Effect of ERAS-based sputum drainage nursing model on improving postoperative pulmonary function recovery in elderly patients with aneurysmal subarachnoid hemorrhage (基于ERAS模式的排痰护理... by CAO Shuonan (曹硕楠), YUAN Qiaoling (袁巧玲), LIU Ranran (刘冉冉)

“…Objective　Methods 120 elderly patients suffering from aneurysmal subarachnoid hemorrhage and receiving craniotomy from June 2019 to June 2021 were enrolled. …”
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Sex-Specific Associations Between Oral Function Impairment and Clinical Outcomes in Hospitalized Older Adults: A Retrospective Observational Study by Lee YY, Weng SC, Lee YS, Chou YY, Kuo FH, Yang SH, Yeh YH, Chu WM, Hsu CY, Lin SY, Lin CF

“…Notably, sex disparities in oral health on clinical outcomes remain an often underappreciated aspect.This study aims to investigate the association between oral function, assessed using the bedside oral examination (BOE), and in-hospital mortality, with an emphasis on sex-specific differences.Patients and Methods: A retrospective cohort study was conducted involving 1,141 patients aged 65 years and older who were admitted to a medical center in Taiwan between 2018 and 2023. …”
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Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial by Li L, Xia M, Chen X, Wang F, Li J, Zhao N, Liu Z, Chen Y

“…This highlights the urgent need for effective and safe therapeutic approaches that can target both nocturnal and daytime symptoms.Objective: To evaluate the clinical efficacy and safety of acupuncture in improving sleep quality and daytime functioning in patients with chronic insomnia, and to optimize its treatment protocol.Methods: This study was a single-blind, randomised, controlled trial. …”
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Inflammatory and Nutritional Biomarker in Different Subtypes of Early Stage Diffuse Large B-Cell Lymphoma: Towards a Diagnostic Model by Oehadian A, Gunadi SV, Mersiana L, Susandi E, Wijaya I, Martha JW, Supriyadi R, Prihatni D

“…Hasan Sadikin General Hospital, Bandung, Indonesia*These authors contributed equally to this workCorrespondence: Delita Prihatni, Department of Clinical Pathology, Padjadjaran University/ Dr. …”
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mHealth Social Support Versus Standard Support for Diabetes Management in Safety-Net Emergency Department Patients: Randomized Phase-III Trial by Elizabeth Burner, Danielle Hazime, Michael Menchine, Wendy Mack, Janisse Mercado, Adriana Aleman, Antonio Hernandez Saenz, Sanjay Arora, Shinyi Wu

“… BackgroundMobile health (mHealth) is a low-cost method to improve health for patients with diabetes seeking care in safety-net emergency departments, resulting in improved medication adherence and self-management. …”
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Evaluation of the Curative Effect of Umbilical Cord Mesenchymal Stem Cell Therapy for Knee Arthritis in Dogs Using Imaging Technology by Bei-ying Zhang, Bing-yun Wang, Shao-chuan Li, Dong-zhang Luo, Xiaoshu Zhan, Sheng-feng Chen, Zhi-sheng Chen, Can-ying Liu, Hui-qin Ji, Yin-shan Bai, Dong-sheng Li, Yang He

“…The aim of this study was to assess the efficacy of canine umbilical cord mesenchymal stem cells (UC-MSCs) on the treatment of knee osteoarthritis in dogs. Methods. Eight dogs were evenly assigned to two groups. …”
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Subfoveal Choroidal Thickness After Successful Retinal Detachment Repair with Persistent Subretinal Fluid at the Macula by Mansour AM, Parodi MB, Uwaydat SH, Lima LH, Charbaji S, Casella AM, López-Guajardo L, Belotto S, Wu L, Schwartz SG, Smiddy WE, Hassoun MM, Pérez-Salvador García E, Mansour HA, Elnahry AG, Hamam RN

