Treatment of severe bleeds with eptacog beta in hemophilia A or B with inhibitors: a post hoc analysis of the PERSEPT 1 and 2 trials by Guy Young, Johnny Mahlangu, Lisa N. Boggio, Manuel Carcao, Yesim Dargaud, Miguel Escobar, Adam Giermasz, Cédric Hermans, Philip Kuriakose, Wolfgang Miesbach, Danielle Nance, Amina Rafique, Robert F. Sidonio, Jr., Kateryna V. Vilchevska, Michael Wang, Steven W. Pipe

“…Satisfactory treatment responses to eptacog beta were typically defined in this post hoc analysis by physician- and patient-reported hemostasis evaluations of “excellent” or “good.” Hemostatic control of an intracranial hemorrhage (ICH) in 1 patient was assessed by computed tomography. …”
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Small Modular Reactor based on NuScale with Thorium base by Diego M. E. Gonçalves, Marcelo Vilela da Silva, C. J. C. M. R. da Cunha, Giovanni L. Stefani

“…To meet substantial computational demands, they ran these simulations on the Lobo Carneiro supercomputer at NACAD/UFRJ. …”
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Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study by Samir Jaber, Karim Asehnoune, Fanny Feuillet, Mickael Vourc’h, Donatien Huard, Gabrielle Baud, Arthur Guichoux, Marielle Surbled, Melanie Tissot, Anne Chiffoleau, Christophe Guitton

“…Using a two-sided t-test with a first species risk of 5% and 80% power, a total of 186 patients will be included. Using a computer-generated randomisation, with a 1:1 allocation ratio, patients will be randomised to HFNC or face mask preoxygenation. …”
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A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass by Chenjie Fei, Chenjie Fei, Chenjie Fei, Ziwen Wang, Ziwen Wang, Yang Hu, Yang Hu, Yang Hu, Li Nie, Li Nie, Li Nie, Jiong Chen, Jiong Chen, Jiong Chen

“…Computational prediction and expression profiling revealed inducible expression of MsPiscidins upon MSRV infection, with distinct tissue-specific patterns. …”
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Adaptive Phage Therapy in the Treatment of Patients with Recurrent Pneumonia (Pilot Study) by N. V. Beloborodova, A. V. Grechko, M. M. Gurkova, A. Yu. Zurabov, F. M. Zurabov, A. N. Kuzovlev, A. Yu. Megley, M. V. Petrova, V. M. Popova, I. V. Redkin, N. I. Sergeyev, E. A. Chernevskaya, M. Yu. Yuriev, A. A. Yakovlev

“…Aim. To evaluate the safety and efficacy of the adaptive phage therapy technique in patients with recurrent pneumonia in neurological critical care.Material and methods. …”
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High-intensity ethanol binge drinking accentuates bone damage in induced apical periodontitis in rats by José Mário Matos-Sousa, Deiweson Souza-Monteiro, Vinicius Ruan Neves dos Santos, Maria Karolina Martins Ferreira, Deborah Ribeiro Frazão, Victória Santos Chemelo, Leonardo de Oliveira Bittencourt, João Daniel Mendonça de Moura, Cristiane do Socorro Ferraz Maia, Fabrício Mezzomo Collares, Luanna de Melo Pereira Fernandes, Rafael Rodrigues Lima

“…This study aimed to evaluate the effects of excessive and episodic consumption of ethanol (EtOH, a high-intensity drinking manner) on induced apical periodontitis in rats. …”
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A time-dependent three-dimensional dayside magnetopause model based on quasi-elastodynamic theory by Y. Gu, Y. Gu, Y. Gu, Y. Wang, Y. Wang, F. Wei, F. Wei, X. Feng, X. Feng, A. Samsonov, X. Song, B. Wang, B. Wang, P. Zuo, P. Zuo, C. Jiang, C. Jiang, Y. Chen, Y. Chen, X. Xu, Z. Zhou

“…The predictive accuracy of the POS model was evaluated using 38 887 observed magnetopause-crossing events. …”
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Construction and validation of an 18F-FDG-PET/CT-based prognostic model to predict progression-free survival in newly diagnosed multiple myeloma patients by Xiaoqing Dong, Ruoyi Wang, Xiuhua Ying, Jiaxuan Xu, Jie Yan, Peipei Xu, Yue Peng, Bing Chen

“…A nomogram was established to individually predict PFS in MM patients. The model was evaluated by calculating the C-index and calibration curve.Results: Here, 4.2 was used as the cut-off value of SUVmax to divide patients into high and low groups. …”
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Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies by Rashid Alavi, Wangde Dai, Sohrab P. Mazandarani, Rebecca J. Arechavala, David A. Herman, Michael T. Kleinman, Robert A. Kloner, Niema M. Pahlevan

“…Methods and Results One hundred seventeen healthy adult male and female rats were exposed to purified air (control), electronic cigarette vapor without nicotine, electronic cigarette vapor with nicotine, and traditional nicotine‐rich cigarette smoke, after which hemodynamics were comprehensively evaluated. IF metrics were computed from invasive carotid pressure waveforms. …”
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Enhancing renewable energy integration through strategic stochastic optimization planning of distributed energy resources (Wind/PV/SBESS/MBESS) in distribution systems by Ahmad K. ALAhmad, Renuga Verayiah, Hussain Shareef, Agileswari Ramasamy, Saleh Ba-swaimi

