Achieving inclusive healthcare through integrating education and research with AI and personalized curricula by Amir Bahmani, Kexin Cha, Arash Alavi, Amit Dixit, Antony Ross, Ryan Park, Francesca Goncalves, Shirley Ma, Paul Saxman, Ramesh Nair, Ramin Akhavan-Sarraf, Xin Zhou, Meng Wang, Kévin Contrepois, Jennifer Li-Pook-Than, Emma Monte, David Jose Florez Rodriguez, Jaslene Lai, Mohan Babu, Abtin Tondar, Sophia Miryam Schüssler-Fiorenza Rose, Ilya Akbari, Xinyue Zhang, Kritika Yegnashankaran, Joseph Yracheta, Kali Dale, Alison Derbenwick Miller, Scott Edmiston, Eva M. McGhee, Camille Nebeker, Joseph C. Wu, Anshul Kundaje, Michael Snyder

“…Addressing these needs requires the integration of computational experts, engineers, designers, and healthcare professionals to develop user-friendly systems and shared terminologies. …”
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Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study by Ian J. Neeland, Fang Zhu, Goncalo Graca, Anastasios Lymperopoulos, Gianluca Iacobellis, Ali Farzaneh, Daniel Bos, Mohsen Ghanbari, Jeffrey J. Goldberger, Maryam Kavousi, Philip Greenland

“…Results A total of 23 571 metabolomic spectral variables were evaluated. In MESA, after adjustment for age, sex, and race and ethnicity, 38 metabolites were positively and 19 metabolites negatively associated with EAT at a false discovery rate P<0.01. …”
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Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer by Federica Sabia, MSc, Camilla Valsecchi, MSc, Roberta Eufrasia Ledda, MD, Giorgio Bogani, MD, Riccardo Orlandi, MD, Luigi Rolli, MD, Michele Ferrari, MD, Maurizio Balbi, MD, Alfonso Marchianò, MD, Ugo Pastorino, MD

“…Methods: This study included 536 consecutive patients with stage I LC who underwent preoperative chest computed tomography followed by surgical resection. …”
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Upfront blood microRNA test in LDCT-reluctant individuals: insights from the biomild trial by Gabriella Sozzi, Federica Sabia, Luigi Rolli, Miriam Segale, Paola Suatoni, Anna Zanghi, Margherita Ruggirello, Alfonso Marchianò, Mattia Boeri, Ugo Pastorino

“…Abstract Background Low-dose computed tomography (LDCT) lung cancer screening can reduce mortality in high-risk individuals, but many individuals with a heavy smoking history may be reluctant to undergo radiologic examinations. …”
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Integrative in silico and in vitro analysis of Pinus roxburghii essential oil: unveiling its antioxidant, antidiabetic, and antiglycation potential by Rubina Naz Qaisrani, Rubina Naz Qaisrani, Shah Iram Niaz, Raheela Bano, Hatem A. Abuelizz, Arooj Mohsin Alvi, Sadia Chaman, Qaiser Aziz, Muhammad Asif Wazir, Muhammad Akram, Saiqa Ishtiaq, Muhammad Ramzan, Adnan Amin, Adnan Amin

“…IntroductionEssential Oils (EOs) are a rich source of secondary metabolites that exhibit various biological activities.MethodsThis study includes GCMS analysis of Pinus roxburghii EO, computational investigation including drug likeness, ADMET properties, molecular docking, and in vitro evaluations for possible antioxidant, antidiabetic, and anti‐AGEs actions.ResultsGCMS analysis identified β‐pinene (30%) as major component, succeeded by caryophyllene (29.37%), o‐xylene (8.98%), aromadendrine (8.29%), and α‐himachalene (6.82%). …”
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Development and initial validation of the implicit internalized sexual orientation stigma affect misattribution procedure by William J. Hall, Hayden C. Dawes, Jason W. Hannay, Denise Yookong Williams, Joseph J. Frey, Ankur Srivastava, Mimi V. Chapman, Ding-Geng Chen, Amy Blank Wilson, Magdelene E. Ramon, B. Keith Payne

