Nanoparticles for Thrombolytic Therapy in Ischemic Stroke: A Systematic Review and Meta-Analysis of Preclinical Studies by Jesús Prego-Domínguez, Fernando Laso-García, Nuria Palomar-Alonso, María Pérez-Mato, Esteban López-Arias, Antonio Dopico-López, Pablo Hervella, María Gutiérrez-Fernández, María Alonso de Leciñana, Ester Polo, Beatriz Pelaz, Pablo del Pino, Francisco Campos, Clara Correa-Paz

“…In order to update and evaluate the efficacy of these nanosystems, we performed a meta-analysis of the selected in vivo preclinical studies. …”
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Identification of dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4) as antagonist of NEK-Family... by Mubashir Aziz, Syeda Abida Ejaz, Pervaiz Ali Channar, Ali G. Alkhathami, Tahir Qadri, Zahid Hussain, Mumtaz Hussaain, Rabail Ujan

“…., dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4)), capable of effectively targeting these proteins using in-vitro cytotoxicity assays and comprehensive computational approaches. Then the inhibitory potential of TAJ4 was evaluated against cell lines of the respective cancers (HeLa cells, MCF-7 cells, and Vero cells). …”
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Bladder-sparing therapy in a case report of huge muscle-invasive bladder IMT treated with 1470 nm diode laser en bloc resection followed by laparoscopic partial cystectomy by Junhao Chu, Huisheng Yuan, Zhihui Zhang, Jiajun Kan, Shishuai Duan, Zilong Wang, Zilong Wang, Zilong Wang, Muwen Wang

“…Computed tomography urography (CTU) and magnetic resonance imaging (MRI) identified a large tumor on the anterior bladder wall with muscle layer invasion, measuring approximately 5.0 × 3.9 × 4.3 cm. …”
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Sustained release of ubiquitin-like protein ISG-15 enhances tendon-to-bone healing following anterior cruciate ligament reconstruction in a mouse model by Jun-Cheng Yao, Jun-Cheng Yao, Jun-Cheng Yao, Jun-Cheng Yao, Jie-Xin Zhang, Jie-Xin Zhang, Jie-Xin Zhang, Jie-Xin Zhang, Xuan Wang, Xuan Wang, Xuan Wang, Xuan Wang, Yu-Hao Wu, Yu-Hao Wu, Hao-Lin Ke, Hao-Lin Ke, Hao-Lin Ke, Jia-Rong Liang, Yan Shao, Yan Shao, Jin-Tao Li, Jin-Tao Li, Jin-Tao Li, Yuan Liu, Dao-Zhang Cai, Dao-Zhang Cai, Jian-Ying Pan, Jian-Ying Pan

“…To assess its therapeutic potential, bone-tendon interface growth was evaluated through histological staining, while micro-computed tomography (Micro-CT) was employed to quantify newly formed bone and bone density within the bone tunnels. …”
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Coronary artery stenosis associated with right ventricular dysfunction in acute pulmonary embolism: A case-control study by Yuejiao Ma, Jieling Ma, Dan Lu, Yinjian Yang, Chao Liu, Liting Wang, Xijie Zhu, Xianmei Li, Chunyan Cheng, Sijin Zhang, Jiayong Qiu, Jinghui Li, Mengyi Liu, Kai Sun, Xin Jiang, Xiqi Xu, Zhi-Cheng Jing, Rongman Jia

“…Conditional logistic regression analysis was used to evaluate the association between CAS and RV dysfunction. …”
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A novel variant c.7104 + 6T > A of ABCA12 linked to autosomal recessive congenital ichthyosis verified by minigene splicing assay by Linyan Zhu, Rui Zhou, Lianxiao Zhang, Mei Chen, Shengmin Zhang, Xiaxi Huang, Yubo Shi, Huiqing Ding

“…According to ACMG guidelines, the c.7104 + 6T > A variant is classified as a Variant of Uncertain Significance (VUS). Computational predictions suggested that this variant affects splicing. …”
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Combined impact of semantic segmentation and quantitative structure modelling of Southern pine trees using terrestrial laser scanning by Jinyi Xia, Timothy A. Martin, Gary F. Peter, Kody M. Brock, Jeff W. Atkins, Matthew A. Gitzendanner, Inacio Bueno, Kim Calders, Ana Paula Dalla Corte, Andrew T. Hudak, Monique Bohora Schlickmann, Michael G. Andreu, Caio Hamamura, Carine Klauberg, Carlos A. Silva

