Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology by Zhao J, Dai R, Zhao Y, Tan J, Hao D, Ren J, Wang X, Chen Y, Peng H, Zhuang Y, Zhou S, Chen Y

“…Identifying distinct clinical phenotypes may enable more targeted therapeutic interventions and improve patient care.Objective: This study aims to use clustering analysis techniques to identify different immune subtypes in sepsis patients and explore their clinical relevance and prognosis.Methods: The study included 236 patients from the EICU at Shanghai Tenth People’s Hospital, who met the Sepsis 3.0 diagnostic criteria. …”
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Comparison of Long-Term Outcomes Between Repeated Hepatic Resection and Radiofrequency Ablation in Patients with Small Recurrent Hepatocellular Carcinoma After Initial Curative Res... by Hsiao CY, Hu RH, Liang PC, Wu CH

“…US- and CT-guided RFA are equally effective alternatives. Keywords: hepatocellular carcinoma, outcome, radiofrequency ablation, recurrence, repeat resection…”
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How to Choose Treatment Regimens for Idiopathic Membranous Nephropathy Patients with PLA2R-Negative: A Single-Center Retrospective Cohort Study by Zhou Z, Zou Y, Ke B, Shen W

“…This study aimed to evaluate the efficacy and adverse events of these three treatment regimens in IMN patients with PLA2R-negative.Methods: This study included 46 PLA2R-negative IMN patients confirmed by renal biopsy and immunofluorescence from the Department of Nephrology, the Second Affiliated Hospital of Nanchang University between September 2021 and October 2023. …”
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Dynamical lymphadenectomy as a component of multidisciplinary approach while doing operative interventions for pancreatic cancer by O. Yu. Usenko, M. Yu. Nychytailo, M. S. Zagriichuk, V. V. Kropelnytskyi, N. E. Klochkova, Yu. V. Nezhentseva, Ya V. Romaniv, O. O. Pidopryhora, D. M. Skrypka

“…The patients were divided into two groups – the main and the comparative one, equally - by 8 of every group. In all the patients pancreaticoduodenal resection was done. …”
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Biotechnological aspects of the technology of preparation of grain-fruit wort from wheat grain and blackcurrant cake by E. M. Serba, E. N. Sokolova, L. V. Rimareva, V. V. Ionov, N. I. Ignatova, M. B. Overchenko

“…The purpose of this work was to study the conditions for the preparation of grain-fruit wort using biotechnological methods for the conversion of polymers of wheat and blackcurrant raw materials. …”
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The Influence of Emphysema on Treatment Response to Biologic Therapy in Severe Asthma by Biener L, Morobeid H, Pizarro C, Kuetting D, Nickenig G, Skowasch D

“…Our aim was to examine the effects of emphysema on biologic treatment response in SA in this retrospective cohort study.Methods: Pulmonary emphysema was examined using computed tomography. …”
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Activation of the Reelin/GSK-3β/p-Tau Signaling Pathway in the Hippocampus of Patients with Temporal Lobe Epilepsy by Lin J, Lin X, Fu YJ, Li X, Li X, Wang Y, Zhao L, Yu S, Piao YS

“…Juan Lin,1,2,* Xinyu Lin,1,* Yong-Juan Fu,1 Xuran Li,3 Xin Li,3 Yujiao Wang,1,4 Lihong Zhao,1 Shun Yu,3 Yue-Shan Piao1,5,6 1Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 2Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 3Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 4Department of Pathology, Shanxi Provincial People’s Hospital, Affiliated People’s Hospital of Shanxi Medical University, Taiyuan, 030012, People’s Republic of China; 5Clinical Research Center for Epilepsy, Capital Medical University, Beijing, 100053, People’s Republic of China; 6National Center for Neurological Disorders, Beijing, 100053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue-Shan Piao, Email yueshanpiao@126.com; Shun Yu, Email yushun103@163.comPurpose: In this study, we evaluated the presence of tau deposition and protein expression of Reelin/GSK-3β/p-Tau signaling pathway in the hippocampus of patients with temporal lobe epilepsy (TLE).Methods: A total of 37 cases of TLE with and without hippocampal sclerosis (HS) were selected histopathologically for our study with 5 autopsy cases as the control group. …”
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Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling by Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X

“…There is still a lack of biomarkers for OA, so it cannot be intervened in time.Methods: OA biomarkers were identified from human cartilage datasets using LASSO and SVM-RFE, followed by ROC analysis. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…This study aimed to investigate the efficacy of combining imeglimin with dipeptidyl peptidase-4 inhibitor (DPP-4i), the most frequently prescribed first-line treatment for patients with type 2 diabetes (T2D) in Japan, to improve glycemic control.Patients and Methods: Eleven patients with T2D treated with DPP-4i alone (6.5% ≤ hemoglobin A1C [HbA1c] < 10%) received 1000 mg imeglimin twice daily for 16 weeks. …”
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FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription by Xie Y, Yan F, Liu X, Yu L, Yan H, Shang Z, Kong Y, Yang Z

