Getting Up in the Morning and Chronotype in Relation to Polycystic Ovarian Syndrome: A Mendelian Randomization and Cross-Sectional Study by Dilimulati D, Lu J, Li J, Cai M, Zhang Y, Shao X, Chen H, Wan Q, He F, Yue C, Zhang M, Qu S

“…Diliqingna Dilimulati,1,* Jiayi Lu,2,* Jinghua Li,2,* Meili Cai,1 Yuqin Zhang,1 Xiaowen Shao,3 Haibing Chen,1 Qian Wan,4 Fang He,4 Chaoyan Yue,5 Manna Zhang,1,6 Shen Qu1 1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 3Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 4Department of Endocrinology and Metabolism, The First People’s Hospital of Chenzhou, Chenzhou, Hunan, 423000, People’s Republic of China; 5Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, People’s Republic of China; 6Department of General Practice, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China*These authors contributed equally to this workCorrespondence: Manna Zhang, Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, No. 301, Middle Yanchang Road, Jingan District, Shanghai, 200072, People’s Republic of China, Tel +86 13774448495, Email mannazhang@126.com Chaoyan Yue, Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Huangpu District, Shanghai, 200011, People’s Republic of China, Tel +86 02133189900, Email 20111250007@fudan.edu.cnBackground: Although a connection between circadian rhythm and polycystic ovarian syndrome (PCOS) has been shown in previous studies, the exact cause of this association is not well understood.Purpose: This study aimed to use Mendelian randomization (MR) method to analyze the potential association between getting up in the morning and chronotype with PCOS, and a cross-sectional study was conducted to further validate these results.Methods: Using summary information from large-scale genome-wide association studies (GWASs) in people of European ancestry, we conducted univariable MR (UVMR) and multivariable MR (MVMR) analyses to examine the causal effect of genetically determined getting up in the morning and chronotype on PCOS. …”
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Follow-Up in Primary Care After Ischemic Stroke – Insights From the Nor-COAST Study by Sande IS, Helgheim KL, Saltvedt I, Røsstad TG, Spigset O, Ellekjær H, Gynnild MN

“…Olavs Hospital, Trondheim, Norway*These authors contributed equally to this workCorrespondence: Mari Nordbø Gynnild, Clinic of Cardiology, St. …”
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A Network Pharmacology-Based Investigation into the Mechanism of Quercetin Combined with Rosuvastatin in Delaying Diabetic Nephropathy via Inhibiting NRK-52E Cell Ferroptosis by Gan M, Lin Z, Ma J, Li N, Wu B

“…This study aimed to investigate the potential synergistic effects of quercetin (QCT) and rosuvastatin (RSV) on inhibiting RTEC ferroptosis and ameliorating DN progression, providing a novel combinatorial therapeutic strategy.Methods: Public database data were analyzed using network pharmacology to identify QCT-DN-related and RSV-DN-related targets, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. …”
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A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol by Yang Y, Liu L, Yuan L, Liu X, Ding H, Zhou X, Cao Q

“…This trial aims to evaluate the efficacy and safety of electroacupuncture in patients with LDHR.Methods: This randomized, single-blind, sham-controlled trial will enroll 170 participants diagnosed with LDHR and who present Numerical Rating Scale (NRS) scores ≥ 4 for both lower back and leg pain. …”
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Association of <i>SEPT9</i> Gene Methylation with the Clinicopathologic Features and <i>Fusobacterium nucleatum</i> Infection in Colorectal Cancer Patients by Siew-Wai Pang, Subasri Armon, Jack-Bee Chook, Kaik-Boo Peh, Suat-Cheng Peh, Sin-Yeang Teow

“…For FN detection, a TaqMan probe-based method targeting the 16S rRNA gene was used. The differences in <i>mSEPT9</i> levels and FN expression between cancer and non-cancer tissues were evaluated. …”
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Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun) by Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z

“…MicroRNA-139-5p participates in various biological processes, including cancer and vascular endothelial injury, while its role in diabetic wound healing has not been reported.Methods: Sprague-Dawley (SD) rats were intraperitoneally injected with streptozotocin and a 1.0 cm full-layer dorsal skin wound was made to establish a diabetic wound model. …”
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A Survey of Physicians and Patients in Pakistan Assessing the Improvement of Visualization of the Cervix, Ease of Use, and Patient Comfort Using a Newly Designed Vaginal Speculum:... by Khan S, Waters-Kellar L, Barsh E, Shannon A, Clark S, Ryznar RJ, Trawick A, Payton M, Bouquet J

