Single cell transcriptomics in blood of patients with chronic obstructive pulmonary disease by Yeonjeong Heo, Jeeyoung Kim, Seok-Ho Hong, Woo Jin Kim

“…Single-cell RNA sequencing (scRNA-seq) provides gene expression profiles at the single-cell level. Hence, we evaluated gene expression in the peripheral blood of patients with COPD. …”
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Identification of two point mutations associated with inherited antithrombin deficiency by Shiue-Wei Lai, Chia-Yau Chang, Hwei-Jen Lee, Yeu-Chin Chen

“…The mutant AT models were evaluated via computational simulations. Results Among the 9 patients with inherited AT deficiency, 8 patients had type I AT deficiency, and one patient had type II AT deficiency with subtype of reactive site mutation. …”
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Coronary heart disease and ischemic stroke polygenic risk scores and atherosclerotic cardiovascular disease in a diverse, population-based cohort study. by Allison Bebo, Jamie A Jarmul, Mark J Pletcher, Natalie R Hasbani, David Couper, Vijay Nambi, Christie M Ballantyne, Myriam Fornage, Alanna C Morrison, Christy L Avery, Paul S de Vries

“…The predictive ability of coronary heart disease (CHD) and ischemic stroke (IS) polygenic risk scores (PRS) have been evaluated individually, but whether they predict the combined outcome of atherosclerotic cardiovascular disease (ASCVD) remains insufficiently researched. …”
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Chatbots in medicine: certification process and applied use case by Mayssam Nehme, Franck Schneider, Esther Amruthalingam, Elio Schnarrenberger, Raphaël Trëmeaud, Idris Guessous

“… Chatbots are computer programs designed to engage in natural language conversations in an easy and understandable way. …”
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Enhancing User Experience in Interactive Virtual Museums for Cultural Heritage Learning Through Extended Reality: The Case of Sanxingdui Bronzes by Xin Huang, Yuzhi Li, Feng Tian

“…We designed and implemented three types of IVMs: a personal computer-based virtual museum (PC-IVM), an augmented reality virtual museum (AR-IVM), and a mixed reality virtual museum (MR-IVM), and evaluates their impact on the museum educational experience. …”
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Cerebral Septic Emboli: A Unique Complication of Induced Myonecrosis by Lily Xu MPH, MD, Iyawnna Hazzard MS, Faith Sumandea MD, Yui Seo MD, Ardavan Afrasiabi MD

“…Therefore, preventative and diagnostic evaluations are imperative with a confirmed C. septicum infection. …”
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Molten Uranium Breeder Reactor (MUBR) and Its Development Steps [version 2; peer review: 2 approved] by Neal Mann, Mihai (Mike) G. M. Pop, Zeyun Wu

“…Methods A proprietary computer program uses parameters to generate MCNP (RSICC request/license 176034) or SCALE input files and initiate MCNP or SCALE burn simulations and other analysis. …”
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Effectiveness of Nurse-Led Intervention on Thirst Intensity and Dryness of Mouth among Postoperative Patients in Surgical Intensive Care Units by Jagadeswari Rajeshkumar, Theranirajan Ethiraj, Shankar Shanmugam Rajendran, Anandhi Duraikannu

“…This study aimed to evaluate the effectiveness of a nurse-led intervention in alleviating thirst intensity and dryness of mouth and examine the association with the selected demographic and clinical variables. …”
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Predictive instrument for rupture of intracranial aneurysms in patients from Sancti Spiritus, Cuba by Jorge Félix Companioni Rosildo, Gretel Mosquera Betancourt, Carlos Rafael Sebrango Rodríguez, Juan Carlos Lage Barroso

“…<br /><strong>Methods:</strong> a sample of 152 patients diagnosed by computed tomography angiography of ruptured (n=138) and unruptured (n=22) saccular intracranial aneurysms was included. …”
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Real-Time Telemedical Oversight Improves Prehospital Stroke Metrics: A Five-Year Cohort Study by Ponlawat Kanchayawong, Kasamon Aramvanitch, Chaiyaporn Yuksen, Satariya Trakulsrichai, Pungkava Sricharoen, Sureerat Suwatcharangkoon, Patcharaporn Sirintaranont, Jesada Keandoungchun, Promphet Nuanprom, Chetsadakon Jenpanitpong, Suthap Jaiboon

“…In March 2022, a structured prehospital stroke protocol was integrated with the ReTMO system in this hospital. We evaluated its impact by comparing stroke patients transported by emergency medical services (EMS) before and after protocol implementation. …”
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Interventional effects of modified constraint-induced movement therapy on upper limb function in patients who had a stroke: systematic review and meta-analysis by Cheng Wang, Jian Liu, Zizhuo Wang, Yunong Zhang

“…Objectives To systematically evaluate the intervention effect of modified constraint-induced movement therapy (m-CIMT) on upper limb function in patients who had a stroke.Design Systematic review and meta-analysis.Data sources A computer-based search was conducted in PubMed, Cochrane Library, Embase, Web of Science and China National Knowledge Infrastructure for randomised controlled trials (RCTs) on the intervention effect of m-CIMT on upper limb function in patients who had a stroke, with the search conducted up until 23 May 2024.Eligibility criteria We included only RCTs in which patients who had a stroke performed m-CIMT or m-CIMT in addition to the control group, and the outcome was upper limb function.Data extraction and synthesis Data extraction and synthesis used the reporting checklist for systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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MRI based paraspinal muscle mass predicts early cage subsidence after posterior lumbar interbody fusion by Zijian Yang, Jie Liang, Dawei Shi, Can Tuo, Yu Wu, Fan Zhang

