LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. …”
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Investigating Remedial Strategies for Missed or Delayed Dose of Sertraline in Chinese Adolescent Patients with Depressive Disorders via Population Pharmacokinetics Modeling and Sim... by Xia H, Deng G, Liang F, Zhang Z, Huang W, Guo Z, Song Q, Wen Y, Shang D, Tan Y

“…Hence, we designed the remedial strategies of different missed dosage scenarios based on population pharmacokinetics (PPK) model simulation, aiming to provide medication guidance to Chinese adolescent depressive patients.Methods: A total of 221 sertraline concentration monitoring data were collected from 103 sertraline-treated adolescent patients with depression. …”
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Relation of oncogenic microRNA-10b and microRNA-21 to glioblastoma size and localization by Nikitović Marina, Stepanović Aleksandar, Arsenijević Tatjana, Petrović Nina

“…Our study aimed to investigate whether there is a link between miR-10b and miR-21 expression levels and tumor size and tumor localization. Methods. The research involved 43 patients diagnosed with glioblastoma. …”
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A comprehensive study of the mechanical properties of rock-like materials for inelastic deformation model establishment by TRIMONOVA Mariia, STEFANOV Yuri, DUBINYA Nikita, BAKEEV Rustam

“…Judging by the dependence of volumetric strains under a lateral load equal to 1.4 MPa, compaction should begin to appear even at lateral loads lower than 3 MPa.   …”
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COST-MINIMIZATION ANALYSIS OF USING SHORT AND LONG-ACTING ERYTHROPOESIS-STIMULATING AGENTS FOR CORRECTION OF NEPHROGENIC ANEMIA AGAINST THE BACKGROUND OF SUBSTITUTION THERAPY by I. S. Krysanov, E. Yu. Ermakova, L. B. Vaskova, M. V. Tiapkina

“…In the hypothetical cohort of patients under study, epoetin alfa, darbepoetin alfa, and methoxy polyethylene glycol – epoetin beta not differ in effectiveness in achieving target Hb values and in safety. With the equal effectiveness of the investigated drugs, in the studied patients, intravenous epoetin alfa can be less expensive drug therapy relative to the equivalent doses obtained by the calculation: darbepoetin by 14–24% and methoxy polyethylene glycol – epoetin beta by 4–30%. …”
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Predictors and regional prevalence of food insecurity in Ethiopia during COVID-19: a multilevel analysis by Henok Wariso Waqo, Gezahegn Mekonnen Woldemedihn, Zeytu Gashaw Asfaw

“…Conclusions Even while food insecurity is a major issue in Ethiopia, not all its regions are at equal status. Household’s food insecurity is determined by his ability to handle the problem economically, and withstand shock events like COVID-19 that subtly disrupts social and economic networks. …”
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The Crucial Role of the PPAR Signaling Pathway in the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: An Analysis of Gene Expression and Macrophage Polarization by Zhang L, Guo R, Wu H, Abudusalamu A, Ding W, Li D, Wei X, Niu L

“…Ling Zhang,* Rong Guo,* Haixia Wu, Abula Abudusalamu, Wei Ding, Dewei Li, Xuemei Wei, Lin Niu Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuemei Wei, Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, People’s Republic of China, Tel +86-13579846469, Email wu1208522@163.com Lin Niu, Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, People’s Republic of China, Tel +86-1319989525, Email 363141843@qq.comPurpose: To explore the role of the peroxisome proliferator-activated receptor (PPAR) signaling pathway in chronic obstructive pulmonary disease (COPD) and identify potential biomarkers and therapeutic targets, given that COPD is a major global health burden and the specific molecular mechanisms of the PPAR pathway in COPD are not fully understood.Patients and Methods: Gene expression data from the GEO database were analyzed to identify key genes and immune cells related to COPD. …”
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Esketamine as an Epidural Adjuvant for Postoperative Analgesia in Gynecological Malignancy Surgery: A Randomized Trial by Luo H, Yang Y, He Z, Pan C, Wu X, Cao S, Zhang J

