Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…This study aimed to investigate the therapeutic effects of AH2QDS on COPD by exploring its mechanisms involving the Keap1-Nrf2 pathway via in vivo and in vitro models.Methods: This study induced COPD-like pathology by using LPS in combination with CS / CSE, establishing both in vivo and in vitro models to evaluate the effects of AH2QDS on lung function, histopathology, oxidative stress markers, levels of inflammatory cytokines, and apoptosis. …”
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Effect of COVID-19 restriction measures on multidrug resistant tuberculosis case notifications and treatment outcomes at treatment centres in Uganda by Pamela Okwir Apio, Lydia Nakiyingi, Charles Batte, Pius Mukisa, John Mukisa, Monica Okwir Acen, Andrew Weil Semulimi, Achilles Katamba, Joan Nakayaga Kalyango

“…Results Before the COVID-19 restrictions, the majority 58.0% were aged less than or equal to 38 years whereas during the restrictions, the majority 51.8% were aged greater than 38 years. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…Our analysis assessed the cost-effectiveness of sotorasib as a second-line treatment in Swiss patients with non-small cell lung cancer from the perspective of the Swiss statutory health insurance system. METHODS: A partitioned survival model based on the CodeBreak 200 trial was constructed with a time horizon of 10 years and a discount rate of 3% for costs and quality-adjusted life years (QALYs). …”
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ROS/pH Dual-Responsive Hydrogel Dressings Loaded with Amphiphilic Structured Nano Micelles for the Repair of Infected Wounds by Wang J, Lin Y, Fan H, Cui J, Wang Y, Wang Z

“…The toxins secreted by bacteria cause persistent inflammation and excessive oxidative stress, resulting in serious tissue damage and ultimately delay wound healing.Methods: Herein, a ROS/pH dual-responsive hydrogel dressing loaded with amphiphilic structured nano micelles was developed for efficiently promoting infected wound healing. …”
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Exploring Biomarkers Related to Cell Adhesion in Polycystic Ovary Syndrome Using Bioinformatics and Conducting Experimental Validation by Zhu J, Qi X, Zhang Z, Zhou Q, Gu R, Wu X, Zhong L

“…This study aimed to identify and analyze the biomarkers associated with cell adhesion-related genes (CRGs) for treating PCOS and their biological mechanisms.Patients and Methods: In this study, GSE80432 was used to identify differentially expressed genes (DEGs) (PCOS vs control group) through differential expression analysis. …”
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Non-Cognitive Behavioral Therapy Psychological Interventions May Not Make the Difference in Children and Adolescents With Chronic Pain by Perlman L, Malka N, Terry O, Nguyen A, Guimarães Ferreira Fonseca L, Ingelmo JI, Ingelmo P

“…The aim of this retrospective cohort study with secondary retrospective matched case–control analysis was to evaluate the impact of interruption of non-CBT psychological interventions, namely psychoanalysis and psychodynamic psychotherapy, on children and adolescents with chronic pain conditions during the SARS-CoV-2 pandemic.Materials and Methods: We included pediatric patients with primary and secondary chronic pain conditions evaluated by our team during the SARS-CoV-2 pandemic. …”
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Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expres... by Xiu C, Luo H, Huang W, Fan S, Yuan C, Chen J, Xu C, Yao C, Hong D, Zhang L

“…Chunmei Xiu,1,2,* Hua Luo,3,* Weixing Huang,4,5,* Shaohua Fan,3 Chiting Yuan,3 Jiangjie Chen,3 Chenghao Xu,3 Can Yao,3 Dun Hong,1,3 Liwei Zhang1,3 1Institute of Bone Metabolism, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 2Department of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, People’s Republic of China; 3Orthopedic Department, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 4General Surgical Department, Taizhou Hospital of Zhejiang Province, School of Medicine, Zhejiang University, Taizhou, 317000, People’s Republic of China; 5Department of Nursing, Zhejiang University School of Medicine First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liwei Zhang, Email medzlw@sina.com Dun Hong, Email hongd@enzemed.comPurpose: To investigate the therapeutic potential of lobetyolin (LBT), a bioactive compound derived from Codonopsis pilosula, against bone loss in postmenopausal osteoporosis (PMOP).Methods: To investigate the therapeutic potential of LBT in osteoporosis, a multifaceted approach involving network pharmacology and molecular docking was employed to identify relevant targets and elucidate mechanisms of action. …”
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Non-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro–Nanochip for Isolating Fetal Nucleated Red Blood Cells by Li N, Sun Y, Cheng L, Feng C, Sun Y, Yang S, Shao Y, Zhao XZ, Zhang Y

“…However, challenges in identifying, enriching, and detecting fNRBCs limit their diagnostic potential.Methods: To overcome these obstacles, we developed a novel biomimetic chip, replicating the micro-nano structure of red rose petals on polydimethylsiloxane (PDMS). …”
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IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis by Guan Y, Yue S, Chen Y, Cheng A, Li H, Yang F, Liu Y, Liang C, Meng J

“…We investigated the potential function of insulin-like growth factor 1 (IGF1) -related ligands in chronic prostatitis in the current study.Methods: In this study, we established the chronic experimental autoimmune prostatitis mouse model H&E staining was used to assess immune cell infiltration in prostate tissue, while RT-qPCR and Western blot analyses were performed to validate gene and protein expression differences across groups, respectively. …”
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Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study by Zhu X, Yin H, Han J, Zhang X, Han Q, Sun W, Liu Y, Tao W, Liu X, Wang G, Li L

