Liang, Rui Sun, Nanhe Lin, Yun Xie, Huanqing Wei, Jianfeng Guan, Chengqiang Mo

“…Propensity scores adjustment was computed to control the confounding factors (p < 0.05). …”
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Nontraumatic headaches in the emergency department: identifying clinical associations and predictive warning signs of intracranial pathologies by Abdulaziz M. Alghamdi, Abdulkarim M. Alghamdi, Yousof Fahad Allarakia, Arwa S. Alghamdi, Abdulaziz S. Alrashid, Abdulwhab M. Alotaibi, Reem Addas, Ahmed I. Lary

“…BACKGROUND: Although headaches are common, only 3–21% are estimated to be secondary, with their causes ranging from non-alarming to life-threatening conditions. OBJECTIVES: Evaluate the associated factors and predictive warning signs of intracranial pathologies in patients presenting with nontraumatic headaches to the emergency document (ED). …”
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A Retrospective Analysis of the Effects of Concomitant Use of Intra-Aortic Balloon Pump (IABP) and Veno-Arterial Extracorporeal Membrane Oxygenation (va-ECMO) Therapy on Procedural... by Farid Ziayee, Hannan Dalyanoglu, Christian Schnitzler, Kai Jannusch, Matthias Boschheidgen, Judith Boeven, Hug Aubin, Bernd Turowski, Marius Georg Kaschner, Christian Mathys

“…<b>Methods:</b> Cranial computed tomography (CCT) scans of consecutive patients receiving va-ECMO therapy were analyzed retrospectively. …”
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Genotype-by-environment interaction across THI classes impacts the selection for body weight at young ages in meat quails by Arícia Chaves Zanetti Reis, Daniele Botelho Diniz Marques, Delvan Alves da Silva, Alessandra Alves da Silva, Eula Regina Carrara, Leila de Genova Gaya, Paulo Sávio Lopes, Luiz F. Brito, Renata Veroneze

“…Variance components and genetic parameters, including heritability and genetic correlation estimates, were computed for BW considering these two classes of THI. …”
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Development and validation of an early diagnosis model for severe mycoplasma pneumonia in children based on interpretable machine learning by Si Xie, Mo Wu, Yu Shang, Wenbin Tuo, Jun Wang, Qinzhen Cai, Chunhui Yuan, Cong Yao, Yun Xiang

“…The clinical applicability of the model was evaluated by DCA and CIC curve. Results After variable selection, eight machine learning models were developed using age, sex and 21 serum indicators identified as predictive factors for SMPP. …”
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Hip disarticulation for non-salvageable primary malignant sarcoma of femur: What were the oncological &amp; functional outcomes? by Vikas Warikoo, Jebin Aron, Abhijeet Ashok Salunke, Nandlal Bharwani, Dhruv Patel, Anish Chowdhury, Arunsrinivas Muralidharan, Ajinkya Pawar, Vivek Bande, Shashank Pandya

“…Results: Among 24 patients, 5 patients had distant metastasis at presentation. The computed median overall survival was 23.1 months (95 % CI:(14.76, 31.44)). …”
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Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach by Sushma Pradeep, Sushma Pradeep, M. R. Sai Chakith, S. R. Sindhushree, Pruthvish Reddy, Esther Sushmitha, Madhusudan N. Purohit, Divya Suresh, Nanjunda Swamy Shivananju, Ekaterina Silina, Natalia Manturova, Victor Stupin, Shiva Prasad Kollur, Chandan Shivamallu, Raghu Ram Achar

“…Pharmacokinetic and toxicity evaluations, conducted using SwissADME and pkCSM, highlighted luteolin’s favorable drug-like properties, including good bioavailability and low toxicity. …”
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Incidence rate of infective endocarditis by socioeconomic position: a Danish nationwide cohort study (2000–2022)Research in context by Søren K. Martiny, Morten Schmidt, Jonas A. Povlsen, Kirstine K. Søgaard, Hans E. Bøtker, Henrik T. Sørensen

“…Average annual percentage changes were computed to evaluate temporal trends. Slope index and relative index of inequality were calculated to obtain inequality gradients. …”
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