The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation by Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X

“…This study aimed to investigate the possible effects of M-Exos on the initiation and development of urethral fibrosis and stricture after injury, and to elucidate the underlying mechanisms.Methods: In this study, we used time-tracking immunofluorescence staining for M1 and M2 macrophage markers to characterize sequential properties in the site of injured urethra. …”
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Challenges to creating primary care teams in a public sector health centre: a co-operative inquiry by Bob Mash, Pat Mayers, Hoffie Conradie, Abraham Orayn, Marjan Kuiper, Joey Marais, Bennie Cornelissen, Shaamelah Titus

“…The teams depended on effective collaboration between the doctors and the CNPs. Methods: A co-operative inquiry group, consisting of two facility managers, an administrator, and medical and nursing staff, met over a period of nine months and completed three cycles of planning, action, observation and reflection. …”
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Association Between Systemic Immune-Inflammation Index in Early Pregnancy and Preeclampsia: A Multicenter Cohort Study by Li Q, Li M, Zhao C, Chen X, Zhang C, Li Y, Chen Y, Yue C

“…The development of preeclampsia (PE) may be attributed to an excessive systemic inflammatory response in pregnant women, however, the relationship between SII and PE remains unclear.Methods: This study included 47,480 singleton pregnant women from three hospitals, comprising 2489 PE patients and 34,835 healthy controls. …”
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Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled... by Juliet Nabbuye Sekandi, Esther Buregyeya, Sarah Zalwango, Damalie Nakkonde, Patrick Kaggwa, Trang Ho Thu Quach, David Asiimwe, Lynn Atuyambe, Kevin Dobbin

“… BackgroundDirectly observed therapy (DOT) is the standard method for monitoring adherence to tuberculosis (TB) treatment. …”
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Heart Rate Variability in Young Adults with Bronchial Asthma with and without Previous COVID-19 Infection: A Cross-sectional Study by Gunaseelan Deivendran, Thamarai Selvi Kanagaraj, Bhavisha Sreenivasan Leelabai, Nalini Jayanthi, Saravanan Ayyavoo

“…Aim: To compare HRV parameters between young adult bronchial asthma patients with and without a history of COVID-19, and assess the extent of autonomic dysfunction attributable to COVID-19. Materials and Methods: This cross-sectional study included 100 bronchial asthma patients aged 20-40 years, equally divided into two groups based on COVID-19 history. …”
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Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer by Liu Y, Li B, Ke L, Luo T, Wu H, Lin J, Deng Y, Huang X, Xu L, Liu Y, Qi J

“…However, no comprehensive study has explored its expression and regulation, discussed its role in tumor prognosis and immune modulation, along with therapy response in pan-cancer until now.Methods: SAPCD2 expression was analyzed using data from The Cancer Genome Atlas database (TCGA) and Human Protein Atlas (HPA) database. …”
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Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study by Zhang HF, Chen JW, Li SS, Wu SW, Li S, Liu CY, Cai C, Lu MQ

“…This study aimed to investigate the clinical characteristics of patients with blood culture-positive KPLA and identify potential predictive indicators.Methods: We performed a retrospective analysis of clinical data from 263 KPLA patients diagnosed at our hospital between January 2019 and December 2023. …”
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Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury by Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

“…This study aimed to investigate the effects of ionizing radiation on human esophageal epithelial cells and explore the role of the ceRNA network in this injury.Methods: Cellular phenotype experiments assessed the effects of ionizing radiation on human esophageal epithelial cells. …”
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Anatomical and morphological features of the heart of a domestic dog (Canis Lupus Familiaris L., 1758) by M. R. Ragulya, L. P. Goralskyi, I. M. Sokulskyi, N. L. Kolesnik, B. V. Gutyj