“…The objective of this study is to clarify the mechanism of action of YFJP in treating HCC.Methods: By constructing networks, the active components and molecular targets of YFJP in the treatment of HCC were explored. …”
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Comparative Evaluation of Enamel Surface Abrasion Produced by Three Different Types of Toothbrush Bristle Designs: An In-vitro Study by Akanksha Mohan Karale, Pramod Waghmare, Vidya Dodwad, Pooja pharne, Akshay Karale

“…In this test, a p-value less than or equal to 0.05 was considered statistically significant. …”
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Global Burden of Kidney Cancer Attributable to High Body Mass Index in Adults Aged 60 and Older from 1990 to 2021 and Projections to 2040: A Systematic Analysis for the Global Burd... by Lin J, Zhang Z, Meng X, Yin X, Pu L, Xiang C, Yang J

“…This study analyzes the burden of kidney cancer attributable to high BMI in those aged ≥ 60, clarifying causes and future trends.Methods: Using Global Burden of Disease (GBD) 2021 study, we assessed kidney cancer burden due to high BMI in population aged ≥ 60 from 1990 to 2021, comparing deaths, disability-adjusted life years (DALYs), age-standardized rate (ASR) of DALYs (ASDR), and mortality (ASMR). …”
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Dyslipidemia in kidney receiver by S. M. Martirosyan, E. D. Kosmacheva

“…The critical significance value while checking statistical  hypotheses in this research was accepted equal 0.05. The method of multifactorial logistic regression was applied to search factors associated with a dyslipidemia. …”
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Pulmonary and Physical Virtual Reality Exercises for Patients With Blunt Chest Trauma: Randomized Clinical Trial by Tjitske D Groenveld, Indy GM Smits, Naomi Scholten, Marjan de Vries, Harry van Goor, Vincent MA Stirler

“…Vital lung capacity at 5 days (or last measurement) was equal between groups with 1830 (SD 591) mL and 1857 (SD 435) mL in the control and VR groups, respectively. …”
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Comparison between ultrasound guided erector spinae plane block and paravertebral block on acute and chronic post mastectomy pain after modified radical mastectomy: randomized cont... by Samy Abdelrahman Amr, Ahmed Hassan Othman, Eman Hassan Ahmed, Romany Gergis Naeem, Shereen Mamdouh Kamal

“…Our goal was to evaluate, in contrast to control group, the effects of ESP & PVB on acute and chronic post-mastectomy pain. Methods One hundred and five female patients undergoing modified radical mastectomy participated in this study, randomly allocated into three equal groups: erector spinae plane block (ESP), thoracic paravertebral (TPV), and control groups. …”
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The Role of Dectin-1-Akt-RNF146 Pathway in &beta;-Glucan Induced Immune Trained State of Monocyte in Sepsis by Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C

“…However, the role of trained immunity in sepsis has not been fully understood.Methods: We profiled the characteristics of peripheral blood mononuclear cells from septic patients using single-cell RNA sequencing (scRNA-seq) analyses. …”
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Water-Sediment Characteristics and Flow-Sediment Diversion Patterns in Typical Bifurcated Channels in the Middle Reaches of Huaihe River by ZHANG Hui, NI Jin, BEN Peng, WANG Jiu-sheng

“…The sediment concentration ratios of each bifurcated channel were approximately equal to the ratios of their respective flow sediment transport capacity. …”
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HSPA4 Expression is Correlated with Melanoma Cell Proliferation, Prognosis, and Immune Regulation by Wang X, Li Z, Xu J, Wang J, Li Y, Li Q, Niu J, Yang R

“…However, its function in cutaneous malignant melanoma (CMM) remains uncertain.Patients and Methods: The gene and protein expression level of HSPA4 in CMM was investigated with public databases. …”
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Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro by Wang W, Li Z, Lyu C, Wang T, Han C, Cui S, Wang J, Xu R

“…In this study, we synthesized a new complex: zinc oxide nanoparticles-luteolin (ZnONPs-Lut) and aimed to investigate its effects on cell death in the AML cell line (MOLM-13) in vitro and to elucidate the underlying mechanisms.Methods: We assessed cell viability, quantified changes in gene expression using real-time quantitative PCR (qRT-PCR), and measured changes in ferrous (Fe2+) content, glutathione (GSH) content, malondialdehyde (MDA) content, reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) levels following treatment with different concentrations of MOLM-13 cells with different concentrations of ZnONPs-Lut. …”
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Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort by Zhou B, Yao Y, Wang Y, Yue W, Zhang J, He Y, Zhang Q, Wang Y, Hu K

“…The metabolic score for insulin resistance (METS-IR) is a novel method for assessing IR. This study aims to explore the relationship between METS-IR and the risk of OSA.Patients and Methods: This cross-sectional study included a total of 8297 subjects from NHANES (National Health and Nutrition Examination Survey) database, as well as 581 patients who underwent sleep monitoring in Renmin Hospital of Wuhan University. …”
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