A Prognostic Nutritional Index-Based Nomogram to Predict Breast Cancer Metastasis: A Retrospective Cohort Validation by Chen Z, Gao H, Cheng M, Song C

“…This study aims to explore the role of PNI in BC metastasis and develop a predictive nomogram model.Methods: A retrospective cohort of 311 BC patients was analyzed. …”
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Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study by Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

“…The greatest economic impact was on exacerbation of COPD in 2015, with an annual cost of €2,726,893 (which equals to US $2,864,628). ConclusionsCOPD exacerbations had the higher prevalence in the Madrid region among the respiratory diseases studied. …”
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Juvenile dermatomyositis in Oman: clinical patterns and disease trajectory from a National cohort by Reem Abdwani, Mahadev J. Mal, Eman Al Masroori, Ruqaiya Al Jashmi, Safiya Al Abrawi, Ibrahim Al-Zakwani

“…Results A total of 30 children diagnosed with JDM were included. They had an equal female to male distribution, 1:1 ratio. The median age at disease onset was 6.78 years (range: 2–13), with a median diagnostic delay of 8.4 months (range:1–23). …”
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Lysophosphatidylcholine 14:0 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Protecting Alveolar Epithelial Barrier by Activation of Nrf2/HO-1 Pathway by Liu X, Su S, Xia L, Lei X, Zou S, Zhou L, Yang R, Li K, Lin P, Li Y

“…Therefore, the effects of LPC14:0 on lung epithelial cells and the underlying mechanism on ALI were investigated.Methods: Lipopolysaccharide (LPS) was instilled intratracheally in vivo while the Murine Lung Epithelial-12 was stimulated by tert-butyl hydroperoxide (t-BHP) in vitro to induce the ALI model. …”
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Effectiveness of a Virtual Reality Serious Video Game (The Secret Trail of Moon) for Emotional Regulation in Children With Attention-Deficit/Hyperactivity Disorder: Randomized Clin... by Marina Martin-Moratinos, Marcos Bella-Fernández, María Rodrigo-Yanguas, Carlos González-Tardón, Chao Li, Ping Wang, Ana Royuela, Pilar Lopez-Garcia, Hilario Blasco-Fontecilla

“…ResultsA total of 76 patients with ADHD participated in the trial, with an equal randomization (MOON: n=38, 50% and control: n=38, 50%) and a total dropout rate of 7. …”
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Rheumatoid Arthritis Aggravates Disease Severity and the Risk of Postoperative Recurrence in Chronic Rhinosinusitis by Zhou X, Wang D, Cao S, Tu Y, Chen R, Huang H, Lou W

“…This study aimed to investigate the associations between RA and CRS disease severity, as well as postoperative recurrence risk.Methods: A retrospective analysis was conducted on CRS patients who underwent functional endoscopic sinus surgery. …”
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Fosfomycin susceptibility in multidrug resistant uropathogens: A retrospective study in the era of antimicrobial resistance by Jasleen Kaur, Priya Bhat, Upasana Bhumbla

“…Samples were processed immediately as per standard microbiological techniques, followed by culture by a semi-quantitative method. Kass criteria were followed for interpretation of significant bacteriuria according to which significant growth was considered if colony count was more than equal to 105 colony forming unit (CFU)/mL. …”
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Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn’s Disease: A Cross-Sectional Study by Sun S, Chen Y, Zheng M, Zhou M, Weng C, Fan Y, Lv B

“…Shaopeng Sun,* Yifei Chen,* Mingxu Zheng, Mi Zhou, Chunyan Weng, Yihong Fan, Bin Lv Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou, Zhejiang Province, 310003, People’s Republic of China, Email lvbin@medmail.com.cnObjective: This study aimed to investigate the potential benefits of physical activity (PA) on patient-reported outcomes (PROs) in individuals with Crohn’s disease (CD) and to examine whether these benefits are associated with gut microbiota.Methods: This cross-sectional study included 251 patients with CD from two inflammatory bowel disease centers in China. …”
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Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD by Hu S, Lai X, Shi Y, Chai H, Guo Z, Liu D, Cui C

