Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study by Zhang X, Yang M, Duan X, Feng X, Fang Y

“…This study aimed to investigate the main component of ZDZX and its underlying mechanism in IgAV treatment.Methods: Combining UHPLC-QE-MS/MS, network pharmacology, 4D-FastDIA proteomics, and a gliadin-induced IgAV murine model, we systematically deciphered ZDZX’s renoprotective and anti-inflammatory mechanisms.Results: 19 key components were identified in ZDZX, targeting 46 IgAV-associated proteins, predominantly enriched in TNF and IL-17 signaling pathways. …”
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The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…However, the relationship between CDDP-induced inflammation and BLB dysfunction remains elusive.Materials and Methods: In vivo and in vitro BLB models were used to explore the inflammatory mechanisms underlying CDDP ototoxicity. …”
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Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks by Wei S, Chen B, Guo Z, Zhang H, Li J, Hu X, Yang C, Li J, Li X, Liu Z, Xu Y, Liu S

“…However, as far as magnetic shock therapy itself is concerned, there are few studies specifically focusing on its efficacy in depth, and the mechanism of MST in treating schizophrenia is still unclear.Methods: This study centered on the key question of “the efficacy of magnetic stunning therapy for patients with schizophrenia and the combined fMRI-EEG to explore the regulatory mechanisms of brain networks”. …”
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Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy by Wei J, Zhang L, Wang H, Wang Q, Jia W, Wang R, Wang R, Cui Z

“…Junhan Wei,1,* Lei Zhang,1,* Haiyan Wang,1 Qianfeng Wang,2 Wei Jia,1 Ru Wang,1 Runsheng Wang,1 Zhili Cui1 1Shaanxi Eye Hospital, Xi’an People’s Hospital (Xi’an Fourth Hospital), Affiliated People’s Hospital of Northwest University, Xi’an, People’s Republic of China; Xi’an Key Laboratory of Digital Medical Technology of Ophthalmologic Imaging, Xi’an, 710004, People’s Republic of China; 2Medical College of Optometry and Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyan Wang, Email haiyanwang@med.nwu.edu.cnPurpose: This study investigated the relationships between structural and functional parameters in non-arteritic ischemic optic neuropathy (NAION).Methods: This retrospective study enrolled 29 patients (58.2 ± 10.4 years old) with unilateral NAION. …”
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Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus by Ma X, Jiang X, Gao G, Ban B, Sheng J, Shi S, Zhao H, Ji B

“…Emphasizing the overall relationship between lipid metabolism and visceral fat accumulation.Methods: This cross-sectional study included 1288 overweight/obese T2DM patients, with VFA measured using bioelectrical impedance analysis and visceral fat obesity (VFO) was defined as VFA ≥ 100 cm². …”
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Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study by Hua Y, Geng Y, Liu S, Xia S, Liu Y, Cheng S, Chen C, Pang C, Zhao Z, Peng B, Dai Y, Ji J, Wu D

“…The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiansong Ji; Dan Wu, Email jjstcty@wmu.edu.cn; 215066083@qq.comObjective: This study investigates the differences in brain functional activity and connectivity patterns between Cancer Pain (CP) patients and Healthy Controls (HCs) using resting-state functional magnetic resonance imaging (rs-fMRI) to identify potential neuroimaging biomarkers.Methods: This study collected rs-fMRI data from 25 CP patients and 25 hCs, processed the functional MRI images, and calculated metrics such as amplitude of low-frequency fluctuation (ALFF), Regional Homogeneity (ReHo), and FC. …”
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The Effect of Laser Biostimulation at Sensitized Acupoints on Chronic Pelvic Pain and Quality of Life in Women with Pelvic Inflammatory Disease: A Randomized Controlled Trial by Marwa Esmael Hasanin, Sobhy Mahmoud Aly, Mona Mohamed Taha, Lama Saad El-Din Mahmoud, Monira I. Aldhahi

“…This study aimed to investigate the effects of laser on sensitized acupoints on pelvic pain perception and quality of life in women with pelvic inflammatory disease. <i>Materials and Methods</i>: Thirty-six women with CPP caused by chronic pelvic inflammatory disease were randomly divided into two equal groups. …”
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Genomic Epidemiology of Clostridioides difficile ST81 in Multiple Hospitals in China by Xia X, Lv T, Zheng L, Zhao Y, Shen P, Zhu D, Chen Y

“…However, given the potential for C. difficile ST81 transmission, research into the epidemiological characteristics of this type of ST remain limited.Methods: We conducted a genomic epidemiology study addressing the genetic characteristics of C. difficile ST81 in five tertiary hospitals covering different regions in China between January 2010 and January 2021. …”
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Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…This study is intended to explore the function and molecular mechanism of ARHGAP18 and miR-613 in COPD pathogenesis.Methods: We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. …”
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Integrated Bioinformatics and Experimental Validation Reveal Macrophage Polarization-Related Biomarkers for Osteoarthritis Diagnosis by He Q, Liu L, Hu X, Lin L, Song Z, Xia Y, Lin Q, Wei J, Li S

“…In this study, we identified crucial genes associated with macrophage polarization in OA and constructed a diagnostic model to provide novel insights for diagnostic and therapeutic strategies.Methods: The GSE55235 and GSE55457 datasets were merged through the GEO database to identify genes related to macrophage polarization by conducting weighted gene co-expression network analysis (WGCNA) and differential expression analysis. …”
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Multimodal Magnetic Resonance Findings in Parkinson&rsquo;s Disease With &ldquo;Antecedent Essential Tremor&rdquo;: A Case Series of a Large Kindred by Kong Y, Yao L, Xiao X, Chen A, Wang K, Yan H, Sun R, Liu R, Kong Q