“…Confirmatory factor analysis was used to evaluate two models: a one-factor model with internalized stigma specified as one overall construct and a two-factor model with internalized stigma specified as two constructs based on binary conceptions of gender (stigma regarding queer women and stigma regarding queer men).ResultsResults showed that the two-factor model best fit the data. …”
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A comprehensive approach to studying motor planning and execution using 3D-printed objects and motion tracking technology by Alexander Vyazmin, Sangram Behera, Sangram Behera, Geok Lan See, Geok Lan See, Victoria Moiseeva, Matteo Feurra

“…This paradigm provides robust tools for fundamental motor control research and has potential clinical applications for evaluating motor planning deficits in patients with neurological impairments.…”
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A novel Fc-enhanced humanized monoclonal antibody targeting B7-H3 suppresses the growth of ESCC by Huiting Wu, Chang Liu, Qiang Yuan, Yan Qiao, Yongwei Ding, Lina Duan, Wenjing Li, Mengjia Zhang, Xuhua Zhang, Yanan Jiang, Jing Lu, Ziming Dong, Tao Wang, Kangdong Liu, Jimin Zhao

“…Here, we developed a humanized and Fc-engineered anti-B7H3 mAb 24F-Hu-mut2 and systematically evaluated its anti-tumor activity in vitro and in vivo. …”
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Preventable diagnostic errors of lower gastrointestinal perforation: a secondary analysis of a large-scale multicenter retrospective study by Taku Harada, Takashi Watari, Satoshi Watanuki, Seiko Kushiro, Taiju Miyagami, Syunsuke Syusa, Satoshi Suzuki, Tetsuya Hiyoshi, Suguru Hasegawa, Shigeki Nabeshima, Hidetoshi Aihara, Shun Yamashita, Masaki Tago, Fumitaka Yoshimura, Kotaro Kunitomo, Takahiro Tsuji, Masanori Hirose, Tomoya Tsuchida, Taro Shimizu

“…Clinical history and computed tomography (CT) imaging information were collected for 138 cases. …”
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Can flexible ureteroscopy using flexible and navigable suction ureteral access sheath (FANS-UAS) minimize postoperative double J stent placement? Results from a propensity score-ma... by Daniele Castellani, Bhaskar Kumar Somani, Khi Yung Fong, Steffi Kar Kei Yuen, Chin Tiong Heng, Mohamed Elshazly, Karl Tan, Thomas R. W. Herrmann, Olivier Traxer, Vineet Gauhar

“…Purpose: To evaluate whether using flexible and navigable suction ureteral access sheath can obviate insertion of double J stent and establish the safety of overnight ureteric catheter placement as alternative following flexible ureteroscopy for kidney stones. …”
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Validation of a classification to identify emergency department visits suitable for subacute and virtual care models: a randomised single-blinded agreement study protocol by Andrew Worster, Ryan P Strum, Walter Tavares, Andrew P Costa, Erich Hanel, Lauren E Griffith, Paul Miller, Shawn Mondoux, Komal Aryal, Fabrice Mowbray, Ravi Sivakumaran

“…Each chart will be reviewed by two physicians independently. We compute our needed sample size to be 79 charts. We will use kappa statistics to measure inter-rater agreement. …”
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Association between prenatal exposure to bisphenols and preterm birth: the interaction effect of anemia by Ya-ling Li, Hong-yu Mao, Lu-ming Yan, Zi-yi Liu, Shu Sun, Ting-ting Jiang, Le-yan Xu, Xin-yi Zhang, Bo-lin Liu, Min Zhu, Ji-an Xie, Jia-hu Hao, Chao Zhang

“…Multiple statistical methods—including quantile g-computation (q-gcomp), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR)—were employed to evaluate cumulative and mixture effects. …”
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3D cone-beam C.T. imaging used to determine the effect of disinfection protocols on the dimensional stability of full arch impressions by Kuei-ling Hsu, Abdulrahman A. Balhaddad, Isadora Martini Garcia, Fabrício Mezzomo Collares, Vineet Dhar, Louis DePaola, Mary Anne Melo

