Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis by Aljuhani HS, Hubayni RA, Qedair J, Bukhari ZM, Alzahrani A, Bawazir RO, Badghaish OS, Alqahtani F

“…Hazem Saleh Aljuhani,1,* Rahaf A Hubayni,2,3,* Jumanah Qedair,2,3 Ziad M Bukhari,4 Ahmed Alzahrani,4 Razan Osama Bawazir,2,3 Orjwan Salah Badghaish,2,3 Faisal Alqahtani5 1Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 3King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 4Ophthalmology Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; 5Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Hazem Saleh Aljuhani, Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia, Tel +966545254296, Email Aljuhanihazem@gmail.comPurpose: To assess the efficacy and safety of aflibercept biosimilars compared to reference aflibercept therapy for neovascular age-related macular degeneration (nAMD) through a systematic review and meta-analysis.Methods: A comprehensive literature search was conducted across multiple databases. …”
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Evaluation of Applying Standardized Patients in Certification Assessment of Clinical Practice Ability Standardized Training for Psychiatric Resident Physicians by Yao F, Chen JS, Chen LH, Ye BY, Yang CJ, Li XZ

“…Fei Yao,1,2,* Jian-Song Chen,1,2,* Li-Hong Chen,1,2 Bi-Yu Ye,1,2 Chan-Juan Yang,1,2 Xuan-Zi Li1,2 1Department of Education, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510370, People’s Republic of China; 2School of Mental Health, Guangzhou Medical University, Guangzhou, Guangdong, 510370, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuan-Zi Li; Chan-Juan Yang, Department of Education, The Affiliated Brain Hospital, School of Mental Health, Guangzhou Medical University, No. 36 mingxin Road, Guangzhou, Guangdong, 510370, People’s Republic of China, Tel +86 20 81268042, Email lixuanzi@gzhmu.edu.cn; yangw2020@gzhmu.edu.cnObjective: The aim of this study was to explore the application of standardized patient (SP) in the certification assessment of clinical practice ability standardized training for psychiatric resident physicians.Methods: Candidates and examiners who participated in the graduation examination of clinical practice ability standardized training for psychiatric resident physicians in Guangdong Province from 2020 to 2023 were selected as the research participants. …”
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Circulating Interleukin-22 Is a Biomarker for Newly Diagnosed Type 2 Diabetes Mellitus and Associated with Hypoglycemic Effect of Sitagliptin by Sun P, Xiao Y, Dong Y, Feng Y, Zheng H, Liao X

“…This study aimed to assess serum IL-22 levels in participants with type 2 diabetes mellitus (T2DM) and analyze the association between IL-22 levels and T2DM risk.Methods: Serum IL-22 concentrations of recruited healthy participants (n=48), newly diagnosed T2DM participants (n=46), and T2DM participants receiving placebo (n=7) or dipeptidyl peptidase-4 inhibitors (DPP-4i) sitagliptin monotherapy (n=7) were measured using a commercial enzyme-linked immunosorbent assay (ELISA) kit. …”
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Comprehensive assessment of the quality of life in heart transplant recipients: experience at Shumakov National Medical Research Center of Transplantology and Artificial Organs by I. I. Muminov, A. A. Yusova, N. N. Koloskova, A. O. Shevchenko, R. Yu. Bangarov, M. S. Nesterova

“…For comparative analysis, HT recipients were divided into three equal groups based on the total score obtained when assessing each factor in the TxEQ questionnaire. …”
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Neutrophil Extracellular Traps Enhance Procoagulant Activity and Predict Poor Prognosis in Patients With Metastatic Breast Cancer by Gong Y, Chen B, Tan Q, Wei W

“…This study aims to determine whether NETs promote hypercoagulability and if NETs and plasma hypercoagulability markers are biomarkers of survival in MBC.Methods: Circulating levels of neutrophil extracellular trap (NET) markers and hypercoagulability markers (TAT, fibrinogen, and D-dimer) were assessed in 112 MBC patients before treatment, compared to 55 healthy controls. …”
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Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis by Yu Cao, Yang Liu, Tian Zhang, Jing Pan, Wei Lei, Boli Zhang

“…SLC6A2, SLC6A4, NOS2, PPARA, PPARG, ACHE, CYP2C19, CYP51A1, and CHRM2 were equally targeted by six herbs and identified as viral myocarditis-associated symbols. …”
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The Succession of Cervical Canal Microbiota in Endometrial Cancer and Cervical Cancer: A Clinical Metagenomics Study by Lei S, Wang J, Zhang M, Huang J, Liu Y, Long Y, Xing Y, Yu Z

