Association Between Lipoprotein(a) and Risk Factors of Atherosclerosis in Russian Population (Data of Observational ESSE-RF study) by S. A. Shalnova, M. V. Ezhov, V. A. Metelskaya, S. E. Evstifeeva, V. I. Tarasov, G. A. Muromtseva, Yu. A. Balanova, A. E. Imaeva, A. V. Kapustina, A. A. Shabunova, O. A. Belova, I. A. Trubacheva, A. Y. Efanov, Z. T. Astakhova, N. V. Kulakova, S. A. Boytsov, O. M. Drapkina

“…A total of 10332 people were examined, of whom 3732 were men (36.0%) and 6600 were women (64.0%), the average age was equal in both sexes.Results. The mean value of Lp(a) reached 22.4 mg/dl (standard deviation 21.3 mg/dl) and significantly differed from the median (11.1 mg/dl; interquartile range from 3.9 to 20.2 mg/dl), forming the right-skewed distribution in both male and female population. …”
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Multidose Dalbavancin Population Pharmacokinetic Analysis for Prolonged Target Attainment in Patients Requiring Long-Term Treatment by Giammarco Baiardi, Michela Cameran Caviglia, Silvia Boni, Antonello Di Paolo, Valeria Marini, Giuliana Cangemi, Alessia Cafaro, Emanuele Pontali, Francesca Mattioli

“…<b>Methods:</b> Pharmacokinetic analysis was based on a nonlinear mixed effects modelling approach performed in NONMEM v7.5/Pirana, while R was used for data management and graphical summaries. …”
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The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure by Masoud Mortezazadeh, Saeed Kalantari, Nooshin Abolghasemi, Mitra Ranjbar, Saeedeh Ebrahimi, Abbas Mofidi, Babak Pezeshkpour, Ensieh Sadat Mansouri, Seyed Zia Tabatabaei, Mehdi Kashani

“…Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation. Methods This study was a randomized double‐blind clinical trial involving 30 patients treated with antiretroviral therapy who had experienced immunological failure despite HIV viral suppression. …”
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HOMESIDE: home-based family caregiver-delivered music and reading interventions for people living with dementia: protocol of a randomised controlled trial by Sabine Braat, Felicity Anne Baker, Imogen Clark, Young-Eun Claire Lee, Thomas Wosch, Helen Odell-Miller, Nicola Lautenschlager, Jodie Bloska, Anna Bukowska, Ming H Hsu, Tone Kvamme, Agnieszka Smrokowska-Reichmann, Karette A Stensaeth

“…Dyads will be randomised equally to standard care (SC), a home-based music programme plus SC, or a home-based reading programme plus SC for 12 weeks. …”
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Universal Bacterium-Vectored COVID-19 Vaccine Expressing Early SARS-CoV-2 Conserved Proteins Cross-Protects Against Late Variants in Hamsters by Qingmei Jia, Helle Bielefeldt-Ohmann, Saša Masleša-Galić, Richard A. Bowen, Marcus A. Horwitz

“…In this study, we evaluate the efficacy of rLVS Δ<i>capB</i>/MN and an enhanced version, rLVS Δ<i>capB</i>::RdRp/MN, which additionally expresses the conserved RNA-dependent RNA polymerase (RdRp) protein from the same strain, in a hamster model. <b>Methods:</b> Both vaccine candidates were administered orally or intranasally to golden Syrian hamsters (equal numbers of males and females) and evaluated against intranasal challenge with SARS-CoV-2 Delta (B.1.617.2-AY.1) and Omicron (BA.5) variants. …”
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Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease by Guus A. de Waard, Sukhjinder S. Nijjer, Martijn A. van Lavieren, Nina W. van der Hoeven, Ricardo Petraco, Tim P. van de Hoef, Mauro Echavarría‐Pinto, Sayan Sen, Peter M. van de Ven, Paul Knaapen, Javier Escaned, Jan J. Piek, Justin E. Davies, Niels van Royen

“…In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. Methods and Results We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure. …”
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6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway by Qiurui Li, Meng Wang, Xuekuan Huang, Shang Wang, Chunli Li, Pan Li, Wei Xiang, Ling Yao, Chengdan Deng, Mingming Zhang, Jianwei Wang

“…The therapeutic effects and underlying mechanisms of NASH-HCC, however, remain poorly understood. Methods Network pharmacology, bioinformatics, single-cell RNA sequencing analysis, and molecular docking were used to identify the main active compounds, targets, and possible mechanisms of ginger in treating NASH-HCC. …”
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Q-Ball high-resolution fiber tractography: Optimizing corticospinal tract delineation near gliomas and its role in the prediction of postoperative motor deficits– A proof of concep... by Pavlina Lenga, Moritz Scherer, Robin Peretzke, Peter Neher, Jessica Jesser, Andreas W. Unterberg, Sandro Krieg, Daniela Becker

“…Research question: This study compares the results of conventional DTI-FT and q-ball (QBI)-high resolution FT with patient's postoperative morbidity, relating postoperative MD with the nearest distance from the lesion to the CST (nD-LCST). Materials and methods: In this ongoing prospective trial, we utilized probabilistic High-Resolution Fiber Tracking (HRFT) through q-ball imaging (QBI-FT) and conventional Diffusion Tensor Imaging Fiber Tracking (DTI-FT), based on equal and standard diffusion-weighted MRI. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…Among patients with CD and DS, 93% had histological damage equal to 3rd grade of Marsh-Oberhuber classification at diagnosis. …”
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Retrospective cohort of prenatal home ultrasound utilization and maternal-neonatal outcomes by Anat Pardo, Erkan Kalafat, Shira Hazon, Monica Pailis, Emilie Klochendler-Frishman, Or Lee Rak, Ofri Samueloff, Rachel Gomez-Tolub, Anat Shmueli, Noam Pardo, Tomer Sela, Leor Wolff, Asnat Walfisch, Arnon Wiznitzer, Eran Hadar