“…Ahmad M Mansour,1,2,* Maurizio Battaglia Parodi,3,* Sami H Uwaydat,4 Luiz H Lima,5 Suzanne Charbaji,6 Antonio Marcelo Casella,7 Lorenzo López-Guajardo,8 Silvana Belotto,9 Lihteh Wu,10 Stephen G Schwartz,11 William E Smiddy,11 Mahdi M Hassoun,1 Eduardo Pérez-Salvador García,12 Hana A Mansour,13 Ayman G Elnahry,14,15 Rola N Hamam1 1Department of Ophthalmology, American University of Beirut, Beirut, Lebanon; 2Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon; 3Department of Ophthalmology, University Vita-Salute Milan, Milan, Italy; 4Jones Eye Institute, University of Arkansas Medical School, Little Rock, Arkansas, USA; 5Department of Ophthalmology and Visual Sciences, Federal University of Sao Paulo, Sao Paulo, Brazil; 6Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon; 7Department of Ophthalmology, Londrina State University, Londrina, Paraná, Brazil; 8Department of Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain; 9Institut Català de Retina, Barcelona, Spain; 10Asociados de Macula Vitreo y Retina de Costa Rica, San José, Costa Rica; 11Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA; 12Servicio de Oftalmología del Hospital Universitario de Burgos, Burgos, Spain; 13Wills Eye Hospital, Thomas Jefferson Medical Center, Philadelphia, Pennsylvania, USA; 14Department of Ophthalmology, Kasr Al-Ainy Hospitals, Cairo University, Cairo, Egypt; 15BayCare Clinic Eye Specialists, Greenbay, Wisconsin, USA*These authors contributed equally to this workCorrespondence: Ahmad M Mansour, Department of Ophthalmology, American University of Beirut, Beirut, Lebanon, Tel +9613377633, Email ammansourmd@gmail.comObjective: To explore the relationship between subfoveal choroidal thickness (SFCT) and persistent subretinal fluid (pSRF) at the macula after successful rhegmatogenous retinal detachment (RRD) surgery.Methods: This is a retrospective multicenter comparative study of Caucasian subjects with successful RRD repair. …”
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Exploring the Mechanism of Lianqiao Jinbei Decoction Inhibiting HER2-Positive Breast Cancer Based on Network Pharmacology and Experimental Verification by Li D, Liu X, Fan H, Dong J, Wei L, Guo N, Wang Z, Du Z, Liu J, Zhao X, Tian X, Han C, Yao X

“…Dehui Li,1,* Xukuo Liu,2,* Huanfang Fan,3 Jingfei Dong,4 Liying Wei,3 Na Guo,3 Zhengrong Wang,3 Zhihua Du,3 Jiao Liu,2 Xiaohui Zhao,2 Xiaotong Tian,2 Changhui Han,3 Xujiong Yao5 1Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang, Hebei Province, People’s Republic of China; 2Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 3Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 4Department of Medical Laboratory, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 5Department of Pathology, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dehui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, 389 Zhongshan East Road, Shijiazhuang, Hebei Province, 050000, People’s Republic of China, Email 258289951@qq.comPurpose: Through network pharmacological prediction and in vitro experimental verification, the mechanism of action of Lianqiao Jinbei Decoction (LJD) in inhibiting HER2-positive breast cancer cells was clarified, providing experimental evidence for its treatment of HER2-positive breast cancer.Methods: Network pharmacology method was used to construct the potential target network of LJD in the treatment of HER2+ breast cancer. …”
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Quality of Care and Outcomes of Inpatients with COPD: A Multi-Center Study in China by Wang F, Wang M, Chen X, Song A, Zeng H, Chen J, Wang L, Jiang W, Jiang M, Shi W, Li Y, Zhong H, Chen R, Liang Z

“…This study aimed to evaluate the quality of care and outcomes among inpatients with COPD and to identify prognostic factors relate to healthcare quality indicators.Methods: A multi-center, retrospective longitudinal study was conducted. …”
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The effect of a complex of melatonin, aluminum oxide and polymethylsiloxane on the cellular composition of the mice spleen kept in round-the-clock lighting conditions by A. V. Shurlygina, S. V. Michurina, L. N. Rachkovskaya, A. E. Serykh, S. M. Miroshnichenko, E. E. Rachkovsky, M. A. Korolev, A. Yu. Letyagin

“…The administration of pure and modified melatonin (Complex M) to animals kept under round-the-clock lighting conditions has an equally pronounced normalizing effect on the cellular composition of B- (CD19) and T- (CD3) lymphocytes of the spleen, bringing the values of the studied parameters to the control values of the intact animals (p ≤ 0.001) Round-the-clock lighting affects the proliferative potential of splenocytes, reducing the number of cells in the G2/M phase, compared with animals treated with melatonin (p ≤ 0.050). …”
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Proteomic Characterization of Extracellular Vesicles from Human Neural Precursor Cells: A Promising Advanced Therapy for Neurodegenerative Diseases by Stricker PEF, de Oliveira NB, Mogharbel BF, Irioda AC, da Rosa NN, Lührs L, Saçaki CS, Munhoz da Rocha I, Alves LR, Poubel SB, Cardoso da Silva J, Carvalho PC, Fischer JSG, de Carvalho KAT