“…This study aimed at determining the morphological, microstructural and iron-related changes in these patients’ brains using multimodal magnetic resonance imaging (MRI).Methods: We reviewed a kindred with ET and PD with “antecedent ET” recruited at our hospital in May 2023. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…But research on the mechanism of HO-1 in macrophage polarization via PMVEC exosomes in sepsis-induced lung injury is lacking.Methods: To investigate the role of HO-1 in the interaction between endothelial cells and macrophages, HO-1 knockout mouse model were established. …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Moreover, diagnostics and treatment are activated simultaneously, without the possibility of switching between two processes.Methods: We used photosensitizer chlorin e6 (Ce6) and luminescent quantum dots (QDs) to create a theranostic nanocomplex. …”
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Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease by Harald Hefter, Max Novak, Dietmar Rosenthal, Sven G. Meuth, Tom Luedde, Philipp Albrecht, Philipp Albrecht, Christian J. Hartmann, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh

“…A patient was classified to be compliant when at least one of at least 8 24 h-UCU-values was lower than or equal to 60 μg/d (COM8-group).ResultsCHE-S was significantly (p &lt; 0.05) different between thus defined compliant or non-compliant patients. …”
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Qing-Luo-Yin Eases T Cells-Mediated Angiogenesis in Adjuvant-Induced Arthritis Rats by Activating PPAR&gamma; by Song MK, Wang MQ, Ruan YQ, Cui C, Chen WG, Olatunji OJ, Li Y, Zuo J

“…The study investigated if and how this property contributes to its anti-angiogenesis effects.Methods: Adjuvant-induced arthritis (AIA) rats were orally treated by QLY or rosiglitazone (a PPARγ agonist), and their monocytes and lymphocytes were co-cultured reciprocally in vitro with different sera. …”
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Prevalence of Urinary Incontinence, Risk Factors and Its Impact: Multivariate Analysis from Indonesian Nationwide Survey by Rochani Sumardi, Chaidir A Mochtar, Junizaf Junizaf, Budi I Santoso, Siti Setiati, Siti A Nuhonni, Partini P Trihono, Harrina E Rahardjo, Firtantyo A Syahputra

“… Aim: to describe the profile of urinary infection (UI) and to analyze its risk factors and impacts. Methods: subjects were enrolled consecutively from pediatric, urology, obstetrics & gynecology, and geriatric outpatient clinics at six teaching hospitals in various regions of Indonesia. …”
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Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…Ziwei Yang,1,2,&ast; Xiao Liang,1,2,&ast; Yuqi Ji,1,2 Wei Zeng,1,2 Yao Wang,1,2 Yong Zhang,3 Fuqing Zhou1,2 1Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Nanchang, 330006, People’s Republic of China; 3Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yong Zhang, Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5036, Email zy830226@163.com Fuqing Zhou, Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5132, Email ndyfy02301@ncu.edu.cnPurpose: To investigate whether functional radiomic features in bilateral hippocampi can identify the cognitively impaired patients from low-back-related leg pain (LBLP).Patients and Methods: For this retrospective study, a total of 95 clinically definite LBLP patients (40 cognitively impaired patients and 45 cognitively preserved patients) were included, and all patients underwent functional MRI and clinical assessments. …”
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Examining the psychosocial model of sense of presence in the learning management system of e-learning center’s Shahid Beheshti university by soraya khazaei, abbas mohammadi, Mahboobeh Arefi, Esmail Jafari

“…Aims: The present study is aimed of providing a model of the sense of presence in the learning management system of e-learning center’s Shahid Beheshti University. Methods: This was a survey-based research. In the first phase, the statistical population included all professors and students of the e-learning center of Shahid Beheshti University and IT specialists in education, who were chosen through judgmental sampling method. …”
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Bloodstream Infections Leading to Sepsis: Clinical and Microbiological Profiling of Bacteremia among Hospitalized Patients in Surabaya, Indonesia by Nuritsna Marwasyifa, Tri Pudy Asmarawati, Firman Setiawan, Pepy Dwi Endraswari

“…Sepsis and septic shock were equally prevalent (35.5%). Mortality (64.5%) occurred primarily due to septic shock (49.3%). …”
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Development and Validation of a Neonatal Hypothermia Prediction Model for In-Hospital Transport Using Machine Learning Algorithms: A Single-Center Retrospective Study by Zhang W, Gu X, Gu C, Yao L, Zhang Y, Wang K

“…Wenyan Zhang,1,&amp;ast; Xiaoying Gu,1,&amp;ast; Chunjie Gu,1 Lili Yao,1 You Zhang,2 Ke Wang1 1Department of Neonatology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 2Information Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ke Wang, Email wangkeyfy@126.com You Zhang, Email 122710487@qq.comObjective: This study aims to predict hypothermia during neonatal in-hospital transport using machine learning techniques, identify risk factors, rank their importance, and visualize the results, allowing healthcare providers to rapidly assess the probability of hypothermia risk during transport.Methods: Clinical data of 9,060 neonates transported within a tertiary maternity hospital in Shanghai between January 2023 and June 2024 were collected, including maternal and neonatal data. …”
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