“…This service provides a handheld, app-connected ultrasound device for remote basic fetal monitoring, with its use determined at the discretion of the patient as a supplement - rather than a replacement - to standard prenatal care. Methods Retrospective analysis comparing maternal and neonatal outcomes among users versus non-users of the home ultrasound service, between January 2020 and December 2022. …”
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Investigating the prevalence of three medically important pathogens in Ixodes pacificus from southern Oregon by Andrew T. Partin, Emilio E. DeBess, Phillip Q. Spinks, Michael J. Yabsley, Michael J. Yabsley, Michael J. Yabsley, Kayla B. Garrett, Kayla B. Garrett, Kayla B. Garrett, James R. Clover, Geoffrey R. Taylor

“…Ixodes pacificus is common in southern Oregon yet there are few published studies on the distribution of tick-borne pathogens in this region. MethodsUsing real-time quantitative PCR, we assessed the prevalence of B. burgdorferi s.l., B. miyamotoi, and A. phagocytophilum among 2,463 unfed I. pacificus adults and nymphs combined into 260 pools (131 nymph, 129 adult) with nearly equal numbers of each life stage from 12 locations in Jackson County, Oregon. …”
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Adverse Drug Reactions to SGLT2i Reported by Type 2 Diabetes New Users: An Active Surveillance Study by Camelia Bucșa, Ioana Frenț, Ramona Stefan, Adriana Fodor, Georgeta Inceu, Andreea Farcaș, Adriana Rusu, Monica Negovan, Cristina Mogoșan

“…<b>Results</b>: In total, 64 patients, with genders being equally represented and with a median age of 59 years (Q1, Q3: 51, 64) were followed-up with. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Sixty-two PDS patients were randomly assigned equally to acupuncture or sham acupuncture arm (3 sessions per week for 4-week). …”
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Use of Rapid Qualitative Analysis to Support Collaborative Synergy Within a Community Coalition for Health Equity in Detroit by Hayley S. Thompson, Ten-Niah Kinney, Carrie Leach, Alexandra Sass, Ariel Washington, Rhonda Dailey, Elizabeth Towner, Alyssa Beavers, Rodlescia Sneed, Karen Solomon Edwards, Ijeoma Nnodim Opara, Arthur Hampton, Zachary Cichon, Afsana Rinky, Joneigh Khaldun

“…Participants defined health equity as equal access to opportunities for a healthy life and emphasized the importance of individual choice in pursuing those opportunities. …”
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The association of heavy metals/metalloid and stroke—Findings in Shanxi, China and the US NHANES from 2011 to 2020 by Yuese Yuan, Li Zhang, Fuying Liu, Haobo Liu, Ying Wang, Xiujuan Yang, Liangpo Liu, Ben Li, Li Wang, Jin Yang, Hongyan Cao, Yulan Qiu, Jinping Zheng, Jian Guo, Yi Gao

“…Background: Previous studies provided contradictory evidence regarding the relationship between metal concentrations and ischemic stroke (IS). Methods: A total of 100 adults with IS were included in this study, as well as an equal number of controls. …”
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OUR EXPERIENCE OF HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY FOR PATIENTS WITH ADVANCED GASTRIC CANCER by A. D. Kaprin, V. M. Khomyakov, D. D. Sobolev, L. V. Bolotina, A. B. Ryabov, V. E. Khoronenko, M. M. Soboleva, L. V. Kramskaya

“…Improvement of the results of treatment of patients with locally advanced and metastatic gastric cancer. Material and methods. From the 2010–2014 we performed 30 surgeries using techniques HICT. …”
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Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center by Rifan Alyami, Ahad E. Alotaibi, Leen Almohayya, Ajyad Al Jawad, Raghad Almukhayzim, Abeer Alhoumedan, Rakan S. Aldusari

“…Laparoscopy is considered safe and feasible for hemodynamically stable patients, and our findings suggest it is equally effective in trauma cases for those who can tolerate the procedure. …”
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Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana by Benedicta Ayiedu Mensah, Henrietta E. Mensah-Brown, Frederica D. Partey, Christabel Addo, Gertrude Buah, Gifty A. Afudego, Daniel Okyere, Mary Tetteh, Ernest Boateng, Michael Wilson, Elijah Paintsil

“…Patients who were in care for less than or equal to five years were more likely to be LTFU compared to those in care for more than five years. …”
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Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy by Xilei Cai, Xiujuan Yang, Pengyue Zhang, Ziyue Dou, Zilian Chen, Chongzhi Zhu, Weiwei Xu, Xinchen Wang, Xiaodan Hong, Zhenhua Zhang

“…This study aimed to determine the distribution of the three clinical subtypes of PHO and compare their clinical characteristics using a large global sample. Methods A systematic literature search was conducted in multiple databases to categorize cases into complete form (CO), incomplete form (IN), and fruste form (FR). …”
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Prescription dose and optimisation strategies in MR-guided online adaptive radiotherapy for kidney tumours: a two-step planning analysis by Takaya Yamamoto, Noriyoshi Takahashi, Shohei Tanaka, Rei Umezawa, Yu Suzuki, Keita Kishida, So Omata, Kazuya Takeda, Hinako Harada, Kiyokazu Sato, Noriyuki Kadoya, Keiichi Jingu

“…However, the ideal strategy for prescription dose selection and reoptimisation remains unclear. Methods This single-centre planning study evaluated kidney tumours located within 1 cm of gastrointestinal OARs. …”
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