“…Shibo Lei,1,2,* Jing Wang,1,* Man Zhang,2 Jing Huang,3 Ying Liu,1 Ying Long,1 Yixuan Xing,4 Zheng Yu2 1The Affiliated Cancer Hospital of Xiangya School of Medicine/Hunan Cancer Hospital, Central South University, Changsha, People’s Republic of China; 2Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, People’s Republic of China; 3Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, People’s Republic of China; 4The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yixuan Xing, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, People’s Republic of China, Email 234428043@qq.com Zheng Yu, Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, People’s Republic of China, Email yuzheng@csu.edu.cnObjective: To define stage-specific cervical canal microbiota signatures across the continuum of gynecologic malignancies from benign endometrial cancer (BE)/cervical cancer precancerous lesions (CIN) to endometrial cancer (EC)/cervical cancers (CC), and to evaluate their potential as diagnostic biomarkers and therapeutic targets.Methods: In the observational study, metagenomic sequencing was employed to investigate the cervical canal microbiota of 45 patients, including BE, EC, CIN, and CC. …”
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Interplay of education and community norms in justifying intimate partner violence among ever-married women aged 15–49 years in Bangladesh: a cross-sectional study by Mohammad Hridoy Patwary, Sumaiya Nusrat Esha

“…This study examines the interplay between education and community norms in shaping the attitudes toward IPV among ever-married women aged 15 to 49 in Bangladesh. Methods This study utilized data from the 2022 Bangladesh Demographic and Health Survey (BDHS). …”
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Prevalence and Associated Factors of Depression in Patients with Ischaemic Stroke: A Cross-Sectional Study by Li Y, Qin W, Chen Y, Zhang D, Zhao Y

“…Yifan Li,1,* Wei Qin,1,* Yitong Chen,2 Dongli Zhang,1 Yongchen Zhao1 1Department of Integrative Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, People’s Republic of China; 2Clinical Specialty of Integrated Chinese and Western Medicine, Hebei University, Baoding, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongli Zhang; Yongchen Zhao, Department of Integrative Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding City, Hebei Province, 071000, People’s Republic of China, Tel +86 0312 5981919, Email zhang_dongli@yeah.net; zhaoyongchen69@outlook.comObjective: To investigate the prevalence and severity of depression in patients with ischaemic stroke and identify its associated factors using a cross-sectional design over a 6-month period.Methods: This cross-sectional study included 499 patients with ischaemic stroke who met the diagnostic and inclusion criteria. …”
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Expert consensus on implementing patient-reported outcomes in telehealth: findings from an international Delphi study by Elizabeth J. Unni, Liv Marit Valen Schougaard, Olalekan Lee Aiyegbusi, Kedar K. V. Mate, Elizabeth J. Austin, Klara Greffin, Natasha Roberts, Birgith Engelst Grove, Holger Muehlan, ISOQOL Clinical practice SIG PROs in Telehealth Working Group

“…This study aimed to generate expert consensus on the utilization of PROs in telehealth. Methods Delphi methodology was used to achieve consensus among international experts with a predetermined consensus threshold of 70%. …”
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Isolation and Characterization of a Novel Lytic Phage N22 and Its Effect on Drug-Resistant Klebsiella Pneumoniae by Liu D, Qin K, Hong C, Huang W, Li W, Lian P, Li M, Chen H, Liu X

“…This study aimed to address the multidrug resistance crisis in intensive care units by exploring the use of ceftazidime/avibactam (CAZ/AVI), a widely used clinical antimicrobial agent, in conjunction with phage therapy.Materials and Methods: We screened a clinical strain of KP from ICU and successfully isolated phage N22 from hospital wastewater. …”
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Institutional Factors Influencing Student Performance in Management of Second Stage of Labour in Kakamega County Hospitals, Kenya by George Lipesa, John Okath, Damaris Ochanda

“…Aim: The study's precise goal was to assess institutional factors influencing student performance in managing the second stage of labour in Kakamega County hospitals, Kenya. Methods: The study employed an analytical cross-sectional research design using a quantitative data collection approach. …”
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Coagulation Parameters in Elderly Patients with Severe Pneumonia: Correlation with Disease Severity and Prognosis by Zhang Q, Liu Y, Tong C, Zhang L, Li R, Guo W, Li J

“…Qiuyue Zhang,1,* Yingchao Liu,1,* Chuntang Tong,2 Lina Zhang,3 Rongchen Li,1 Wenbin Guo,4 Jianliang Li5 1Department of Clinical Laboratory, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 2Department of Respiratory Medicine, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 3Department of Scientific Research Management Division, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 4Department of Intensive Care Unit, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 5Department of Thoracic Surgery, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianliang Li, Department of Thoracic Surgery The Second People’s Hospital of Liaocheng, 306 health Street, Linqing, Shandong, 252600, People’s Republic of China, Tel +86 15020622456, Email lijianliangl724@163.comObjective: This study aimed to investigate the levels of coagulation parameters in elderly patients with severe pneumonia and analyse their correlation with disease severity and prognosis.Methods: A retrospective study was conducted on 207 elderly patients (aged ≥ 60 years) with severe pneumonia admitted to our hospital between January 2022 and December 2023. …”
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Inhibitory effect of rutin on the growth and metastasis of osteosarcoma in vitro and in vivo by LI Xiang, WEI Ming, WU Wenxi, LUO Xiaoqin, YAO Biao, WU Siyu

