Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…., Internal Medicine, Shijiazhuang, 050000, People’s Republic of China; 2Department of Neurology, Baoding First Central Hospital, Baoding, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zheng Li, Email lizheng741789@163.comBackground: Refractory epilepsy poses significant challenges in clinical management due to its resistance to standard antiepileptic therapies, necessitating the exploration of more effective treatment regimens. …”
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T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing by Xiong Y, Zhang Z, Liu S, Shen L, Zheng L, Ding L, Liu L, Wu L, Hu Z, Li L, Hu Z, Zhang Z, Zhou L, Xu M, Yao Y

“…Herein, we fabricated an innovative immune cell membrane-coated zeolitic imidazolate framework-8 (ZIF-8) nano-delivery platform and explored its effects on myocarditis.Methods: ZIF-8 nanoparticles loaded with siRNA targeting IRF1 (siIRF1) were coated with a T lymphocyte-macrophage hybrid membrane (siIRF1@ZIF@HM NPs) via sonication and extrusion. …”
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Knowledge, Attitudes, and Practices Among Patients Undergoing Gastrointestinal Endoscopy in the Endoscopy Unit of a Tertiary-Care Hospital by Wei L, Niu Q, Ma L, Liu G, Zhang H, Zheng X, Lin Y, Du N, Li L

“…Our objective was to assess the KAP regarding gastrointestinal endoscopy in the Endoscopy Unit among those referred for diagnostic procedures.Patients and Methods: Patients scheduled for gastrointestinal endoscopy completed self-administered questionnaires to gather demographic information and evaluate their KAP scores. …”
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Contribution of Interleukin-1 Receptor-Associated Kinase 1 Gene Polymorphism to Systemic Lupus Erythematosus in Chinese Patients by Zhao L, Xu W, Du S, Xi F, Shi X, Liu R

“…The aim of the current study was to analyze the association between the IRAK1 polymorphisms (rs3027898 and rs1059702) and SLE in a Chinese cohort.Patients and Methods: A total of 150 SLE patients and 168 healthy controls of Chinese ethnicity were included in this study. …”
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Effects of Preoperative Magnesium Sulphate Infusion on Emergence Agitation and Postoperative Quality of Recovery in Patients Undergoing Thoracoscopic Lobectomy by Pu Y, Geng X, Wang M, Lv G, Hu Z, Fang C, Zhang X, Li W, Fan X, Chen X

“…This study aimed to examine the effects of preoperative magnesium sulphate infusion on emergence agitation and postoperative quality of recovery in patients undergoing thoracoscopic lobectomy.Patients and Methods: 84 patients undergoing thoracoscopic lobectomy were randomly assigned to either the magnesium sulphate group (group M) or the control group (group C). …”
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A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE by Wu L, Chen L, Zhang L, Liu Y, Ouyang D, Wu W, Lei Y, Han P, Zhao H, Zheng C

“…Lastly, the SHapley Additive exPlanations (SHAP) method was used to interpret the final ML model.Results: A total of 636 patients were included. …”
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Shear bond strength to sound and caries-affected dentin of sim-plified “etch-and-rinse” and “self-etch” adhesives and the hybrid layer micromorphology by Drobac Milan, Stojanac Igor, Ramić Bojana, Premović Milica, Petrović Ljubomir

“…All tested compsite systems bond equally well on sound and caries-affected dentin. …”
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IINS Vs CALLY Index: A Battle of Prognostic Value in NSCLC Patients Following Surgery by Cheng H, Ma J, Zhao F, Liu Y, Wu J, Wu T, Li H, Zhang B, Liu H, Fu J, He H, Zhu C, Ren H, Yang C, Qin S

“…Hao Cheng,1,* Jiao Ma,1,* Fengyu Zhao,2 Yiwei Liu,3 Jie Wu,4 Tao Wu,1 Hui Li,1 Boxiang Zhang,3 Hui Liu,5 Junke Fu,3 Haiqi He,3 Cailin Zhu,3 Hong Ren,3 Chengcheng Yang,2 Sida Qin3 1Department of Rehabilitation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Radiation Oncology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, People’s Republic of China; 5Biobank, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sida Qin, Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 15388666585, Email qinsida@xjtu.edu.cn Chengcheng Yang, Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 17629260656, Email ccyang@xjtufh.edu.cnObjective: This research sought to assess the predictive potential of the inflammation-immunity-nutrition score (IINS) and the high-sensitivity C-reactive protein-albumin-lymphocyte (CALLY) index in individuals with NSCLC post-surgery.Methods: The study enrolled 506 patients with NSCLC undergoing R0 resection at the First Affiliated Hospital of Xi’an Jiaotong University. …”
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EC50 and EC95 of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation... by Lan H, Liu S, Liao Y, Xu B, Lin Y, Wu X, Chen Q, Chen H, Guan X

“…The EC50 and EC95 values of remifentanil required to alleviate the responses to FOB were calculated using Dixon’s up-and-down method for both male and female groups. Probit analysis was used to generate a dose-response curve.Results: Thirty-nine patients (19 males and 20 females) were enrolled. …”
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Effects of Short Naps on EEG Microstates: Improving Sleep Deprivation-Induced Cognitive Impairment by Ma C, Peng J, Li Y, Ouyang A, Huang Y, He W, Zhu Y, Fang P