“…Although quantitative computed tomography (QCT) offers improved accuracy, it can be compromised by calcified structures. …”
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A novel prognostic model utilizing TMTV and SUVmax from 18F-FDG PET/CT for predicting overall survival in patients with extranodal NK/T- cell lymphoma by Hua Wang, Demei Feng, Yiwen Mo, Huangming Hong, Yingying Hu, Li Huang, Xiaolei Wei, Yajun Li, Haibin Huang, Runhui Zheng, Yonghua Li, Hui Zeng, Robert Peter Gale, Tian Ying, Jing Guo, Zhenshu Xu, Wei Fan, Tongyu Lin

“…Abstract Background Survival prediction accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in extra-nodal natural killer/T-cell lymphoma (ENKTL) is controversial. …”
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First online field measurements of chlorothalonil volatilisation using proton transfer mass spectrometry and inverse modelling by Benjamin Loubet, Carole Bedos, Julien Kammer, Céline Decuq, Florence Lafouge, Baptiste Esnault, Raluca Ciuraru, Sandy Bsaibes, Pauline Buysse, Enrique Barriuso, Maria Raffaella Vuolo, Valérie Gros

“…The main finding of this study is that chlorothalonil volatilisation, computed by inverse dispersion modelling, was sustained for more than three weeks after application. …”
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The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles by Chaoming Hu, Yichi Zhang, Yao Wu, Junhao Tu, Mengjia Yi, Yixin Mao, Yixin Mao, Yang Chen, Yang Chen, Xiaoyu Sun, Xiaoyu Sun, Zengqiang Song, Shengbin Huang, Shengbin Huang, Shufan Zhao, Shufan Zhao, Bin Li

“…Femoral bone structure was assessed by micro-computed tomography (micro-CT), osteoclast numbers were quantified, gut microbial composition was analyzed via 16S rRNA sequencing, and fecal metabolites were profiled using LC-MS/MS.Results4aa concentrations below 20 μM were non-cytotoxic to MC3T3-E1 and RAW264.7 cells. …”
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Iceball growth 3D simulation model based on finite element method for hepatic cryoablation planning by Shengwei Li, Yumeng Zhang, Fanyu Zhou, Sheng Xu, Yufeng Wang, Lin Cheng, Zhixin Bie, Bin Li, Xiao-Guang Li

“…The simulated results for three cryoprobe types were evaluated in the ex vivo porcine livers and clinical data. …”
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Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging by Marco Iannone, Marcelo Kravicz, Paolo Rainone, Paolo Rainone, Paolo Rainone, Antonia I. Antoniou, Stefano Stucchi, Stefano Stucchi, Silvia Valtorta, Silvia Valtorta, Silvia Valtorta, Silvia Valtorta, Arianna Amenta, Elia Anna Turolla, Elia Anna Turolla, Sara Pellegrino, Sara Pellegrino, Daniele Passarella, Elisa Vino, Sergio Todde, Sergio Todde, Sergio Todde, Francesca Re, Francesca Re, Pierfausto Seneci, Rosa Maria Moresco, Rosa Maria Moresco, Rosa Maria Moresco, Rosa Maria Moresco

“…The in vivo uptake of these liposomes is evaluated in an orthotopic glioma mouse model (Gli36ΔEGFR cell line) using PET/computed tomography (CT).Results and discussionThe results demonstrate a higher tumor/background ratio, a faster clearance rate, and a lower uptake in healthy brain tissue and peripheral regions for mApoE- and MSLP-functionalized liposomes than for non-functionalized liposomes, prompting further characterization. …”
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Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning by Yude Hong, Xiao Hu, Libo Chen, Mingyong Li, Mingxiao Zhang, Weiming Deng

“…Various methods were used to evaluate immune cell infiltration and biological characteristics. …”
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Shaping ability and apical debris extrusion after root canal preparation with rotary or reciprocating instruments: a micro-CT study by Emmanuel João Nogueira Leal da Silva, Sara Gomes de Moura, Carolina Oliveira de Lima, Ana Flávia Almeida Barbosa, Waleska Florentino Misael, Mariane Floriano Lopes Santos Lacerda, Luciana Moura Sassone

“…ObjectivesThe aim of this study was to evaluate the shaping ability of the TruShape and Reciproc Blue systems and the apical extrusion of debris after root canal instrumentation. …”
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Optimising ensemble streamflow predictions with bias correction and data assimilation techniques by M. Tanguy, M. Tanguy, M. Eastman, M. Eastman, A. Chevuturi, E. Magee, E. Cooper, R. H. B. Johnson, K. Facer-Childs, J. Hannaford, J. Hannaford

“…<p>This study evaluates the efficacy of bias correction (BC) and data assimilation (DA) techniques in refining hydrological model predictions. …”
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