“…One such component released is extracellular vesicles containing proteins and genetic materials with immunomodulatory functions and facilitating cell-to-cell communication.Purpose: The study’s main objective was to characterize extracellular vesicles (EVs) from Human Neural Precursor Cells (hNPCs).Methods: Wharton’s Jelly mesenchymal stem cells (WJ-MSCs) were isolated by explant technique and characterized by flow cytometry and trilineage differentiation. …”
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KRT23 as a Potential Target for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): Evidence From Bioinformatics Analysis, Human Gene Polymorphism and Animal Experiments by Hao Y, Zhang T, Tuerxunmaimaiti S, Tian Y, Wang X, Li Z, Zhao L, Bai L, Chen Q, Li C, Abulitipu A, Wang R, Jiang S, Du G

“…Keratin 23 (KRT23), a liver-enriched protein linked to metabolic regulation, remains understudied in MAFLD genetics.Objective: To investigate associations between KRT23 gene polymorphisms, expression, and MAFLD in Xinjiang.Methods: This study enrolled 1,795 MAFLD patients diagnosed via ultrasonography and metabolic criteria. …”
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A Cross-Sectional Evaluation of Opioid Dispensing Competencies in Final-Year Pharm-D Students: A Multicenter Study from Punjab, Pakistan by Mubarak N, Rahman Rana F, Zahid T, Ijaz UEB, Shabbir A, Ghulam Bari A, Niaz B, Kanwal S, Saif-Ur-Rahman N, Iqbal Z, Khan AM, Zin CS, Mahmood K, Elnaem MH, Tariq S

“…Opioid dispensing competencies are critical for pharmacy graduates to promote the rational use of opioids.Purpose: To evaluate the opioids dispensing competencies among the final year Pharm-D students in Punjab, Pakistan.Design: A multicenter cross-sectional study.Methods: A validated survey was used to evaluate 11 competencies related to opioid use from the final year Pharm-D students from diversely located accredited institutes. …”
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Characteristics of positive and negative effects on the quality of life of breast cancer patients by Jin Zhao, De-Shuang Yang, Yi-Qi Liu, Yan-Kun Wu, Chao Chen, Ji-Tao Li, Ren-Gang Wu

“…In the rehabilitation phase, the highest proportion of patients had PA greater than or equal to the NA (PA ≥ NA). The relationship between PA and QoL was an inverted U-shaped curve (P < 0.05), whereas the relationship between NA and QoL was a positive U-shaped curve (P < 0.05). …”
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Scopoletin and Scoparone from Viola philippica Attenuate the Virulence of Pseudomonas aeruginosa by Inhibiting Quorum Sensing-Related Genes by Luo Y, Zhang S, Ou S, Shen C, Xiao Q, Chen W, Pu J, Zeng J, Zheng D, Huang B, Chen C

“…We aimed to reveal the effects of scopoletin and scoparone from V. philippica Cav. extract (VPE) on QS-related virulence phenotypes and genes in P. aeruginosa PAO1.Materials and Methods: Compounds in VPE were identified using ultrahigh-performance liquid chromatography coupled with Q-exactive hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q Exactive-Orbitrap MS). …”
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Prediction of methylphenidate treatment response for ADHD using conventional and radiomics T1 and DTI features: Secondary analysis of a randomized clinical trial by Mingshi Chen, Zarah van der Pal, Maarten G. Poirot, Anouk Schrantee, Marco Bottelier, Sandra J.J. Kooij, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan

“…Methods: We performed a secondary analysis of a randomized clinical trial (ePOD-MPH), involving 47 stimulant-naive ADHD participants (23 boys aged 11.4 ± 0.4 years, 24 men aged 28.1 ± 4.3 years) who underwent 16 weeks of treatment with MPH. …”
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Advanced Characterization of Vitreous Hyperreflective Dots via OCT-Derived Metrics: A Cross-Sectional Study by William Rojas-Carabali, Jinghan Lin, Paola Saboya-Galindo, Eunice Jin Hui Goh, Joewee Boon, Carlos Cifuentes-González, Rupesh Agrawal