“…At the same time, the nuclear-cytoplasmic ratio of cardiomyocytes of the left ventricle is equal to 0.0224±0.0076, cardiomyocytes of the right ventricle are more important – 0.0275 ± 0.0081, and cardiomyocytes of the atria are the most important – 0.0367 ± 0.0105. …”
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Biospeckle Optical Coherence Tomography in Visualizing the Heat Response of Skin: Age-Related Differences by Ryosuke Nakasako, Jun Yamada, Takahiro Kono, Hirofumi Kadono, Uma Maheswari Rajagopalan

“…Currently, research related to the visualization of cutaneous vascular changes to heat stress depending on age and gender is limited to methods such as laser Doppler flowmetry and plethysmography, which do not provide any spatially resolved information at high resolution. …”
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Effects of Prophylactic Infusion of Equivalent Doses of Norepinephrine and Phenylephrine in Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery on Fetal and M... by Mao J, Lin K, Liu X, Liu J, Liang G, Sheng Z

“…We aimed to compare the effects of norepinephrine and phenylephrine at equivalent doses on fetal and maternal outcomes, and assess their efficacy at the 90% effective dose (ED90).Methods: A total of 100 parturients scheduled for cesarean delivery were randomly allocated to receive either 0.10 μg/kg/min norepinephrine (Group NE) or 0.60 μg/kg/min phenylephrine (Group PE) to prevent spinal anesthesia-induced hypotension. …”
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A Nomogram Based on Fibrinogen-to-Neutrophil Ratio as a Novel Predictor of Lymph Node Metastasis in Patients with Cervical Cancer and Type 2 Diabetes Mellitus by Kuang H, Yang D, Lin R, Tang Y, Luo Y, Wang S, Xia T, Lou G, Chen H

“…In this regard, we propose the fibrinogen-to-neutrophil ratio (FNR) as an innovative and promising biomarker for evaluating pelvic lymph node metastasis in cervical cancer patients with type 2 diabetes.Methods: The study was conducted on 141 patients diagnosed with cervical cancer and concomitant type 2 diabetes, who were treated at the First Affiliated Hospital of Xiamen University. …”
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Gender-Related Characterization of Acne in Chinese: A Multiple-Center Cross-Sectional Survey on 13085 Cases by Zhu T, Ge Y, Zhang J, Chen Y, Zhong H, Yang L, Zhang J, Li K, Yang S

“…Other gender-related characteristics of acne have not been well elucidated yet.Objective: We compared characteristics of skin lesions, severity and risk factors of acne between males and females in Chinese.Methods: Investigator-administered questionnaire was used to collect demographic data, clinical feature and risk factors of acne from May 2020 to August 2021. …”
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A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation by Liu Y, Liu J, Li Y, Zhao Z, Lyu D, Dong K, Wei M, Huang R, Lu B, Pan X

“…This study aimed to comprehensively analyze NPR3’s role across multiple cancers, focusing on its potential as a prognostic biomarker, particularly in kidney cancer.Methods: A comprehensive pan-cancer study of NPR3 was conducted using 20 different databases and datasets. …”
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Adeno‐Associated Virus 8 and 9 Myofibre Type/Size Tropism Profiling Reveals Therapeutic Effect of Microdystrophin in Canines by Matthew J. Burke, Braiden M. Blatt, James A. Teixeira, Dennis O. Pérez‐López, Yongping Yue, Xiufang Pan, Chady H. Hakim, Gang Yao, Roland W. Herzog, Dongsheng Duan

“…In uDys‐treated DMD dogs, slow and fast myofibres were equally transduced. Notably, uDys‐expressing myofibres were significantly larger than uDys‐negative myofibres irrespective of the AAV serotype (p < 0.0001). …”
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The Mediation Role of Insulin Resistance and Chronic Systemic Inflammation in the Association Between Obesity and NAFLD: Two Cross-Sectional and a Mendelian Randomization Study by Huang X, Chen Q, Su Q, Gong J, Wu L, Xiang L, Li W, Chen J, Zhao H, Huang W, Du S, Ye W

