MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Abstract Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer (EOC). …”
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Global, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045 by Chengling Liu, Xingchen Liu, Li Hu, Xin Li, Haiming Xin, Sailin Zhu

“…To address this, we analyzed epidemiological patterns and investigated risk factors for CMM-related mortality.MethodsThis study analyzed CMM using data from the 2021 Global Burden of Diseases survey, covering 204 countries and territories. …”
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Protective effect of erythropoietin preconditioning on kidney ischemia-reperfusion injury by ZHANG Jiong, WANG Jia, WANG Fang, LI Gui-sen

“…Objective To explore the protective effect of erythropoietin(EPO)on renal ischemia-reperfusion injury(IRI)in rats.Methods Thirty male SD rats were randomly divided into sham operation group(Sham),renal IRI group(IRI)and EPO pretreatment group(EPO),10 rats in each group.The renal IRI model was constructed by clamping the left renal pedicle for 1h,removing the right kidney,and reperfusion for 24 h.In EPO group,EPO(1 000U/kg)was intraperitoneally injected at 1hbefore operation,while Sham group and IRI group were intraperitoneally injected with equal volume of normal saline.The left renal pedicle was clamped for 45 min in EPO and IRI groups,but not in Sham group.Renal perfusion was restored for 24 h,and then kidneys and serum were obtained.Enzyme linked immunosorbent assay(ELISA)was used to detect serum creatinine(SCr),blood urea nitrogen(BUN),pro-inflammatory cytokines [interleukin-6(IL-6);interferon gamma(IFN-γ)and tumor necrosis factor alpha(TNF-α)]and anti-inflammatory cytokine(IL-10 and TGF-β).The reverse transcriptase polymerase chain reaction(RT-PCR)was used to detect renal pro-inflammatory cytokines(IL-6,IFN-γand TNF-α)and anti-inflammatory cytokines[IL-10 and transforming growth factor beta(TGF-β)]mRNA expression levels.Western blotting was used to detect EPO receptor(EPOR),phosphorylated EPOR(p-EPOR),tyrosine kinase-2(JAK2),signal transducer and activator of transcription 3(STAT3),phosphorylated JAK2(p-JAK2),phosphorylated STAT3(pSTAT3)protein expression levels.Periodic acid Schiff staining(PAS)was used to examine the pathological changes of renal tissues.Results As compared with Sham group,the expression levels of pEPOR,p-JAK2,p-STAT3,SCr,BUN,IL-6,TNF-αand IFN-γwere significantly increased,pathological changes of renal tissues obviously alleviated,and expression levels of IL-10 and TGF-βwere markedly reduced in IRI group.There was no significant difference in EPOR,JAK2 and STAT3levels between Sham group and IRI group.As compared with IRI group,the expression levels of p-EPOR,p-JAK2,p-STAT3,IL-10 and TGF-βwere significantly increased,the levels of SCr,BUN,IL-6,TNF-αand IFN-γwere significantly reduced,and the pathological changes of renal tissues were significantly alleviated in EPO group,but there was no significant difference in EPOR,JAK2 and STAT3expression between IRI group and EPO group.Conclusions EPO preconditioning can alleviate inflammation by inhibiting renal IRI,which may be related with the activation of EPOR/JAK2/STAT3 signaling pathway.…”
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ILF-neurofeedback in clinical practice: examining symptom change and performance metrics across diagnostic groups by Thomas Theis, Ute Bolduan, Sigrid Seuß, Johannes Spallek, Bernhard Wandernoth, René Mayer-Pelinski, René Mayer-Pelinski

“…IntroductionNeurofeedback (NF), particularly Infra-Low Frequency (ILF) Neurofeedback, is an emerging method of neuromodulation aimed at enhancing the brain’s self-regulation. …”
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Global Burden of Alzheimer’s Disease Attributable to High Fasting Plasma Glucose: Epidemiological Trends and Machine Learning Insights by Ma Y, Huang S, Dong Y, Jin Q

“…This study aims to analyze global trends in AD death rates and disability-adjusted life years (DALYs) rates attributable to HFPG from 1990 to 2021 and assess the potential of glucose-related biomarkers in predicting cognitive impairment.Methods: Data from the Global Burden of Disease 2021 database were used to analyze AD death rates and DALY rates due to HFPG across 204 countries. …”
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Comparison of Percutaneous Transforaminal Endoscopic Surgery (PTES) With MIS-TLIF for Treating Lumbar Degenerative Disease in Obese Patients by Fan W, Chen Y, Zhou T, Xu Y, Gu Y

