GA-LDV: A Promising Derivative of 18β-Glycyrrhetinic Acid with Enhanced in vitro and in vivo Anti-Cancer Properties by Zheng J, Feng Q, Gao Q, Wang Y, Zhao S, Zhang X, Zhao M

“…Jiaying Zheng,1,* Qiqi Feng,1,* Qi Gao,1 Yaonan Wang,1 Shurui Zhao,1 Xiaoyi Zhang,1 Ming Zhao1,2 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China; 2Beijing Laboratory of Biomedical Materials and Key Laboratory of Biomedical Materials of Natural Macromolecules, Department of Biomaterials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Zhao, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China, Tel +861083911535, Fax +861083911533, Email maozhao@126.com Xiaoyi Zhang, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, No. 10, Youanmenwaixitoutiao, Fengtai District, Beijing, 100069, People’s Republic of China, Tel +861083911530, Fax +861083911533, Email zhangdd@ccmu.edu.cnPurpose: The clinical translation of 18β-Glycyrrhetinic acid (GA) is impeded by its relatively low antitumor potency and poor aqueous solubility, we developed a novel derivative of GA by incorporating the Leu-Asp-Val (LDV) tripeptide to enhance its anti-tumor and anti-metastatic activities both in vitro and in vivo, thereby increasing its potential as a therapeutic agent for cancer treatment.Methods: The water solubility of GA-LDV was evaluated. …”
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Retrospective Analysis of Factors Associated with a Prolonged Nucleic Acid Conversion Time in Patients with COVID-19 at Fangcang Shelter Hospital by Li Y, Wei Y, Wang Y, Chen Q, Hou X

“…Yang Li,1,* Yang Wei,2,* Yu Wang,1 Qiuxia Chen,1,3 Xianhua Hou1,3 1Department of Neurology, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China; 2Department of Vascular Surgery, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China; 3Department of Neurology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianhua Hou, Department of Neurology, The First Affiliated Hospital of Army Medical University, No. 30 Gaotanyan Main St, Shapingba District, Chongqing, 400038, People’s Republic of China, Email houxianhua@tmmu.edu.cn Qiuxia Chen, Department of Neurology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, No. 29 Jianxin East Road St, Jiangbei District, Chongqing, 400020, People’s Republic of China, Email chenqiuxia@tmmu.edu.cnObjective: The aim of this study was to explore the related factors for prolonged nucleic acid conversion time (NCT) in patients with SARS-CoV-2 Omicron variant, so as to help to prevent and control the epidemic.Methods: This study retrospectively included 307 patients diagnosed with mild to moderate COVID-19 who were hospitalized in Shanghai International Exhibition Fangcang Shelter Hospital. …”
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The Duration of Prophylactic Antibiotic Use for Esophageal Cancer Patients with Postoperative Infection and Nutritional Status by Ning D, Zhou L, Shi G, Fu M

“…Dong Ning,1,* Lin Zhou,2,* Guidong Shi,1 Maoyong Fu1 1Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Ning, Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Shunqing District, Nanchong, Sichuan, 63000, People’s Republic of China, Email dongningcb@21cn.comObjective: To verify the hypothesis that “the prophylaxis use time of antibiotics after esophageal cancer (EC) surgery ≤ 24 hours is associated with a lower postoperative infection rate and improvement of nutritional indicators”, a retrospective cohort analysis was conducted to compare the infection incidence and differences in serum nutritional indicators among patients with different medication durations (< 24 hours, 24– 48 hours, > 48 hours), and to identify independent risk factors for postoperative infection.Methods: A retrospective analysis was conducted on the data of 566 patients who underwent EC surgery in Affiliated Hospital of North Sichuan Medical College from January 2020 to October 2022. …”
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3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity. …”
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EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF CONNECTIVE AND SOFT TISSUE by V. M. Merabishvili, O. F. Chepik, E. N. Merabishvili

“…According to official data a one-year lethality of patients with tumors of connective and soft tissue in 2013 was 20.1 %, and for all malignant tumors – 25.3 %, however the index accuracy for all malignant tumors was equal to 0.72, and for malignant tumors of connective and soft tissue – 0.88. …”
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Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prosp... by Pu J, Guo C, Xiao Y, Cao Y, Liu Z, Jin Y, Hu Y