“…Aim: This study aimed to investigate the dimensional stability of irreversible hydrocolloid and polyvinylsiloxane (P.V.S.) impressions after exposure to four commercial disinfectants using cone-beam computed tomography (CBCT). Materials and Methods: Two different impression materials were tested: irreversible hydrocolloid and P.V.S. …”
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Multi-Centre Study of Progression Factors and Intravesical Recurrence in Patients with Urothelial Carcinoma of the Upper Urinary Tract by Lucía García-Morales, Francisco Javier Contreras-Matos, Ana Blanca-Pedregosa, Alejandro Mellado-Castillero, Juan Pablo Campos-Hernández, María Fernanda Lara, Ignacio Puche-Sanz, Enrique Gómez-Gómez

“…Methods: Progression-free survival (PFS) and IVR-free survival were evaluated using a Kaplan–Meier survival curve and a Log-Rank test. …”
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Chronic heavy alcohol consumption impairs the ability of demineralized allogenic bone matrix to support osteoinduction in alcohol-naïve rats by Russell T. Turner, Amida F. Kuah, Cynthia H. Trevisiol, Kathy S. Howe, Adam J. Branscum, Urszula T. Iwaniec

“…Bone formed during osteoinduction was measured by micro-computed tomography. Experiment 1: Bone volume was lower in DBM harvested from ethanol-consuming donors 6 weeks following implantation into recipients fed control diet, indicating that exposure of the donor rats to ethanol lowered osteoinductive capacity. …”
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N-Glycoside of Indolo[2,3-<i>a</i>]pyrrolo[3,4-<i>c</i>]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking S... by Nikolay Kalitin, Natalia Koroleva, Anna Lushnikova, Maria Babaeva, Nadezhda Samoylenkova, Ekaterina Savchenko, Galina Smirnova, Yulia Borisova, Alexander Kostarev, Aida Karamysheva, Galina Pavlova

“…Quantitative RT-PCR was used to evaluate the gene expression. The protein expression was assessed by Western blotting. …”
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Implementation of Principal Component Analysis (PCA)/Singular Value Decomposition (SVD) and Neural Networks in Constructing a Reduced-Order Model for Virtual Sensing of Mechanical... by M. A. Melgarejo, A. Pérez, D. Ruiz, A. Casas, F. González, V. González de Lena Alonso

“…Thus, the approach significantly reduces computational complexity while maintaining a high degree of precision, enabling efficient real-time monitoring. …”
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Associations of healthy eating index 2020 and its components with non-alcoholic fatty liver disease in type 2 diabetes patients and the mediating roles of metabolic indicators: NHA... by Jingxiong Chen, Jingxiong Chen, Haizhou Diao, Yuling Zhang, Ben Hu, Kai Qian, Kaiguang Zhang, Tengyue Zhang, Jizhong Song, Jizhong Song

“…The HEI-2020, which assesses diet quality, was computed based on 24-h dietary recall data. Key metabolic indicators such as the triglyceride-glucose (TyG) index, metabolic score (MS), mean arterial pressure, uric acid levels, and total cholesterol were evaluated.ResultsThe findings indicated that higher HEI-2020 scores were associated with a lower likelihood of NAFLD (odds ratio 0.978, 95% confidence interval: 0.959–0.998), with the strongest inverse associations observed in the top quartiles of diet quality. …”
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EFNA2 Mediates Stiffness-Regulated Hypopharyngeal Cancer Progression by Songqun Hu, Yuanru Liu, Min Cheng, Min Xu, Huiting Liu, Ying Shan, Haosheng Ni, Tian Xia, Qicheng Zhang, Zhenxin Zhang, Bo You

“…Methods Immunohistochemical analysis and cervical enhanced computed tomography (CT) data were used to evaluate correlations among CT values, matrix stiffness, and prognosis, and to develop a prognostic model for HPC. …”
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A clinical-radiomics nomogram based on automated segmentation of chest CT to discriminate PRISm and COPD patients by TaoHu Zhou, Yu Guan, XiaoQing Lin, XiuXiu Zhou, Liang Mao, YanQing Ma, Bing Fan, Jie Li, WenTing Tu, ShiYuan Liu, Li Fan

“…Model performance was evaluated by receiver operating characteristic (ROC) curve, calibration curve, and decision curve analyses (DCA). …”
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