“…Wenshuai Fan,1,2,* Yuheng Chen,1,* Tianyao Zhou,1 Yun Xu,3,4 Yutong Gu1,4 1Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, People’s Republic of China; 2Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Centre for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People’s Hospital, Zhejiang, People’s Republic of China; 4Shanghai Southwest Spine Surgery Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yutong Gu, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, 200032, People’s Republic of China, Email 447574313@qq.com Yun Xu, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China, Email xuyun65204@163.comPurpose: The purpose of this study is to compare clinical outcomes of obese patients with lumbar degenerative disease (LDD) receiving either percutaneous transforaminal endoscopic surgery (PTES) or minimally invasive surgery-transforaminal lumbar interbody fusion (MIS-TLIF).Methods: There were 26 patients underwent PTES, and 29 patients were treated with MIS-TLIF between June 2014 and June 2019. …”
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Evaluation of the tubular penetration of two different types of nanoparticle root canal sealers over apically separated files: a scanning electron microscopic study (in vitro study... by Alaa H. Nagdi, Nayera A. Mokhless, Mahmoud R. Aboelseoud

“…Teeth were randomly divided into four equal groups based on the type of sealer used. Group I: Adseal (Rs) (Meta Biomed, Cheongju, Korea) resin-based sealer, group II: Adseal resin-based sealer modified with silver nanoparticles (Rs/Ag), group III: Ceraseal (BC) (Meta Biomed, Cheongju, Korea) bioceramic sealer and group IV: Ceraseal bioceramic sealer modified with bioactive glass nanoparticles (BC/BG). …”
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Distribution of Angle Alpha in a Large Population in Eastern China: An Analysis of the 30705 Eyes Using the Ray Tracing Aberrometer by Hua Z, Zeng Q, Zhang L, Shen J, Yang J

“…Zhixiang Hua,1– 5,* Qiulin Zeng,6,* Limei Zhang,7 Jiying Shen,7,* Jin Yang1– 5,* 1Department of Ophthalmology and the Eye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, People’s Republic of China; 2The Key Laboratory of Myopia, Ministry of Health, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People’s Republic of China; 4Key National Health Committee of the Key Laboratory of Myopia, Fudan University, Shanghai, People’s Republic of China; 5The Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, People’s Republic of China; 6Department of Ophthalmology, Shanghai Xinshijie Dongqu Eye Hospital, Shanghai, People’s Republic of China; 7Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Yang, Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People’s Republic of China, Tel +008613671632525, Email jin_er76@hotmail.com Jiying Shen, Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China, Tel +008613817505149, Email susu22yoyo@163.comPurpose: To describe the distribution of angle alpha orientation and magnitude in a large population and to analyze the impact of eye laterality, gender, and age on angle alpha.Setting: EENT Hospital of Fudan University and Shanghai Heping Eye Hospital, 2017– 2023.Design: A retrospective analysis utilizing the iTrace system to examine preoperative angle alpha in patients undergoing cataract surgery.Methods: Angle alpha orientation and magnitude were collected from 30,705 individuals. …”
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Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study by Liu X, Liu X, Han Y, Cheng Y, Luo H, Liu Y, Li D, Guo W, Jiang H, Guo L, Jiang X

“…Xinjin Liu,1,2,* Xu Liu,1,2,* Yanbing Han,1,2 Yifei Cheng,1,2 Hongjie Luo,1,2 Yichen Liu,1,2 Dingling Li,1,2 Weihong Guo,1,2 Haoyu Jiang,1,2 Linghong Guo,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, Tel +86 189 8060 1693, Email jiangxian@scu.edu.cn Linghong Guo, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, +86 18380131660, Email Linhom.guo@foxmail.comPurpose: To identify the primary concerns and unmet needs of patients with melasma on social media using qualitative analysis and AI-based keyword extraction.Patients and Methods: We conducted a qualitative study of melasma patient discussions using publicly available posts on Facebook and Baidu. …”
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Parents’ perspective on children’s access to healthcare services and associated factors: a cross-sectional study by Nona Salimi, Javad Javan-Noughabi, Vahid Ghavami, Reza Matinfar, Fatemeh Kokabisaghi

“…To make health services more appropriate, it is necessary to train the staff about professional ethics and equal treatment of all patients.…”
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NOSOLOGICAL DIAGNOSIS OF JUVENILE ARTHRITIS AT DIFFERENT FOLLOW-UP STAGES by Svetlana Olegovna Salugina