“…Group GA was injected bilaterally with equal amounts of saline in the same way. Sleep was monitored using wearable devices on the first day before surgery (P1) and the first and third day after surgery (D1 and D3). …”
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Cecal coccidiosis in Japanese quails (Coturnix Japonica): Eimeria tsunodai identification and comparative prophylactic phytochemotherapy with immune stimulant impact by Reham M. ElBakrey, Amal A.M. Eid, Ahmed A. ElKholy, Mohamed R. Mousa, Mohamed A. El-Morsy, Walaa S. Abdelaziz

“…A selected E. tsunodai was used to evaluate the comparative anticoccidial efficacy of a commercial herbal product containing oregano and garlic essential oils (EOs) as a prophylactic supplement via drinking water taking into consideration that it had never been applied in quails' coccidiosis before. Methods: A total of 300 Japanese quails were equally assigned to four groups. …”
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A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis by Liu M, You T, Li S, Hao Y, Wang Z, Huang F, Wang J

“…Meili Liu,1,2,* Tao You,3,* Shifeng Li,1,* Yan Hao,1,* Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Wang; Fang Huang, Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, People’s Republic of China, Email dr_wangjun@suda.edu.cn; blue-virus@163.comObjective: To evaluate the prognosis significance of a newly simplified immune-dysregulation index, interleukin-6-to-lymphocyte ratio (IL-6/LY), in individuals diagnosed with sepsis.Methods: This was a retrospective cohort study enrolling consecutive patients diagnosed with sepsis who qualified the inclusion criteria and were admitted to the intensive care unit of the First Affiliated Hospital of Soochow University between March 2017 and January 2023. …”
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Eepidemiological Interregional Multicenter Study of Healthcare-Associated Infections in the Intensive Care Units. First Results by R. V. Polibin, E. B. Brusina, O. V. Kovalishena, E. V. Glushkova, A. A. Gridina, B. I. Aslanov, N. I. Briko

“…The intensive development of medical technologies is accompanied by equally rapid changes in the epidemic process of healthcare-associated infections (HAIs). …”
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Integration of Diaphragmatic Ultrasonography and Intra-Abdominal Pressure Measurement for Optimizing Weaning from Mechanical Ventilation by Su D, Li R, Chen Z, Cui N, Yu Z, Ding X, Wu J

“…Dan Su,1,* Ruixin Li,1,* Zhi Chen,2 Na Cui,1 Zhanbiao Yu,1 Xiaoxu Ding,1 Jiaqian Wu1 1Intensive Care Unit, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhi Chen, Department Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13832296881, Fax +86 0312-5983782, Email chenzhi6295@126.com Na Cui, Intensive Care Unit, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13503382865, Fax +86 0312 5983752, Email nacuilika@126.comObjective: The objective of this study was to evaluate the effectiveness of diaphragmatic ultrasonography in conjunction with intra-abdominal pressure (IAP) measurement for assessing diaphragm function and determining the optimal timing for weaning from mechanical ventilation (MV).Methods: A cohort of 100 patients undergoing MV at the intensive care department of the Affiliated Hospital of Hebei University between January 2023 and July 2023 was enrolled. …”
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Application Effectiveness of a Pre-Analytical Quality Management Pathway Based on the Structure–Process–Outcome Model by Cui L, Li W, Li Y, Feng X, Wang Y, Gao P

“…Liping Cui,1,* Wanling Li,1,2,* Yueqin Li,3 Xiaofang Feng,3 Yue Wang,4 Pei Gao4 1Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 2Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Nursing College, Shanxi Medical University, Taiyuan, 030032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueqin Li, Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No. 99 Longcheng Street, Xiaodian District, Taiyuan, Shanxi, 030032, People’s Republic of China, Tel +86 0351-8368114, Email li_yueqin@163.comObjective: This single-center, before-and-after study applied the structure–process–outcome (SPO) model to pre-analytical quality control to investigate its effect on laboratory testing quality, nursing practices, patient satisfaction, and clinician trust in test results.Methods: A before-and-after design was conducted in a provincial Class A tertiary hospital. …”
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PENGARUH PERAN KEPEMIMPINAN DAN DISIPLIN KERJATERHADAP KINERJA KARYAWAN PADA PERUSAHAAN DAERAH AIR MINUM (PDAM) KABUPATEN KARAWANG by Cecep Hermana, Uswatun Nurhasanah

“…Teknik analisis yang digunakan yaitu teknik analisis skala likert dan analisis jalur dengan menggunakan alat bantu Method Of Successive Interval (MSI), Microsoft Office dan SPSS versi 16. …”
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Designing Survey-Based Mobile Interfaces for Rural Patients With Cancer Using Apple’s ResearchKit and CareKit: Usability Study by Alyssa Donawa, Christian Powell, Rong Wang, Ming-Yuan Chih, Reema Patel, Ralph Zinner, Eliah Aronoff-Spencer, Corey E Baker

