Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling by Tao X, Zhao M, Gao K, Zhang W, Xu D, Li W, Mu F, Lin R, Guo C, Li R, Wang J

“…However, the potential of Wel to improve ischemic stroke (IS) and the underlying mechanisms remain unclear.Methods: The middle cerebral artery occlusion and reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) were established to evaluate the potential neuroprotective of Wel. …”
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Psychological rehabilitation of individuals with alcohol use disorder, drug addiction, gambling disorder, and codependency by Aidos Ibragim, Bakytgul Issatayeva, Kundyz Kuanzhanova, Almagul Mandykayeva, Aliya Mambetalina

“…By the end of the study, the final sample sizes in the experimental groups were 72 (alcohol use disorder), 70 (drug addiction), 74 (gambling disorder), and 73 (codependent behavior) individuals. An equal number of participants in the corresponding control groups were reassessed. …”
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Melatonin Activates KEAP1/NRF2/PTGS2 Pathway to Attenuate Hyperoxia-Driven Ferroptosis in Bronchopulmonary Dysplasia by Deng X, Xie A, Ye D, Ma Y, Bao Z, Xie Q, Luo Z, Wang R, Li H, Yu R

“…This study aimed to test the hypothesis that melatonin mitigates hyperoxia-induced BPD by inhibiting ferroptosis in alveolar epithelial cells, specifically through modulation of the KEAP1/NRF2/PTGS2 signaling pathway.Methods: Hyperoxia-induced MLE-12 cells and neonatal mice were used to establish BPD models. …”
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Fracture activation in the overburden and aquiclude stability under the mining of close-distance coal seams by Jian CAO, Haitao SU, Chao WANG, Jianwei LI, Liang LI, Xuwei MAO

“…This is prone to cause aquiclude instability, leading to groundwater loss. MethodsThis study aims to reveal the characteristics of fractures in the overburden and the aquiclude stability in the mining of close-distance coal seams. …”
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Intralesional Bleomycin in Periungual Warts: A Prospective Randomised Controlled Study by Kallolinee Samal, Nibedita Dixit, Srigopal Mohanty, Debjit Kar, Siddhartha Dash, Manoj Kumar Nayak

“…A total of 56 patients with PW were randomised equally by block randomisation into two groups: Group A and Group B. …”
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Associations of Leukocyte-Derived Chemotaxin-2 (LECT2) with Insulin Resistance and Metabolic Syndrome in Type 2 Diabetes: A Cross-Sectional Study by Sha Y, Lu J, Jin R, Li L, Zhang M

“…The results could offer fresh perspectives on the diagnosis and therapeutic strategies for T2D and associated metabolic disorders.Methods: A cross-sectional study was conducted on 148 T2D patients, including 90 with MetS and 58 without MetS. …”
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Characterization of a Highly Virulent Klebsiella michiganensis Strain Isolated from a Preterm Infant with Sepsis by Xu P, Zhang D, Zhuo W, Zhou L, Du Y, Zhang P, Ma L, Wang Y

“…In future, it will be necessary to investigate the concept of the high virulence of K. michiganensis to determine the treatment method.Keywords: Klebsiella michiganensis, whole-genome sequencing, preterm infant, sepsis…”
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Comparative Analysis of Short-Term Outcomes in Thoracoscopic Minimally Invasive Versus Traditional Mitral Valve Replacement: Randomized Clinical Trial Study by Yusuf Shieba, Abd Elhalim Shalaby, Tamer Elbanna, Mohamed-Adel Elgamal, Ahmed El-minshawy

“…Objective: The aim of this research is to investigate the short-term outcomes of thoracoscopic minimally invasive mitral valve replacement in comparison with the conventional technique. Subjects and Methods: This study included 100 patients with isolated mitral valve disease, who were randomly divided into two equal groups. …”
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Stakeholders’ Perceptions of the Peer-to-Peer Energy Trading Model Using Blockchain Technology in Indonesia by Faisal Yusuf, Riri Fitri Sari, Purnomo Yusgiantoro, Tri Edhi Budhi Soesilo

“…The results of filling out the questionnaire were analyzed using four methods: IFE/EFE matrix; IE matrix; SWOT matrix; and SPACE matrix to assess the results and their suitability to each other. …”
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Association Between Sarcopenia Susceptibility and Cesarean Section: A Study Based on National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization by Tian F, Pan H, Wu Q, Jiang D

“…Feng Tian,1,2,* Huiying Pan,3,4,* Qi Wu,2 Dapeng Jiang2 1Department of Pediatric Surgery, Suzhou Wujiang District Children’s Hospital, Suzhou, Jiangsu Province, People’s Republic of China; 2Department of Oncology (Ward 2), Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dapeng Jiang, Department of Oncology (Ward 2), Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China, Email jdp509@163.comObjective: To investigate the relationship between sarcopenia susceptibility and cesarean section (CS) and to assess causality using Mendelian randomization (MR).Methods: Data from 1,316 individuals aged from 20– 59 in National Health and Nutrition Examination Survey (NHANES) 2013– 2016 were included in the study. …”
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Effect of combination antihypertensive therapy, including renin-angiotensin-aldosterone system inhibitors, on oxidative stress and arterial remodeling in hypertensive patients with... by Z. M. Akhilgova, A. P. Roitman, N. G. Rakova, A. V. Bugrov, E. A. Pavlovskaya, M. S. Zastrozhin, A. G. Avtandilov