“…Among the patients with uveitis, the equal number (37.5%) RA or one of the types of SA; a diagnosis could not be specified in 25%, it was formulated as CJA (UA) or other diseases. …”
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MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index by Huang B, Li X, Zhang XX, Li SW, Wang M, Chen Q, Cao YD, Cui JQ

“…Therefore, our study specifically investigates the relationship between MHR and HUA in a T2DM population.Methods: This cross-sectional study enrolled 1,261 T2DM patients. …”
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Varicella-zoster virus vasculopathy: a rare complication of Ramsay Hunt Syndrome: a literature review by Di Wu, Mian Song

“…Detection of VZV IgG antibodies and VZV DNA in the CSF has equal sensitivity. Antiviral combined with steroid therapy represents the optimal treatment approach.…”
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“It’s the Time they Take to Give Feedback; it has Become a Problem” Exploring Barriers and Facilitators for Research Supervision in Postgraduate Medical Education... by Abeid M, Mbekenga C, Jusabani AM, Kassamali SA, Mgonja ML, Sibuma M, Sirili N, Noorani M

“…We aimed to explore the barriers and facilitators for research supervision in postgraduate medical education in Tanzania.Methods: We adopted an exploratory qualitative case study and conducted key informant interviews with three purposively selected faculty in leadership and four focus group discussions with 14 postgraduate trainees and 10 faculty members. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of CD4+T subsets and gut microbiota.Methods: Fifty-eight major compounds in HED were identified by UPLC-Q-TOF/MS. …”
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Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Lea... by Chen L, Fang CP, Chen Y, Gu WH, Wang SL, Niu N, Zhang QH

“…Li Chen,1,* Cai-Ping Fang,1,* Yan Chen,1 Wei-Hua Gu,1 Sai-Li Wang,1 Ning Niu,1 Qin-Hua Zhang2 1Department of Gynecology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, People’s Republic of China; 2Department of Gynecology, Shanghai Shuguang Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qin-Hua Zhang, Email bzie564@163.comObjective: To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.Methods: A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. …”
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Machine Learning-Based Prediction Model for Multidrug-Resistant Organisms Infections: Performance Evaluation and Interpretability Analysis by Zhao W, Sun P, Li W, Shang L

“…This study evaluated an interpretable machine learning model incorporating SHapley Additive exPlanations (SHAP) to predict MDRO infections in ICU patients.Methods: A retrospective cohort study was conducted on 888 ICU patients (2020– 2022) from a tertiary hospital in China. …”
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Evaluation of Medical Device Aging and Replacement Decisions within Hospital Environments: A User-Centered Approach by Park S, Seo G, Park Y, Kim EJ, Lee H, Lee M, Jakovljevic M

“…We seek to prioritize criteria for medical device replacement and develop feasible strategies applicable to real-world healthcare settings.Methods: This analysis was conducted by reviewing previous studies to identify the key factors in medical device replacements. …”
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The Accuracy of Dynamic Parameters for Prediction of Fluid Responsiveness in Elderly Patients with Septic Shock by Paphawin S, Theerawit P, Junhasavasdikul D, Sutherasan Y

“…Sittikorn Paphawin,1,* Pongdhep Theerawit,2,* Detajin Junhasavasdikul,3 Yuda Sutherasan3 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand*These authors contributed equally to this workCorrespondence: Yuda Sutherasan, Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +6622011619, Fax +6622011629 Ext 2, Email Sutherasan_yuda@yahoo.comPurpose: Assessed the accuracy of stroke volume variation (SVV), pulse pressure variation (PPV), and dynamic arterial elastance (Eadyn) in predicting fluid responsiveness (FR) and mean arterial pressure (MAP) response in elderly patients with septic shock.Patients and Methods: Mechanically ventilated patients aged over 65 with septic shock were enrolled. …”
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A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma by Zhou L, Du Y, Shang Y, Xiang D, Xia X

“…In this study, we used triptolide (TP), a bioactive constituent in Tripterygium wilfordii Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.Results: The prepared FA+TPP-TP-Lips had a particle size of 99.28 ± 5.7 nm, a PDI of 0.20 ± 0.02, a zeta potential of 1.2 ± 0.08 mV, and an encapsulation rate of 74.37% ± 1.07%.FA+TPP-TP-Lips facilitates the cellular uptake of drug delivery systems and improves their targeted delivery to mitochondria. …”
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