Causal Associations Between Sleep Traits and Delirium: A Bidirectional Two-Sample Mendelian Randomization Study by Liu H, Zhang Z, He Y, Ding L, Wu T, Wang Y, Ma W

“…This bidirectional two-sample Mendelian randomization (MR) study was conducted to examine the possible causal relationships between sleep traits and delirium.Patients and Methods: Utilizing genome-wide association studies (GWAS), we identified ten sleep traits: chronotype, sleep duration, short sleep duration, long sleep duration, daytime napping, daytime sleepiness, insomnia, number of sleep episodes (NSE), sleep efficiency, and rapid eye movement sleep behavior disorder (RBD). …”
Get full text

In Vitro Fertilization and Dichorionic-Diamniotic Twin Pregnancies in Nulliparous Women: A Retrospective Cohort Study Comparing Pregnancy Outcomes Between Advanced and Younger Mate... by He MP, Jian WQ, Yuan CL, He SM, He MR, Yan J, Huang JC, Zhao KS

“…Mei Ping He,* Wen Qian Jian,* Chun Lan Yuan, Shi Mei He, Mei Rong He, Jian Yan, Jian Chun Huang, Kai Sun Zhao Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, Nanning, Guangxi, 530031, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Sun Zhao, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13737085418, Email 339609234@qq.com Jian Chun Huang, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13207801809, Email huangjc3081@163.comObjective: To compare pregnancy outcomes between advanced maternal age (AMA, ≥ 35 years) and younger maternal age (YMA, 20– 34 years) nulliparous women with IVF-conceived dichorionic-diamniotic (DCDA) twin pregnancies.Methods: We conducted a retrospective analysis on 141 nulliparous women undergoing cesarean delivery at The Second Nanning People’s Hospital (2020– 2024). …”
Get full text

Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity by Lu M, Dai Z, Lin Y, Sun C, Li S, Guo Z, Liu Y, Liu X, Li S, Liu R, Xu B, Lei H

“…Recent findings suggest that targeting the STING signaling pathway may provide an alternative strategy for slowing the progression of fibrosis.Methods: We synthesized liver-targeted co-assembled SHG nanoparticles (SHG NPs) that incorporate sorafenib and a hederagenin derivative (Hed), which acted as a STING pathway inhibitor. …”
Get full text

The Evaluation of Reference Values of Plasma and Effect-Site Concentrations of Propofol and Remifentanil During Extubation in Patients Who Had Hysteroscopy Procedures by Wei Y, Wang J, Xu Z, Ma R

“…Yu Wei,1– 3,* Jianwei Wang,1– 3,* Zifeng Xu,1– 3 Rui Ma1– 3 1Department of Anesthesiology, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, Peoples Republic of China; 3Shanghai Municipal Key Clinical Specialty, Shanghai, Peoples Republic of China*These authors contributed equally to this workCorrespondence: Rui Ma; Zifeng Xu, Department of Anesthesiology, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Huashan Road 1961, Shanghai, 200030, People’s Republic of China, Tel +86-021-64070434, Email marui_merrygood@163.com; xuzf@shsmu.edu.cnAim: This study aimed to assess the correlation of plasma concentration (Cp) and effect-site concentration (Ce) of propofol and remifentanil with level of consciousness and evaluate their reference values during extubation in patients scheduled day-case operative hysteroscopy under propofol-remifentanil anesthesia.Methods: Propofol (Marsh model) and remifentanil (Minto model) were simultaneously administered using a target-controlled infusion (TCI) pump for the induction and maintenance of anesthesia. …”
Get full text

Association Between High-Sensitivity C-Reactive Protein Trajectories and the Incidence of Metabolic Syndrome:A Retrospective Cohort Study by Pan J, Cai X, Chen J, Xu M, Hu J, Mao Y, Chen T, Li L, Jin M, Chen L

“…JianJiang Pan,1,* XiXuan Cai,1,* JieRu Chen,1 MingYing Xu,1 JingYu Hu,1 YueChun Mao,1 Tao Chen,2 LuSha Li,1 MengQi Jin,1 LiYing Chen1 1Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, People’s Republic of China; 2Department of General Practice, Jianqiao Community Health Service Center, Hangzhou, Zhejiang, 310021, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiYing Chen, Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email 3197020@zju.edu.cnPurpose: Understanding the role of systemic inflammation in the development of Metabolic Syndrome (MetS) is crucial for identifying individuals at a higher risk of this cluster of conditions that increase the risk of heart disease, stroke, and diabetes.Patients and Methods: A retrospective cohort study was conducted with 4,312 participants who were free from MetS at the study’s onset and had high-sensitivity C-reactive protein (hsCRP) levels measured. …”
Get full text