“…These findings highlight the importance of selecting segmentation algorithms based on specific research goals, balancing accuracy and computational feasibility in forest structural modeling.…”
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Alcohol-induced bone loss driven by dysregulated spatial distribution of gut microbiota and PGD2-IL17 pathway-mediated osteoclast activation by Haoyu Guo, Haoyu Guo, Yujing Bi, Gongzi Zhang, Shicheng Luo, Xiaopeng Jia, Xiaopeng Jia, Ruifu Yang, Ye Peng, Lihai Zhang

“…We further sought to evaluate the potential of microbiota supplementation and targeted immunosuppressants as therapeutic strategies for related bone diseases.MethodsAn osteoporosis model using mice was established using alcohol drinking bottles, and bone loss was validated using micro-computed tomography. …”
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Respiratory outcomes of adrenergic beta-antagonists in patients undergoing tracheal extubation: a systematic review and meta-analysis of randomized controlled trials by Lucas Cael Azevedo Ramos Bendaham, Altair Pereira de Melo Neto, Hilária Saugo Faria, André Richard da Silva Oliveira Filho, Carlos Henrique de Oliveira Ferreira, Marcela da Silva Kazitani Cunha, Victor Gonçalves Soares, Ocílio Ribeiro Gonçalves, Milene Vitória Sampaio Sobral, Mohamed Doma, Denis Maltz Grutcki, Fabrício Tavares Mendonça

“…We conducted a meta-analysis to evaluate the safety and efficacy of beta-blockers in patients undergoing tracheal extubation. …”
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Rationale and design of the THIRST Alert feasibility study: a pragmatic, single-centre, parallel-group randomised controlled trial of an interruptive alert for oral fluid restricti... by Yang Chen, Anoop Shah, Folkert W Asselbergs, R Thomas Lumbers, Daniel Higgins, Yogini Jani, Nausheen Saleem, Kris Chafer, Matthew Robert Sydes

“…A series of secondary outcomes are specified to evaluate the effectiveness of the alert, adherence to the randomised treatment allocation and the quality of data generated from routine care, relevant to the outcomes of interest.Ethics and dissemination This study was approved by Riverside Research Ethics Committee (Ref: 22/LO/0889) and will be published on completion.Trial registration number NCT05869656.…”
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Thermogenic preworkout supplement induces alveolar bone loss in a rat model of tooth movement via RANK/RANKL/OPG pathway by Gurgiane Rodrigues Gurgel CAVALCANTE, Mariana Cabral MORENO, Flavia Queiroz PIRIH, Vanessa de Paula SOARES, Éricka Janine Dantas da SILVEIRA, José Sandro Pereira da SILVA, Hallissa Simplício Gomes PEREIRA, Katherine Pennington KLEIN, Maria Luiza Diniz de Sousa LOPES, Aurigena Antunes de ARAUJO, Agnes Andrade MARTINS, Ruthinéia Diógenes Alves Uchôa LINS

“…Maxillary tissue was collected and evaluated by immunohistochemistry for receptor activator of NF-κB (RANK), receptor activator of NF-κB ligand (RANKL), and osteoprotegerin (OPG). …”
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Linking Diet and Homocysteine to complexity of coronary artery disease using SYNTAX score – A cross sectional study by Sowndarya Kollampare, Anupama Hegde, Arpit Jain, Padmanabh Kamath, Ramya Shenoy, Poornima A. Manjrekar

“…SYNTAX score was calculated using a computer program. Hcy was estimated on the COBAS Pro c503, vitamin B12 (B12) and FA levels were estimated on the COBAS Pro e801 using ROCHE kits. …”
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Modulating Osteoclast Activity and Immune Responses with Ultra-Low-Dose Silver Nanoparticle-Loaded TiO₂ Nanotubes for Osteoporotic Bone Regeneration by Zhen Wang, Penghui Xiang, Zhe Xu, Meiqi Gu, Rui Zhang, Yifei Li, Fei Xin, Chengla Yi

“…In vitro assays focused on evaluating cell viability and osteoclast function, while in vivo assessments employed osteoporotic rat models to monitor bone healing via histological examination and micro-computed tomography (micro-CT) imaging. …”
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Spring-assisted posterior vault expansion in children over 2 years of age with craniosynostosis by Karin Säljö, Madiha Bhatti-Søfteland, Peter Tarnow, Robert Olsson, Tobias Hallén, Wen-Chih Chao, Lars Kölby, Giovanni Maltese