“…Abstract Introduction The use of optical coherence tomography (OCT) as a potential tool for the measurement of vitreous inflammation has been previously described as a more objective and reproducible method when compared to historically known subjective scales. …”
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M-CSF Protects Against Ulcerative Colitis via Aconitate: Mendelian Randomization and Experimental Evidence by Zhang Y, Huang L, Yue N, Mai Z, Kong C, Tian C, Wei DR, Yao J, Wang L, Li D

“…Yuan Zhang,1,2,&amp;ast; Longbin Huang,3,&amp;ast; Ningning Yue,3,&amp;ast; Zhiliang Mai,3,&amp;ast; Chen Kong,3 Chengmei Tian,4 Dao-ru Wei,5 Jun Yao,1 Lisheng Wang,1 Defeng Li1 1Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 2Department of Medical Administration, Huizhou Institute for Occupational Health, Huizhou, Guangdong, People’s Republic of China; 3Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, People’s Republic of China; 4Department of Emergency, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 5Department of Rehabilitation, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Lisheng Wang, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Luohu District, Shenzhen, 518020, People’s Republic of China, Tel +86 755 25533018, Email wanglsszrmyy@163.com Defeng Li, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Luohu District, Shenzhen, 518020, People’s Republic of China, Tel +86 755 25533018, Email ldf830712@163.comBackground: Although cytokines have been implicated in the development of ulcerative colitis (UC), the potential mediating role of metabolite levels in this association remains unclear.Methods: Utilizing data from genome-wide association studies (GWAS) encompassing 91 circulating cytokines, 1400 blood metabolites, and 178,689 UC cases, we performed a two-sample Mendelian randomization (MR) analysis to investigate the effect of metabolites mediated cytokines on the development of UC. …”
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Association of Admission HbA1c Levels and Clinical Outcomes in Patients with Large Vessel Occlusion Following Endovascular Treatment: A Secondary Analysis of RESCUE BT Trial by Gao F, Tan X, Li L, Zhou C, Guo C, Yang J, Liu G, Wang L, Shi X, Yang S, Ma J, Xu X, Yang D, Sun W, Yu N, Fan S, Xu R, Song J, Zi W, Shang Z

“…Fei Gao,1,&amp;ast; Xiaolin Tan,2,&amp;ast; Linyu Li,1,3,&amp;ast; Chao Zhou,4 Changwei Guo,1 Jie Yang,1 Guojian Liu,1 Lilan Wang,1 Xiaolei Shi,1 Shihai Yang,1 Jinfu Ma,1 Xu Xu,1 Dahong Yang,1 Wenzhe Sun,1 Nizhen Yu,1 Shitao Fan,1 Rui Xu,1 Jiaxing Song,3 Wenjie Zi,1 Zhenying Shang5 1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 2Department of Neurology, Meishan Second People’s Hospital, Sichuan, People’s Republic of China; 3Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 4Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Jiangsu, People’s Republic of China; 5Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Wenjie Zi, Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), No. 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, People’s Republic of China, Email ziwenjie1981@163.com Zhenying Shang, Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, 221002, People’s Republic of China, Email drshang01@163.comBackground: This study aimed to analyze the association of HbA1c levels and outcomes in patients with large vessel occlusion (LVO) undergoing endovascular treatment (EVT).Methods: Patients with recorded HbA1c values were enrolled from The Endovascular Treatment With vs Without Tirofiban for Patients with Large Vessel Occlusion Stroke (RESCUE BT) trial. …”
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Genomic and Transcriptomic Profiles in Smokers and Never-Smokers Lung Squamous Cell Carcinoma Patients by Canale M, Virga A, Angeli D, Fonzi E, Gnetti L, Dubini A, Tedaldi G, Urbini M, Bocchialini G, Petracci E, Verlicchi A, Cravero P, Citarella F, Bennati C, Andrikou K, Delmonte A, Crinò L, Carbognani P, Ulivi P, Ampollini L

“…Molecular profiling of SCC in never-smokers could unveil tumor vulnerabilities and new treatment strategies.Patients and Methods: We considered a patient cohort of 17 former or current smokers (51.5%) and 16 never-smoker SCC patients (48.5%). …”
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