“…This study aimed to evaluate three of these limitations (visualization of the cervix, ease of use, and relative comfort) using a newly designed vaginal speculum that was hypothesized to overcome these limitations.Methods: This pilot prospective observational clinical study was conducted at five hospitals in Karachi, Pakistan. …”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…Impact: Registered nurses, health professionals, inpatients. Reporting Method: STROBE checklist for cross‐sectional studies. …”
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Increased CD163+ Macrophage Activation and High Expression of CD163 Promote Granulosa Cell Apoptosis in Polycystic Ovary Syndrome by Ye J, Wang S, Wang Z, Jiang Y, Jia J, Yang Y, Huo L, Liu X, Zhou Y, Yang Z, Mao J, Ma Y, Wang X

“…However, the precise mechanisms by which inflammation influences granulosa cell function remain poorly understood.Methods: Differentially expressed genes (DEGs) were identified from the GSE34526 dataset, with the inflammatory marker CD163 selected for further investigation due to its upregulation in ovarian granulosa cells in PCOS. …”
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Incidence of malignant brain and other central nervous system tumors (С70–C72) in Siberia and the Russian Far East by L. D. Zhuikova, E. L. Choynzonov, O. A. Ananina, L. V. Pikalova, I. N. Odintsova, G. A. Kononova

“…In females, brain and other central nervous system malignances were the 16th most common cancers, with the equal incidence of 1.3 % in 2010 and 2020. Overall, the incidence rate of malignant brain and other central nervous system tumors in Siberian and the Russian Far Eastern regions increased from 5.1 to 5.6 per 100 000 with rate of increase of 9.8 %, including the territories of the Republic of Kamchatka (238.5 %), Amur (147.8 %), Khakassia (89.1 %), Irkutsk (65,1 %), Krasnoyarsk (37.8 %), and Primorsky (33.3 %) regions. …”
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Jacmel, entre rêve et réalité by Jean Davoigneau, Isabelle Duhau

“…The local commercial bourgeoisie rebuilt their houses and warehouses using imported construction methods and materials. The Bord de Mer neighbourhood, the seaside neighbourhood, acquired a new appearance with structures in brick, in moulded cast iron, in riveted steel and in wrought iron. …”
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Respiratory bacterial and viral pathogen spectrum among influenza-positive and influenza-negative patients by Jing Shi, Shi Han, Yating Zhang, Xiaohua Lu, Yunxia Gan, Narenqimuge Tong, Lu Ma, Hang Zhuan, Ying Dai, Yaqi Ji, Guoming Li, Dan Chen, Lu Yang

“…The gender distribution among the influenza-positive and influenza-negative patients was approximately equal with males slightly outnumbering females. The age range of the participants varied from one month to 97 years old. …”
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The Impact of Microwave Ablation on Recurrence and Metastasis of Hepatocellular Carcinoma: Insights From Animal Studies and Cytokine Profiling by Wang Y, Tan H, Wen C, Chen S, Zheng G, Qi H, Xie L, Shen L, Cao F, Fan W

“…The role of cytokine alterations in this post-ablation inflammatory microenvironment is crucial for understanding how MWA impacts tumor behavior.Purpose: This study aims to investigate the impact of post-ablation inflammatory responses on HCC recurrence and metastasis through animal experiments and cytokine profiling, with the goal of identifying potential biomarkers or therapeutic targets.Materials and Methods: This study involved 35 male C57BL/6 mice (6– 8 weeks old) to establish metastatic and orthotopic cancer models. …”
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Functional Brain Activity Alterations in Type 1 Narcolepsy Patients with Anxiety and Depression: A 7-Tesla Resting State-Functional Magnetic Resonance Imaging Study by Chen Y, Ye J, Chen J, Zhen Z, Tang C, Ren S, Han Q, Gao D