“…Objective·To investigate the effects of rutin on proliferation, apoptosis, migration and invasion of osteosarcoma cells and its possible molecular mechanisms.Methods·Human osteosarcoma MG63 and U2OS cells were treated with rutin at concentrations of 10, 20 and 40 μmol/L, respectively. …”
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Doxycycline: An Antibiotic Attenuates Oxidant Stress, Perturbation of Lipid Metabolites, and Antioxidants against Vanadium Toxicity in Rat Hepatocytes by Ezeddin Salem Gassar, Negia Abdullah Emtawel Mohamed, Fatema Abdullah Emtawel, Rehab M. Elfakhri, Syed Saleem Haider

“…Aim The present study was designed to evaluate the protective effects of doxycycline against vanadium-induced hepatoxicity. Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into the following four groups: control group (received 0.2 mL of physiological saline), doxycycline control group (received 4 mg/kg body weight on day 1 and 2 mg/kg body weight daily thereafter), vanadium group (received elemental vanadium 1.5 mg/kg-body weight in distilled water), and concomitantly treated group (doxycycline + vanadium) received (doxycycline 4 mg/kg body weight on day 1 and 2 mg/kg body weight thereafter + vanadium 1.5 mg/kg body weight), all given orally for 10 consecutive days. …”
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Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imagin... by Tan G, Huang X, Ye L, Wu A, He L, Zhong Y, Jiang N, Zhou F, Shao Y

“…Gang Tan,1,2,* Xin Huang,1,3,* Lei Ye,1 An-Hua Wu,2 Li-Xian He,2 Yu-Lin Zhong,1 Nan Jiang,1 Fu-Qing Zhou,4 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 2Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, 3Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 4Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: The aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude of low-frequency fluctuation (ALFF) method and its relationship with their clinical manifestations.Patients and methods: A total of 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs, 16 males and two females) closely matched in age, sex, and education were recruited in this study. …”
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Primary Biliary Cholangitis and Seropositive Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study by Deng Z, Lei W, Kuang X, Liu X, Tai W

“…Inverse variance weighting (IVW) was the primary analysis method, complemented by Bayesian weighted MR (BWMR), robustly adjusted profile scores (MR-RAPS), MR-Egger, and weighted median approaches. …”
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The Value of Systemic Inflammatory Index and Nutritional Marker in Predicting Acute Calculus Cholecystitis and Its Severity by He B, He Q, Lai Z, Niu Z, Zhang J, Wang Y

“…Bing He,1,* Qiguang He,2,* Zhiyong Lai,3 Zhiqiang Niu,3 Jijun Zhang,3 Yingkai Wang3 1Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of First Clinical Medical College, China Medical University, Shenyang, Liaoning, People’s Republic of China; 3Department of Biliopancreatic Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jijun Zhang; Yingkai Wang, Department of Biliopancreatic Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email 1207978528@qq.com; 1120873027@qq.comBackground: The study aimed to evaluate the accuracy with which various nutritional and inflammatory indicators, including Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Systemic Immune-Inflammation Index (SII), Monocyte-to-Lymphocyte Ratio (MLR), Systemic Inflammatory Response Index (SIRI), and Prognostic Nutritional Index (PNI), can predict the severity of acute calculus cholecystitis.Methods: 109 cases of chronic calculus cholecystitis (CCC) and 130 cases of acute calculus cholecystitis (ACC), including 62 cases of acute simple cholecystitis (ASC), 35 cases of acute purulent cholecystitis (APC), and 33 cases of acute gangrenous cholecystitis (AGC), were encompassed in the retrospective cohort study. …”
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Changes in Knowledge and Compliance with Pitch Count Recommendations Among Youth Baseball Coaches: A Cross-Sectional Comparison at Two Time Points by Makita M, Onishi M, Kouno C, Kawabe R, Doi N, Tahu Y, Aoyama T, Nagai-Tanima M

“…Although it is important for coaches to have prior knowledge of injuries in order to prevent the incidence of Little League Elbow, few studies have assessed the actual experience of coaches.Methods: Of the 242 coaches belonging to the Kyoto Boys’ Baseball Association who participated, 172 with valid responses were analyzed. …”
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Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-D... by Lu X, Chen K, Xuan Y, Shen M, Lei W, Huang Y, Sun J

“…This study aimed to determine the optimal dose (90% minimum effective concentration [MEC90]) of intraoperative oxycodone to prevent shivering during caesarean section.Methods: This study was designed by the biased-coin up-and-down method. …”
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