X-RAY PROGRESSION AND ITS IMPACT ON THE FUNCTIONAL STATUS OF PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING A 5-YEAR FOLLOW-UP by Yu. A. Ermakova, D. E. Karateev, E. L. Luchikhina, N. V. Demidova, A. V. Smirnov

“…At baseline, after 1, 2, 3, 4, and 5 years, the total erosion scores (modified Sharp score) was equal to 0 [0; 0], 0 [0; 1], 0 [0; 4], 1 [0; 8], 3 [0; 12], 6 [0; 14], respectively. …”
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Xijiao Dihuang Decoction for Sepsis-Induced Acute Lung Injury: Network Pharmacology and Molecular Dynamics Insights by Xu J, Jiao C, Du H, Guo X, Wang M, Ma Y, Yin Y, Liu M, Shao R

“…Jiaqi Xu,1– 3,* Conghan Jiao,2– 4,* Haiwei Du,2,5 Xiaojing Guo,1– 3 Mutian Wang,1– 3 Yuening Ma,1,2 Yanzhong Yin,1,2 Min Liu,1,2 Rongjiang Shao2,5 1Department of Infectious Diseases, the First Teaching Hospital of Tianjin University of TCM, Tianjin, People’s Republic of China; 2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China; 3Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4Department of Hematology, the First Teaching Hospital of Tianjin University of TCM, Tianjin, People’s Republic of China; 5Department of General Surgery, the First Teaching Hospital of Tianjin University of TCM, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rongjiang Shao, Department of General surgery, The First Teaching Hospital of Tianjin University of TCM, No. 88, Changling Road, Xiqing District, Tianjin, 300381, People’s Republic of China, Tel +86 13920987128, Email 13920987128@163.com Min Liu, Department of Infectious Diseases, The First Teaching Hospital of Tianjin University of TCM, No. 88, Changling Road, Xiqing District, Tianjin, 300381, People’s Republic of China, Tel +86 13132296378, Email liumintcm@163.comObjective: This study investigates the therapeutic mechanisms of Xijiao Dihuang Decoction (XJDHD) in sepsis-induced acute lung injury (SALI) through an integrated approach, including network pharmacology, molecular docking, molecular dynamics simulations, and in vitro experiments.Methods: Network pharmacology identified active ingredients and targets in Xijiao Dihuang Decoction. …”
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The Application of Opacification-Development Ratio Based on CT Scan for Diagnosing Pediatric Chronic Rhinosinusitis by Zhang J, Yang A, Chen T, Cao Y, Lv Q, Xu Y, Liao Z, Chen X, Ye Z, Lai R, Hong H

“…Jun Zhang,1,* Anni Yang,1,* Tengyu Chen,1,* Yufeng Cao,1 Qiliang Lv,1 Yingxiang Xu,1 Zhenpeng Liao,1 Xianzhen Chen,1 Zhongkang Ye,1 Renjie Lai,1 Haiyu Hong1,2 1Department of Otolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, People’s Republic of China; 2Allergy Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyu Hong, Department of Otolaryngology, Head and Neck Surgery, Allergy Center, The Fifth Affiliated Hospital of Sun Yat-sen University, 52 of Meihua East Road, Zhuhai, Guangdong, 519000, People’s Republic of China, Tel +8607562528832; +8613823070089, Email honghy@sysu.edu.cnPurpose: To investigate the diagnostic potency of the opacification-development ratio (ODR) for pediatric chronic rhinosinusitis based on CT scanning.Patients and Methods: Children aged 0– 15 years who underwent nasal CT scanning from August 2011 through July 2021 were included in the research. …”
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Effect of Age, Sex and Season on Acute Myeloid Leukemia Clinical Characteristics: A Retrospective Study by Wan X, Tao T, Zhang J, Li N, Gou Y, Yang W, Han X, Wu S, Zhang C, Peng X, Liu S, Zhang X

“…In order to elucidate the correlations between these factors, we performed a comprehensive data collection and analysis of AML patients in our hospital from 2013 to 2023.Methods: Totally, 2798 newly diagnosed AML patients and 220 relapsed AML patients who were admitted to our hospital from January 1, 2013 to December 31, 2023 were included for analysis. …”
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PLK1 Mediates the Proliferation and Contraction of Airway Smooth Muscle Cells and Has a Role in T2-High Asthma with Neutrophilic Inflammation Model by Pan Y, Xue Y, Fei X, Zhao L, Han L, Su H, Lin Y, Zhou Y, Zhang Y, Xie G, Kong D, Bao W, Zhang M

“…However, the downstream mediator of S1P remains unclear, as does its role in T2-high asthma with neutrophilic inflammation.Methods: Ovalbumin- and ozone-induced murine models were used to replicate T2-high asthma with neutrophilic inflammation and primary ASMCs were applied to explore the underlying effects. …”
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FFMI: A Pivotal Indicator Bridging Pulmonary, Sleep, and Systemic Factors in COPD–OSA Overlap Patients by Wang L, Shen YY, Qian RQ, Zhang XQ, Shen XR, Chen C