“…To study the effect of triple combination therapy on oxidative stress and arterial remodeling in hypertensive patients with heart failure with preserved ejection fraction (HFpEF).Material and methods. The study involved 76 people with diagnosed HFpEF. …”
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Copper-Based Nanoparticles for Effective Treatment Against Sepsis-Induced Lung Injury in Mice Model by Li JM, Zhang L, Pei SL, Guo L, Shen HL, He J, Guo YY, Zhang WQ, Lin F

“…In this study, a novel class of ultrasmall nanoparticles (Cu4.5O USNPs) was developed to address sepsis-induced lung injury (SILI).Methods: The synthesized nanoparticles were thoroughly characterized to assess their properties. …”
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Non-Pharmaceutical Interventions on COVID-19 in Workers and Residents of Nursing Homes in Geneva: A Mixed Qualitative and Quantitative Study by Lakshmi Krishna Menon, Ania Wisniak, Simon Regard, Silvia Stringhini, Idris Guessous, Jean-François Balavoine, Omar Kherad, The SEROCoV-WORK + Study Group

“…Incident rate ratios (IRRs) were the calculated levels of NPI restrictiveness. Methods: We used a mixed methodology to identify factors that might have affected COVID-19 expansion in nursing homes in the canton of Geneva, Switzerland. …”
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Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning by Zuo B, Jin L, Sun Z, Hu H, Yin Y, Yang S, Liu Z

“…This model is capable of predicting in advance whether an inpatient’s length of stay will exceed the average duration, thereby enhancing its clinical application and utility.Methods: The study included 568 COPD patients with hypercapnic respiratory failure, 426 inpatients from the Department of Respiratory and Critical Care Medicine of Yancheng First People’s Hospital in the modeling group and 142 inpatients from the Department of Respiratory and Critical Care Medicine of Jiangsu Provincial People’s Hospital in the external validation group. …”
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In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing by Li J, Meng H, Guo W, Zhou L, Wu S, Gao G, Liu Q, You D, Qu W

“…The high porosity of biomaterials induces more M2 macrophages, while the natural compound kaempferol inhibits the expression of matrix metalloproteinase 9 (MMP9) and thus inhibits the associated inflammatory and immunological responses.Methods: portable electrospinning dressings (PEDs) were prepared from the spinning solution using a portable electrospinning device. …”
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Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells by Wu M, Wang H, Wu X, Zeng H, Miao M, Song Y

“…Mingming Wu,1,2,* Huayu Wang,2,3,* Xiangxiang Wu,1,2 Huahui Zeng,1,2 Mingsan Miao,1,2 Yagang Song1,2 1Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 2Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, 450046, People’s Republic of China; 3College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yagang Song, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China, Tel/Fax +86-0371-65962546, Email songyagang1016@163.comObjective: The aim of this study is to investigate the recurrence and progression of liver cancer by focusing on the energy metabolism of liver cancer stem cells.Methods: A comprehensive literature search was conducted using databases including CNKI, PubMed, Wanfang, and Citexs to analyze the etiology and treatment of hepatocellular carcinoma (HCC), the factors and mechanisms contributing to HCC recurrence, and the impact of energy metabolism in HCC stem cells on the development of HCC. …”
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LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency by Yan C, Li Y, Li X, Li Y, Zhang Y, Sun J, Ding Q, Zhao X, Li B

“…Furthermore, it sought to identify pharmacological agents that could mitigate the cardiotoxic effects of ATO and establish viable intervention targets for the prevention and management of acLQTS.Methods: First, we employed gene chip arrays to identify target long noncoding RNAs (lncRNAs). …”
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Glymphatic System Dysfunction in Elderly Patients with Late-Onset Epilepsy and Comorbid Chronic Insomnia Revealed by Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS... by Wang Y, Hu J, Zhang YY, Wang FY, Wu JC, Wang L

“…Yu Wang,1,2,* Jie Hu,2,3,* Yue-Yu Zhang,2,3 Fu-Yu Wang,4 Jun-Cang Wu,2 Long Wang2 1Graduate School of Wan Nan Medical College, Wuhu, Anhui, 241002, People’s Republic of China; 2Department of Neurology, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China; 3The Fifth Clinical Medical College of Anhui Medical University, Hefei, Anhui, 230032, People’s Republic of China; 4Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Long Wang, Department of Neurology, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China, Email guxindao606@126.comPurpose: This study assessed the influence of glymphatic system (GS) dysfunction on cognitive decline in patients with late-onset epilepsy (LOE) and comorbid chronic insomnia utilizing diffusion tensor imaging along the perivascular space (DTI-ALPS).Methods: Clinical data were collected from 42 elderly LOE patients, 17 with and 25 without chronic insomnia, as well as from 22 healthy controls (HCs) matched for age and sex. …”
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Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial by Xiong M, Liu Y, Liang Y, Wang H, Zhang L, Zhang Z, Fang M

“…This study compared the efficacy of OFA and OSA in managing postoperative pain and recovery after laparoscopic cholecystectomy (LC).Patients and Methods: A single-center, randomized controlled trial was conducted with 86 adults undergoing LC. …”
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Effectiveness of eHealth interventions for reducing mental health conditions in employees: A systematic review and meta-analysis. by Elizabeth Stratton, Amit Lampit, Isabella Choi, Rafael A Calvo, Samuel B Harvey, Nicholas Glozier

“…<h4>Background</h4>Many organisations promote eHealth applications as a feasible, low-cost method of addressing mental ill-health and stress amongst their employees. …”
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