“… Background: This study evaluated spring-assisted posterior vault expansion (SA-PVE) in children aged > 2 years with craniosynostosis and signs of high intracranial pressure (ICP). …”
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Combination of robot-assisted glove and mirror therapy improves upper limb motor function in subacute stroke patients: a randomized controlled pilot study by Jin Qian, Chong Liang, Run Liu, Jingyi Yu, Tangzhu Yang, Tangzhu Yang, Dingqun Bai

“…Before treatment, 4 weeks after treatment, Fugl-Meyer Assessment-Upper Extremity (FMA-UE), Brunnstrom Hemiplegic Rating Scale, Functional test for the Hemiplegic Upper Extremity–HongKong (FTHUE-HK), Functional Independence Measure (FIM) were used to evaluate the upper limb function and activities of daily living (ADL) of patients.ResultsCompared with baseline, FMA-UE, Brunnstrom upper limb and hand grade and FIM score were observed across all three groups post-intervention (p < 0.05). …”
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A novel subcutaneous islet transplantation method using a bioabsorbable medical device to facilitate the creation of a highly vascularized transplantation site by Norio Emoto, Takayuki Anazawa, Kei Yamane, Nanae Fujimoto, Takaaki Murakami, Hiroyuki Fujimoto, Cui Jialin, Satoshi Ishida, Kouki Kurahashi, Aya Izuwa, Hang Su, Kenta Inoguchi, Seiichiro Tada, Kazuyuki Nagai, Etsuro Hatano

“…The presence of islets was confirmed using single-photon emission computed tomography (SPECT/CT), histological examination. …”
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Releasing the octoPus, an open-source digital tool to promote Integrated Pest Management by Simone Bregaglio, Eugenio Rossi, Lorenzo Ascari, Gabriele Mongiano, Eleonora Del Cavallo, Sofia Bajocco, Luisa Maria Manici, Antonio Gerardo Pepe, Chiara Bassi, Rocchina Tiso, Fabio Pietrangeli, Giovanna Cattaneo, Camilla Nigro, Marco Secondo Gerardi, Simone Bussotti, Angela Sanchioni, Danilo Tognetti, Mariangela Sandra, Irene De Lillo, Paolo Framarin, Sandra Di Ferdinando, Riccardo Bugiani

“…We evaluated the behavior of the eight disease models through gridded simulations across the whole Italian grapevine areas from 2001 to 2020. …”
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Chemically functionalized Eggs capsules of Sea Snail (ess) banded dye-murex for bioremediation applications by Marilena Donnaloia, Francesco De Mastro, Carlo Porfido, Maria Michela Giangregorio, Roberto Terzano, Gennaro Brunetti, Danilo Vona

“…The material was morphologically investigated via high-resolution X-ray micro-computed tomography (HR X-ray μ-CT), and characterized using Raman spectroscopy, Fourier Transformed Infrared-attenuated total reflectance (FTIR-ATR), micro-IR, elemental, and BET analysis, after the bioorganic decoration. …”
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A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity by Victoria Shevchenko, R. Austin Benn, Robert Scholz, Wei Wei, Carla Pallavicini, Ulysse Klatzmann, Francesco Alberti, Theodore D. Satterthwaite, Demian Wassermann, Pierre-Louis Bazin, Daniel S. Margulies

“…We developed a pipeline which allows us to aggregate over a million different features and assess their predictive potential in a single, computationally efficient experiment. We selected top 1% of features with the largest permutation feature importance and trained 13 classifiers on them using 10-fold cross-validation. …”
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A modified METRIC model for high resolution partitioning and mapping of evapotranspiration over irrigated agricultural landscapes in Morocco by Jamal Elfarkh, Bouchra Ait Hssaine, Salah Er-Raki, Jamal Ezzahar, Matthew F. McCabe, Abdelghani Chehbouni

“…These temperatures are used by METRIC to calculate two ET components, one for the soil and another for the vegetation, which are subsequently weighted by the fractional vegetation cover (fc) to compute E and T. Soil and vegetation temperatures are estimated using the hourglass method, which is driven by the surface temperature and fc. …”
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