“…This study aims to explore the effects of napping on cognitive impairments cause by SD and the potential mechanisms of cognitive recovery.Patients and Methods: We recruited forty-two healthy volunteers and recorded their EEG signals and psychomotor vigilance task (PVT) data at three time points: rested wakefulness, post-SD, and post-nap. …”
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Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…This two-sample Mendelian Randomization (MR) study investigated the causal relationship between lipid traits and pregnancy complications and evaluated the impact of lipid-modifying drug targets.Methods: Genetic instruments for lipid traits and targets for lipid-modifying drugs were obtained from the Global Lipids Genetics Consortium. …”
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Exploring the Role of Allergenic Components in Children with House Dust Mite-Induced Allergic Diseases by Xu Q, Shang Y, Li X, Ran S, Lu M, Cheng L

“…Qiuyan Xu,1,* Yunxia Shang,1,* Xiang Li,1 Shuangqin Ran,1 Min Lu,1 Lei Cheng2,3 1Department of Pediatrics, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, People’s Republic of China; 2Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 3International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cn Min Lu, Department of Pediatrics, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, 1 Lijiang Road, Suzhou, 215153, People’s Republic of China, Email samy_lm@163.comPurpose: To investigate the main characteristics of HDM-induced allergic diseases in children and to explore allergen component-specific sensitization patterns, features, and correlations with clinical symptoms.Methods: Serum samples were collected from children with HDM-induced allergic diseases. …”
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Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention by Wang Y, Ying Y, Zhu Z, Wang L, Yang Y, Zhang L, Yu W, Liang Y, Zhang H, Ji Y, Pan Y

“…This study aimed to examine changes in intrinsic brain activity in SD and their further alterations after ICBT intervention.Patients and Methods: Twenty-five individuals with SD and 25 matched healthy controls (HC) were enrolled. …”
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Automatic Real-Time Detection and Diagnosis of Liver Tumor with Ultrasound by Wu CH, Sheu JC, Chou PL, Lee J, Nien HC

“…We aimed to develop deep learning (DL) models to automatically diagnose and detect hepatic lesions in a larger dataset, with HCC as the dominant malignancy.Methods: We enrolled patients diagnosed with hepatic tumors using abdominal ultrasound between January 2002 and December 2020 in a retrospective cohort with a diagnosis of malignant and benign lesions. …”
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IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation by Xia R, Shi X, Zhang H, Zeng W, Yang Z, Xu J, Wang J, Miao Y, Liao T

“…In this study, we investigate the preventive efficacy and underlying mechanism of IL-6/IL-6R signaling blockade.Methods: The CR model in mice was constructed using allogeneic cardiac transplantation with CTLA4-Ig injection. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Residual right-to-left shunting was minimal in both groups, with RLS grades 0 and 1 observed in 82.35% of patients in the nitinol group and 78.87% in the bioabsorbable group at the 12-month follow-up.ConclusionBoth biodegradable and nitinol PFO occluders were equally effective in alleviating migraine symptoms, with excellent procedural success and safety profiles. …”
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Distribution characteristics, source apportionment, and health risk assessment of metals and metalloids in PM2.5 in a southern city in 2019 by Yaxin QU, Suli HUANG, Chao WANG, Jie JIANG, Jiajia JI, Daokui FANG, Shaohua XIE, Xiaoheng LI, Ning LIU

“…ObjectiveTo assess the distribution characteristics of metals and metalloids in outdoor PM2.5 in a southern city of China, conduct source apportionment, and evaluate the associated health risks, thereby providing theoretical support for further pollution control measures. MethodsPM2.5 samples were collected in districts A, B, and C of a southern China city, and the concentrations of 17 metals and metalloids were detected by inductively coupled plasma-mass spectrometry (ICP-MS). …”
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Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study by Ranran Bi, Yupeng Shi, Manrong Li, Xiaochen Liu, Zhenchao Ma, Yiqing Huang, Bingyin Liang, Fang Cui

“…This study aims to provide further results.Materials and methodsThis study examined cross-sectional data from patients aged 18 years or older with a diagnosis of stroke confirmed by cranial CT or MRI within 24 h of admission, gathered from January 2020 to August 2022. …”
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Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial by Feng Y, Jia C, Liu H, Bao T, Wang C, Wang Z, Huang J, Jiang Y, Wang X, Zhang R, Zhang Y, Zhang S, Zhu S, He C

“…Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.Patients and Methods: This randomized controlled trial will include patients with CLBP who have not received exercise therapy in the past three months. …”
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Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Ya-Bing Ding,1,2,* Yuan Zhao,1– 3,* Bing-Yu Chen,1 Qian Wang,1 Zhao-Yan Wang,1 Zuo Luan,1,2 Bin Yi4 1Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Neonatology, Children’s Hospital of Shanxi, Women Health Centre of Shanxi, Taiyuan, People’s Republic of China; 4Department of Pediatrics, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo Luan, Department of Peadiatric, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Tel +86-18600310270, Fax +86-1066958303, Email luanzuodoctor@126.com Bin Yi, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, 730000, People’s Republic of China, Email www.0931@163.comObjective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. …”
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