Clinical and Microbiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Associated Recurrent Urinary Tract Infections by Cao H, Cheng H, Zhou J, Zhao J, Xu M, Fei Y

“…Investigating its features in rUTIs may provide insights into effective prevention strategies.Methods: We analyzed a cohort of patients with rUTIs caused by Klebsiella pneumoniae from April 2020 to April 2024. …”
Get full text

Clinical Features and Outcomes of Pediatric Intraspinal Paragonimiasis by Jiang Y, Yang Y, Zheng H, Hong S, Li X, Jiang L, Tan C

“…This study aimed to provide experience for diagnosis and treatment strategies of pediatric intraspinal paragonimiasis.Methods: We performed a retrospective clinical analysis of patients hospitalized for intraspinal paragonimiasis between January 1, 2015, and December 31, 2021.Results: Nine patients were included. …”
Get full text

Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children by Andrew O. Agbaje

“…In isotemporal substitution analyses, longitudinal replacement of 10 min of ST with equal time in LPA during childhood, adolescence and young adulthood cumulatively decreased systolic BP by −2.63 mmHg [95% CI −3.17 to −2.08] (p < 0.0001) and diastolic BP by −1.93 mmHg [95% CI −2.36 to −1.50] (p < 0.0001). …”
Get full text

Antimicrobial-Resistant <i>Staphylococcus</i> spp. Harbored by Hedgehogs (<i>Erinaceus europaeus</i>) in Central Italy by Fabrizio Bertelloni, Francesca Pauselli, Giulia Cagnoli, Roberto Biscontri, Renato Ceccherelli, Valentina Virginia Ebani

“…Background/Objectives: European hedgehogs (<i>Erinaceus europaeus</i>) are present in areas where there is human activity; therefore, they can be a source of pathogens for other animals and humans. Methods: Eighteen hedgehog carcasses were collected and analyzed for <i>Staphylococcus</i> spp. …”
Get full text

The Recovery of Ciprofol, Remimazolam and Remimazolam-Flumazenil for General Anesthesia Undergoing Fundus Surgery: A Single-Center, Prospective, Randomized, Controlled Clinical Stu... by Zhang S, Liu Y, Liu Y, Xu T

“…The primary objective of this study was to compare the recovery of HSK3486 with that of remimazolam during successful general anesthesia.Patients and Methods: This prospective, randomized, double-blind study included 93 patients who had undergone fundus surgery. …”
Get full text

Improving retention of pediatric feeding tubes with a nasal bridle: a randomized controlled trial by Megan Foster, Veronica Armijo-Garcia, Jonathan Gelfond, Andrew D. Meyer

“…Results A total of 35 patients were randomized and equally split to the bridle (n = 17) and tape arm (n = 18). …”
Get full text

Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1&nbsp;Min Jia,1&nbsp;1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People&rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People&rsquo;s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. …”
Get full text

Clinical Characteristics Analysis of 30 Cases of Interferon-&gamma; Autoantibody-Positive Patients with Concurrent Mycobacterial Infection: A 6-Year Retrospective Study by Zhao CY, Song C, He HW, Huang XZ, Meng XY, Huang AC, Xu CY, Luo LL, Xi SY, Lan YQ, Li WW, Lin YR, Zhu QD

“…Chun-Yan Zhao,1,2,&ast; Chang Song,1,2,&ast; Hua-Wei He,1,&ast; Xian-Zhen Huang,1 Xia-Yan Meng,1 Ai-Chun Huang,1 Chao-Yan Xu,1 Li-Li Luo,1 Shao-Yong Xi,3 Yan-Qun Lan,1 Wei-Wen Li,1 Yan-Rong Lin,1 Qing-Dong Zhu1 1Department of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Clinical Medical School, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Clinical Laboratory, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qing-Dong Zhu; Yan-Rong Lin, Department of Tuberculosis, The Fourth People’s Hospital of Nanning, No. 1 Changgang Two-Li, Xingning District, Nanning, 530023, People’s Republic of China, Tel +8615207717261 ; +860771-5636973, Email zhuqingdong2003@163.com; linyanrong2009@126.comPurpose: This study aimed to investigate and elucidate the clinical characteristics, immune status, infection types and patterns, treatment responses, and disease progression in patients with positive anti-interferon-gamma (IFN-γ) autoantibodies in combination with Mycobacterium infections.Patients and Methods: We conducted a retrospective analysis of clinical data from patients with positive anti-IFN-γ autoantibodies and concurrent Mycobacterial infections, including Mycobacterial infections (MTB) and non-tuberculous mycobacteria (NTM). …”
Get full text