“…Monte Carlo Simulation (MCS) models uncertainties in wind speed, solar irradiation, load power, and energy prices, while the backward reduction method (BRM) mitigates computational complexities. A hybrid optimization approach combining the non-dominated sorting genetic algorithm (NSGAII) and multi-objective particle swarm optimization (MOPSO) with a decision-making algorithm is proposed to solve the planning problem. …”
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Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy by Marlon L. Wong, Lisa M. McTeague, Gabriel Gonzalez, Juan P. Gonzalez, Jessica L. Bolanos, Peter J. Hosein, Danylo F. Cabral, Peter J. Fried

“…Test-retest reliability was evaluated, and changes in TMS measures following transcutaneous auricular vagus nerve stimulation were computed.ResultsPre-intervention TMS measures showed smaller-than-medium sized differences between CIPN and DN groups. …”
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Bolton Ratio of Different Angle’s Classifications in a School Children Sample of Erbil City: A Cross‑sectional Study by Amanj R. Ibrahim, Zana Q. Omer, Hasan S. Hasan, Walaa M. Saleem AlMola

“…The overall and anterior ratios between the maxillary and mandibular teeth were computed and evaluated using Bolton’s method. The results revealed that the mean anterior ratio (78.863) was higher and statistically significantly different from anterior Bolton’s (77.2) and also the mean overall ratio was not statistically significant different from Bolton’s ratio (91.3) (P = 0.239), with respect to the overall and anterior ratios among all the groups, statistically significant differences were found. …”
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Individual-level brain phenotypes in first-episode mania: normative modelling of brain morphometry and brainAGE by Kevin Yu, Ruiyang Ge, Yuetong Yu, Shalaila Haas, Nicole Sanford, Lakshmi N. Yatham, Sophia Frangou, Trisha Chakrabarty

“…Ridge regression and support vector machine models were used to evaluate whether z-scores predicted symptom severity, IQ or diagnosis. …”
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GRAP2: A Novel Immune-Related Prognosis Biomarker in Cervical Cancer by Shixin Lin, Jun Zhu, Xiaoling Mao, Gang Lin, Dan Yang, Yun Guan, Jun Gao

“…Thus, based on the Gene Expression Omnibus (GEO) and TCGA databases, we evaluated GRAP2’s influence on clinical prognosis. …”
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Effect of forward-facing concavity on the aerodynamic and aerothermodynamic characteristics of an atmospheric Re-entry vehicle by Khalid A. Juhany, Anirudh Renganathan, Rohit S. Varma, Karthik Vel E, Amjad Ali Pasha, D. Siva Krishna Reddy, Seraj Alzhrani, S. Nadaraja Pillai

“…Furthermore, the monostability characteristics have been evaluated as well. From the analyses, comparing with the baseline model, M6 (d/D = 2.9) has the highest increment in drag of about 15 %. …”
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Effects of short‐term exposure to moderate amounts of alcohol on brain volume by Sakiko Tsugawa, Fumihiko Ueno, Mutsuki Sakuma, Hideaki Tani, Ryo Ochi, Ariel Graff‐Guerrero, Yoshihiro Noda, Hiroyuki Uchida, Masaru Mimura, Shunji Oshima, Sachio Matsushita, Shinichiro Nakajima

“…Cortical, subcortical, and ventricular volumes were computed after segmentation with FreeSurfer. Repeated measures analysis of variance was used to evaluate longitudinal changes in brain volume at 96 regions. …”
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The role of malnutrition on outcomes of multisystem inflammatory syndrome in children (MIS-C) due to COVID-19 by Tutku Soyer, Kübra Aykaç, Gözde Özer, Yasemin Özsürekçi, H. Nursun Özcan, Kaya Yorgancı, Osman Abbasoğlu

“…Patients with MIS-C were evaluated for demographic features, anthropometric parameters, clinical findings and outcomes. …”
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Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data by Vasiliki (Vicky) Bikia, Dionysios Adamopoulos, Dionysios Adamopoulos, Dionysios Adamopoulos, Marco Roffi, Marco Roffi, Georgios Rovas, Stéphane Noble, Stéphane Noble, François Mach, François Mach, Nikolaos Stergiopulos

“…The significant reduction in computational time of our method for SV assessment should make it suitable for real-time clinical applications.…”
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SA-MARL: Novel Self-Attention-Based Multi-Agent Reinforcement Learning With Stochastic Gradient Descent by Rabbiya Younas, Hafiz Muhammad Raza Ur Rehman, Ingyu Lee, Byung-Won On, Sungwon Yi, Gyu Sang Choi

“…However, these solutions presented challenges such as computational intensity and susceptibility to local minima. …”
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Fracture resistance of CAD/CAM milled versus direct hand-made interim laminate veneers by Salahaldeen Abuhammoud, Banan Emtier, Chin-Chuan Fu, Silvia Rojas-Rueda, Carlos A. Jurado, Kelvin I. Afrashtehfar

“…Background: Comparative studies of interim veneer restorations crafted using subtractive computer-aided manufacturing (s-CAM) milling technology and traditional direct hand-made approaches are needed. …”
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