“…Huanyu Luo,1,2,* Yuecheng Yang,1,2,* Zhiyong He,1,2 Congxia Pan,1,2 Xing Wu,1,2 Shumei Cao,1,2 Jun Zhang1,2 1Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Zhang, Department of Anesthesiology, Shanghai Cancer Center, Fudan University, No. 270 Dong-An Road, Shanghai, 200032, People’s Republic of China, Tel +86-021-64175590, Fax +86-021-64174774, Email snapzhang@aliyun.comObjective: This study aims to evaluate the efficacy of esketamine as an epidural adjuvant in mitigating postoperative pain, particularly following the discontinuation of epidural analgesia in patients undergoing open surgery for gynecological malignancies.Design: A randomized controlled trial.Methods: Eighty-eight patients were randomized to receive either esketamine (0.4 mg/kg) combined with sufentanil and ropivacaine (eskatamine group) or sufentanil and ropivacaine alone (control group) via patient-controlled epidural analgesia. …”
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Peri-implant bone behavior after single drilling technique versus undersized drilling technique of immediately loaded implant in posterior maxilla: a one-year prospective study by Mohamed Ahmed Galal Sadek, Mohamed Zaghlool Amer, Nesma El-Gohary, Heba Abo-Elfetouh Elsheikh

“…This study was directed to evaluate the peri-implant bone behavior of the undersized drilling technique versus the single drilling technique of immediately loaded dental implants inserted in the posterior maxilla. Patients and methods 32 patients were selected for prosthetic replacement of a missing maxillary posterior single tooth by an immediately loaded dental implant and divided randomly into two equal groups. …”
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Male adolescents’ attitude towards justifying wife beating: a study on 20 low and lower-middle-income countries by Nahid Hassan Nishan, M. Z. E. M. Naser Uddin Ahmed, Sayantan Chakraborty, Saidur Rahman Mashreky, Katja Gillander Gådin, Koustuv Dalal

“…Data analysis was conducted using Stata 17 software, applying weighting methods from the DHS Program to ensure the results accurately represented the target population. …”
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Chemical, optical, and morphological properties of TPU and PET-G samples after aging in artificial saliva: an in vitro study by Edoardo Staderini, Giuseppe Chiusolo, Massimiliano Papi, Mario Palone, Luca Lombardo, Massimo Cordaro

“…The analysis focused on the morphological, chemical, and optical properties of the samples, including thickness, weight, and surface roughness. Methods The study examined 48 thermoplastic samples, equally divided between PET-G and TPU. …”
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Genetic Evidence for Causal Effects of Immune Cell Subtypes on Postherpetic Neuralgia by Chen T, Tang S, Chen R, Ding W, Chen Y, Jian Z, Wu M, Jia M, Zhang X

“…However, the specific dynamic immune profile, the underlying molecular mechanisms, and especially the causal relationship between immune cells and PHN have yet to be comprehensively elucidated.Methods: We implemented a comprehensive analytical framework incorporating two-sample Mendelian randomization (MR), multivariable Mendelian randomization(MVMR), and colocalization analyses to elucidate the causal relationships between immune cell phenotypes and PHN. …”
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Local Effect of Insulin on Healing of Extraction Socket of Diabetic Rabbits (Experimental Study) by Waqass S. Thanoon, Omar W. Majid, Ali Khalil Marie

“…A secondary post-extraction standardized dose was split equally and injected buccally and palataly around the gingival margins of the studied socket on the 2nd, 4th, and 6th day post extraction only for the treated side. …”
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Factors Influencing Decision-Making Preferences Among Patients with Inflammatory Bowel Disease: A Cross-Sectional Study in China by Wang Y, Zhang S, Fang W, Yao Y, Yu Q, Zhao X, Zhang X

“…Yizhen Wang,1,2,* Shijing Zhang,1,2,* Wenjuan Fang,2 Yanli Yao,1 Qun Yu,1 Xia Zhao,1 Xinqiong Zhang1 1School of Nursing, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinqiong Zhang, School of Nursing, Anhui Medical University, Hefei, Anhui, People’s Republic of China, 230032, Email hixqzhang@163.comPurpose: This study aimed to evaluate the current status and the discrepancies between anticipated and actual involvement in decision-making roles among patients with inflammatory bowel disease, as well as to explore the factors that influenced actual decision-making participation.Patients and Methods: From December 2023 to June 2024, a convenience sampling method was employed to recruit patients with inflammatory bowel disease from the Department of Gastroenterology at a tertiary hospital in Anhui, China. …”
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Potential of Using New Indole- and Benzimidazo[1,2-C]quinazolines in Anticancer Therapy Based on Mesenchymal Stem Cells by Radzikowska-Bűchner E, Radej S, Niezabitowska E, Sitarz R, Szewc M