Immune pre-stimulation by injected yeast beta-glucan as a strategy to prevent calf diarrhea and bovine respiratory disease during the first 74 days of age by Fang Yan, Zhihong Zhang, Xiaorong Zhan, Wenqian Yang, Junhu Yao, Xiurong Xu

“…The CON group received an equal volume of sterile saline at the same time. …”
Get full text

Impact of Probiotics Supplementation on Enteral Feed Tolerance in Very Low Birth Weight Neonates: An Open Label Randomised Controlled Trial by Narain Das Vaswani, Hunny Verma, Jagjit Singh Dalal, Seema Lekhwani, Kirty Verma, Neeraj Kumar, Mohan Lal Kundu, Dinkar Yadav

“…A total of 100 participants were recruited and divided equally into two groups (n=50 each): the probiotic group and the control group. …”
Get full text

Caregiver Burden and Its Associated Factors Among Family Caregivers of Hospitalized Patients with Neurocritical Disease: A Cross-Sectional Study by Wei L, Zhao X, Chen X, He Y, Liu J, Xian J, Yang Y

“…Previous studies have focused on caregiver burden for patients in the home rehabilitation stage, while few studies investigate caregiver burden among informal caregivers of early postoperative inpatients.Objective: This study aimed to investigate caregiver burden for caregivers of patients with neurocritical diseases during hospitalization and to identify predictive factors related to caregiver burden.Methods: From November 2023 to April 2024, a cross-sectional study was conducted using a convenience sampling method to assess patients with neurocritical disease and their family caregivers. …”
Get full text

Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19 by Zhang X, Zhou L, Peng P, Zhang W, Liang C

“…This study aimed to assess the impact of AMS at a Chinese tertiary care hospital on inpatient antimicrobial use and bacterial resistance during the COVID-19 outbreak.Methods: An interrupted time-series regression analysis was conducted to compare inpatient antimicrobial use between pre- and post-intervention periods. …”
Get full text

Distribution of Pathogenic Bacteria and Drug Resistance in ICU of a Newly Built Hospital by Zeng H, Liu R, Cheng C, Yang N, Luo L, Long S, Zhou R, Yan K, Huang H

“…Hui Zeng,1,&ast; Rong Liu,1,2,&ast; Chuanli Cheng,2,&ast; Nana Yang,2 Luwen Luo,1,2 Shengshuang Long,3 Renjia Zhou,4 Kai Yan,1 Huantao Huang1 1Nursing Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2School of Nursing of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Infection Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 4ICU of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hui Zeng, Email zenghui.1221@163.comObjective: This study investigated the distribution and resistance patterns of pathogens in the intensive care unit of a newly established hospital in Guizhou Province to promote the rational use of antibiotics to reduce multidrug resistance.Methods: A retrospective analysis was conducted on the distribution of pathogens and changes in drug resistance in the ICU of a newly built hospital in Guizhou Province from March 2019 to December 2023. …”
Get full text

Differential Diagnosis Value of Neutrophil Gelatinase Associated Lipocalin as a Noninvasive Biomarker in Perianal Fistulizing Crohn&rsquo;s Disease by Ma K, Li Y, Wu J, Fu Y, Yin L, Xu S, Weng F, Yao Y, Wang C

“…This study aimed to evaluate NGAL’s potential as a noninvasive diagnostic biomarker between pfCD and cryptoglandular (CG) perianal fistula, and its correlation with disease severity in pfCD.Methods: Serum, fecal, and fistula tissue samples were collected from 96 patients with pfCD and 97 patients with CG perianal fistula as controls. …”
Get full text

Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis by Shen Q, Huang JB, Zhu M, Ji DJ, Huang SJ, Li J

“…Imbalance in copper (Cu2+) metabolism is related to a series of diseases, but its role in COPD has not been specified.Methods: A dataset relevant to COPD was downloaded from Gene Expression Omnibus database, among which a total of 18 cuproptosis-related genes (CRGs) were screened. …”
Get full text