“…This study aimed to investigate the relationship between SIRI and frailty in older patients with CVD, and to develop a nomogram for predicting the risk of frailty in this population.Methods: A total of 234 older patients with CVD were included. …”
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Role of hydrops MRI in differentiating between Menière’s disease and vestibular migraine: a prospective study by Anja Bernaerts, Morgana Sluydts, Vincent Liégeois, Catherine Blaivie, Floris L. Wuyts, Floris L. Wuyts, Joost van Dinther, Andrzej Zarowski, Filip Deckers, Bert De Foer

“…However, in the MD group, only two patients had normal CEH, one patient had normal VEH, and six patients demonstrated equal PLE in both ears. The logistic regression analysis using both VEH and CEH correctly predicted all cases of MD and VM, achieving 100% diagnostic accuracy for both conditions. …”
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Dosimetric comparison of the carotid arteries in patients of T1 and T2 N0 M0 carcinoma glottis by three-dimensional conformal radiotherapy versus carotid sparing intensity-modulate... by Sathya SB, Sathiyan K, Harish Karthick R, Vijayasree TN

“…Aims and Objectives: This study aimed to compare the dosimetric impact of three-dimensional conformal RT (3DCRT) and Cs-IMRT on carotid artery exposure in patients with T1 and T2 N0 M0 carcinoma of the glottis. Materials and Methods: This prospective comparative study included 30 patients equally divided into 3DCRT and Cs-IMRT treatment arms. …”
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Itraconazole Loaded Micelle Based on Methoxy Poly(Ethylene Glycol)-Poly(D, L-Lactic Acid) for Ocular Drug Delivery: In vitro and in vivo Evaluation by He J, Yang J, Liang Z, Zhang Z, Pu G, Dong F, Lu P, Xia H, Zhang J

“…Jijun He,* Jingjing Yang,* Zhen Liang, Zhen Zhang, Guojuan Pu, Fudan Dong, Ping Lu, Huiyun Xia, Junjie Zhang Henan Eye Hospital, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junjie Zhang, Email zhangjunjie@zzu.edu.cnPurpose: This study aimed to develop itraconazole (ITZ)-loaded polymer micelles using methoxy poly(ethylene glycol)-poly(D, L-lactic acid) (mPEG-PDLLA) as a carrier to improve the ocular bioavailability of ITZ after topical administration.Methods: ITZ-loaded mPEG-PDLLA micelles (ITZ-M) were prepared using the thin-film dispersion method and were characterized by droplet size (DS), zeta potential (ZP), polydispersity index (PDI), morphology, entrapment efficiency (EE%), and critical micelle concentration (CMC). …”
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Urinary Ferritin as an Early Indicator of Tubular Injury in Diabetic Kidney Disease: Insights from NHANES and Clinical Cohorts by Huang B, Ding X, Wen W, Ye S

“…Bin Huang,1,* Xiangyu Ding,2,* Wenjie Wen,3 Shandong Ye1 1Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2First Clinical Medical College, Anhui Medical University, Hefei, Anhui, 230001, People’s Republic of China; 3School of Stomatology, Wannan Medical College, Wuhu, Anhui, 241002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shandong Ye, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China, Email 981257013@qq.comObjective: To investigate the association between iron metabolism disorders and diabetic kidney disease (DKD) and to evaluate the potential of urinary ferritin as an early marker of tubular injury in diabetic patients.Methods: This study utilized data from 1,306 diabetic patients and 1,306 propensity score-matched non-diabetic controls from the NHANES (2017–March 2020) dataset. …”
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Factors Associated with Successful Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infections Using Intravenous Colistin Sulfate in China: A Real-World Retrospective Study by Gao W, Li W, Liu H, Xu D, Tian L, Zhang J, Liu D, He Y