“… BackgroundDespite the increased accessibility and availability of technology in recent years, equality and access to health-related technology remain limited to some demographics. …”
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Association of the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Neutrophil to High-Density Lipoprotein Cholesterol Ratio With the Severity of New-Onset Coronary Arter... by Shu H, Han S, Qiu W, Li J, Zhang X, Su H, Wu H, Zhao G, Li Q

“…However, the correlation between MHR, NHR, and the severity of newly diagnosed coronary artery disease (CAD) has not been thoroughly explored.Methods: In this retrospective study, we enrolled 1489 patients who underwent coronary angiography for the first time between January 2022 and December 2023, of which 1143 were diagnosed with CAD. …”
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Obesity and metabolic syndrome as risk factors for the development of non-alcoholic fatty liver disease as diagnosed by ultrasound by Petrović Gordana, Bjelaković Goran, Benedeto-Stojanov Daniela, Nagorni Aleksandar, Brzački Vesna, Marković-Živković Bojana

“…Metabolic syndrome was determined in 48 (87.27%) patients of the study group. An equal number of patients, 16 of them (29.09%), had 3, 4 and 5 components of MS. …”
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Evaluation of Estimated Glucose Disposal Rate with Neutrophil-to-Lymphocyte Ratio Integrated for Prognosticating Adverse Cardiovascular and Cerebrovascular Events and Risk Stratifi... by Feng X, Liu Y, Yang J, Zhou Z, Yang S, Zhou Y, Guo Q

“…Xunxun Feng,1,2 Yang Liu,1 Jiaqi Yang,1 Zhiming Zhou,1 Shiwei Yang,1 Yujie Zhou,1,* Qianyun Guo1,* 1Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA*These authors contributed equally to this workCorrespondence: Yujie Zhou; Qianyun Guo, Email azzyj12@163.com; gqydyx3000@163.comObjective: This research aimed to address the critical need for effective prognostic tools in patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) undergoing percutaneous coronary intervention (PCI) by exploring the potential significance of integrating estimated glucose disposal rate (eGDR) and neutrophil-to-lymphocyte ratio (NLR).Methods: Major adverse cardiovascular and cerebrovascular events (MACCE) were the primary endpoint. …”
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Dysphagia and Body Composition in Cornelia de Lange Syndrome by Aleksandra Mędza, Aleksandra Cieszko, Małgorzata Gliwa, Michał Brzeziński, Jolanta Wierzba, Agnieszka Szlagatys-Sidorkiewicz, Katarzyna Sznurkowska

“…Dysphagia may be a sign or a complication of GERD (gastroesophageal reflux disease), which is the most frequent gastroenterological disorder in CdLS patients; Methods: Fourteen Polish patients with a clinical or genetic diagnosis of CdLS were included in the study. …”
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Characteristics of the Emotional and Behavioral Reactions of Rats under Chronic Stress Immobilization During Treatment with 5-R-thio-tetrazol [1,5-c] quinazoline Derivatives by О. Y. Tozyuk

“…RESEARCH MATERIALS AND METHODS. Chronic stress immobilization was modeled by keeping rats in small wooden cases for 16 hours / day for 18 days. …”
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Combination of Three Treatment Modes of 1064 nm Nd: YAG Laser in the Treatment of Melasma: A Retrospective Observational Study by Qiu H, Zhu Y, Wu B, Zhou S, Zhou X, Pan F

“…To investigate a more effective laser-based approach, this retrospective study evaluates the clinical outcomes of combining Low-fluence QS 1064 nm Nd: YAG laser, Fractional-mode QS 1064 nm Nd: YAG laser, and Long-pulsed 1064 nm Nd: YAG laser in the treatment of melasma.Methods: This retrospective observational study enrolled 43 patients with clinically diagnosed melasma, all of whom underwent treatment with a 1064 nm Nd: YAG laser using a combination of three modes: low-fluence QS, fractional-mode QS, and long-pulsed settings. …”
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Prediction of Ki-67 Expression in HIV-Associated Lung Adenocarcinoma Patients Using Multiple Machine Learning Models Based on CT Imaging Radiomics by Song C, Chen J, Zhao C, Song S, Yang T, Huang A, Liu R, Pan Y, Xu C, Chen C, Zhu Q

“…Therefore, developing a non-invasive and accurate method for Ki-67 prediction holds significant clinical importance. …”
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