“…The aim of this study was to evaluate the cytotoxic activity of 4-(6-indolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound A) and 4-(6-benzimidazolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound B) relative to the adipose-derived mesenchymal stem cells line (ASC52-telo) and the fibroblast line (HDFa).Materials and Methods: The test was performed on commercial cell lines: ASC52-telo and HDFa which were incubated with compounds A and B at four concentrations: 1 μg/mL, 2 μg/mL, 4 μg/mL, 8 μg/mL for 48 and 72 hours. …”
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Potential hepatoprotective role of Amphora coffeaeformis algae against diazinon-induced hepatotoxicity in adult Sprague–Dawley rats by Hager Ali Fathy, Sahar Hassan Orabi, Ahmed Farag Elkirdasy, Eman Mohamed Abd El Fattah, Reda M. S. Korany, Hanem Kamal Khalifa, Mohamed Mohamed Ahmed

“…This study aimed to investigate the potential protective effects of Amphora coffeaeformis (A. coffeaeformis) algae against DZN-induced hepatotoxicity in male Sprague–Dawley rats and to elucidate the underlying mechanisms. Methods Thirty-six rats were randomly allocated into six equal groups (n = 6 per group) and treated for 8 weeks. …”
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Comparative analysis of a survey of outand inpatient physicians on secondary prevention of noncommunicable diseases by M. N. Mamedov, V. A. Kutsenko, B. U. Mardanov, O. M. Drapkina

“…Patients aged 60-64 years, regardless of sex, equally often seek outpatient and inpatient care. …”
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Association between sleep disorders and subsequent heart failure by Jamschid Sedighi, Mark Luedde, Julia Gaensbacher-Kunzendorf, Hans-Joerg Hippe, Pascal Bauer, Birgit Assmus, Samuel Sossalla, Karel Kostev

“…Results: The study analyzed data from 123,516 patients with HF and an equal number of matched controls. The mean age of participants was 73.3–73.4 (SD 12.4) years, with 53.2% being women. …”
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Lactiplantibacillus plantarum P101 Ameliorates TiO2 NP-Induced Bone Injury in Young Rats by Remodeling the Gut Microbiota and Inhibiting the Production of Pro-Inflammatory Cytokine... by Xie L, Feng L, Tang X, Xu Y, Xu H, Liu Y

“…Lixin Xie,1,* Lihua Feng,1,* Xiaomin Tang,1 Yunping Xu,1 Hengyi Xu,2 Yang Liu1 1Department of Pediatrics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hengyi Xu, State Key Laboratory of Food Science and Resources, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, People’s Republic of China, Tel +0086-791-8830-4447-ext-9520, Fax +0086-791-8830-4400, Email kidyxu@163.com; HengyiXu@ncu.edu.cn Yang Liu, Department of Pediatrics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 minde Road, Nanchang, 330006, People’s Republic of China, Tel +86-791-8631-1209, Email ocean3166@yeah.netPurpose: To evaluate the therapeutic effect of oral administration of Lactiplantibacillus plantarum P101 (P101) on skeletal injury in young rats exposed to titanium dioxide nanoparticles (TiO2 NPs), and explore the potential mechanism.Methods: Four-week-old male rats were orally administration to TiO2 NPs and supplemented with P101 2 hours later for 4 weeks. …”
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Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors by Zhang G, Bai M, Du H, Yuan Y, Wang Y, Fan W, Zhu H, Wu D, He P, Xue B

“…This review aims to provide a comprehensive overview of the current landscape and future perspectives of CAR-T therapy in both hematological malignancies and solid tumors.Methods: A thorough literature search was conducted to identify relevant preclinical and clinical studies, as well as review articles, focusing on CAR-T therapy in various hematological malignancies and solid tumors. …”
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