“…Weixi Gao,1,2,* Wei Li,1,* Huali Liu,3,* Dong Xu,4 Lei Tian,5 Jinwen Zhang,1 Dong Liu,1 Yan He1 1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 3Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 4Department of Infection Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 5Clinical Microbiology Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan He, Email heyan_may@hotmail.com Jinwen Zhang, Email jinwen_zhang0308@126.comObjective: To evaluate the efficacy of intravenous colistin sulfate (CS) in the treatment of carbapenem-resistant Gram-negative bacilli (CR-GNB) infections in real-world clinical settings and to identify factors influencing its therapeutic outcomes, with the aim of promoting the rational use of CS.Methods: A retrospective analysis was conducted on the clinical characteristics and treatment outcomes of 174 patients diagnosed with CR-GNB infection who received intravenous CS at our center between January 2021 and December 2023. …”
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Preschool and Me: Educational-clinical linkage to improve health equity for children with developmental delays and disabilities from historically marginalized communities by Tina L. Schuh, Kathleen R. Diviak, Sarai Coba-Rodriguez, Emily Pela, Raphael Kinney, Michael L. Berbaum, Amanda Klemas, Kruti Acharya, Molly Martin, Reshma Shah

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Microcirculatory and functional changes in the retina and visual channels in multiple sclerosis by E. P. Lantukh, M. V. Zueva, I. V. Tsapenko, O. V. Zaitseva, M. N. Zakharova, N. M. Maglakelidze, T. O. Simaniv

“…Conclusion: Early changes of the retinal function were documented in patients with recent MS and ON history with almost equal involvement of the retinal ganglion cells of the parvo-, mango- and koniocellular systems into the pathological process. …”
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Combined Transcriptomic and Mendelian Randomisation Explores the Diagnostic Value of Ubiquitination-Related Genes in Sepsis by Bai X, Liu R, Tang Y, Yang L, Niu Z, Hu Y, Zhang L, Chen M

“…This study combined bioinformatics and Mendelian randomization (MR) analyses to identify ubiquitin-related genes (UbRGs) with unique roles in sepsis.Methods: Relevant genes were obtained from the GSE28750 dataset and GSE95233, weighted gene co-expression network analyses were performed to identify gene modules, and differentially expressed UBRGs (DE-UBRGs) were generated by differentially expressed genes (DEGs) crossover with key modular genes and UBRGs in sepsis and normal samples. …”
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Pharmaceutico Analytical and Clinical Evaluation of Modified Dosage Forms (Lepa guti) of Varun Twak Lepa and Krushnatiladi Lepa in Vyanga (Melasma): A Research Protocol for Randomi... by Pratiksha Mahure, Bharat Rathi

“…Aim: To conduct a pharmaceutical and analytical evaluation of modified dosage forms (Lepa guti) of Krushnatiladi Lepa and Varun Twak Lepa, as well as, to assess their clinical efficacy in managing Vyanga (melasma). Materials and Methods: A randomised double-blind, controlled clinical trial will be conducted Department of Rasa Shastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College and Research Centre (MGACH and RC), Salod (H), Wardha, Maharashtra, India, from August 2024 to August 2025. …”
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Comparison between sulcus-implanted three-piece hydrophobic intraocular lens and bagal-implanted single-piece intraocular lens in combined diabetic phacoemulsification and pars pla... by Mohsen Abou Shousha, Mohamed H. Said

“…The eyes were equally randomized according to the indication for surgery and the severity of the disease into two groups, group 1: phaco-vitrectomy with hydrophobic acrylic three-piece sulcus IOL (60 eyes of 35 patients) and group 2: phaco-vitrectomy with hydrophobic acrylic one-piece in the bag IOL (57 eyes of 38 patients). …”
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Serum miR-130a-3p and miR-326: Correlation with Airway Inflammation and Prognostic Implications in Pediatric Bronchial Asthma by Liu D, Liao F, Wang H

“…Danhong Liu,* Fanda Liao,* Hongbing Wang Department of Pediatrics, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing Wang, Department of Pediatrics, Suizhou Hospital, Hubei University of Medicine, No. 60 Long Men Street, Zengdu District, Suizhou, Hubei, 441300, People’s Republic of China, Email wanghongbingwhb@21cn.comObjective: To investigate the relationship between serum microRNA (miR)-130a-3p, miR-326 and airway inflammation in children suffering from bronchial asthma.Methods: A retrospective study was conducted on 122 children suffering from bronchial asthma. …”
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