“…This study aimed to evaluate the association between UHR and MASLD in a T2DM population.Methods: In this cross-sectional study, we analyzed clinical data from 1081 T2DM patients (464 without MASLD, 617 with MASLD). …”
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Tracing Sentinel Lymph Nodes and Inhibiting Lymphatic Metastasis with TiN Nanobipyramids Through Photothermal Therapy by Xu YN, Bai X, Chen JL, Wu X, Yin D, Yuan G, Dai R, Zhu XM, Wang J

“…Herein we report on the synthesis of TiN nanobipyramids (NBPs) with large sizes for multimodal SLN mapping.Methods: A hydrothermal method and post nitridation treatment were used to prepare the TiN NBPs. …”
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Ductular reaction or hepatic reparative complex: immunohistochemical features in liver cirrhosis in patients with chronic hepatitis by V. A. Tumanskiy, S. V. Fen’

“…When the severity of micronodular liver cirrhosis increases, when the area of hepatic lobules and pseudotypes becomes equal to or less than the area of the surrounding fibrosis, there is a parallel increase in the number of Ki-67+ cells in portal-lobular ductules and chains, as well as the number of Ki-67+ hepatocytes in hepatic lobules and pseudolobes. …”
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The Hourly Apnea-Hypopnea Duration Better Correlates with OSA-Related Nocturnal Hypoxemia and Excessive Daytime Sleepiness Rather Than AHI by Wang Y, Yue W, Zhou B, Zhang J, He Y, Wang M, Hu K

“…This study evaluated whether hourly apnea-hypopnea duration (HAD) and mean apnea-hypopnea duration (MAD) could complement or outperform AHI.Methods: This study included 1069 OSA patients, of whom 754 completed the Epworth Sleepiness Scale (ESS). …”
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Synthesis and properties of magnetically sensitive nanocomposites based on magnetite and gemcitabine by A. L. Petranovska, M. V. Abramov, N. M. Opanashchuk, S. P. Turanska, N. V. Kusyak, P. P. Gorbyk

“…It has been determined by the magnetic granulometry methods that the thickness of GC shell in the composition of Fe3O4/GC NC is (2.4±0.1) nm. …”
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Efficacy of total transanal laparoscopic pull‑through and pure transanal endorectal pull‑through in the treatment of common‑type Hirschsprung disease by Guizhen Huang, Wenqian Huang, Chi Sun, Meng Li, Chaosheng He, Yi Su, Weili Xu, Suolin Li

“…The patients were divided into 2 equal-size groups according to the treatment method. …”
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GALNT14 Genetic Variants Harbor Differential Prognostic Values Linking to Distinct Macrophage Cell Types in Hepatocellular Carcinoma by Chu YD, Ho PH, Chen WT, Shih YL, Lai MW, Hsu CW, Yeh CT

“…This study aims to identify an SNP panel to improve prognosis prediction and explore its role in modulating tumor-infiltrating immune cells (TIICs).Patients and Methods: We included 345 HCC patients underwent surgical resection: 15 in the exploration cohort and 330 in the validation cohort. …”
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Triglycerides and HDL Cholesterol Mediate the Association Between Waist Circumference and Hyperuricemia in Normal-Weight Men by Cui WX, Wang SW, Gao L, Mu DH, Li N, Pan FH, Zhou WH, Hu Y

“…The aim of this research was to explore the mediating roles of TG and HDL-C in the association between WC and hyperuricemia in normal-weight men.Methods: A retrospective observational study was conducted among normal-weight men (18.5 ≤ BMI < 24 kg/m2) aged ≥ 18 years who underwent health checkups in Nanjing from 2021– 2023. …”
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Epidemiology and Molecular Drug-Resistance Patterns of Tuberculosis in Non-Elderly Patients in Luoyang, China, 2019-2023 by Wang Z, Xu L, Guo T, Liu J, Jin J, Zhang Q, Jiang T, Zhao Z, Xue Y

“…This study aimed to analyze TB transmission and molecular resistance profiles among non-elderly patients (&lt; 60 years) in Luoyang City.Patients and Methods: From 2019– 2023, 24,706 non-duplicate sputum samples from 10 TB-designated hospitals were tested for Mycobacterium tuberculosis complex (MTBC) via IS6110-targeted real-time PCR. …”
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The study of the elemental composition of peppermint (Mentha piperita) by K. V. Andrianov, Yu. A. Fedchenkova, O. P. Khvorost

“…In all studied objects the equal elemental content has been determined. Every object had not less than 5 macro-, 15 micro-, 4 ultramicroelements, the content of the last ones was lower than 0,03mg /100 g. …”
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The Decision-Making Experience of Self-Management Behaviors in Home Peritoneal Dialysis for Patients with Diabetic Nephropathy: A Qualitative Study Using the Theory of Planned Beha... by Song Z, Xiao Y, Su Y, Qin G, Yang J

“…In this study, the Theory of Planned Behavior (TPB) was used to clarify patients’ decision-making processes and understand the reasons for adhering to and changing behaviors.Methods: Semi-structured interviews were conducted with 16 DKD patients who were undergoing follow-up and receiving home PD. …”
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