“…Xiaoyin Huang,1,&ast; Qianni Chen,2,&ast; Qingling Su,1,&ast; Jiamin Gong,1 Liqin Wu,2 Liangguang Xiang,3 Wanxin Li,1 Jun Chen,1 Hongwei Zhao,4 Wuqing Huang,1 Shanshan Du,5 Weimin Ye1,5,6 1Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Ultrasonography, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 3Department of General Surgery, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 4Division of Occupational and Environmental Health, University of Utah, Salt Lake City, UT, USA; 5Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China; 6Department of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden&ast;These authors contributed equally to this workCorrespondence: Shanshan Du, Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 9594, Email dushanshan1007@163.com Weimin Ye, Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 2023, Fax +86 591 2286 2510, Email ywm@fjmu.edu.cnPurpose: We aimed to identify the association between obesity and nonalcoholic fatty liver disease (NAFLD) and to quantify the mediating effects of insulin resistance (IR) and chronic inflammation through observational studies and Mendelian randomization (MR).Patients and Methods: In the current study, three IR-related indicators and three indicators of inflammation were included. …”
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Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer by Zhang X, Liu N, Wei M, Yang C, Lin Y, Zeng Y, Li Y, Zhou L, Li T, Zheng Q, Yu H, Zhang J, Gu Y, Xia N, Li S

“…Strategies to synergistically enhance ICD induction and elucidate the underlying molecular mechanisms remain to be fully explored.Methods: We analyzed the mode of apoptosis and immunogenicity of cancer cells post-treatment using Western blotting, flow cytometry, and confocal microscopy. …”
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Performance of specific CMIP6 GCMs for simulating the historical rainfall and temperature climatology of Lake Tana sub-basin, Ethiopia by Tadele Melese Lebeza, Temesgen Gashaw, Haimanote Kebede Bayabil, Pieter R. van Oel, Abeyou W. Worqlul, Yihun T. Dile, Abebe Demissie Chukalla

“…The finding suggested that one of the best performing CMIP6 models for simulating precipitation (ACCESS-ESM1-5) did not equally perform well for representing Tmax and Tmin. …”
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The Joint Association of Sleep Quality and Outdoor Activity with Asthma and Allergic Rhinitis in Children: A Cross-Sectional Study in Shanghai by Lu R, Zhang Y, Chen Y, Lyu J, Li R, Kang W, Zhao A, Ning Z, Hu Y, Lin X, Tong S, Lu Z, Li S

“…Ruoyu Lu,1,&ast; Ye Zhang,1,&ast; Yiting Chen,1 Jiajun Lyu,1 Rong Li,1 Wenhui Kang,1 Anda Zhao,1,2 Zidi Ning,1 Yabin Hu,3 Xiaya Lin,4 Shilu Tong,3 Zhaohui Lu,3 Shenghui Li1,5 1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 3National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, Hainan Province, People’s Republic of China; 5MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaohui Lu, National Children’s Medical Center; Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Pudong District, Shanghai, 200127, People’s Republic of China, Tel +86-18930830796, Email luzhaohui@sjtu.edu.cn Shenghui Li, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Huangpu District, Shanghai, 200025, People’s Republic of China, Tel +86-21-63846590, Email lsh9907@163.com; submission9907@163.comPurpose: Aiming to investigate the combined association of sleep quality and outdoor activity with the risk of asthma and allergic rhinitis in children.Patients and Methods: 16,936 children from kindergartens and primary schools in 13 administrative districts of Shanghai, China were involved in the analyses. …”
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Identification of Ferroptosis -Related Genes in MAFLD/MASH and HQHF Validation by Liu S, Zhang L, Xu J, Zhao Q, Shang D, Liu X, Zhang Q, Liu M, Zhao W

“…This study aims to identify differentially expressed genes (DEGs) associated with MAFLD/MASH and explore their potential link to ferroptosis, a form of regulated cell death.Methods: We conducted differential expression analysis using two datasets from the GEO database. …”
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