“…This study aims to compare the Fat - Free Mass Index (FFMI) between OVS and simple COPD patients and analyze subgroup differences in OVS for better early identification and severity assessment.Methods: Clinical data of 364 patients (203 in COPD group, 161 in OVS group) were analyzed regarding clinical features, pulmonary function, sleep apnea, etc. …”
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Persisting Short or Long Sleep Duration Predicts Post-Stroke Depression One year After Stroke and Transient Ischemic Attack by Hu Y, Zuo L, Pan Y, Yan H, Wang Y, Zhao X

“…However, the association of changes in sleep duration with functional outcome and depression after acute ischemic stroke (AIS) or transient ischemic attack (TIA) is still unclear.Methods: All patients diagnosed with AIS or TIA in the impairment of cognition and sleep (ICONS) from the China National Stroke Registry III were included. …”
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Combining Experimental Validation and Network Pharmacology to Reveal the Action Mechanism of Panax Notoginseng-Radix Salviae on Atherosclerosis by Song N, Zhang X, Yin H, Zhang L, Li C, Li J, Li Y, Wu J

“…This study aims to explore the potential bioactive ingredients and molecular mechanisms of PN-RS in the treatment of AS.Materials and Methods: C57BL/6J mice were fed a common diet as the control group. …”
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Self-Management of Kidney Transplant Recipients Research: A Comprehensive Bibliometric Analysis by Lou J, Hu Z, Yuan M, Luo R, Zhang T, Ye Q, Zhou X, Feng B

“…Jiaao Lou,1,2,* Zhengbin Hu,1,* Menglin Yuan,1 Rui Luo,1 Tao Zhang,1 Qifa Ye,1,3 Xin Zhou,1 Bilong Feng2 1Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-Based Medical Materials, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, People’s Republic of China; 2Department of Nursing, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, People’s Republic of China; 3Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, The 3rd Xiangya Hospital of Central South University, Changsha, Hunnan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Zhou, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, People’s Republic of China, Tel +86 027-67813423, Email 13545133367@163.com Bilong Feng, Department of Nursing, Zhongnan Hospital, Wuhan University, #169, East Lake Road, Wuchang District, Wuhan, Hubei Province, 430071, People’s Republic of China, Tel +86 027-67812888, Email fbl1019@126.comObjective: This study analyzes research trends in self-management among kidney transplant recipients to inform future directions.Methods: Bibliometric analysis was performed on 444 English articles related to self-management of kidney transplant recipients in the Core Collection of Web of Science and Scopus databases using COOC 12.8, R software, Microsoft Excel 2019, VOSviewer, and CiteSpace, with a focus on citation ranking, publication year, journal, country, organization, author, impact factor, and keywords.Results: Four hundred and forty-four English articles revealed the United States as the leading publisher on kidney transplant recipient self-management. …”
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Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China by Shen D, Cai X, Hu J, Song S, Zhu Q, Ma H, Zhang Y, Ma R, Zhou P, Yang W, Hong J, Zhang D, Li N

“…This study investigates the relationship between inflammatory indices and MAFLD in hypertensive patients and assesses the predictive accuracy of these indices for MAFLD.Methods: We performed a cross-sectional analysis involving 34,303 hypertensive patients from a Chinese hospital-based registry. …”
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Advances in Coking Wastewater Treatment and Zero Discharge Technology by Huaqiang CHU, GLADYS Chimfwembe, Pengyuan WEI, Jie XU, Guihong SHUI, Jiaying MA, Xuefei ZHOU, Yalei ZHANG

“…Optimization of process integration is equally crucial; intelligent combination of treatment steps can minimize energy consumption while maximizing resource recovery. …”
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Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial by Yanan Wu, Yaning Yang, Xiaomei Wang, Li Sun, Yunpeng Hei, Yuhua Zou, Zhenhai Ye, Zhi Yu

“…Patients were randomly assigned to esketamine group or placebo group using a random number table method. Patients in the esketamine group received continuous intraoperative infusion of esketamine, 0.5 mg/kg/h while those in the placebo group were given an equal volume of normal saline. …”
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Self-Management Intervention for Reducing Epilepsy Burden Among Adult Ugandans with Epilepsy (SMART-U): Randomised Clinical Trial Protocol by Mbalinda SN, Kaddumukasa M, Najjuma JN, Birungi DR, Kaddumukasa MN, Levin JB, Still CH, Burant CJ, Modi AC, Katabira ET, Sajatovic M

“…The purpose of this 2-site randomised controlled experiment is to investigate this further, based on encouraging preliminary evidence.Methods: A total of 188 adult people with epilepsy (PWE) attending the neurology clinics at Mulago and Mbarara hospitals and consent to participate in the study will be recruited. …”
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Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota by Li JH, Xu J, Huang C, Hu JX, Xu HM, Guo X, Zhang Y, Xu JK, Peng Y, Zhang Y, Zhu MZ, Zhou YL, Nie YQ