“…Yang Chen,1,2,&amp;ast; Jingyi Ye,3,&amp;ast; Jiafei Chen,4 Zhiming Zhen,4 Chenglin Tang,2 Shuancheng Ren,5 Qi Han,4 Dong Gao3 1College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 2College of Acupuncture and Tuina, Chongqing College of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Department of Sleep and Psychology, Chongqing University Affiliated Renji Hospital, the Fifth People’s Hospital of Chongqing, Chongqing, People’s Republic of China; 4 7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China; 5Department of Physiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Dong Gao, Email gaodong1973@163.com Qi Han, Email hanqi1227@tmmu.edu.cnPurpose: This study aimed to investigate abnormal changes in brain region functional activity in type 1 narcolepsy (NT1) patients comorbid with anxiety and depression.Methods: Twenty NT1 patients and 20 healthy controls (HCs) underwent subjective/objective sleep assessments (polysomnography, SAS, SDS) and 7T rs-fMRI to analyze regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF).Results: Compared with the HCs group, NT1 patients had higher SAS and SDS scores. …”
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Identifying and prioritizing the Factors Affecting Drug Addiction to Drug Addiction Centers in Sistan and Baluchistan Province by Ali Reza Moradi, Hadi Nouri

“…It has been made and referred to the documents. The sampling method, and the sampling method, were also targeted clusters. …”
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Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway by CAO Ya, LIU Yang, WANG Yang

“…Fourteen female nude mice (4~6 weeks old, weighing 18~20 g) were randomly and equally divided into 2 groups of subcutaneous xenograft models: the control group (OSCs suspension) and the experimental group (OSCs+HUVEC-T1 mixed suspension). …”
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SERUM LncRNA SNHG16: A Biomarker for Diagnosing Childhood Obesity and Predicting Its Progression to Metabolic Syndrome by Hu J, Zheng Z, Liang D, Zhang Y, Chen J, Zhou C, You C, Liu Q

“…This study explores the expression and clinical significance of long non-coding RNA SNHG16 (SNHG16) in childhood obesity and its complications with MS (obesity-MS).Patients and Methods: Healthy controls and obese children (categorized as those with simple obesity or obesity-MS) were enrolled. …”
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Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy by Geng X, Pu Y, Hu Z, Zhang H, Wang M, Fang C, Lv G, Li W, Zhang X, Fan X, Liu S, Chen X, Wu J

“…We investigated the effects of intraoperative esketamine combined with intravenous dexmedetomidine on the incidence of POSD and postoperative sleep architecture.Methods: A single-center, randomized, double-blind controlled trial was conducted. …”
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Insight into Antiviral Activity of Ag/TiO2 Nanocomposites Against Influenza H1N1 Virus and Its Antiviral Mechanism by Ma Y, Xiao X, Wang Y, Sun J, Tang P, Li J, Sun X, Xu D, Yang Z, Chen S, Liu X

“…Yihe Ma,1– 3,&ast; Xiaojun Xiao,2,&ast; Yutao Wang,3,&ast; Jie Sun,4 Ping Tang,5 Jing Li,3 Xizhuo Sun,5 Damo Xu,1,2 Zifeng Yang,3 Shiguo Chen,4 Xiaoyu Liu2 1Department of Respiratory and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China; 3State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Nanshan District Key Laboratory for Biopolymers and Safety Evaluation, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, People’s Republic of China; 5Department of General Practice, Third Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaoyu Liu, State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China, Email lxy0901@szu.edu.cnPurpose: Synthesis and characterization of silver (Ag)/titanium dioxide (TiO2) nanocomposite (ATA) to investigate its antiviral activity against the H1N1 influenza virus and antiviral mechanisms.Materials and Methods: A water-dispersible ATA was prepared by a photocatalytic reduction process from AgNO3 and TiO2. …”
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Impact of Plasmapheresis on the Time Course of Changes in Cytokines After Operations on the Heart and Great Vessels by A. A. Yeremenko, A. A. Ragimov, S. A. Poreshina, M. A. Babayev, L. I. Vinnitsky, I. N. Solovyeva

“…To assess the impact of plasmapheresis on the time course of changes in pro- and anti-inflammatory interleukins and the results of treatment in patients after complicated operations on the heart and great vessels.Material and methods. 44 patients were examined. In 33 patients, the intra- and postoperative period was complicated by a prolonged extracorporeal circulation (EC), massive blood loss, acute hemolysis, the development of disseminated intravascular coagulation. …”
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