“…This study aims to evaluate the efficacy of HELNs in treating colitis in mice and investigate its potential mechanisms.Methods: HELNs were isolated from H. cordata for characterization, and their safety and stability were evaluated. …”
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Patient-Specific Instrumentation Benefits for INBONE II Total Ankle Arthroplasty by Charlotte Jones BS, Allison Boden MD, Patricia Friedmann MS, Suzy Wang MS, Ricardo Villar MD, Constantine Demetracopoulos MD, Jonathan Deland MD, Elizabeth Cody MD, Matthew Conti MD, Jensen Henry MD, Scott Ellis MD

“…This study aimed to determine the accuracy of PSI regarding implant alignment and implant size, and compare outcomes between PSI implantation and the traditional jig method. We hypothesized that compared to the standard jig method (non-PSI group), PSI will improve alignment accuracy, deformity correction, and reduce radiation exposure, tourniquet and operative time. …”
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The Future of Hospital Medicine in Japan: Lessons From the United States Hospital Medicine System by Suzuki T, Katayama K, Houchens N, Hartley S, Tokuda Y, Watari T

“…Marianna University School of Medicine, Kanagawa, Japan; 3Medicine Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA; 4Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; 5Muribushi Okinawa Center for Teaching Hospitals, Urasoe, Okinawa, Japan; 6Tokyo Foundation for Policy Research, Tokyo, Japan; 7Kyoto University Hospital, Integrated Clinical Education Center, Kyoto, Japan; 8General Medicine Center, Shimane University Hospital, Shimane, Japan*These authors contributed equally to this workCorrespondence: Takashi Watari, Shimane University Hospital, General Medicine Center, 89-1 Enya, Izumo city, Shimane prefecture, Shimane, Japan, Email wataritari@gmail.comPurpose: To compare hospitalist roles and training systems between the United States (US) and Japan, identifying strengths and challenges to guide development of Japan’s emerging hospital medicine program.Methods: A qualitative, descriptive narrative study was conducted during a 10-day observational site visit to the Veterans Affairs Ann Arbor Healthcare System and University of Michigan Hospital in October 2022. …”
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From medical school to global health leadership: 35-year career outcomes and gender disparities from the Aga Khan University Medical College by Adil H. Haider, Maham Vaqar, Asma Altaf Hussain Merchant, Sharjeel Ahmad, Komal Abdul Rahim, Namra Qadeer Shaikh, Noreen Afzal, Shayan Shah, Anum Rahim, Saad Bin Zafar Mahmood, Saqib Kamran Bakhshi, Sadaf Khan, Muhammad Tariq

“…After the exclusion of missing data, 862 responses were analyzed. Both genders were equally represented (49.8%). Most participants had completed residency (82.0%) and fellowship (56.0%) training. …”
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Effectiveness of a Care Plan Based on the Multi-Theory Model in Reducing Fear of Disease Progression and Improving Quality of Life in Breast Cancer Patients: A Randomized Controlle... by Zhang J, Zhuang J, Chen X, Chu T, Zhang Q, Ma L, Zhou H, Wu Y, Chen L

“…Our research aimed to evaluate the effectiveness of a care plan based on the Multi-Theory Model of health behavior change in reducing fear of progression in breast cancer patients undergoing adjuvant chemotherapy.Patients and Methods: This randomized controlled trial enrolled 108 eligible participants receiving adjuvant chemotherapy at Jiangnan University Affiliated Hospital between May and December 2024. …”
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Strategies to Enhance Health Communication Participation Among Medical Students in Chinese Universities: A Cross-Sectional Study by Jiang N, Chen M, Yan T, Liu Q, Shu Q, Liang X, Tao Z, Nie W, Yang X, Guo Y, Li X, Zhu DJ, Fu Y, Li L

“…This study aimed to explore the current status and influencing factors of medical students’ participation in health communication and offer specific suggestions.Methods: In this cross-sectional study, an online self-designed questionnaire was distributed to medical students during August 2022 to September 2022. …”
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The Association Between Specific Oral Behaviors and the Number of Temporomandibular Disorder Symptoms in the General Population: A Cross-Sectional Study by Tian Y, Tan Y, Yang M, Lv X, Zheng Y, Zhang Q, Sun Y, Wang J, Xiong X

“…Yihong Tian,1,2,* Yanyue Tan,3,* Ming Yang,1 Xiayang Lv,3 Yunhao Zheng,1 Qiang Zhang,4 Yanyu Sun,1 Jun Wang,1,2 Xin Xiong1,2 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu, Sichuan, People’s Republic of China; 2Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Nursing, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Department of Orthodontics, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Wang; Xin Xiong, West China Hospital of Stomatology, Sichuan University, No. 14 section 3, Renmin South Road, Chengdu, 610041, People’s Republic of China, Email wangjunv@scu.edu.cn; drxiongxin@scu.edu.cnObjective: This study aimed to thoroughly explore the relationship between individual oral behavior and the differing numbers of temporomandibular disorder (TMD) symptom in the general population.Methods: A total of 565 participants were recruited and completed a questionnaire containing demographic characteristics, eight specific oral behaviors, and five major TMD symptoms (5Ts) checklist. …”
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